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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 潘子明(Tzu-Ming Pan) | |
| dc.contributor.author | Si-Shi Lu | en |
| dc.contributor.author | 呂思詩 | zh_TW |
| dc.date.accessioned | 2021-05-16T16:18:28Z | - |
| dc.date.available | 2018-08-27 | |
| dc.date.available | 2021-05-16T16:18:28Z | - |
| dc.date.copyright | 2013-08-27 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-08-14 | |
| dc.identifier.citation | 陳彥霖。1999。紅麴與高血壓。科學與技術。32: 54-59。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5931 | - |
| dc.description.abstract | 本研究以過度糖化終產物 (advanced glycation end-products, AGEs) 建立糖尿病小鼠之動物模式，並同時以腹腔注射 monascin (MS) 和lovastatin (LOV)，評估MS和LOV能否改善胰島素阻抗和血糖調節機制。
研究結果顯示， AGE誘導能夠降低小鼠之胰島素敏感性和葡萄糖耐受性。MS 和LOV 能藉由提升胰島中胰島素的合成和抗氧化酵素的表現以降低AGE誘導產生之高血糖和胰島素阻抗之症狀。結果顯示AGE可能會導致小鼠胰臟β細胞功能障礙和氧化壓力從而產生胰島素抗性。 本研究發現與控制組相比AGE組有胰島素阻抗之現象，包括血糖上升，血清胰島素含量增加，而血清TG，TC 也分別上升。抗發炎方面，AGE組促發炎細胞激素TNF-α、IL-6和IL-1β表現量顯著提升，而MS和LOV處理後會有抑制促發炎細胞激素表現之效果。抗氧化方面，AGE組肝臟p47phox (NADPH oxidase subunit) 蛋白質表現顯著增加 (p < 0.05)，且超氧化物歧化酶 (superoxide dismutase, SOD)、觸酶 (catalase, CAT) 和麩胱甘肽 (glutathione, GSH) 皆顯著較控制組低。同時用MS和LOV處理後，肝臟p47phox蛋白質表現量受到抑制，抗氧化酵素SOD、CAT與GSH亦有上升的趨勢。 | zh_TW |
| dc.description.abstract | The aim of this study is to investigate the improvement of moanscin (MS) and lovastatin (LOV) on insulin resistance and the mechanism of MS and LOV for blood glucose regulation.
In this study we also provide evidence that advanced glycation end-products (AGEs) are able to affect insulin sensitivity and glucose tolerance in vivo. AGE also reduced expression of islet insulin. Together these results suggest that the AGEs pathway may play an important role in the loss of functional β-cell mass in diabetes, at least in part through the induction of oxidative stress and the alternation of β-cell differentiation and survival. We found that AGE induction significantly resulted in hyperglycemia in BALB/c mice, but MS and LOV effectively inhibited inflammation and hyperglycemia caused by AGE. MS and LOV inhibited TNF-α, IL-6, IL-1β expression in pancreases, liver and kidney. We also found that MS and LOV inhibited p47phox (NADPH subunit) expression in liver. Results demonstrated that MS and LOV elevated antioxidant enzyme: superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) in pancreases, liver and kidney. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-16T16:18:28Z (GMT). No. of bitstreams: 1 ntu-102-R00b22054-1.pdf: 3126882 bytes, checksum: cd64a52f2738c56d71d7bb6b20814cfa (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 縮寫表………………………………………………………………...VII
摘要.................................................... IX Abstract…………………………………………………………………………………..X 目錄………………………………………………………….... .... Ⅱ 圖目錄…………………………………………................... IV 表目錄………………………………………………………………....VI 第一章 前言………………………………………………………...1 第二章 文獻回顧……………………………….................3 一、糖尿病…………….......................................3 二、過度糖化最終產物…………………………...................4 三、胰島素訊息傳遞路徑…………………………………………....11 四、胰島素阻抗………………………………………..…..........15 五、核因子-紅血球之 2 相關因子-2 (nuclear factor-erythroid 2 related factor-2; Nrf2) 與糖尿病之關系..................16 六、抗氧化防禦系統……………………........................17 七、紅麴……………………..................................21 (一) 紅麴之菌種特性 ………………………………............21 (二) 紅麴生產之二級代謝產物 …………………..............22 (三) 紅麴對糖尿病之應用 ………………………………………..26 (四) 紅麴改善胰島素阻抗之可能機制 ………………………….28 八、研究大綱與目的………………………………………………....28 第三章 材料與方法……………………………….................31 一、實驗材料………………………………………................31 (一) 藥品試劑 …………………………………................31 (二) 儀器設備 ………………………………………………………31 (三) 其他 ………………………………………………………....32 (四) 溶液製備 …………………………………………………….32 二、實驗方法………………………………………………………….32 (一) 過度糖化最終產物製備 …………………………………….33 (二) 動物實驗 ………………………………….............….33 (三) 生物統計分析方法 …………………………………………40 第四章結果與討論………………………………………………………42 第一節Monascin 及 lovastatin 對 AGE 在肝臟中累積之影響…………………...42 第二節Monascin 和 lovastatin 對 AGE 誘導之小鼠胰島素抗性之影響…….......42 (一) 禁食血糖 ……………………………………………………………………...42 (二) 口服葡萄糖耐量實驗 (oral glucose tolerance test, OGTT) 及胰島素耐受實驗(insulin tolerance test, ITT)…………………………………………………….45 (三) 血清胰島素 …………………………………………………………………...48 (四) HOMA-IR 指數 ……………………………………………..........................50 第三節Monascin及lovastatin對胰島素蛋白質表現之影響…………………………53 (一) 胰島素蛋白質之表現 ……………………………………………...................53 (二) PDX-1 (pancreatic duodenal homeobox-1, PDX-1) mRNA表現 ………........ 53 (三) CCAAT enhancer binding protein β (C/EBPβ) 之表現 ……………............. ..56 (四) 第二型葡萄糖轉運蛋白 (glucose transporter 2; GLUT2) mRNA之表現…...60 第四節Monascin 及 lovastatin 對 AGE 誘導糖尿病小鼠脂質累積影響…….......62 (一) 血脂質………………………………………………………….………...….62 (二) 肝臟脂質…………………………………………………………….............64 第五節Monascin及lovastatin對AGE誘導糖尿病小鼠促發炎細胞激素之影響…...65 (一)胰臟促發炎細胞激素…………………………………………………………...65 (二)肝臟促發炎細胞激素………………………………………………..………….68 (三)腎臟促發炎細胞激素…………………………………………………………...72 第六節 Monascin 和 lovastatin 對 AGE 造成氧化壓力之影響…..........................74 (一) 肝臟p47phox (NADPH oxidase subunit) 之表現 …………………………...74 (二) 抗氧化酵素之表現 …………………………………………………...............78 (三) 肝臟及腎臟病理分析 ……………………………………………...................82 (四) 小結 ……………………………………………………………………...........90 第五章 綜合討論…………………………………………………...............................93 第六章 參考文獻……………………….......................................................................98 | |
| dc.language.iso | zh-TW | |
| dc.subject | 過度糖化終產物 | zh_TW |
| dc.subject | 抗氧化酵素 | zh_TW |
| dc.subject | 胰島素阻抗 | zh_TW |
| dc.subject | monascin | zh_TW |
| dc.subject | monascin | en |
| dc.subject | antioxidant enzymes | en |
| dc.subject | insulin resistance | en |
| dc.subject | advanced glycation end-products | en |
| dc.title | 探討紅麴二次代謝物monascin和lovastatin對過度糖化終產物誘導的第二型糖尿病小鼠之影響 | zh_TW |
| dc.title | The effects of monascin and lovastatin on type 2 diabetes in advanced glycation end-product (AGEs) induced mice | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蘇遠志(Yuan-Chi Su),曾慶瀛(Chin-Yin Tseng),方繼(Tony J Fang),謝淑貞(Shu-Chen Hsieh) | |
| dc.subject.keyword | monascin,過度糖化終產物,胰島素阻抗,抗氧化酵素, | zh_TW |
| dc.subject.keyword | monascin,advanced glycation end-products,insulin resistance,antioxidant enzymes, | en |
| dc.relation.page | 106 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2013-08-15 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| 顯示於系所單位： | 生化科技學系 | |
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