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  1. NTU Theses and Dissertations Repository
  2. 生物資源暨農學院
  3. 農藝學系
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59318
完整後設資料紀錄
DC 欄位值語言
dc.contributor.advisor劉仁沛(Jen-Pei liu)
dc.contributor.authorSsu-Ming Chenen
dc.contributor.author陳斯明zh_TW
dc.date.accessioned2021-06-16T09:20:21Z-
dc.date.available2022-07-20
dc.date.copyright2017-07-20
dc.date.issued2017
dc.date.submitted2017-07-03
dc.identifier.citationAltman, D. G., & Bland, J. M. (1995). Statistics notes: Absence of evidence is not evidence of absence. British Medical Journal, 311(7003), 485.

Anderson, T. W. (1984). An Introduction to Multivariate Statistical Analysis, 2nd Edition, New York, Wiley: 156-163.

Bai, Z., & Saranadasa, H. (1996). Effect of high dimension: by an example of a two sample problem. Statistica Sinica, 311-329.

Cai, T., Liu, W., & Luo, X. (2011). A constrained ℓ 1 minimization approach to sparse precision matrix estimation. Journal of American Statistical Association, 106(494), 594-607.

Cai T., Liu W., & Xia, Y. (2014). Two-sample test of high dimensional means under dependence. Journal of the Royal Statistical Society: Series B (Statistical Methodology), 76(2), 349-372.

Chen, S. X., & Qin, Y. L. (2010). A two sample test for high dimensional data with applications to gene-set testing. The Annals of Statistics, 808-835.

Chiu, C. H. (2016). A study on high-dimensional equivalence test of means. Unpublished Master Thesis, National Taiwan University.

Chow, S. C., & Liu, J. P. (2009). Statistical assessement of biosimilar products. Journal of Biopharmaceutical Statistics, 20(1), 10-30.

Dempster, A. P. (1958). A high dimensional two sample significance test. The Annals of Mathematical Statistics, 995-1010.

Fan, J., Han, F., & Liu, H. (2014). Challenges of big data analysis. National Science Review, 1(2), 293-314.

Febrero-Bande, M., & de la Fuente, M. O. (2012). Statistical computing in functional data analysis: The R package fda. usc. Journal of Statistical Software, 51(4), 1-28.

Food and Drug Administration. (2003). Guidance for Industry: bioavailability and bioequivalence studies for orally administrated drug products─general considerations. Food and Drug Administration, Washington, DC.

Gandomi, A., & Haider, M. (2015). Beyond the hype: big data concepts, methods, and analytics. International Journal of Information Management, 35(2), 137-144.

Gregory, K. B., Carroll, R. J., Baladandayuthapani, V., & Lahiri, S. N. (2015). A two-sample test for equality of means in high dimension. Journal of the American Statistical Association, 110(510), 837-849.

Hauck, W. W., & Anderson, S. (1984). A new statistical procedure for testing equivalence in two-group comparative bioavailability trials. Journal of Pharmacokinetics and Pharmacodynamics, 12(1), 83-91.

Parzen, E. (1961). Mathematical considerations in the estimation of spectra. Technometrics, 3(2), 167-190.

Politis, D. N., & Romano, J. P. (1995). Bias‐corrected nonparametric spectral estimation. Journal of Time Series Analysis, 16(1), 67-103.

Ruiz-Meana, M., Garcia-Dorado, D., Pina, P., Inserte, J., Agullo, L., & Soler-Soler, J. (2003). Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions. American Journal of Physiology-Heart and Circulatory Physiology, 285(3), H999-H1006.

Schuirmann, D. J. (1987). A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. Journal of Pharmacokinetics and Pharmacodynamics, 15(6), 657-680.

Simon, R. M. (2003). Design and Analysis of DNA Microarray Investigations. Springer Science & Business Media: 102-103.

Srivastava, M. S. (2007). Multivariate theory for analyzing high dimensional data. Journal of The Japan Statistical Society, 37(1), 53-86.

Srivastava, M. S. (2013). On testing the equality of mean vectors in high dimension. Acta et Commentationes Universitatis Tartuensis de Mathematica, 17(1), 31.

Walker, E., & Nowacki, A. S. (2011). Understanding equivalence and noninferiority testing. Journal of General Internal Medicine, 26(2), 192-196.
dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59318-
dc.description.abstract一般來說,我們使用Hotelling T2是為了檢定兩母體平均向量間是否存在顯著上的差異。然而在高維度的資料下,資料可能會出現變項個數遠遠超過於樣本數的狀況,這會導致Hotelling T2的值無法被算出來,其中的原因出在它的共變異數矩陣是不可逆。針對此問題,統計學家們紛紛提出各自的作法。由於過去提出的方法均是平均向量間差異的顯著性檢定,因此在這篇論文中,我們利用前人研究發展出兩個對等性檢定。
考量到有關高維度下對等性檢定的文獻相當稀少以及由Chiu (2016)提出的最大Z2檢定只看最大的變項差異。我們提出來的兩個檢定都有考慮到每一個變項的差異。第一個檢定是應用Gregory, et al. (2015)所提出來的方法把它應用在對等性的假設檢定,我們把它命名為廣義成分對等性檢定,由於該方法是只考慮到變項與變項間的距離大小,而未考慮差異的方向性。有鑑與此,我們提出第二個檢定也就是複合共變量對等性檢定。
在此篇論文裡,我們將提供在各種條件及組合下的模擬結果。另外我們也會針對提出來的方法做實際資料的分析。根據結果發現,複合共變量對等性檢定不但能有效的控制型一誤差,同時檢定力也相對比較高。
zh_TW
dc.description.abstractTraditionally, the Hotelling T2 test is applied to detect the difference in mean vectors between two populations. However for the high-dimensional data where the number of variables (p) is greater than the sample size (n), the inverse of the covariance matrix does not exist, and hence the Hotelling T2 statistic can not be calculated. Various methods were proposed to resolve this issue for the high-dimensional data. However these methods are to test the difference, not equivalence in mean vectors between two populations.
The literature on the average equivalence in high-dimensional data is scarce. Chiu (2016) first applied a supremum-based method by Cai, et. al. (2014) to high-dimensional average equivalence problem. However, Chiu’s method depends upon only the variable with the largest difference and ignore the information provided from the rest of other variables. In this thesis, we proposed two equivalence tests for high-dimensional data.
The first method, the General Component Equivalence Test (GCET) extended the procedure by Gregory (2015) to the high-dimensional average equivalence problem. Since the GCET is the average of squared t-statistics of p-variables, it ignores the directions of mean differences. To outcome this shortcoming, we further propose the Compound Covariate Equivalence Test (CCET).
Extensive simulation studies were conducted under various conditions to investigate the performance on the size and power of the two proposed methods. Simulation results reveal that the CCET not only control the size at the nominal level but also can provide sufficient power. A numerical example illustrates applications of the proposed methods.
en
dc.description.provenanceMade available in DSpace on 2021-06-16T09:20:21Z (GMT). No. of bitstreams: 1
ntu-106-R04621208-1.pdf: 6289382 bytes, checksum: 896da5d93f387459279bfc413ec1308c (MD5)
Previous issue date: 2017
en
dc.description.tableofcontents誌謝 ii
中文摘要 iii
Abstract iv
CONTENTS vi
LIST OF FIGURES vii
LIST OF TABLES xi
Chapter 1 Introduction 1
1.1 Background of Equivalence test and Big Data 1
1.2 Objectives 3
Chapter 2 Literature Review 6
2.1 Hypotheses for Difference Testing 6
2.2 High Dimension Approaches 8
Chapter 3 Proposed Methods 16
3.1 General Component Equivalence Test 16
3.2 Compound Covariate Equivalence Test 19
Chapter 4 Numerical Examples 23
Chapter 5 Simulation Studies 33
5.1 Empirical size 36
5.2 Empirical Power 38
Chapter 6 Discussion and Conclusion 144
References 156
Appendix A 159
Appendix B. R codes for Test Functions 160
Appendix C. R codes for Empirical Size 165
Appendix D. R codes for Empirical Power 169
dc.language.isoen
dc.subject複合共變量對等性檢定zh_TW
dc.subject高維度資料zh_TW
dc.subject平均對等性zh_TW
dc.subject廣義成分對等性檢定zh_TW
dc.subjectGeneral Component Equivalence Testen
dc.subjectHigh-dimensional dataen
dc.subjectAverage Equivalenceen
dc.subjectCompound Covariate Equivalence Test.en
dc.title應用廣義成分方法於高維度平均值對等性檢定zh_TW
dc.titleA Study on Applications of the Generalized Component Approach to the High-dimensional Equivalence Test of Meansen
dc.typeThesis
dc.date.schoolyear105-2
dc.description.degree碩士
dc.contributor.oralexamcommittee季瑋珠(Wei-Chu Chie),林志榮(Jr-Rung Lin)
dc.subject.keyword高維度資料,平均對等性,廣義成分對等性檢定,複合共變量對等性檢定,zh_TW
dc.subject.keywordHigh-dimensional data,Average Equivalence,General Component Equivalence Test,Compound Covariate Equivalence Test.,en
dc.relation.page172
dc.identifier.doi10.6342/NTU201701287
dc.rights.note有償授權
dc.date.accepted2017-07-03
dc.contributor.author-college生物資源暨農學院zh_TW
dc.contributor.author-dept農藝學研究所zh_TW
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