請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59168
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 孔繁璐(Fan-Lu Kung) | |
dc.contributor.author | Fei-Yang Tzou | en |
dc.contributor.author | 鄒飛洋 | zh_TW |
dc.date.accessioned | 2021-06-16T09:17:06Z | - |
dc.date.available | 2022-09-08 | |
dc.date.copyright | 2017-09-08 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-07-13 | |
dc.identifier.citation | 1. Fu, X., Mcgrath, S., Pasillas, M., Nakazawa S., and M.P. Kamps, EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1. Oncogene, 1999. 18: p. 4920-4929.
2. Xu, H. and M.D. Hebert, A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC Cell Biology, 2005. 6(23). 3. Jordan, B.A., Fernholz B.D., Khatri, L, E.B. Ziff, Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis. Nature neuroscience, 2007. 10(4): p. 427-435. 4. Tindi, J.O., Chávez A.E., Cvejic, S., Calvo-Ochoa, E., Castillo, P.E., Jordan, B.A. ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. The Journal of Neuroscience, 2015. 35(24): p. 8986-8996. 5. Ghersi, E., Noviello, C. and L. D'adamio, Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. The journal of biological chemistry, 2004. 279: p. 49105-49112. 6. Herberich, S.E., Klose, R., Moll, I., Yang, W.J., Wüstehube-Lausch, J. and A. Fischer, ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis. PLoS ONE, 2015. 10(12): p. e0145304. 7. Eckel-Passow, J.E., Serie, D.J., Bot, B.M., Joseph, R.W., Cheville, J.C., Parker, A.S., ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. BMC Urology, 2014. 14: p. 14-14. 8. Lee, B.H., Kim, J.H., Kim, J.M., Heo, S.H., Kang, M., Kim, G.H., Choi, J.H., Yoo, H.W., The early molecular processes underlying the neurological manifestations of an animal model of Wilson's disease. Metallomics, 2013. 5(5): p. 532-540. 9. Lin, J., Lu, C., Stewart, D.J., Gu, J., Huang, M., Chang, D.W., Lippman, S.M., Wu, X., Systematic evaluation of apoptotic pathway gene polymorphisms and lung cancer risk. Carcinogenesis, 2012. 33(9): p. 1699-1706. 10. McClay, J.L., Adkins, D.E., Åberg, K., Stroup, S., Perkins, D.O., Vladimirov, V.I., Lieberman, J.A., Sullivan, P.F., van den Oord, E.J.C.G., Genomewide Pharmacogenomic Analysis of Response to Treatment with Antipsychotics. Molecular psychiatry, 2011. 16(1): p. 76-85. 11. Lincoln, J., Coopersmith, R., Harris, E.W., Cotman, C.W., Leon, M., NMDA receptor activation and early olfactory learning. Brain Res, 1988. 467(2): p. 309-12. 12. Kleinschmidt, A., M. Bear, and W. Singer, Blockade of 'NMDA' receptors disrupts experience-dependent plasticity of kitten striate cortex. Science, 1987. 238(4825): p. 355-358. 13. Wigstrom, H. and B. Gustafsson, A possible correlate of the postsynaptic condition for long-lasting potentiation in the guinea pig hippocampus in vitro. Neurosci Lett, 1984. 44(3): p. 327-32. 14. Harris, E.W., A.H. Ganong, and C.W. Cotman, Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res, 1984. 323(1): p. 132-7. 15. Collingridge, G.L., S.J. Kehl, and H. McLennan, Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. The Journal of Physiology, 1983. 334(1): p. 33-46. 16. Bliss, T.V. and T. Lomo, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol, 1973. 232(2): p. 331-56. 17. Ikonomidou, C., et al., Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain. Science, 1999. 283(5398): p. 70-74. 18. Johnson, J.W. and P. Ascher, Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature, 1987. 325(6104): p. 529-31. 19. Kleckner, N.W. and R. Dingledine, Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science, 1988. 241(4867): p. 835-7. 20. Sather, W., Dieudonne, S., MacDonald, J.F., Ascher, P., Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones. J Physiol, 1992. 450: p. 643-72. 21. Schell, M.J., Brady, R.O., jr., Molliver, M.E., Snyder, S.H., D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J Neurosci, 1997. 17(5): p. 1604-15. 22. Berger, A.J., S. Dieudonne, and P. Ascher, Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J Neurophysiol, 1998. 80(6): p. 3336-40. 23. Mothet, J.-P., Parent, A.T., Wolosker, H., Brady, R.O., Linden, D.J., Ferris, C.D., Rogawski, M.A., Snyder, S.H., D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proceedings of the National Academy of Sciences, 2000. 97(9): p. 4926-4931. 24. Lester, R.A.J., Clements, J.D., Westbrook, G.L., Jahr, C.E., Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature, 1990. 346(6284): p. 565-567. 25. Forsythe, I.D. and G.L. Westbrook, Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones. J Physiol, 1988. 396: p. 515-33. 26. MacDermott, A.B., Mayer, M.L., Westbrook, G.L., Smith, S.J., Barker, J.L., NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature, 1986. 321(6069): p. 519-22. 27. Burnashev, N., et al., Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science, 1992. 257(5075): p. 1415-9. 28. Mayer, M.L., G.L. Westbrook, and P.B. Guthrie, Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature, 1984. 309(5965): p. 261-3. 29. Ascher, P. and L. Nowak, The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture. The Journal of Physiology, 1988. 399: p. 247-266. 30. Nowak, L., Bregestovski, P., Ascher, P., Herbet, A., Prochiantz, A., Magnesium gates glutamate-activated channels in mouse central neurones. Nature, 1984. 307(5950): p. 462-465. 31. Takai, H., Katayama, K,-I., Uetsuka, K., Nakayama, H., Doi, K., Distribution of N-methyl-d-aspartate receptors (NMDARs) in the developing rat brain. Experimental and Molecular Pathology, 2003. 75(1): p. 89-94. 32. Wenzel, A., Fritschy, J.M., Mohler, H., Benke, D., NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins. Journal of Neurochemistry, 1997. 68(2): p. 469-478. 33. Brothwell, S.L., Barber, J.L., Monaghan, D.T., Jane, D.E., Gibb, A.J., Jones, S., NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol, 2008. 586(3): p. 739-50. 34. Clarke, R.J. and J.W. Johnson, NMDA receptor NR2 subunit dependence of the slow component of magnesium unblock. Journal of Neuroscience, 2006. 26(21): p. 5825-5834. 35. Erreger, K., Dravid, S.M., Banke, T.G., Wyllie, D.JA., Traynelis, Stephen F., Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. The Journal of physiology, 2005. 563(2): p. 345-358. 36. Fayyazuddin, A., Villarroel, A., Le Goff, A., Lerma, J., Neyton, J., Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn 2+ binding to NMDA receptors. Neuron, 2000. 25(3): p. 683-694. 37. Furukawa, H., Singh, S.K., Mancusso, R., Gouaux, E., Subunit arrangement and function in NMDA receptors. Nature, 2005. 438(7065): p. 185-192. 38. Liu, Y., Wong, T.P., Aarts, M., Rooyakkers, A., Liu, L., Lia, T.W., Wu, D.C., Lu, J., Tymianski, M., Craig, A.M., NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. Journal of Neuroscience, 2007. 27(11): p. 2846-2857. 39. Soriano, F.X., Martel, M.-A., Papadia, S., Vaslin, A., Baxter, P., Richman, C., Forder, J., Tymianski, M., Duncan, R., Aarts, M., Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. Journal of Neuroscience, 2008. 28(42): p. 10696-10710. 40. Barria, A. and R. Malinow, Subunit-specific NMDA receptor trafficking to synapses. Neuron, 2002. 35(2): p. 345-353. 41. Tovar, K.R. and G.L. Westbrook, The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. Journal of Neuroscience, 1999. 19(10): p. 4180-4188. 42. Groc, L., Heine, M., Cousins, S.L., Stephenson, F.A., Lounis, B., Cognet, L., Choquet, D., NMDA receptor surface mobility depends on NR2A-2B subunits. Proceedings of the National Academy of Sciences of the United States of America, 2006. 103(49): p. 18769-18774. 43. Harris, A.Z. and D.L. Pettit, Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices. Journal of Physiology, 2007. 584(2): p. 509-519. 44. Petralia, R.S., Wang, Y.X., Hua, F., Yi, Z., Zhou, A., Ge, L., Stephenson, F.A., Wenthold, R.J., Organization of NMDA receptors at extrasynaptic locations. Neuroscience, 2010. 167(1): p. 68-87. 45. Luo, J., Wang, Y., Yasuda, R.P., Dunah, A.W., Wolfe, B.B., The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Molecular Pharmacology, 1997. 51(1): p. 79-86. 46. Sheng, M., Cummings, J., Roldan, L.A., Jan, Y.N., Jan, L.Y., Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature, 1994. 368(6467): p. 144-147. 47. Cousins, S.L., W. Dai, and F.A. Stephenson, APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression. Journal of Neurochemistry, 2015. 133(6): p. 879-885. 48. Dosemeci, A., Toy, D., Reese, T.S., Tao-Cheng, J.-H., AIDA-1 Moves out of the Postsynaptic Density Core under Excitatory Conditions. PLoS ONE, 2015. 10(9): p. e0137216. 49. Dosemeci, A., Toy, D., Burch, A., Bayer, K.U., Tao-Cheng, J.-H., CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core. FEBS Letters, 2016. 590(17): p. 2934-2939. 50. Hardy, J.A. and G.A. Higgins, Alzheimer's disease: The amyloid cascade hypothesis. Science, 1992. 256(5054): p. 184-185. 51. Young-Pearse, T.L., Chen, A.C., Chang, R., Marquez, C., Selkoe, D.J., Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev, 2008. 3: p. 15. 52. Kimberly, W.T., Zheng, J.B., Guenette, S.Y., Selkoe, D.J., The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem, 2001. 276(43): p. 40288-92. 53. Sabo, S.L., Ikin, A.F., Buxbaum, J.D., Greengard, P., The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. The Journal of cell biology, 2001. 153(7): p. 1403-1414. 54. Multhaup, G., Schlickupp, A., Hesse, L., Beher, Dirk., Ruppert, T., Master, C.L., Beyreuther, K., The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I). Science, 1996. 271(5254): p. 1406-1409. 55. Grimm, M.O., Grimm, H.S., Pätzold A.J., Zinser, E.G., Halonen, R., Duering, M., Tschäpe, J.-A., De Strooper, B., Müller, U., Shen, J., Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin. Nature cell biology, 2005. 7(11): p. 1118-1123. 56. Tyan, S.-H., Shih, A.Y.-J., Walsh, J.J., Murayama, H., Sarosoza, F., Ku, L., Eggert, S., Hof, P.R., Koo, E.H., Dickstein, D.L., Amyloid precursor protein (APP) regulates synaptic structure and function. Molecular and cellular neurosciences, 2012. 51(1-2): p. 43-52. 57. Fanutza, T., Del Prete, D., Ford, M.J., Castillo, P.E., D'Adamio, L., APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses. eLife, 2015. 4: p. e09743. 58. Taylor, C.J., Ireland, D.R., Ballagh, I., Bourne, K., Marechal, N.M., Turner, P.R., Bilkey, D.K., Tate, Warren P., Abraham, W.C., Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of Disease, 2008. 31(2): p. 250-260. 59. Gu, Z., W. Liu, and Z. Yan, β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca(2+)/Calmodulin-dependent Protein Kinase II Synaptic Distribution. The Journal of Biological Chemistry, 2009. 284(16): p. 10639-10649. 60. Nikolaev, A., McLaughlin, T., O'Leary, D.D., Tessier-Lavigne, M., APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature, 2009. 457(7232): p. 981-9. 61. Enrico ghersi, P.V., Peter Lopez, Mona Abdallah and Luciano D'Adamio, The intracellular localization of amyloid beta precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing. Jounal of Alzheimer's Disease, 2004. 6: p. 67-78. 62. Karim Bordji, J.B.-O., Oliver Nicole, and Alain Buisson, Activation of extrasynaptic, but not synaptic NMDA receptors modifies amyloid precusor protein expression pattern and increases amyloid-beta production. Neurobiology of Disease, 2010. 30(47): p. 15927-15942. 63. Sarah E. Hoey, R.J.W., and Michael S. Perkinton, Synaptic NMDA receptor activation sitmulates alpha-secretase amyloid precusor protein processing and inhibits amyloid-beta production. Neurobiology of Disease, 2009. 29(14): p. 4442-4460. 64. Lee, M.-C., Ting, K.K., Adams, S., Brew, B.J., Chung, R., Guillemin, G.J. Characterisation of the Expression of NMDA Receptors in Human Astrocytes. PLOS ONE, 2010. 5(11): p. e14123. 65. Zhou, X., Moon, C., Zheng, F., Luo, Y., Soeliner, D., Nuñez, J.L., Wang, H., NMDA-stimulated ERK1/2 Signaling and the Transcriptional Up-regulation of Plasticity-related Genes are Developmentally Regulated following in vitro Neuronal Maturation. Journal of neuroscience research, 2009. 87(12): p. 2632-2644. 66. Weber M., L.U.G., Muller K., The human SH-SY5Y cell line does not express functional ionotropic glutamate receptors - a patch clamp study. 2010. 67. Trayneilis, S.F., Hartley, M., Heinemann, S.F., Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science, 1995. 268(5212): p.873-876 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/59168 | - |
dc.description.abstract | N-methyl-D-aspartate receptor (NMDAR) 是很重要的神經受器,它參與了許多神經的功能,例如神經突觸的可塑性、神經分化、學習,與記憶等功能。NMDA受器在結構、位置,以及功能上的多樣性,造就了它大量與複雜的訊息傳遞。NMDA受器的訊息傳遞相關的作用因子,在神經突觸後的位置聚集、彼此合作以完成相關的神經活動,或進一步將訊息傳遞下去。而其中一個作用因子,是蛋白質ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B)。ANKS1B是後突觸質密區的骨架蛋白,在NMDA受器的活化之下,ANKS1B發生轉位入核的活動,並藉此調控了細胞整體的蛋白合成。相對於NMDAR對ANKS1B的影響,研究也發現ANKS1B參與了NMDAR次單位的運輸。此外,ANKS1B又稱作amyloid precursor protein Intracellular Domain Associated protein 1 (AIDA-1),取名自它與amyloid precursor protein intracellular domain (AICD)之間的交互作用,然而此交互作用的重要性尚無人探討。在此研究當中,試圖找出AICD和ANKS1B之間的交互作用,與NMDA受器訊息傳遞的相關性。本研究在SH-SY5Y神經瘤細胞株中,表現野生型 (wild-type) 或突變後失去與AICD交互作用的ANKS1B蛋白,並活化NMDA受器,觀察其在細胞核、質之間的活動;此外,本研究觀察表現野生型或突變後失去與AICD交互作用的ANKS1B,對於NMDA受器次單元的mRNA的表現量有何影響。初步的結果顯示,當ANKS1B失去與AICD的交互作用時,在細胞核內的表現量會上升。另一方面,在SH-SY5Y細胞中大量表現ANKS1B對NMDA受器的基因轉錄並沒有顯著的影響。 | zh_TW |
dc.description.abstract | N-methyl-D-aspartate (NMDA) receptors are crucial for many neuronal functions, and the structural, local, and functional diversities of NMDARs contributes to its tremendous signaling pathways. At post-synapse, effectors of NMDAR signaling gather and coordinate with each other, regulating specific cellular processes and/or passing up the signaling cascades. One of the effectors of NMDAR is ANKS1B, a scaffold protein of post-synaptic density (PSD), which translocates into nucleus upon NMDAR stimulation and regulates protein synthesis. Besides being a downstream effector of NMDAR signaling, ANKS1B was found to control the transport of NMDAR subunits. On the other hand, ANKS1B interacts with intracellular domain of amyloid precursor protein (AICD), yet the physiological significance of this partnership remain unknown. Here, we wanted to identify the role of ANKS1B-AICD interaction in specific NMDAR signaling. We observed the nuclear localization of overexpressed wild-type or mutant ANKS1B without AICD interaction upon NMDAR stimulation in SH-SY5Y cells. In addition, we evaluate the effect of overexpressing wildtype or mutant ANKS1B on the expression profiles of NMDAR subunits. Preliminary results showed that the interaction between AICD and ANKS1B might regulate the nuclear localization of ANKS1B; moreover, overexpression of ANKS1B had no significant effect on transcription profile of NMDA receptor subunits. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T09:17:06Z (GMT). No. of bitstreams: 1 ntu-106-R03423011-1.pdf: 2075107 bytes, checksum: 03bdafcd7110b979c73d03287b235f52 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 口試委員審定書--------------------------------------------------------------------- i
致謝----------------------------------------------------------------------------------- ii Table of Contents------------------------------------------------------------------ iii 中文摘要----------------------------------------------------------------------------- 1 Abstract------------------------------------------------------------------------------ 2 Abbreviation------------------------------------------------------------------------ 3 Introduction------------------------------------------------------------------------- 5 Objective----------------------------------------------------------------------------- 13 Materials and Methods----------------------------------------------------------- 14 Results-------------------------------------------------------------------------------- 22 Discussion---------------------------------------------------------------------------- 27 Figures-------------------------------------------------------------------------------- 31 References---------------------------------------------------------------------------- 50 | |
dc.language.iso | en | |
dc.title | ANKS1B與APP之間的交互作用與NMDA受器訊息傳遞之相關性研究 | zh_TW |
dc.title | Correlation study of NMDA receptor signaling and the interaction between ANKS1B and APP | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 許麗卿,忻凌偉 | |
dc.subject.keyword | NMDA受器,ANKS1B,阿茲海默氏症, | zh_TW |
dc.subject.keyword | NMDA receptor,ANKS1B,APP,AICD, | en |
dc.relation.page | 61 | |
dc.identifier.doi | 10.6342/NTU201600152 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-07-13 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 藥學研究所 | zh_TW |
顯示於系所單位: | 藥學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-106-1.pdf 目前未授權公開取用 | 2.03 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。