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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蕭寧馨(Ning - Sing Shaw) | |
| dc.contributor.author | Pin - Chu Chen | en |
| dc.contributor.author | 陳品竹 | zh_TW |
| dc.date.accessioned | 2021-06-16T08:30:21Z | - |
| dc.date.available | 2014-01-27 | |
| dc.date.copyright | 2014-01-27 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-12-28 | |
| dc.identifier.citation | 1 Food and Nutrition Board Institute of Medicine. in Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc Ch. 8, 258 - 289 (National Academy Press, 2001).
2 International Council for the Control of Iodine Deficiency Disorders. The need for iodine - more detail, <http://www.iccidd.org/p142000340.html> (2013). 3 Patrick, L. Iodine: deficiency and therapeutic considerations. Alternative medicine review : a journal of clinical therapeutic 13, 116 - 127 (2008). 4 Lewis E. Braverman, D. S. C. in Werner & Ingbar's the thyroid : a fundamental and clinical text Ch. 4, 32-73 (Wolters Kluwer/Lippincott Williams & Wilkins Health, 2013). 5 Paulev, P.-E. in New Human Physiology Ch. 28, (Copenhagen Medical Publishers, 1999). 6 Fisher, D. A. & Oddie, T. H. Thyroid iodine content and turnover in euthyroid subjects: validity of estimation of thyroid iodine accumulation from short-term clearance studies. Journal of Clinical Endocrinology & Metabolism 29, 721-727 (1969). 7 Nath, S., Moinier, B., Thuillier, F., Rongier, M. & Desjeux, J. Urinary excretion of iodide and fluoride from supplemented food grade salt. International journal for vitamin and nutrition research. 62, 66 (1992). 8 蕭寧馨, 鄧錦泉 & 劉奕方. in 國人膳食營養素參考攝取量及其說明 591 - 608 (行政院衛生署食品藥物管理局, 2012). 9 Glinoer, D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine reviews 18, 133 -152 (2004). 10 黃博超 & 游素玲. in 營養學精要 Ch. 20, 458 -461 (健康文化事業股份有限公司, 2005). 11 Hetzel, B. Iodine deficiency disorders (IDD) and their eradication. The Lancet 322, 1126 - 1129 (1983). 12 International Council for the Control of Iodine Deficiency Disorders. The adverse effects of iodine deficiency, <http://www.iccidd.org/p142000263.html> (2013). 13 Lammi-Keefe, C. J., Couch, S. C. & Philipson, E. H. Handbook of nutrition and pregnancy. 13 (Springer, 2008). 14 Bleichrodt, N. & Born, M. P. A meta-analysis of research on iodine and its relationship to cognitive development. The damaged brain of iodine deficiency, New York : Cognizant Communication, 195-200 (1994). 15 Hetzel, B. S. & Smith, R. M. in Fetal brain disorders : recent approaches to the problem of mental deficiency Ch. 5, 119 - 148 (Elsevier/North-Holland Biomedical Press, 1981). 16 Delange, F., Burgi, H., Chen, Z. P. & Dunn, J. T. World status of monitoring iodine deficiency disorders control programs. Thyroid : official journal of the American Thyroid Association 12, 915-924, doi:10.1089/105072502761016557 (2002). 17 Hetzel, B. S. & Pandav, C. S. SOS for a billion: the conquest of iodine deficiency disorders. (Oxford University Press, 1994). 18 Jooste, P. L. & Strydom, E. Methods for determination of iodine in urine and salt. Best Practice & Research Clinical Endocrinology & Metabolism 24, 77 - 88 (2010). 19 World Health Organization, United Nations Children's Fund & International Council for the Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. (2007). 20 Garry, P. J., Lashley, D. W. & Owen, G. M. Automated measurement of urinary iodine. Clinical chemistry 19, 950-953 (1973). 21 World Health Organization. Indicators for assessing iodine deficiency disorders and their control through salt iodization. (1996). 22 Zimmermann, M. B. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. The American journal of clinical nutrition 89, 668S-672S, doi:10.3945/ajcn.2008.26811C (2009). 23 Mattsson, S. & Lindstrom, S. Diuresis and voiding pattern in healthy schoolchildren. British journal of urology 76, 783-789 (1995). 24 Larsson, G. & Victor, A. Micturition patterns in a healthy female population, studied with a frequency/volume chart. Scandinavian journal of urology and nephrology. Supplementum 114, 53 - 57 (1988). 25 Hetzel, B. S. The story of iodine deficiency: an international challenge in nutrition. (1989). 26 Gutekunst, R. et al. Goitre epidemiology: thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden. Acta endocrinologica 112, 494-501 (1986). 27 Benmiloud, M. et al. Oral iodized oil for correcting iodine deficiency: optimal dosing and outcome indicator selection. Journal of Clinical Endocrinology & Metabolism 79, 20-24 (1994). 28 Merson, M. H., Black, R. E. & Mills, A. J. in Global health : diseases, programs, systems, and policies Ch. 6, 289 - 294 (Jones & Bartlett Learning, 2012). 29 Zimmermann, M. B. Iodine deficiency. Endocrine reviews 30, 376-408, doi:10.1210/er.2009-0011 (2009). 30 Office of Dietary Supplements. Dietary Supplement Fact Sheet : Iodine. (2011). <http://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/#h1>. 31 Zimmermann, M. B., Ito, Y., Hess, S. Y., Fujieda, K. & Molinari, L. High thyroid volume in children with excess dietary iodine intakes. The American journal of clinical nutrition 81, 840-844 (2005). 32 Albert, A. & KEATING, F. R. Metabolic studies with I131 labeled thyroid compounds: distribution and excretion of radiodiiodotyrosine in human beings. The Journal of Clinical Endocrinology 11, 996-1011 (1951). 33 Vought, R. & London, W. Iodine intake, excretion and thyroidal accumulation in healthy subjects. Journal of Clinical Endocrinology & Metabolism 27, 913-919 (1967). 34 Hays, M. T. Localization of human thyroxine absorption. Thyroid : official journal of the American Thyroid Association 1, 241-248 (1991). 35 Pinchera, A., MacGillivray, M. H., Crawford, J. D. & Freeman, A. G. Thyroid refractoriness in an athyreotic cretin fed soybean formula. New England Journal of Medicine 273, 83-87 (1965). 36 Shepard, T. H., Pyne, G. E., Kirschvink, J. F. & McLean, M. Soybean goiter: report of three cases. New England Journal of Medicine 262, 1099-1103 (1960). 37 Gaitan, E. Environmental Goitrogenesis. (CRC Press, 1989). 38 Gaitan, E. Goitrogens in food and water. Annual review of nutrition 10, 21-37 (1990). 39 Zimmermann, M. B., Jooste, P. L. & Pandav, C. S. Iodine-deficiency disorders. The Lancet 372, 1251-1262 (2008). 40 Elnour, A., Hambraeus, L., Eltom, M., Dramaix, M. & Bourdoux, P. Endemic goiter with iodine sufficiency: a possible role for the consumption of pearl millet in the etiology of endemic goiter. The American journal of clinical nutrition 71, 59-66 (2000). 41 Perron, B., Rodriguez, A. M., Leblanc, G. & Pourcher, T. Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. The Journal of endocrinology 170, 185-196 (2001). 42 Laurberg, P., Nohr, S. B., Pedersen, K. M. & Fuglsang, E. Iodine nutrition in breast-fed infants is impaired by maternal smoking. The Journal of clinical endocrinology and metabolism 89, 181-187 (2004). 43 Zimmermann, M., Adou, P., Torresani, T., Zeder, C. & Hurrell, R. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Cote d'Ivoire. The American journal of clinical nutrition 71, 88-93 (2000). 44 Zimmermann, M. B. et al. Addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous, iron-deficient children: a randomized, double-blind, controlled trial. European journal of endocrinology 147, 747-753 (2002). 45 Zimmermann, M. B., Wegmuller, R., Zeder, C., Chaouki, N. & Torresani, T. The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children. The Journal of clinical endocrinology and metabolism 89, 5441-5447, doi:10.1210/jc.2004-0862 (2004). 46 Mason, J. in Second report on the world nutrition situation. Volume 1: global and regional results Ch. 3, 76 - 78 (1992). 47 World Health Organization. Global prevalence of iodine deficiency disorders. (1993). 48 The United Nations Children's Fund. Plan of Action for Implementing the World Declaration on the Survival, Protection and Development of Children in the 1990s, <http://www.unicef.org/wsc/plan.htm> ( 49 蔡叔翹. 鹽，生命賴以繼之, <http://www.reocities.com/Augusta/9885/lifesalt.html> ( 50 De Benoist, B., McLean, E., Andersson, M. & Rogers, L. Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull 29, 195-202 (2008). 51 台塩. 鹽業史誌, <http://cigu.tybio.com.tw/history/01a_history.jsp> ( 52 Chen, K., Lin, C.-C., Wu, H.-Y., Wu, T.-H. & SUN, C.-T. Pilot project on endemic goiter prevention with iodized salt in Hsinchu County, Taiwan, China. Memoirs Coll Med Nat Taiwan Univ 10, 73-92 (1964). 53 國史館臺灣文獻館電子報. 日核災搶碘風潮看臺鹽「加碘鹽」檔案, <http://www.th.gov.tw/epaper/view2.php?ID=80&AID=1104> (2011). 54 Chen, K. P. et al. Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. Journal of the Formosan Medical Association 75, 471-482 (1976). 55 張天鈞. 臺灣地方性甲狀腺腫的回顧與前瞻. 中華民國內科醫學雜誌, 51-56 (2000). 56 K, K. & Y, H. Distribution of endemic goiter of aborigine in Taiwan. J Formos Med Assoc 43, 374-386 (1944). 57 蕭寧馨. 市售鹽品碘含量監測暨健康風險評估(研究計畫編號：DOH101 - FDA - 31410). (行政院衛生署食品藥物管理局, 2012). 58 李宛臻. 孕婦孕程之生化營養狀況追蹤. 國立臺灣大學生命科學院生化科技學系碩士論文 (2011). 59 Vogel, A. I. & Jeffery, G. H. in Vogel's textbook of quantitative chemical analysis Ch. 10, 384 - 400 (Longman Scientific & Technical. Wiley, 1989). 60 East, Central and Southern African Health Community. Manual of laboratory methods for fortified foods. 5 - 9 (2007). 61 Merck. The Merck index : an encyclopedia of chemicals, drugs, and biologicals. 14 edn, (Inc. Whitehouse Station, NJ, 2006). 62 行政院衛生署食品藥物管理局. 食品化學檢驗方法之確效規範. (2011). 63 Gonzalez, C., Farina, J. & Figueroa, L. A critical assessment of a viscometric assay for measuring Saccharomycopsis fibuligera α-amylase activity on gelatinised cassava starch. Enzyme and microbial technology 30, 169 - 175 (2002). 64 Xiao, Z., Storms, R. & Tsang, A. A quantitative starch–iodine method for measuring alpha-amylase and glucoamylase activities. Analytical biochemistry 351, 146-148 (2006). 65 Ensuring the Quality of Urinary Iodine Procedures & Centers for Disease Control and Prevention. EQUIP booklet - The challenge of iodine deficiency disorder 39 - 51 (2011). 66 Štolc, V. Optimal conditions for the catalytic action of iodine in the Sandell-Kolthoff reaction. Microchimica Acta 49, 710-720 (1961). 67 Zhang, W., Mnatsakanov, A., Hower, R., Cantor, H. & Wang, Y. Urinary iodine assays and ionophore based potentiometric iodide sensors. Frontiers in Bioscience 10, 88-93 (2005). 68 Ohashi, T., Yamaki, M., Pandav, C. S., Karmarkar, M. G. & Irie, M. Simple microplate method for determination of urinary iodine. Clinical chemistry 46, 529-536 (2000). | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58775 | - |
| dc.description.abstract | 甲狀腺腫曾列臺灣十大最常見疾病，食鹽加碘後成功降低罹病率。然臺灣於
2002 年加入 WTO，於 2004 年廢止鹽政條例，許多廠商由國外進口天然鹽品， 民國 93 - 97 年國人尿碘中位數降至臨界值。缺碘導致甲狀腺腫，更造成胎兒智 能低下，此時評估碘營養狀況指標更顯重要，因此本研究建立鹽碘與尿碘檢驗 法，應用於調查鹽品供碘狀況與癌存者碘營養狀況。 市場調查發現進口鹽傾向天然無添加，國產鹽強調有複合礦物質。83 項鹽 品中僅 7 項加碘，平均碘含量約為 13 ppm，檢測值與標示相符。檢測方法為 iodometric titration，回收率標準為 100 ± 15%、精密度為 < 5%，結果碘酸鉀強 化鹽之 CV 與回收率皆符合；未加碘鹽回收率範圍為 -11–120%；CV 範圍由 0–69%，是因為濃度過低導致；碘化鉀強化鹽 CV 為 4%，回收率 < 79%，表 示此部分檢驗方法建立不佳。結果岩鹽之碘酸鉀皆低於偵測極限；海鹽含約 0.5 ppm 碘。 尿碘檢驗方法是Ammonium persulfate digestion on microplate method (APDM) 法，選用 Quality control (QC)、精密度與回收率做為判斷標準，QC 進 行 12 天的檢驗後，訂定後續檢驗 QC 落於 mean ± 1 SD 為佳，回收率與精密 度依照濃度區分，< 100 ug / L 者 CV 需 < 10%，回收率為 100 ± 15%，>100 ug / L 者則各標準皆減少 5%。三項標準皆達到，才可作為該受試者尿碘檢驗結 果。收尿採用86 位癌存者尿碘之隨機尿液，部分受試者捐尿時不斷喝水幫助排 尿，因此範圍為 7.5 ~ > 143384 ug / L，中位數為 156.5 ug / L，屬於正常範圍。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-16T08:30:21Z (GMT). No. of bitstreams: 1 ntu-102-R00b22040-1.pdf: 4648118 bytes, checksum: cf196371e2dfc298174b67bcf48f6526 (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 謝誌 III
中文摘要 V 英文摘要 VI 縮寫對照表 VIII 總目錄 IX 碩士委員會審定書 II IX 圖目錄 XIV 表目錄 XV 前言 1 第一章 文獻回顧 2 第一節 碘之重要性與營養需求 2 一、 碘之生理功能 2 1. 碘之吸收 3 2. 碘之功能：合成甲狀腺荷爾蒙 4 3. 碘之排除 5 二、 碘需要量 6 三、 碘缺乏症 7 四、 碘營養指標 10 1. 尿碘濃度 (urinary iodine concentration) 10 2. 甲狀腺體積 (thyroid size) 11 3. 血清促甲狀腺素濃度(serum thyroid stimulating hormone concentration)、甲狀腺素與三碘甲狀腺素濃度(T4 and T3 concentration) 12 4. 血清甲狀腺球蛋白濃度 (serum thyroglobulin concentration) 12 五、 影響碘營養狀況之因子 13 1. 食物來源 13 2. 生體可用率 14 3. 致甲狀腺腫物 (goitrogens) 14 第二節 世界碘史 16 一、 世界加碘鹽沿革 16 二、 臺灣加碘鹽沿革 18 三、 國人碘營養狀況 19 第三節 研究目的 20 第二章 市售鹽品供碘狀況之分析調查 21 第一節 材料與試劑 22 一、 實驗器材 22 二、 藥品與試劑 22 三、 試劑配製 23 第二節 實驗方法 25 一、 市售鹽品調查 25 二、 碘酸鉀強化鹽含碘量檢測 26 1. 標定硫代硫酸鈉 27 2. 標準曲線、偵測極限與碘化鉀特性試驗 29 3. 樣品檢驗 33 4. 確效驗證 34 三、 碘化鉀強化鹽含碘量檢測 35 1. 標定硫代硫酸鈉 36 2. 標準曲線 36 3. 樣品檢驗 37 4. 確效驗證 37 第三節 結果 38 一、 市售鹽品調查 38 二、 碘酸鉀強化鹽含碘量檢測 39 1. 標準曲線 39 2. 偵測極限 39 3. 碘化鉀特性試驗 40 4. 碘酸鉀強化鹽含碘量檢驗 40 三、 碘化鉀強化鹽含碘量檢測 42 第四節 討論 43 一、 市售鹽品調查 43 二、 碘酸鉀強化鹽含碘量檢測 43 三、 碘化鉀強化鹽含碘量檢測 45 第三章 尿碘檢驗法 60 第一節 研究對象與材料 61 一、 尿碘研究設計 61 二、 研究場域及檢體來源 62 三、 實驗儀器 63 四、 藥品與試劑 63 五、 試劑配製 64 第二節 實驗方法 65 一、 Quality control (QC) 65 1. QC 收集 65 2. 同質性分析 (Homogeneity testing) 65 3. QC 範圍 65 二、 方法確效 66 1. 標準曲線 66 2. 精密度 (Precision) 66 3. 回收率 (Recovery) 66 4. 準確度 (Accuracy and quality assurance) 66 5. 偵測極限 (limit of detection, LOD) 67 三、 尿碘檢驗 67 1. 以 8 x 12 PCR (ABI) 檢驗 68 2. 以 7 x 5 PCR (biometra) 檢驗 70 第三節 結果 72 一、 QC 72 1. 同質性分析 72 2. QC 範圍 72 二、 實驗方法與結果確效 72 1. 標準曲線 72 2. 精密度 72 3. 回收率 73 4. 準確度 73 5. 檢體檢驗 74 第四節 討論 74 一、 QC 74 1. 同質性分析 74 2. QC 範圍 75 二、 回收率 75 三、 準確度 75 四、 檢體檢驗結果 76 第四章 結論 84 第五章 參考文獻 85 附錄一. 強化碘鹽含碘量轉換表 90 附錄二. 市售鹽品詳細資料表 91 附錄三.受訪者知情同意書 118 附錄四. 人體試驗委員會研究計畫通過函 121 附錄五. EQUIP 報告書 122 | |
| dc.language.iso | zh-TW | |
| dc.subject | 碘缺乏症 | zh_TW |
| dc.subject | 尿碘 | zh_TW |
| dc.subject | 鹽碘 | zh_TW |
| dc.subject | Iodized salt | en |
| dc.subject | Urinary iodine | en |
| dc.subject | Iodine deficiency disorders (IDD) | en |
| dc.title | 鹽碘與尿碘檢驗方法之調查與應用 | zh_TW |
| dc.title | Application of Methods to Survey Iodine Content in Salt and Urine | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 孫寶年(Bao-nian Sun),龔瑞林(Zwe-Ling Kong) | |
| dc.subject.keyword | 鹽碘,尿碘,碘缺乏症, | zh_TW |
| dc.subject.keyword | Iodized salt,Urinary iodine,Iodine deficiency disorders (IDD), | en |
| dc.relation.page | 122 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-12-30 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| 顯示於系所單位： | 生化科技學系 | |
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