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標題: | 龍葵葉片95%酒精萃取物之抗氧化能力及抗醣化作用分析 Antioxidation and antiglycation of 95% ethanolic extracts prepared from the leaves of Solanum nigrum |
作者: | Tsung-Han Hou 侯宗翰 |
指導教授: | 張祖亮(Tsu-Liang Chang) |
關鍵字: | 最終醣化蛋白,抗氧化活性,龍葵,抗醣化作用,抗糖尿病, advanced glycation end-products (AGEs),antioxidative activity,Solanum nigrum,antiglycation,anti-diabetes, |
出版年 : | 2013 |
學位: | 碩士 |
摘要: | 最終醣化蛋白(advanced glycation end-products, AGEs)的形成,導致發炎反應的發生與胰島素抗性(insulin resistance)的產生。有證據顯示抗氧化劑可以抑制活性氧(reactive oxygen species, ROS)的形成,經由抑制糖基化(glycation)減少醣化終產物的生成。龍葵(Solanum nigrum)可以作為改善血糖的藥用食物,然而其活性成分與作用機轉仍然不清楚。本研究結果顯示,龍葵95%乙醇萃取物的抗氧化活性高於龍葵50%乙醇萃取物和龍葵水萃取物。此外,龍葵95%乙醇萃取物具有抑制糖基化的活性,可以抑制果糖胺(fructosamine)與α-二羰基化合物(α-dicarbonylcompiund)的生成。在每毫克龍葵95%乙醇萃取物中,solasonine與solamargine的量分別為0.484毫克和0.183毫克。基於上述,龍葵具備當作萃取抗糖基化和抗糖尿病活性成分的潛力。 Solanum nigrum are recently not only considered to be the brand-new source of functional ingredients that exerts antiglycation and anti-diabetes activities but also to be kind of medicinal food for improving blood glucose. However, there are only few identities of the active compounds and how those above-mentioned compounds counteract diabetes are still unknown. To induces insulin resistance occurs in an inflammatory response that requires the hyperglycemia results in the formation of advanced glycation end-products (AGEs). Evidence indicates that antioxidants can suppress the formation of reactive oxygen species, decrease levels of AGEs by inhibiting glycation. In this research demonstrates that 95% ethanolic extracts of Solanum nigrum exerted significant antioxidative activity compared with 50% ethanolic extracts and aqueous extracts. Moreover, 95% ethanolic extracts of S. nigrum produced antiglycative activity, which contributed to the inhibition of fructosamine and generation of α-dicarbonyl compounds. The results indicate that 95% ethanolic extracts of S. nigrum are with great bioactivities on antiglycation and anti-diabetes. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58633 |
全文授權: | 有償授權 |
顯示於系所單位: | 園藝暨景觀學系 |
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