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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳秀男(Shiu-Nan Chen) | |
dc.contributor.author | Yu-Sheng Wu | en |
dc.contributor.author | 吳育昇 | zh_TW |
dc.date.accessioned | 2021-06-16T08:05:08Z | - |
dc.date.available | 2017-08-11 | |
dc.date.copyright | 2014-08-11 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-06-26 | |
dc.identifier.citation | 1. Tacke F, Luedde T, Trautwein C: Inflammatory pathways in liver homeostasis and liver injury. Clin Rev Allergy Immunol 2009, 36(1):4-12.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/58051 | - |
dc.description.abstract | 活性氧反應中產生之過氧化氫具有吸引肝臟駐留巨噬細胞,活化其吞噬能力的功能性存在。研究結果顯示,發炎性反應導致肝臟細胞產生大量活性氧物質,並誘導肝臟駐留巨噬細胞遷移至發炎區域且活化巨噬細胞進行清除外來物質的功能。
NAPDH Oxidase受到抑制後,組織、細胞進行傷害試驗,結果指出,組織、細胞無法有效進行活性氧物質反應,將導致組織、細胞的修復功能被抑制。本論文指出,活性氧物質具有'訊息者'的角色,生物體受到內在或外來刺激時,大量產生的活性氧物質不僅針對清除外來病原菌,亦具有活化週遭免疫細胞,如:駐留巨噬細胞,血液單核球/巨噬細胞,並且誘導受傷區塊的組織、細胞進行修復等功能。 | zh_TW |
dc.description.abstract | After the injury or wound, the series of physiological response was initiated that induce the early stage of immune response moreover the late stage of wound repair process. In the series responses, inflammation is a very important role of the physiological reaction that including inflammation materials such as ROS, RNS, inflammatory substances and anti-inflammatory substances, etc., for the modulation of injury response and to avoid the invasion of pathogenic organisms . In the end stage of the inflammation reaction, the injured cell or tissue are supposed to be in the process of wound repair to recover and remodel the function and status of injured tissue. Reactive oxygen species (ROS) may act as signaling molecules in the physiology responses and the present study aims to investigate the effect of extracellular hydrogen peroxide on macrophages cellular response. The results obtained in the present study showed that the extracellular hydrogen peroxide affectively alter the membrane potential of the cell membrane and ion exchange channels in the cell membrane through intracellular NAD turnover that may lead to an intracellular calcium ion concentration alteration and subsequently induce the downstream signal activation, furthermore to realize the role of NADPH generation ROS involved in the tissue repair. We consider that from the wound to the healing process, the physiology point key to linkage of the process is still unclear. The process from inflammation to the wound healing is divided into three phase: 1. inflammation process, 2. tissue formation, and 3. tissue remodeling. The inflammation program including cell produced related factors and immune cells infiltration. We thought the inflammation factors that may be also involved in the followed healing process. But the question is “what kind of factor is the major key involved in the end of the inflammation then to initiate the healing”. We suspect that the apoptosis of immune cell may be the major key to end of inflammation and to initiate the healing. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T08:05:08Z (GMT). No. of bitstreams: 1 ntu-103-D97b45004-1.pdf: 6798118 bytes, checksum: ac637f0d08692fea74378ab46b917579 (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | Directory
Acknowledgements 摘要……………………………………………………………………………………...1 Abstract..............................................................................................................................2 Directory............................................................................................................................3 Arms of Study and Highlights……………………………………………………….......7 General Introduction……………………………………………………………………..8 CHAPTER 1. Review of the Literature …......................................................................10 1.1 Wound Healing and Inflammation…………………………………………….……10 1.2 Inflammation Process……………………………………………………………....12 1.3 Mediators of Inflammation………………………………………………………....13 1.4 Immune cell- Wound healing……………………………………………………….15 1.5 Apoptotic cell-Wound healing…………………………………………………...…17 CHAPTER 2. General Materials and Methods Materials and Methods ………….……19 Effect of Hydrogen Peroxide on Macrophage Cellular Response………………….19 2.1 Animal 2.2 Examination of Extracellular Hydrogen Peroxide in the Macrophages 2.2-1 Cell Culture of Macrophages 2.2-2 Effect of Hydrogen Peroxide on Cell Viability 2.2-3 Effect of Hydrogen Peroxide on Macrophages Migration 2.2-4 Effect of Hydrogen Peroxide on Phagocytosis of Macrophages 2.2-5 Immunohistochemistry of Tilapia Liver Morphology 2.2-6 Effect of Reduced ROS Production by DPI in Liver Observation 2.2-7 Cell Calcium Flux 2.2-8 NAD Turnover 2.2-9 Membrane Potential Measurement 2.2-10 Calpain Activity Assay in Living Cells Inhibition of NADPH Oxidase in the Wound Healing……………………………...25 2.2-11 Examination of ROS role in the Wound Healing 2.2-12 Partial Hepatectomy of Tilapia 2.2-13 Effect of Hydrogen Peroxide on Tilapia Hepatocyte 2.2-14 Brd-U ELISA Examination of Tilapia Hepatocyte 2.2-15 Immunohistochemistry of Tilapia Liver 2.2-16 Measurement of ALT and AST after Partial Hepatectomy 2.2-17 Statistical Analysis CHAPTER 3. Results......................................................................................................29 3.1 Tilapia Liver Resident Macrophage 3.2 Effect of Hydrogen Peroxide on Tilapia Macrophages --- In Vitro Test 3.3 Histological Observation on Reduction of ROS production by DPI in Liver 3.4 Oxidative Stress Induce Intracellular Calcium Influx, NAD Turnover, Calpain Activity and Membrane Potential 3.5 Effect of Hydrogen Peroxide on Cellular Proliferation --- In Vitro Test 3.6 Histological Observation of Liver Morphology CHAPTER 4. Discussion................................................................................................43 CHAPTER 5. Summary and Conclusions………………………………………….......49 CHAPTER 6. References................................................................................................50 | |
dc.language.iso | en | |
dc.title | 活性氧物質對吳郭魚肝臟駐留巨噬細胞與組織修復之影響 | zh_TW |
dc.title | The Effect of Reactive Oxygen Species on the Tilapia Liver Resident Macrophage and Tissue Repair | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 李國誥(Kuo-Kau Lee),劉秉忠(Ping-Chung Liu),黃世鈴(Shih-Ling Huang),冉繁華(Fan-Hua Nan) | |
dc.subject.keyword | 巨噬細胞,活性氧物質,發炎,修復,細胞生理, | zh_TW |
dc.subject.keyword | Macrophage,Reactive Oxygen Species,Inflammation,Repair,Cellular physiology, | en |
dc.relation.page | 99 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2014-06-26 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
顯示於系所單位: | 漁業科學研究所 |
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