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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/57466Full metadata record
| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 張麗冠 | |
| dc.contributor.author | Hsiao-Chein Huang | en |
| dc.contributor.author | 黃筱茜 | zh_TW |
| dc.date.accessioned | 2021-06-16T06:47:19Z | - |
| dc.date.available | 2019-08-13 | |
| dc.date.copyright | 2014-08-13 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-07-25 | |
| dc.identifier.citation | Abaitua F, O'Hare P (2008) Identification of a highly conserved, functional nuclear localization signal within the N-terminal region of herpes simplex virus type 1 VP1-2 tegument protein. J Virol 82: 5234-5244
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/57466 | - |
| dc.description.abstract | Epstein-Barr virus (EB病毒) 屬於人類皰疹病毒科，與上皮細胞及淋巴的惡性腫瘤與鼻咽癌有密切關係，其生活史包含了潛伏期和溶裂期，病毒感染細胞後以潛伏期的情況在細胞中，當受到特定因子刺激後，會誘導病毒進入溶裂循環。在溶裂循環時期，病毒會開始複製其遺傳物質及病毒蛋白質，而病毒蛋白質依照表現的先後順序可以分為極早期蛋白質、早期蛋白質及晚期蛋白質，並且透過這些蛋白質包裹遺傳物質，組裝形成病毒顆粒。泛素化修飾在病毒的複製及感染中扮演重要的角色，而許多的病毒蛋白質都可以被泛素修飾，甚至是身為泛素化修飾中酵素的一員，而本篇研究中的BSLF1為EB病毒的複製蛋白質且已被報導具有去泛素化 (deubiquitinase, DUB) 的活性。本研究利用純化出的BSLF1抗體，發現細胞被誘導進入溶裂期後十二到四十八小時BSLF1都有表現，並以免疫螢光染色觀察其在細胞中的分佈。接著利用In vitro DUB assay確認BSLF1具有去泛素化的活性。然後以共免疫沉澱分析發現BSLF1會與EB病毒的外鞘蛋白BFRF3及BORF1有交互作用，並且以GST pulldown assay發現BSLF1與BFRF3有直接的交互作用，且可以讓BFRF3的蛋白質較穩定，顯示BSLF1可以將BFRF3去泛素化，不會被送到proteasome降解。最後，設計了一系列的BSLF1截切突變株，發現所有突變株都可以與BFRF3結合，但只有BSLF1-N710還具有去泛素化的活性，而N540及N640則否，因此推論BSLF1的第640到710胺基酸對於去泛素活性是重要的。以上結果顯示，具有去泛素化活性的BSLF1可以藉由與外鞘蛋白BFRF3的交互作用，使得BFRF3被去泛素化而趨於穩定，因為外鞘蛋白質的穩定性提高，可能使得EB病毒顆粒釋出的量也隨之增加。 | zh_TW |
| dc.description.abstract | Epstein-Barr virus (EBV) is a human herpesvirus that infects up to 90% population and causes malignancies such as Burkitt’s lymphoma, nasopharyngeal carcinoma, and lymphoproliferative diseases. This virus contains two distinct life cycles, and is usually maintained under latent conditions after infection, and turns to the lytic phase after lytic induction. During the lytic phase, the virus encodes immediate-early, early, and late genes to produce virus particles. BSLF1 encodes a primase, which is required for lytic DNA replication. Previous study showed that BSLF1 contains deubiquitinase (DUB) activity. In this study, we aim to find the effects of BSLF1 on capsid proteins of EBV. This study finds that BSLF1 is expressed at 24 hrs after lytic induction. In vitro DUB assay revealed that BSLF1 contains DUB activity. Moreover, immunoprecipitation indicated that BSLF1 interacts with two EBV capsid proteins, BFRF3 and BORF1. Futhermore, GST pulldown assay shows that BSLF1 interacts with BFRF3 directly. BSLF1 overexpression reduces the levels of ubiquitinated BFRF3 and BORF1, thereby increasing the stability of BFRF3. Deletion analysis of BSLF1 showed that the region between amino acid 640 and 710 is important to the DUB activity on BFRF3. Taken together, BSLF1 plays a critical role on stabilizing the capsid proteins. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T06:47:19Z (GMT). No. of bitstreams: 1 ntu-103-R01b22037-1.pdf: 2754584 bytes, checksum: 9260d914b1e2abba8d10572a5e79ab3d (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 目錄
致謝 i 中文摘要 ii Abstract iii 目錄 v 圖表目錄 vii 附錄目錄 viii 壹、前言 1 一、EB病毒的發現 1 二、EB病毒的致病性 1 三、EB病毒的結構 2 四、EB病毒的生活史 3 五、皰疹病毒的外鞘殼體 5 六、泛素化修飾與去泛素化修飾 8 七、病毒與宿主泛素化系統的交互作用 10 貳、研究目的 15 參、材料與方法 16 一、細胞株 (cell line) 及EB病毒的溶裂期誘導 16 二、質體與抗體 16 三、質體DNA萃取 16 四、細胞轉染 (cell transfecction) 17 五、大腸桿菌轉型作用 (transformation) 17 六、蛋白質的誘導表現 17 七、GST融合蛋白質 (Glutathione S-transferase fusion proteins) 的表現與純化 18 八、抗原親和性層析純化抗體 (Antibody purification with antigen affinity chromatography) 18 九、胞外去泛素化酵素活性分析 (in vitro deubiquitination assay) 19 十、GST pull-down分析 (Glutathione S-transferase pull-down assay) 19 十一、免疫沉澱分析 (Immunoprecipitation) 20 十二、變性免疫沉澱分析 (Denatre immunoprecipitation) 20 十三、免疫螢光染色分析 (Immunofluorescence analysis) 21 十四、西方點墨法分析 (Wesatern blot analysis) 21 十五、SDS-PAGE膠體蛋白質染色分析 22 肆、結果 23 一、抗BSLF1抗體的純化 23 二、以抗BSLF1抗體偵測BSLF1蛋白質 24 三、BSLF1在EB病毒溶裂期的表現與在細胞內的分佈位置 24 四、BSLF1與EB病毒外鞘蛋白質在細胞內的結合 25 五、BSLF1與BFRF3在細胞體外的直接結合 26 六、BSLF1會將BFRF3和BORF1去泛素化 26 七、BSLF1的刪除突變株與BFRF3的結合關係 29 八、BSLF1的刪除突變株對於BFRF3去泛素化的影響 29 九、BSLF1對於BFRF3穩定性的影響 30 伍、討論 31 BSLF1於P3HR1及B95.8細胞溶裂期的表現時間點及分佈位置 31 BSLF1與BFRF3及BORF1外鞘蛋白質的結合 33 BSLF1降低BFRF3及BORF1外鞘蛋白質的泛素化程度 33 BSLF1能使BFRF3的穩定性增加 35 陸、圖表 36 柒、附錄 59 捌、參考文獻 67 | |
| dc.language.iso | zh-TW | |
| dc.title | EB病毒的BSLF1蛋白質對於外鞘蛋白質的影響 | zh_TW |
| dc.title | Effects of BSLF1 on capsid proteins of Epstein-Barr virus | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 劉世東,張沛鈞,莊健盈,張世宗 | |
| dc.subject.keyword | EB病毒,BSLF1,去泛素化,deubiquitinase,外鞘蛋白質,BFRF3,BORF1, | zh_TW |
| dc.subject.keyword | Epstein-Barr Virus (EBV),BSLF1,deubiquitinase (DUB),capsid proteins,BFRF3,BORF1, | en |
| dc.relation.page | 82 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-07-25 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| Appears in Collections: | 生化科技學系 | |
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