Please use this identifier to cite or link to this item:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/57202Full metadata record
| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 王金和(Ching-Ho Wang) | |
| dc.contributor.author | Ting-Hsiang Hsiao | en |
| dc.contributor.author | 蕭庭翔 | zh_TW |
| dc.date.accessioned | 2021-06-16T06:37:43Z | - |
| dc.date.available | 2016-08-01 | |
| dc.date.copyright | 2014-08-01 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-07-31 | |
| dc.identifier.citation | 林佳瑤。2008。由台灣鵝分離鑑定家禽網狀內皮增生症病毒與序列分析。國立台灣大學獸醫學研究所碩士論文。pp. 1-103。
鄭宛芯。2005。台灣家禽網狀內皮症病毒分離鑑定與序列分析。國立台灣大學獸醫學研究所碩士論文。pp. 1-103。 陳秋麟及謝快樂。1987。台灣鵝的網狀內皮增殖病及其病原性研究。台灣省畜牧獸醫學會會報。49:1-19。 吳乃慧。2009。家禽網狀內皮增生症病毒酵素連結免疫吸附法診斷試劑之開發。國立台灣大學獸醫學研究所碩士論文。pp. 1-146。 Acharya, A. and Gopinathan, K. P. 2001. Indentification of an enhancer-like element in the polyhedron gene upstream region of Bombyx mori nucleopolyhedrovirus. J Gen Virol. 82:2811-9. Allen, P. T., Mullins, J. A., Harris, C. L., Hellman, A., Garry, R. F. and Waite, M. R. F. 1979. Replication of reticuloendotheliosis virus in mammalian cells (abstract). Amer Soc Microbiol Annual Meeting. 100:256. Aly, M. M., Smith, E. J. and Fadly, A. M. 1993. Detection of reticuloendotheliosis virus infection using the polymerase chain reaction. Avian Pathol. 22:543-54. Anderson, J. 1984. Use of monoclonal antibody in a blocking ELISA to detect group specific antibodies to bluetongue virus. J Immunol Methods. 74:139-49. Aulisio, C. G. and Shelokov, A. 1969. Prevalence of reticuloendotheliosis in chickens: immunofluorescence studies. Proc Soc Exp Biol Med. 130:178-81. Awad, A. M., Abd El-Hamid, H. S., Abou Rawash, A. A. and Ibrahim, H. H. 2010. Detection of reticuloendotheliosis virus as a contaminant of fowl pox vaccines. Poult Sci. 89:2389-95. Ban, J., First, N. L. and Temin, H. M. 1989. Bovine leukemia virus packaging cell line for retrovirus-mediated gene transfer. J Gen Virol. 70:1987-93. Bagust, T. J. and Grimes, T. M. 1979. Experimental infection of chickens with an Australian strain of reticuloendotheliosis virus 2. serological responses and pathogenesis. Avian Pathol. 8:375-89. Bagust, T. J., Grimes, T. M. and Ratnamohan, N. 1981. Experimental infection of chickens with an Australian strain of reticuloendotheliosis virus 3. persistent infection and transmission by the adult hen. Avian Pathol. 10:375-85. Barbacid, M., Hunter, E. and Aaronson, S. A. 1979. Avian reticuloendotheliosis viruses: evolutionary linkages with mammalian type C retroviruses. J Virol. 30:508-14. Barbosa, T., Zavala, G., Cheng, S. and Villegas, P. 2007a. Full genome sequence and some biological properties of reticuloendotheliosis virus strain APC-566 isolated from endangered Attwater’s prairie chickens. Virus Res. 124:68-77. Barbosa, T., Zavala, G., Cheng, S. and Villegas, P. 2007b. Pathogenicity and transmission of reticuloendotheliosis virus isolated from endangered prairie chickens. Avian Dis. 51:33-9. Baxter-Gabbard, K. L., Campbell, W. F., Padgett, F., Raitano-Fenton, A. and Levin, A. S. 1971. Avian reticuloendotheliosis virus (strain T). II. Biochemical and biophysical properties. Avian Dis. 15:850-62. Beemon, K. L., Faras, A. J., Hasse, A. T., Duesberg, P. H. and Maisel, J. E. 1976. Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna virus. J Virol. 17:525-37. Bendheim, U. 1973. A neoplastic disease in turkeys following fowl pox vaccination. Refu Vet. 30:35-41. Blank, V., Kourilsky, P. and Israel, A. 1992. NF-κB and related protein: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem Sci. 17:135-40. Bohls, R. L., Linares, J. A., Gross, S. L., Ferro, P. J., Silvy, N. J. and Collisson, E. W. 2006. Phylogenetic analyses indicate little variation among reticuloendotheliosis viruses infecting avian species, including the endangered Attwater’s prairie chicken. Virus Res. 119:187-94. Bose, H. R., Jr. 1992. The Rel family: models for transcriptional regulation and oncogenic transformation. Biochim Biophys Acta. 1114:1-17. Bose, H. R., Jr. and Levine, A. S. 1967. Replication of the reticuloendotheliosis virus (strain T) in chicken embryo cell culture. J Virol. 1:1117-21. Calvert, J. G. and Nazerian, K. 1994. An immunoperoxidase plaque assay for reticuloendotheliosis virus and its application to a sensitive serum neutralization assay. Avian Dis. 38:165-71. Campbell, W. F., Baxter-Gabbard, K. L. and Levine, A. S. 1971. Aivan reticuloendotheliosis virus (strain T). I. Virological characterization. Avian Dis. 15:837-49. Chen, I. S., Mark, T. W., O’Rear, J. J. and Temin, H. M. 1981. Characterization of reticuloendotheliosis virus strain T DNA and isolation of a novel variant of reticuloendotheliosis virus strain T by molecular cloning. J Virol. 40:800-11. Chen P. Y., Cui, Z., Lee, L. F. and Witter, R. L. 1987. Serologic differences among nondefective reticuloendotheliosis viruses. Arch Virol. 93:233-45. Cheng, W. H., Huang, Y. P. and Wang, C. H. 2006. Serological and virological surveys of reticuloendotheliosis in chickens in Taiwan. J Vet Med Sci. 68:1315-20. Choi, J. G., Kim, M. C., Kang, H. M., Kim, K. I., Lee, K. J., Park, C. K., Kwon, J. H., Kim, J. H. and Lee, Y. J. 2013. Protective efficacy of baculovirus-derived influenza virus-like particles bearing H5 HA alone or in combination with M1 in chickens. Vet Microbiol. 162:623-30. Crespo, R., Woolcock, P. R., Fadly, A. M., Hall, C. and Shivaprasad, H. L. 2002. Characterization of T-cell lymphomas associated with an outbreak of reticuloendotheliosis in turkeys. Avian Pathol. 31:355-61. Crowther, J. R. 1995. ELISA theory and practice. Humana Press, Totowa, New Jersey, USA. Crowther, J. R. 2001. The ELISA Guidebook. Humana Press Inc, Totowa, New Jersey. Cui, Z. Z., Lee, L. F., Silva, R. F. and Witter, R. L. 1986. Monoclonal antibodies against avian reticuloendotheliosis virus: identification of strain-specific and strain-common epitopes. J Immunol. 136:4237-42. Cui, Z. Z., Lee, L. F., Smith, E. F., Witter, R. L. and Chang, T. S. 1988. Monoclonal-antibody-mediated enzyme-linked immunosorbent assay for detection of reticuloendotheliosis viruses. Avian Dis. 32:32-40. Davidson, I. and Braveman, Y. 2005. Insect contribution to horizontal transmission of Reticuloendotheliosis virus. J Med Entomol. 42:128-33. Davidson, I. and Malkinson, M. 1996. A non-radioactive method for identifying enzyme-amplified products of the reticuloendotheliosis provirus env and LTR genes using psoralen-biotin labeled probes. J Virol Methods. 59:113-9. Davidson, I. and Malkinson, M. 1997. Epidemiology and control of Reticuloendotheliosis virus in chickens and turkeys in Isael. In: Fadly, A. M., Schat, K. A. and Spencer, J. L. (Eds), Diagnosis and control of neoplastic diseases of poultry, American Association of Avian Pathologists: Kennett Square, PA, pp. 70-75. Davidson, I., Shkoda, I. and Perk, S. 2008. Integration of the reticuloendotheliosis virus envelope gene into the poultry fowlpox virus genome is not universal. J Gen Virol. 89:2456-60. Davidson, I., Tang, H., Witter, R. L. and Malkinson, M. 1996. The immunodominant proteins of reticuloendotheliosis virus. Vet Microbiol. 49:273-84. Deng, X., Qi, X., Gao, Y., Wang, Y., Qin, L., Gao, H., Gao, L. and Wang, X. 2010. Development of a loop-mediated isothermal amplification method for rapid detection of reticuloendotheliosis virus. J Virol Methods. 168:82-6. Dren, C. N., Nemeth, I., Gyorvari, I. and Horvath, P. 1988a. Isolation and characterization of reticuloendotheliosis virus from turkeys. Acta Vet Hung. 36:265-82. Dren, C. N., Nemeth, I., Sari, I., Ratz, F., Glavits, R. and Somogyi, P. 1988b. Isolation of a reticuloendotheliosis-like virus from naturally occurring lymphoreticular tumors of domestic goose. Avian Pathol. 17:259-77. Dren, C. N., Saghy, E., Glavits, R., Ratz, F., Ping, J. and Sztojkov, V. 1983. Lymphoreticular tumor in pen-raised pheasants associated with a reticuloendotheliosis like virus infection. Avian Pathol. 12:55-71. Embretson, J. E. and Temin, H. M. 1986. Pseudotyped retroviral vectors reveal restrictions to reticuloendotheliosis virus replication in rat cells. J Virol. 60:662-8. Embretson, J. E. and Temin, H. M. 1987. Transcription from a spleen necrosis virus 5’ long terminal repeat is suppressed in mouse cells. J Virol. 61:3454-62. Engelhard, E. K., Kam-Morgan, L. N., Washburn, J. O. and Volkman, L. E. 1994. The insect tracheal system: a conduit for the systemic spread of Autographa californica M nuclear polyhedrosis virus. Proc Natl Acad Sci U S A. 91:3224-7. Fadly, A. M. and Nair, V. 2008. Leukosis/Sarcoma Group. In: Saif, Y. M., Fadly, A. M., Glisson, J. R., Mcdougald, L. R. and Swayne, D. E. (Eds), Diseases of poultry, 12th ed, Blackwell Publishing Ltd, Ames, Iowa, USA, pp. 514-68. Fadly, A. M. and Witter, R. L. 1997. Comparative evaluation of in vitro and in vivo assays for the detection of reticuloendotheliosis virus as a contaminant in a live vaccine of poultry. Avian Dis. 41:695–701. Fadly, A. M., Witter, R. L., Smith, E. J., Silva, R. F., Reed, W. M., Hoerr, F. J. and Putman, M. R. 1996. An outbreak of lymphomas in commercial broiler breeder chickens vaccinated with a fowlpox vaccine contaminated with reticuloendotheliosis virus. Avian Pathol. 25:35–47. Fadly, A. M. Zavala, G. and Witter, R. L. 2008. Reticuloendotheliosis. In: Saif, Y. M., Fadly, A. M., Glisson, J. R., Mcdougald, L. R. and Swayne, D. E. (Eds), Diseases of poultry, 12th ed, Blackwell Publishing Ltd, Ames, Iowa, USA, pp. 568-88. Flipsen, J. T., Martens, J. W., van Oers, M. M., Vlak, J. M. and van Lent, J. W. 1995. Passage of Autographa californica nuclear polyhedrosis virus through the midgut epithelium of Spodoptera exigua larvae. Virology. 208:328-35. Garcia, M., Narang, N., Reed, W. M. and Fadly, A. M. 2003. Molecular characterization of reticuloendotheliosis virus insertions in the genome of field and vaccine strains of fowl poxvirus. Avian Dis. 47:343-54. Gautier, R., Jiang, A., Rousseau, V., Dornburg, R. and Jaffredo, T. 2000. Avian reticuloendotheliosis virus strain A and spleen necrosis do not infect human cells. J Virol. 74:518-22. Glocker, B., Hoopes, R. R. Jr. and Rohrmann, G. F. 1992. In vitro transactivation of baculovirus early genes by nuclear extracts from Autographa californica nuclear polyhedrosis virus-infected Spodoptera frugiperda cells. J Virol. 66:3476-84. Goff, S. P. 2001. Retroviridae: The Retroviruses and their replication. In: Knipe, D. M., Howley, P. M., Griffin, D. E., Lamb, R. A., Martin, M. A., Roizman, B. and Straus, S. E. (Eds), Fields Virology, 4th ed, Philadelphia, PA, pp. 1871-1940. Granados, R. R., Derksen, A. C. and Dwyer, K. G. 1986. Replication of the Trichoplusia ni granulosis and nuclear polyhedrosis viruses in cell cultures. Virology. 152:472-6. Grimes, T. M. and Purchase, H. G. 1973. Reticuloendotheliosisin a duck. Aust Vet J. 49:466-71. Harlow, E. and Lane, D. 1988. Antibodies: a laboratory manual. Cold spring harbor labatory, New York, USA. Hauck, R., Prusas, C., Hafez, H. M. and Luschow, D. 2009. Serologic response against fowl poxvirus and reticuloendotheliosis virus after experimental and natural infections of chickens with fowl poxvirus. Avian Dis. 53:205-10. Hertig, C., Coupar, B. E., Gould, A. R. and Boyle, D. B. 1997. Field and vaccine strains of fowlpox virus carry integrated sequences from the avian retrovirus, reticuloendotheliosis virus. Virology. 235:367–76. Himly, M., Foster, D. N., Bottoli, I., Iacovoni, J. S. and Vogt, P. K. 1998. The DF-1 chicken fibroblast cell line: transformation induced by diverse oncogenes and cell death resulting from infection by avian leukosis viruses. Virology. 248:295-304. Hoelzer, J. D., Franklin, R. B. and Bose, H. R. 1979. Transformation by reticuloendotheliosis virus: development of a focus assay and isolation of a nontransforming virus. Virology. 93:20-30. Ianconescu, M. 1977. Reticuloendotheliosis antigen for the agar gel precipitation test. Avian Pathol. 6:259-67. Imperiali, B. and O'Connor, S. E. 1999. Effect of N-linked glycosylation on glycopeptide and glycoprotein structure. Curr Opin Chem Biol. 3:643-9. Isfort, R., Witter, R. L. and Kung, H. J. 1987. C-myc activation in an unusual retrovirus-induced avian T-lymphoma resembling Marek’s disease: proviral insert 5’ of exon one enhances the expression of an intron promoter. Oncogene Res. 2:81-94. Jackson, C. A., Dunn, S. E., Smith, D. I., Gilchrist, P. T. and Mcqueen, P. A. 1977. Proventriculitis “Nakanuko” and reticuloendotheliosis in chickens following vaccination with herpesvirus of turkeys (HVT). Aust Vet J. 53:457–9. Jeang, K.T., Holmgren-Konig, M. and Khoury, G. 1987. A baculovirus vector can express intron-containing genes. J Virol. 61:1761-4. Kang, C. Y. 1975. Characterization of endogenous RNA-directed DNA polymerase activity of reticuloendotheliosis viruses. J Virol. 16:880-6. Keshet, E. and Temin, H. M. 1979. Cell killing by spleen necrosis virus is correlated with a transient accumulation of spleen necrosis virus DNA. J Virol. 31:376-88. Kewalramani, V. N., Panganiban, A. T. and Emerman, M. 1992. Spleen necrosis virus, an avian immunosuppressive retrovirus, shares a receptor with the type D simian retroviruses. J Virol. 66:3026-31. King, G. A., Daugulis, A. J., Faulkner, P. and Goosen, M. F. 1992. Recombinant beta-galactosidase production in serum-free medium by insect cells in a 14-L airlift bioreactor. Biotechnol Prog. 8:567-71. Kohler, G. and Milstein, C. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 256:495-7. Larose, R. N. and Sevoian, M. 1965. Avian lymphomatosis. IX. Mortality and serological response of chickens of various ages to graded doses of T strain. Avian Dis. 9:604-10. Leisy, D. J. and Rohrmann, G. F. 1993. Characterization of the replication of plasmids containing hr sequences in baculovirus-infected Spodoptera frugiperda cells. Virology. 196:722-30. Li, J., Calnek, B. W., Schat, K. A. and Graham, D. L. 1983. Pathogenesis of reticuloendotheliosis virus infection in ducks. Avian Dis. 27:1090-105. Li, K., Gao, H., Gao, L., Qi, X., Qin, L., Gao, Y., Xu, Y. and Wang, X. 2012. Development of TaqMan real-time PCR assay for detection and quantitation of reticuloendotheliosis virus. J Virol Methods. 179:402-8. Lin, C. Y., Chen, C. L., Wang, C. C. and Wang, C. H. 2009. Isolation, identification, and complete genome sequence of an avian reticuloendotheliosis virus isolated from geese. Vet Microbiol. 136:246-9. Ludford, C. G., Purchase, H. G. and Cox, H. W. 1972. Duck infectious anemia virus associated with Plasmodium lophurae. Exp Parasitol. 31:29-38. Majima, K., Kobara, R. and Maeda, S. 1993. Divergence and evolution of homologous regions of Bombyx mori nuclear polyhedrosis virus. J Virol. 67:7513-21. Maldonado, R. L. and Bose, H. R. 1971. Separation of reticuloendotheliosis virus from avian tumor viruses. J Virol. 8:813-5. McDougall, J. S., Biggs, P. M. and Shilleto, R. W. 1978. A leukosis in turkeys associated with infection with reticuloendotheliosis virus. Avian Pathol. 7:557-98. McDougall, J. S., Shilleto, R. W. and Biggs, P. M. 1980. Experimental infection and vertical transmission of reticuloendotheliosis virus in the turkey. Avian Pathol. 9:445-54. Miller, L. K. 1988. Baculoviruses for foreign gene expression in insect cells. Biotechnology. 10:457-65. Motha, M. X. 1984. Distribution of virus and tumor formation in ducks experimentally infected with reticuloendotheliosis virus. Avian Pathol. 13:303-9. Motha, M. X. 1987. Clinical effects, virological and serological responses in chickens following in-ovo inoculation of reticuloendotheliosis virus. Vet Microbiol. 14:411-7. Motha, M. X. and Egerton, J. R. 1987. Vertical transmission of reticuloendotheliosis virus in chickens. Avian pathol. 16:141-8. Motha, M. X., Egerton, J. R. and Sweeney, A. 1984. W. Some evidence of mechanical transmission of Reticuloendotheliosis virus by mosquitos. Avian Dis. 28:858-67. Mussman, H. C. and Twiehaus, M. J. 1971. Pathogenesis of reticuloendothelial virus disease in chicks-an acute runting syndrome. Avian Dis. 15:483-502. Nicholas, R. A. and Thornton, H. D. 1987. An enzyme-linked immunosorbent assay for the detection of antibodies to avian reticuloendotheliosis virus using whole cell antigen. Res Vet Sci. 43:403-4. Noori-Daloii, M. R., Swift, R. A., Kung, H. J., Crittenden, L. B. and Witter, R. L. 1981. Specific integration of REV proviruses in avian bursal lymphomas. Nature. 294:574-6. Paul, P. S., Johnson, K. H., Pomeroy, K. A., Pomeroy, B. S. and Sarma, P. S. 1977a. Experimental transmission of reticuloendotheliosis in turkeys with the cell-culture-propagated reticuloendotheliosis viruses of turkey origin. J Natl Cancer Inst. 58:1819-24. Paul, P. S., Pomeroy, K. A., Muscoplat, C. C., Pomeroy, B. S. and Sarma, P. S. 1977b. Characteristics of two new reticuloendotheliosis virus isolates of turkeys. Am J Vet Res. 38:311-5. Paul, P. S., Pomeroy, K. A., Sarma, P. S., Johnson, K. H., Barnes, D. M., Kumar, M. C. and Pomeroy, B. S. 1976. Brief communication: naturally occurring reticuloendotheliosis in turkeys: transmission. J Natl Can Inst. 56:419-21. Paul, P. S. and Werdin, R. W. 1978. Spontaneously occurring lymphoproliferative disease in ducks (case reports). Avian Dis. 22:191-5. Perk, K., Malkinson, M., Gazit, A., Yaniv, A. and Zimber, A. 1981. Reappearance of an acute undifferentiated leukemia in a flock of Muscovy ducks. Proceedings of the 10th International Symposium on Comparative Leukemia and Related Diseases. pp. 99-100. Potter, M., Pumphrey, J. G. and Walters J. L. 1972. Growth of primary plasmacytomas in the mineral oil-conditioned peritoneal environment. J Natl Cancer Inst. 49:305-8. Purchase, H. G., Ludford, C., Nazerian, K. and Cox, H. W. 1973. A new group of oncogenic viruses: reticuloendotheliosis, chick syncytial, duck infectious anemia, and spleen necrosis viruses. J Natl Cancer Inst. 51:489-99. Ratnamohan, R., Bagust, T. J., Grimes, T. M. and Spradbrow, P. B. 1979. Transmission of an Australian strain of reticuloendotheliosis virus to adult Japanese quail. Aust Vet J. 55:506. Rehacek, J., Dolan, T., Thompson, K., Fischer, R. G., Rehacek, Z. and Johnson, H. 1971. Cultivation of oncogenic viruses in mosquito cells in vitro. Curr Top Microbiol Immunol. 55:161-4. Robinson, F. R. and Twiehaus, M. J. 1974. Isolation of the avian reticuloendothelial virus (strain T). Avian Dis. 18:278-88. Rushlow, C. and R, Warrior, R. 1992. The rel family of proteins. Bioessays. 14:89-95. Schaefer-Klein, J., Givol, I., Barsov, E. V., Whitcomb, J. M., VanBrocklin, M., Foster, D. N., Federspiel, M. J. and Hughes, S. H. 1998. The EV-O-derived cell line DF-1 supports the efficient replication of avian leukosis-sarcoma viruses and vector. Virology. 248:305-11. Salter, D. W., Smith, E. J., Hughes, S. H., Wright, S. E. and Crittenden, L. B. 1986. Transgenic chickens: Insertion of retroviral genes into the chicken germ line. Virology. 157:236-40. Sanchez-Vizcaino, J. M. and Alvarez, M. C. 1987. Enzyme immunoassay techniques, ELISA, in animal and plant diseases. Office international Des Epizooties, Paris, France. Santos, V. L., Williams, S. M., Zavala, G., Barbosa, T., Zhang, J., Cheng, S., Shivaprasad, H. L., Hafner, S., Fadly, A., Santos, R. L. and Brown, C. C. 2008. Detection of reticuloendotheliosis virus by immunohistochemistry and in situ hybridization in experimentally infected Japanese quail embryos and archived formalin-fixed and paraffin-embedded tumors. Avian Pathol. 37:451-6. Sevoian, M. R., Larose, R. N. and Chamberlain, D. M. 1964. Avian lymphomatosis. VI. A virus of unusual potency and pathogenicity. Avian Dis. 3:336-347. Simek, S. and Rice, N. R. 1980. Analysis of the nucleic acid components in reticuloendotheliosis virus. J Virol. 33:320-9. Singh, P., Kim, T. J. and Tripathy, D. N. 2000. Re-emerging fowlpox: evaluation of isolates from vaccinated flocks. Avian Pathol. 29:449–55. Smith, E. J. and Witter, R. L. 1983. Detection of antibodies against reticuloendotheliosis viruses by an enzyme-linked immunosorbent assay. Avian Diseases. 20:735-47. Smith, G. E., Summers, M. D. and Fraser, M. J. 1983. Production of human beta interferon in insect cells infected with a baculovirus expresssion vector. Molecular and Cellular Biology 3:2156-65. Tadese, T., Fitzgerald, S. and Reed, W. M. 2008. Detection and differentiation of re-emerging fowlpox virus (FWPV) strains carrying integrated reticuloendotheliosis virus (FWPV-REV) by real-time PCR. Vet Microbiol. 127:39-49. Tadese, T. and Reed, W. M. 2003. Detection of specific reticuloendotheliosis virus sequence and protein from REV-integrated fowlpox virus strain. J Virol Methods. 110:99-104. Tajima, M., Nunoya, T. and Otaki, Y. 1977. Pathogenesis of abnormal feathers in chickens inoculated with reticuloendotheliosis virus. Avian Dis. 21:77-89. Theilen, G. H., Zeigel, R. F. and Twiehaus, M. J. 1966. Biological studies with RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. J Natl Cancer Inst. 37:731-743. Trager, W. 1959. A new virus of ducks interfering with development of malaria parasite (Plasmodium lophurae). Proc Soc Exp Biol Med. 101:578-82. Treanor, J. J., Betts, R. F., Smith, G. E., Anderson, E. L., Hackett, C. S., Wilkinson, B. E., Belshe, R. B. and Powers, D. C. 1996. Evaluation of a recombinant hemagglutinin expressed in insect cells as an influenza vaccine in young and elderly adults. J Infect Dis. 173:1467-70. Treanor, J. J., El Sahly, H., King, J., Graham, I., Izikson, R., Kohberger, R., Patriarca, P. and Cox, M. 2011. Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine (FluBlokR) against influenza in healthy adults: a randomized, placebo-controlled trial. Vaccine. 29:7733-9. Tsai, W. P., Copeland, T. D. and Oroszlan, S. 1985. Purification and chemical and immunological characterization of avian reticuloendotheliosis virus gag-gene-coded structural proteins. Virology. 140:289-312. Tsai, W. P., Copeland, T. D. and Oroszlan, S. 1986. Biosynthesis and chemical and immunological characterization of avian reticuloendotheliosis virus env gene-coded proteins. Virology. 155:567-83. Tsai, W. P. and Oroszlan, S. 1988a. Novel glycosylation pathways of retroviral envelope proteins identified with avian reticuloendotheliosis virus. J Virol. 62:3167-74. Tsai, W. P., and Oroszlan, S. 1988b. Site-directed cytotoxic antibody against the c-terminal segment of the surface glycoprotein gp90 of avian reticuloendotheliosis virus. Virology. 166:608-11. Tweeten, K. A., Bulla, L. A. and Consigli, R. A. 1980. Characterization of an extremely basic protein derived from granulosis virus nucleocapsids. J Virol. 33:866-76. Venugopal, K., Howes, K., Barron, G. S. and Payne, L. N. 1997. Recombinant env-gp85 of HPRS-103 (subgroup J) avian leukosis virus: antigenic characteristics and usefulness as a diagnostic reagent. Avian Dis. 41:283-8. Wakabayashi, T. and Kawamura, H. 1975. Virus of endotheliosis virus group: Persistent infection in chickens and viral transmission to fertile egg. Proc 79th Ann Mtg Jap Soc Vet Sci. pp. 12-13. Wang, M. Y., Kuo, Y. Y., Lee, M. S., Doong, S. R., Ho, J. Y. and Lee, L. H. 2000. Self-assembly of the infectious bursal disease virus capsid protein, rVP2, expressed in insect cells and purification of immunogenic chimeric rVP2H particles by immobilized metal-ion affinity chromatography. Biotechnol Bioeng. 67:104-11. Watanabes, S. and Temin, H. M. 1982. Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5' long terminal repeat and the start of the gag gene. Proc Natl Acad Sci U S A. 79:5986-90. Watanabes, S. and Temin, H. M. 1983. Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors. Mol Cell Biol. 3:2241-9. Weaver, T. A., Talbot, K. J. and Panganiban, A. T. 1990 Spleen necrosis virus gag polyprotein is necessary for particle assembly and release but not for proteolytic processing. J Virol. 64:2642-52. Witter, R. L. and Johnson, D. C. 1985. Epidemiology of reticuloendotheliosis virus in broiler breeder flocks. Avian Dis. 29:1140-54. Witter, R. L., Lee, L. F., Bacon, L. D. and Smith, E. J. 1979. Depression of vaccinal immunity to Marek’s disease by infection with reticuloendotheliosis virus. Infect Immun. 26:90-8. Witter, R. L., Peterson, I. L., Smith, E. J. and Johnson, D. C. 1982. Serologic evidence in commercial chicken and turkey flocks of infection with Reticuloendotheliosis virus. Aivan Dis. 26:753-62. Witter, R. L., Purchase, H. G. and Burgoyne, G. H. 1970. Peripheral nerve lesions similar to those of Marek’s disease in chickens inoculated with reticuloendotheliosis virus. J Natl Cancer Inst. 45:567-77. Witter, R. L. and Salter, D. W. 1989. Vertical transmission of reticuloendotheliosis virus in breeder turkeys. Avian Dis. 33:226-35. Witter, R. L., Smith, E. J. and Crittenden, L. B. 1981. Tolerance, viral shedding, and neoplasia in chickens infected with non-defective reticuloendotheliosis viruses. Avian Dis. 25:374-94. Wong, T. C. and Lai, M. M. 1981. Avian reticuloendotheliosis virus contains a new class of oncogene of turkey origin. Virology. 111:289-93. Wu, N. H., Tsai, W. T., Chen, H. W., Wang, L. C. and Wang, C. H. 2013. Detection of anti-reticuloendotheliosis virus antibody by blocking enzyme-linked immunosorbent assay with expression envelope protein. Avian Dis. 57:71-5. Yang, H. C. and Gao, Y. 1997. Detection of antibody to reticuloendotheliosis virus in sera by a modified blocking ELISA. Chin J Vet Med. 23:3-5. Yuasa, N., Yoshida, I. and Taniguchi, T. 1976. Isolation of a reticuloendotheliosis virus from chickens inoculated with Marek’s disease vaccine. Natl Inst Anim Health Q (Tokyo). 16:141-51. Zeigel, R. F., Theilen, G. H. and Twiehaus, M. J. 1966. Electron microscopic observations on RE virus (strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. J Natl Cancer Inst. 37:709-29. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/57202 | - |
| dc.description.abstract | 家禽網狀內皮增生症病毒（avian reticuloendotheliosis virus, REV），可感染多種鳥禽類，包括雞、鴨、鵝、雉及孔雀等。被感染之家禽並未出現明顯病徵，故於台灣家禽疾病中較不被重視，但其卻會引起飼養場重大的經濟損失，於現場尚未有有效預防及控制之方法，為此需開發有效檢測REV之方法。本研究之目的為利用桿狀病毒/昆蟲表現系統進行REV封套蛋白質之真核表現，並評估其重組蛋白質應用於抗體之酵素連結免疫吸附法之發展潛力。以台灣病毒株goose/3410/06之封套序列作為模板，以此建構帶有封套基因之baculovirus-env重組桿狀病毒並進一步感染Sf9昆蟲細胞，收取受感染之昆蟲細胞，進行西方點墨法分析可檢測到符合預期大小約62 kDa位置之重組封套蛋白質，並通過鎳離子親和力管柱進行純化。將重組封套蛋白質塗鍍作為抗原，以棋盤格方式獲得間接型ELISA之最佳化條件，並以血清中和試驗作為抗體檢測之金標準，比較182個田間樣本血清，其中種雞138隻及台灣土雞44隻，結果顯示重組封套蛋白質用於間接型ELISA之敏感性為88.5%及特異性為97.7%。其於敏感性及特異性皆有相當不錯之結果，表示若應用於現場初步診斷使用，應具有良好之發展潛力。額外與實驗室先前所研究以大腸桿菌表現重組封套蛋白質之阻斷行ELISA進行比較，以相同樣本進行測試，結果顯示敏感性為84.6%及特異性為95.3%。此兩種方式所檢測結果相似，但本實驗所發展之間接型ELISA具有所需使用樣本量低、二抗取得容易及成本低等優點。 | zh_TW |
| dc.description.abstract | Reticuloendotheliosis virus (REV) infects variety animals including chickens, ducks, geese, pheasants, peafowl and other birds. REV is ignored in Taiwan because the infected poultry without obvious clinical signs. REV causes severe economic losses in commercial poultry, such as runting disease syndrome and immunosuppression. Currently, the disease lacks effective prevention and control in the field. The purpose of this study is to develop a rapid, reliable, convenient and economic method for detecting REV antibody. We use baculovirus/insect cells expression system to express REV envelope protein, and to evaluate the potential of the recombinant protein to be used as the antigen in enzyme linked-immunosorbent assay (ELISA). To use the laboratory isolated Taiwan strain goose/3410/06 as the cloning template. The full-length of REV envelope was cloned into bacmid vector and then the constructed recombinant baculoviruse-env was infected the Sf9 insect cells. The infected insect cells showed expected recombinant envelope protein in western blotting which size was about 62 kDa. The expressed recombinant envelope protein was purified by Ni-NTA (nitrilotriacetic acid) column. The purified recombinant envelope protein used as the coated antigen. Then, we test optimization condition of indirect ELISA by checkerboard method. Using 182 field samples (138 broilers and 44 Taiwan Country Chickens) to compare virus neutralization tested as the gold standard with the indirect ELISA. The result showed the sensitivity and the specificity of the indirect ELISA were 88.5% and 97.7%, respectively. Both values were good enough to screen detection in the field. The indirect ELISA of recombinant envelope protein possesses potential of development. Additional, we used blocking ELISA which envelope protein was expressed by E. coli to compare with the result of indirect ELISA. The result showed the sensitivity and the specificity were 84.6% and 95.3%, respectively. The two kind of methods displayed similar result, but the indirect ELISA possess advantages of lower usage amount of samples, easier obtainable secondary antibody and cheaper. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T06:37:43Z (GMT). No. of bitstreams: 1 ntu-103-R01629005-1.pdf: 3372392 bytes, checksum: 27bac6003277ca218543e2fc9f6d69d7 (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 口試委員會審定書 i
致謝 ii 摘要 iii Abstract iv 目錄 vi 表次 xii 圖次 xii 第一章 序言 1 第二章 文獻回顧 3 第一節 歷史背景與簡介 3 第二節 病原學 3 2.2.1 病毒型態與特性 3 2.2.2 病毒分類 4 2.2.3 病毒基因體 4 2.2.4 致癌基因 5 2.2.5 病毒蛋白質 5 2.2.6 病毒複製 6 第三節 宿主 7 2.3.1 宿主範圍 7 2.3.2 自然宿主 8 第四節 流行病學 8 2.4.1 傳播途徑 8 2.4.1.1 水平傳播 8 2.4.1.2 垂直傳播 9 2.4.1.3 受汙染之生物材料 10 2.4.2 台灣狀況 10 第五節 致病機轉與病理變化 11 2.5.1 潛伏期 11 2.5.2 臨床症狀 11 2.5.3 病理變化 12 第六節 實驗室診斷 13 2.6.1 病毒分離 13 2.6.2 分子生物學診斷 13 2.6.3 血清學診斷 14 2.6.4 病毒之預防與控制 14 第七節 桿狀病毒表現系統 15 2.7.1 蛋白質表現系統 15 2.7.2 桿狀病毒 16 2.7.3 桿狀病毒表現系統 16 2.7.4 轉譯後修飾作用 18 第八節 單株抗體 18 第九節 酵素連結免疫吸附法 19 2.9.1 酵素連結免疫吸附法介紹 19 2.9.2 本研究相關ELISA 20 2.9.2.1 間接型酵素連結免疫吸附分析法（indirect ELISA） 20 2.9.2.2 阻斷型酵素連結免疫吸附分析法（blocking ELISA） 20 第三章 材料與方法 21 第一節 REV病毒增殖及力價測定 21 3.1.1 病毒來源 21 3.1.2 病毒增殖 21 3.1.2.1 細胞培養 21 3.1.2.2 病毒增殖 22 3.1.3 病毒力價測定 22 3.1.3.1 病毒接種 22 3.1.3.2 計算細胞數目 23 3.1.3.3 計算病毒力價 23 3.1.4 血清中和試驗 23 3.1.4.1 樣本來源 23 3.1.4.2 血清中和試驗 23 第二節 重組病毒蛋白質之建構與表現 24 3.2.1 病毒封套基因之bacmid-env建構 24 3.2.2 Bacmid-env序列確認 26 3.2.2.1 抽取重組Bacmid 26 3.2.2.2 聚合酶鏈鎖反應 (Polymerase chain reaction, PCR) 26 3.2.2.3 電泳分析 27 3.2.2.4 封套基因產物純化及定序 28 3.2.3 昆蟲細胞與桿狀病毒 28 3.2.4 重組桿狀病毒之製備 29 3.2.4.1 Bacmid-env之轉染作用 29 3.2.4.2 轉染作用之確認 29 3.2.4.3重組病毒Baculovirus-env增殖 30 3.2.4.4 病毒力價測定 30 3.2.5 重組蛋白質表現及純化 30 3.2.5.1 重組蛋白質表現及最佳化 30 3.2.5.2 重組蛋白質純化 31 3.2.5.3 蛋白質濃縮 32 3.2.5.4 SDS-PAGE與Western blotting分析 32 3.2.5.5 蛋白質定量 33 3.2.6 以原核系統表現重組封套蛋白質 34 3.2.6.1 病毒來源 34 3.2.6.2重組封套基因pET-32b-env之建構 34 3.2.6.3 重組封套蛋白質表現 34 3.2.6.4 透析 35 第三節 單株抗體 35 3.3.1 單株抗體之製備 35 3.3.2 純化單株抗體 36 3.3.2.1 以Protein A Sepharose純化抗體 36 3.3.2.2 單株抗體定量 36 第四節 酵素連結免疫吸附法之應用 36 3.4.1 桿狀病毒表現之重組封套蛋白的間接型ELISA 36 3.4.1.1 重組封套蛋白質之辨識能力 36 3.4.1.2 間接型ELISA之條件最佳化 37 3.4.1.3 間接型ELISA製備 37 3.4.1.4 計算間接型ELISA之cut-off值 38 3.4.1.5 敏感性與特異性分析 38 3.4.2 原核表現之重組封套蛋白質的阻斷型ELISA 39 3.4.2.1 單株抗體標示過氧化氫（horseradish peroxidase, HRP） 39 3.4.2.2 阻斷型ELISA之條件最佳化 39 3.4.2.2.1 阻斷型ELISA之條件 39 3.4.2.2.2阻斷型ELISA最佳化 39 3.4.2.3 阻斷型ELISA製備 40 3.4.2.4 計算阻斷型ELISA之cut-off值 40 3.4.2.5 敏感性與特異性分析 40 第四章 結果 41 第一節 REV病毒增殖及力價測定 41 4.1.1 病毒增殖 41 4.1.2 病毒力價測定 41 4.1.3 使用田間樣本進行血清中和試驗 41 第二節 重組病毒蛋白質之建構與表現 41 4.2.1 重組bacmid-env質體確認 41 4.2.2 重組桿狀病毒（baculovirus-env）製備 42 4.2.3 重組封套蛋白質表現及確認 42 4.2.4重組蛋白質表現條件最佳化 42 4.2.5 重組蛋白質純化 43 4.2.6 以原核系統表現重組封套蛋白質 43 4.2.6.1重組封套蛋白質表現與確認 43 4.2.6.2 單株抗體定量 44 第三節 酵素連結免疫吸附法之應用 44 4.3.1 桿狀病毒表現之重組封套蛋白的間接型ELISA 44 4.3.1.1 間接型ELISA之塗鍍抗原濃度及樣本稀釋倍數 44 4.3.1.2 以Receiver operator characteristic curve （ROC curve）畫出間接型ELISA最佳敏感性及特異性 44 4.3.1.3 間接型ELISA之敏感性與特異性分析 45 4.3.2 原核表現之重組封套蛋白質的阻斷型ELISA 45 4.3.2.1 阻斷型ELISA之塗鍍抗原濃度及tracer稀釋倍數 45 4.3.2.2 阻斷型ELISA條件最佳化 46 4.3.2.3 以Receiver operator characteristic curve （ROC curve）畫出阻斷型ELISA最佳敏感性及特異性 46 4.3.2.4 阻斷型ELISA之敏感性與特異性分析 46 4.3.3 間接型ELISA與阻斷型ELISA之敏感性與特異性分析 47 4.3.4 三種檢測方式比較 47 第五章 討論 48 第六章 參考文獻 54 表一、本實驗所使用之特異性引子 70 表二、本實驗所使用之樣本資料來源 71 表三、以血清樣本畫出ROC curve並計算間接型ELISA之cut-off值 73 表四、間接型Env-ELISA與血清中和試驗之結果比較 75 表五、以血清樣本畫出ROC curve並計算阻斷型ELISA之cut-off值 76 表六、阻斷型Env-ELISA與血清中和試驗之結果比較 79 表七、間接型Env-ELISA與阻斷型Env-ELISA之結果比較 80 表八、血清中和試驗、間接型ELISA及阻斷型ELISA之檢測結果比較 81 圖一、反轉錄病毒顆粒之結構及帶有蛋白質之示意圖 82 圖二、ELISA方式之示意圖 83 圖三、REV（goose/3410/06）病毒增殖 84 圖四、測定病毒之力價（TCID50） 85 圖五、本實驗所使用之載體 86 圖六、確認重組之bacmid-env 87 圖七、確認重組桿狀病毒之形成及複製 88 圖八、病毒斑試驗（virus plaque assay） 89 圖九、昆蟲細胞表現重組封套蛋白質之情形 90 圖十、重組蛋白質表現條件最佳化 91 圖十一、重組封套蛋白質之純化 92 圖十二、E. coli表現重組封套蛋白質之情形 93 圖十三、以棋盤格方式找出最適之間接型ELISA的塗鍍抗原濃度及樣本稀釋倍數 94 圖十四、以Receiver operator characteristic curve（ROC curve）分析間接型ELISA之最佳敏感性及特異性 95 圖十五、間接型ELISA之敏感度分析 96 圖十六、間接型ELISA之特異性分析 97 圖十七、以棋盤格方式找出最適之阻斷型ELISA的塗鍍抗原濃度及tracer稀釋倍數 98 圖十八、以Receiver operator characteristic curve（ROC curve）分析阻斷型ELISA之最佳敏感性及特異性 99 圖十九、阻斷型ELISA之敏感度分析 100 圖二十、阻斷型ELISA之特異性分析 101 | |
| dc.language.iso | zh-TW | |
| dc.subject | 桿狀病毒/昆蟲細胞表現 | zh_TW |
| dc.subject | 家禽網狀內皮增生症病毒 | zh_TW |
| dc.subject | 間接型酵素連結免疫吸附法 (ELISA) | zh_TW |
| dc.subject | 重組封套蛋白質 | zh_TW |
| dc.subject | baculovirus/insect cells expression | en |
| dc.subject | reticuloendotheliosis virus | en |
| dc.subject | indirect enzyme linked immunosorbent assay (ELISA) | en |
| dc.subject | recombinant envelope protein | en |
| dc.title | 桿狀病毒表現家禽網狀內皮增生症病毒封套蛋白質之酵素連結免疫吸附法檢測抗體開發 | zh_TW |
| dc.title | Detection of reticuloendotheliosis antibody by enzyme-linked immunosorbent assay with baculovirus expressed envelope protein | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 謝快樂(Happy K. Shieh),沈瑞鴻(Jui-Hung Shien),張伯俊(Poa-Chun Chang),陳慧文(Hui-Wen Chen) | |
| dc.subject.keyword | 家禽網狀內皮增生症病毒,桿狀病毒/昆蟲細胞表現,重組封套蛋白質,間接型酵素連結免疫吸附法 (ELISA), | zh_TW |
| dc.subject.keyword | reticuloendotheliosis virus,baculovirus/insect cells expression,recombinant envelope protein,indirect enzyme linked immunosorbent assay (ELISA), | en |
| dc.relation.page | 101 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-07-31 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| Appears in Collections: | 獸醫學系 | |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| ntu-103-1.pdf Restricted Access | 3.29 MB | Adobe PDF |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.