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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張建成 | |
| dc.contributor.author | Shih-Peng Chuang | en |
| dc.contributor.author | 莊世鵬 | zh_TW |
| dc.date.accessioned | 2021-06-16T05:23:02Z | - |
| dc.date.available | 2017-08-21 | |
| dc.date.copyright | 2014-08-21 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-15 | |
| dc.identifier.citation | [1] '2013癌症報告',癌康協會出版,2013
[2] Frei, Emil; Kufe, Donald W.; Holland, James F. Cancer medicine 6. Hamilton, Ont, 2003: BC Decker. ISBN 1-55009-213-8. [3] Simon CJ, Dupuy DE, Mayo-Smith WW, 'Microwave ablation: principles and applications', Radiographics, 2005;25(1):S69-83 [4] Zhou Y, Kargl SG, Hwang JH, 'The effect of the scanning pathway in high-intensity focused ultrasound therapy on lesion production', Ultrasound in Medicine and Biology, 2011 Sep;37(9):1457-68 [5] 放射科住院醫師教學手冊（2010）•血管攝影及血管內介入性治療•4-5.10 射頻腫瘤滅除術 170-172 [6] Mast TD, Pucke DP, Subramanian SE, Bowlus WJ, Rudich SM, Buell JF, 'Ultrasound monitoring of in vitro radio frequency ablation by echo decorrelation imaging', Ultrasound in Medicine, 2008;27(12):1685-97 [7] Stafford RJ, Kallel F, Price RE, Cromeens DM, Krouskop TA, Hazle JD, Ophir J, 'Elastographic imaging of thermal lesions in soft tissue: a preliminary study in vitro', Ultrasound in Medicine and Biology, 1998;24(9):1449-58 [8] Liu JB, Goldberg BB, Merton DA, Rawool NM, Needleman L, Forsberg F, 'The role of contrast-enhanced sonography for radiofrequency ablation of liver tumors', Ultrasound in Medicine, 2001;20(5):517-23 [9] Daniels MJ, Varghese T, Madsen EL, Zagzebski JA, 'Non-invasive ultrasound-based temperature imaging for monitoring radiofrequency heating-phantom results', Physics in Medicine and Biology, 2007;52(16):4827-43 [10] Saini k, Dewal ML, Rohit M, 'Ultrasound Imaging and Image Segmentation in the area of Ultrasound: A Review', International Journal of Advanced Science and Technology, 2010;24:41-60 [11] Sickles, EA. et al. 'Benign breast lesions: ultrasound detection and diagnosis.' Radiology 1984,May;151(2):467-70. [12] Yoshida T, Mori M, Nimura Y, Hikita G, Takagishi S, Nakanishi K,Satomura S. 'Analysis of heart motion with ultrasonic Doppler method and its clinical application'. American Heart Journal. 1961.61:61--75. [13] RJ. Stafford , F. Kallel, RE. Price , DM. Cromeens , TA. Krouskop , JD. Hazle , et al. 'Elastographic imaging of thermal lesions in soft tissue: a preliminary study in vitro'.Ultrasound in Medicine and Biology,1998. 24(29):1449-1458. [14] L. Wang, & He, D. C. 'A new statistical approach for texture analysis'. Photogrammetric Engng Remote Sensing, 1990, 56, 61-66. [15] S. Siebers, M. Schwabe, U. Scheipers, C. Welp, J. Werner, & Ermert, H. 'Evaluation of ultrasonic texture and spectral parameters for coagulated tissue characterization'. IEEE Ultrasonics Symposium, 2004. 3, 1804-1807. [16] W. Ning, Y. Wei, C. Lei, Z. Su, & C. Ya-zhu. ' Texture analysis of B-mode ultrasound images on tissue in radiofrequency ablation '. Chinese Journal of Medical Imaging Technology, 2007. 23(21). [17] J.Ophir, I. Cespedes, H. Ponnekanti, Y. Yazdi, & Li, X. 'Elastographt:A quantitative method for imaging the elasticity of biological tissues'. Ultrasonic Imaging, 1991.vol. 13,pp. 111-134. [18] I.Winkler , & Adam, D. 'Monitoring radio-frequency thermal ablation with ultrasound by low frequency acoustic emissions--in vitro and in vivo study'. Ultrasound in Medicine & Biology, 2011. 37(5), 755-767. [19] T. Douglas, P. Daniel, E. Swetha, J. William, M. Steven, & Joseph F. Buell. 'Ultrasound monitoring of in vitro radio frequency ablation by echo decorrelation imaging'. J Ultrasound Med, 2008. 27(12), 1685-1697. [20] T. Hall, W. Svensson, J. Malin , Y. Zhu, von Behren, Spalding C, et al.. 'Lesion size ratio for differentiating breast masses'. IEEE Ultrason Symp, 2003.2: 1247-1250. [21] T. Hall, Y. Zhu, & Spalding, C. 'In vivo real-time freehand pal-pation imaging'. Ultrasound Med Biol, 2002.29(23):427- 435. [22] Burckhardt CB. 'Speckle in ultrasound B-mode scans'. IEEE Trans Son. Ultrason. 1978;25:1-6. [23] Tuthill TA, Sperry RH, Parker KJ. 'Deviations from Rayleigh Statistics in Ultrasonic Speckle'. Ultrason. Imaging 1988;10:81-89. [24] Jakeman E, Tough RJA. 'Generalized K-Distribution – a Statistical-Model for Weak Scattering'. J. Opt. Soc. Am. 1987;4:1764-1772. [25] Weng L, Reid JM, Shankar PM, Soetanto K. 'Ultrasound Speckle Analysis Based on the K-Distribution '. J. Acoust. Soc. Am. 1991;89:2992-2995. [26] Dutt V, Greenleaf JF. Ultrasound echo envelope analysis using a homodyned K distribution signal model. Ultrason. Imaging 1994;16:265-287. [27] Narayanan VM, Shankar PM, Reid JM. Non-Rayleigh Statistics of Ultrasonic Backscattered Signals. IEEE Trans Ultrason. Ferr. 1994;41:845-852. [28] Shankar PM, Molthen R, Narayanan VM, Reid JM, Genis V, Forsberg F, Piccoli CW, Lindenmayer AE, Goldberg BB. Studies on the use of non-Rayleigh statistics for ultrasonic tissue characterization. Ultrasound Med. Biol. 1996;22:873-882. [29] Dutt V, Greenleaf JF. Ultrasound echo envelope analysis using a homodyned K distribution signal model. Ultrason. Imaging 1994;16:265-287. [30] Shankar PM. A general statistical model for ultrasonic backscattering from tissues. IEEE Trans Ultrason. Ferr. 2000;47:727-736. [31] Tsui P H, Huang C C, Chang C C,Wang S H and Shung K K Feasibility study of using high-frequency ultrasonic Nakagami imaging for characterizing the cataract lens in vitro Phys. Med. Biol. 2007; 52 6413–25 [32] Huang CC, Tsui PH, Wang SH. Detection of coagulating blood under steady flow by statistical analysis of backscattered signals. IEEE Trans Ultrason. Ferr. 2007;54:435-442 [33] P. H. Tsui, Y. Y. Liao, C. C. Chang, W. H. Kuo, K. J. Chang and C. K. Yeh, “Classification of benign and malignant breast tumors by 2-D analysis based on contour description and scatterer characterization,” IEEE Trans. Med. Imaging, 29: 513-522, 2010. [34] Lin YH, Huang CC, Wang SH In vivo assessment of inflammatory skin using high frequency ultrasound image and quantitative parameters 2010. In: Ultrasonics Symposium (IUS), 2010 IEEE, pp 2311-2314 [35] C.Y. Wang, X. Geng, T.S. Yeh, H.L. Liu , P. H. Tsui Monitoring radiofrequency ablation with ultrasound Nakagami imaging 2013. Med. Phys. 40 (7),072901-12 [36] Vishruta A. Dumane and P. Mohana Shankar.Use of Frequency Diversity and Nakagami Statistics in Ultrasonic Tissue Characterization.2001. IEEE, vol. 48, no. 5,1139-1146 [37] D. Nicholas, et al.. Tissue characterization from ultrasound B-scan data. Ultrasound in medicine & biology, 1986. 12(2): p. 135. [38] . W.C. Yeh, et al.. Elastic modulus measurements of human liver and correlation with pathology. Ultrasound in medicine & biology, 2002. 28(4): p. 467. [39] P.H. Tsui, et al.. Classification of breast masses by ultrasonic Nakagami imaging: a feasibility study. Physics in Medicine and Biology, 2008. 53(21): p. 6027-6044 [40] http://iqonline.eu/patient-safety-interventional-radiology/ [41] Molthen RC, Shankar PM, Reid JM,'Characterization of ultrasonic B-modes using non-Rayleigh statistics', Ultrasound in Medicine and Biology, 1995;21(2):161-70 [42] Tsui PH, Chang CC, 'Imaging local scatterer concentrations by the Nakagami statistical model', Ultrasound in Medicine and Biology, 2007;33(4):608-19 [43] K. Shung, K. Smith, M. B. & Tsui, & W, B. M. (1992). Principles of medical imaging(San Diego: Academic Press). [44] http://medicalterms.info/anatomy/Skeletal-Muscles/ | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/56313 | - |
| dc.description.abstract | 隨著醫療的進步，治療肝癌的方法不斷改進，射頻燒灼治療為近年來新興的一種局部消除治療法，也廣泛的運用在臨床治療上。為了監控射頻燒灼治療，需要一個輔助、導引的工具來評估燒灼區域，超音波影像即為臨床上最常使用評估工具，具有非侵入性、即時呈像、非游離輻射、易攜帶、價格便宜等優點。傳統的超音波影像為B-mode影像，但B-mode影像在評估熱燒灼時，很難評估燒灼區域。
因此本研究目的是利用本實驗室所開發的超音波Nakagami影像做為監控射頻燒灼治療的新工具。超音波Nakagami影像已被證實能藉由局部散射子的分布排列、濃度上的差異來辨別局部組織特性，再結合可提升靈敏度的頻率分集與複合的技術，搭配後來提到的多項式逼近影像，去發展出一個即時的超音波監控系統，並且利用離體實驗去驗證方法和系統在監控射頻燒灼上的效能和可行性。 實驗中利用離體實驗(豬肝組織)進行評估組織燒灼的面積大小，驗證出在多項式逼近影像中的-6 dB的燒灼面積與我們真實燒灼豬肝的組織切片的面積的相關係數是最高的，因此制定-6 dB為影像面積的標準。 實驗嘗試使用不同射頻燒灼的電極長度對豬肝組織進行燒灼面積的驗證，由結果顯示，使用即時參數化影像系統監控射頻燒灼，利用小電極長度(0.5、1.0公分)偵測組織的燒灼面積的評估會相較於準確。 | zh_TW |
| dc.description.abstract | With medical improvements , continue to improve methods of treating liver cancer, radiofrequency ablation(RFA) is an emerging therapy in recent years as , also widely used in the clinical treatment. In order to monitor RFA, requiring an auxiliary, guiding tool to evaluate ablation zone, ultrasound imaging is the most commonly used clinical evaluating tools, with a non-invasive, real-time, non-ionizing radiation, easy to carry, and inexpensive . Conventionally, ultrasound imaging is displayed as B-mode imaging, but B-mode imaging can’t identify thermal zone clearly.
In this study, we investigate the use of ultrasound Nakagami developed in our laboratory imaging as a new tool for monitoring RFA therapy. Ultrasound Nakagami imaging has been shown to be capable of differentiating the characteristics of local tissues through the distribution, arrangement, and concentration differences in local scattering, combined to enhance the sensitivity of the frequency diversity and compounding technology, with later polynomial approximation imaging . We develop the real-time ultrasound monitoring system. Using in vitro to verify the effectiveness and feasibility on the RFA monitoring system. Using in vitro (liver tissue) to evaluate tissue ablation zone, we can verify imaging ablation area and true ablation area of liver tissue sections in the polynomial approximation imaging of -6 dB of the correlation coefficients is highest. Therefore we regulate -6 dB as the standard of imagnig area. In the experiments ,we try to use different electrode lengths for verifying ablation area. The results show that the use of real-time parametric imaging system monitoring radiofrequency ablation, using small electrode length (0.5, 1.0 cm) to detect ablation area of tissue assessment will be compared accurately. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T05:23:02Z (GMT). No. of bitstreams: 1 ntu-103-R01543075-1.pdf: 9950673 bytes, checksum: 5c2111202da0fdfcb7d108f35e657b2c (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 第一章緒論 1
1.1 前言 1 1.2 研究背景 4 1.3 文獻回顧 6 1.3.1 超音波逆散射統計模型 6 1.3.2 Nakagami影像文獻回顧 8 1.4 研究目的 9 第二章理論基礎 10 2.1 超音波原理及簡介 10 2.1.1 聲波傳遞的基本原理 10 2.1.2 超音波之反射與折射 13 2.1.3 超音波之能量衰減 15 2.2射頻燒灼原理 16 2.3超音波散射分析 17 2.3.1 散射現象 17 2.3.2 單一散射子之分析 18 2.3.3 多散射子之分析 19 2.4 逆散射訊號統計模型 21 2.4.1 Rayleigh統計分佈 21 2.4.2 Rician統計分佈 22 2.4.3 K統計分佈 23 2.4.4 Nakagami統計分佈 24 2.5 超音波訊號處理-頻率分集技術 26 第三章實驗材料與方法 29 3.1 實驗系統架構及材料 29 3.2 射頻燒灼系統 30 3.3 多參數超音波影像系統操作說明 33 3.3.1 系統介面 33 3.3.2 按鍵控制 34 3.3.2 按鈕控制 36 3.4 實驗前置準備(仿體及0.9%食鹽水製作) 38 3.5 豬肝與里肌肉組織燒灼實驗步驟 39 3.5.1 豬肝組織燒灼實驗 39 3.5.2 里肌肉組織燒灼實驗 40 3.6 演算法流程 40 3.7 Nakagami數據分析 41 3.8 多項式逼近影像分析 42 3.9 燒灼面積測量 43 第四章實驗結果與討論 45 4.1 B-mode影像、Nakagami影像與多項式逼近影像比較結果 45 4.2.1 豬肝組織燒灼影像結果 49 4.2.2 電擊長度0.5公分對豬肝組織燒灼的實驗結果 50 4.2.3 電擊長度1.0公分對豬肝組織燒灼的實驗結果 54 4.2.4 電擊長度1.5公分對豬肝組織燒灼的實驗結果 58 4.2.5 豬肝組織射頻燒灼的結果討論 62 4.3 里肌肉組織燒灼影像結果 66 4.3.1 電擊長度0.5公分對里肌肉組織燒灼的實驗結果 67 4.3.2電擊長度1.0公分對里肌肉組織燒灼的實驗結果 71 4.3.3 電擊長度1.5公分對里肌肉組織燒灼的實驗結果 75 4.3.5 里肌肉組織射頻燒灼的結果討論 79 4.4 病理切片－染色影像與分析 80 4.5 結果討論 83 4.5.1 參數變化對影像效果的影響 83 4.5.2 燒灼後的組織切片與多項式逼近影像面積比較 85 第五章結論與未來展望 87 5.1 結論 87 5.2 未來展望 87 參考文獻 88 | |
| dc.language.iso | zh-TW | |
| dc.subject | Nakagami影像 | zh_TW |
| dc.subject | 超音波 | zh_TW |
| dc.subject | 射頻燒灼治療 | zh_TW |
| dc.subject | 頻率分集與複合技術 | zh_TW |
| dc.subject | Ultrasound | en |
| dc.subject | Radiofrequency | en |
| dc.subject | Nakagami imaging | en |
| dc.subject | Frequency diversity and compounding technology | en |
| dc.title | 即時超音波參數化影像系統於射頻燒灼監控之驗證 | zh_TW |
| dc.title | Validation of a Real-Time Ultrasound Parametric Imaging System for Monitoring Radio-Frequency Ablation | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 崔博翔 | |
| dc.contributor.oralexamcommittee | 林真真,黃執中,陳建甫 | |
| dc.subject.keyword | 射頻燒灼治療,超音波,Nakagami影像,頻率分集與複合技術, | zh_TW |
| dc.subject.keyword | Radiofrequency,Ultrasound,Nakagami imaging,Frequency diversity and compounding technology, | en |
| dc.relation.page | 92 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2014-08-15 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 應用力學研究所 | zh_TW |
| 顯示於系所單位： | 應用力學研究所 | |
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