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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 伍安怡(Betty A. Wu-Hsieh) | |
dc.contributor.author | Jung-Chen Lin | en |
dc.contributor.author | 林榮辰 | zh_TW |
dc.date.accessioned | 2021-06-16T05:13:55Z | - |
dc.date.available | 2019-10-09 | |
dc.date.copyright | 2014-10-09 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-08-18 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/56046 | - |
dc.description.abstract | 登革出血現象經常伴隨著一系列登革病症而發生。許多研究集中於探討免疫因子在登革出血致病過程中的角色,對於登革病毒本身如何參與在登革疾病過程卻很少探討。登革病毒抗原會存在具有嚴重登革症狀的病人之血管內皮細胞中,而血管內皮細胞的凋亡現象也能在病人身上以及動物疾病模式中被觀察到。這些結果顯示血管內皮細胞凋亡與疾病發展過程之間存在著關連性。
本實驗研究目的為探討登革病毒對於血管內皮細胞凋亡以及登革出血現象的分子致病機制。先前動物實驗結果顯示血管內皮細胞的凋亡對於登革出血發展扮演重要的角色。我們的研究結果顯示在血管內皮細胞凋亡的過程中,登革病毒蛋白酵素是一個致病因子。並且鑑定出登革病毒蛋白酵素會與宿主蛋白IκBα和IκBβ結合。登革病毒蛋白酵素透過切割IκBα和IκBβ與活化IKK 進而活化NF-κB而導致血管內皮細胞凋亡。利用重組腺相關病毒之活體內的實驗系統,我們將登革病毒蛋白酵素送入老鼠皮膚血管內皮細胞,發現登革病毒蛋白酵素會造成老鼠皮下出血。此外,大量表現IκBα和IκBβ蛋白會減低血管內皮細胞凋亡的發生。實驗結果也發現登革蛋白酵素能和登革病毒感染一樣造成血管內皮細胞中NF-κB 活化,並造成IL-32 與TNFRSF9 表現量增加。IL-32 與TNFRSF9 均被報導過在發炎過程中扮演著重要角色。 本篇研究結論為登革病毒造成的細胞凋亡與登革出血現象是經由登革病毒蛋白酵素引發NF-κB活化來達成。這些發現對於我們在了解登革病毒如何參與血管內皮細胞凋亡以及出血過程的分子機制,提供了一個新的方向。 | zh_TW |
dc.description.abstract | Hemorrhagic manifestations occur frequently accompanying a wide range of dengue disease syndromes. Much work has focused on the contribution of immune factors to the pathogenesis of hemorrhage, but how dengue virus (DENV) participates in the pathogenic process has never been explored. DENV antigen is detected in the endothelium of tissues from patients with severe disease. The link between endothelial cell death and severe disease is reported in fatal cases and in dengue hemorrhage mouse model. The goal of this study is to explore the molecular basis of the contribution of DENV to endothelial cell death and hemorrhage development. Our previous results showed in dengue hemorrhage mouse model that endothelial cell apoptosis is important to hemorrhage development in mice. We discovered that DENV protease is a viral factor that participates in the pathogenesis of dengue hemorrhage and interacts with new cellular proteins, IκBα and IκBβ. DENV protease activates NF-κB through cleavage of IκBα and IκBβ and activation of IKK, thereby inducing endothelial cell apoptosis. In addition, DENV protease targeted to endothelium by AAV9 induces hemorrhage in mice. Over-expression of IκBα or IκBβ protects endothelial cells from DENV-induced apoptosis. Transduction of endothelial cells with DENV protease, as it was in DENV infection, induces NF-κB activation and in the mean time up-regulated IL-32 and TNFRSF9, both of which are known to play a role in inflammatory response. In summary, these results reveal DENV induces endothelial cell apoptosis and hemorrhage development through viral protease-induced NF-κB activation. Our findings provide novel insights into the molecular mechanism of how DENV causes endothelial cell apoptosis and participate in the hemorrhage development. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T05:13:55Z (GMT). No. of bitstreams: 1 ntu-103-D95449001-1.pdf: 71249240 bytes, checksum: b016a6c2a56cf24d5189a7b3c02b50f9 (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 摘要 i
Abstract iii Table of Contents v List of Figures ix List of Tables xiiii CHAPTER I Introduction 1 Part A. Dengue disease 3 A-1. Epidemiology of dengue virus (DENV) infections 3 A-2. Clinical manifestations 5 A-3. Course of disease 6 A-4 New dengue classifications and warning signs 8 Part B. DENV 9 B-1. Characteristics of DENV 9 B-2. DENV genome and replication 12 B-3. Viral protease 14 Part C. The Pathogenesis of Dengue 15 C-1. Host and viral factors in the pathogenesis of DENV 16 C-2. Hemorrhage development in DENV infection 18 Part D. Role of endothelial cells in DENV infection 20 D-1. Effects of DENV infection on endothelial cells 20 D-2. Vascular damage in dengue 24 D-3. The role of viral protease in endothelial cell apoptosis 26 CHAPTER II Aims of The Study 29 CHAPTER III Materials & Methods 33 Part A. Materials 35 A-1. Mice 35 A-2. Antibodies 35 A-3. Buffer, solutions and media 38 A-4. Kits 44 A-5. Chemicals and reagents 45 A-6. Equipments and disposable plastics 47 Part B. Methods 49 B-1. DENV stock and infection 49 B-2. Cell cultures 50 B-3. Western blot analysis 50 B-4. Apoptosis assay 51 B-5. Plasmid construction and Transfection 53 B-6. Lentivirus preparation 53 B-7. Immunoprecipitation and Western Blotting 54 B-8. Measurement of IκBα and IκBβ Stability 55 B-9. Yeast-two-hybrid system 55 B-10. ELISA assay 62 B-11. RNA extraction, reverse transcription and PCR 64 B-12. Characterization of NF-κB Activation 68 B-13. Detecting the Cleavage Forms of IκBα and IκBβ 70 B-14. Model of hemorrhage in AAV-transduced mice system 70 B-15. Stable expression of IκBα or IκBβ in HMEC-1 cells 71 B-16. Microarray analysis 71 B-17. RNA interference 72 B-18. Statistical analysis 72 CHAPTER IV Results 73 Part A. DENV protease induces HMEC-1 cell death and hemorrhage development through its protease activity 75 Part B. DENV 2B-3 interacting proteins are found using yeast two-hybrid system 78 Part C. DENV 2B-3 interacts with IκBα and IκBβ and reduces their stability 80 Part D. DENV protease activates NF-κB by cleaving IκBα and IκBβ and activating IκB kinase 82 Part E. DENV protease induces endothelial cell apoptosis through NF-κB activation 83 Part F. DENV protease induces IL-32 and TNFRSF9 expression in endothelial cell 85 Part G. DENV protease-induced IL-32 expression in HMEC-1 is protease activity- and NF-κB-dependent 87 CHAPTER V Discussion 89 Flaviviral proteases interacts with IκB-α/β 91 DENV proteases interact with IκB-α/β through ANK repeats 92 IκBα and IκBβ may be cleaved by DENV protease at PR62GS and ERR127G, respectively 93 Flaviviral protease activity plays an important role in virus-mediated cell apoptosis 94 The NS2B is not necessary for DENV protease-mediated cell apoptosis 95 Flavivirus protease induces cell apoptosis through extrinsic apoptotic pathway 95 DENV-induced NF-κB activation causes cell apoptosis via its protease activity 98 The role of cleaved IκBα in viral protease-induced cell apoptosis 99 The host cellular protein as substrates for DENV protease 100 DENV protease successfully targets endothelial cells in mice using AAV system 100 DENV productively infects endothelial cells in vitro 101 DENV infection of endothelial cells in patients 102 The mechanism of DENV-induced vascular leakage 103 The problems in explanation of relationship between endothelial cell apoptosis and vascular leakage in humans 105 Conclusion 106 References 109 Figures 133 Tables 195 Appendix 203 | |
dc.language.iso | en | |
dc.title | 剖析登革病毒蛋白酵素造成登革出血以及微血管內皮細胞凋亡之分子機制 | zh_TW |
dc.title | To dissect the mechanism of dengue viral protease-mediated hemorrhage and endothelial cell apoptosis | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 繆希椿(Shi-Chuen Miaw),鄧述諄(Shu-Chun Teng),張雯(Wen Chang),施信如(Shin-Ru Shih) | |
dc.subject.keyword | 登革出血致病機制,登革蛋白酵素,IκB蛋白,NF-κB,血管內皮細胞死亡, | zh_TW |
dc.subject.keyword | Pathogenesis of dengue haemorrhage,Dengue viral protease,IκB proteins,NF-κB,Endothelial cell death, | en |
dc.relation.page | 208 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2014-08-18 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 免疫學研究所 | zh_TW |
顯示於系所單位: | 免疫學研究所 |
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