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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蔡坤憲(Kun-Hsien Tsai) | |
dc.contributor.author | Wan-Hsiu Yang | en |
dc.contributor.author | 楊婉秀 | zh_TW |
dc.date.accessioned | 2021-06-16T05:12:12Z | - |
dc.date.available | 2019-10-20 | |
dc.date.copyright | 2014-10-20 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-08-18 | |
dc.identifier.citation | Adams, J. R., E. T. Schmidtmann, and A. F. Azad.1990. Infection of colonized cat fleas, Ctenocephalides felis (Bouche), with a rickettsia-like microorganism. Am. J. Trop. Med. Hyg. 43: 400-409.
Assarasakorn S., J. K. V., J.R. Hawley, M.M. Brewer, A.K. Morris, A.E. Hill, M.R. Lappin. 2012. Prevalence of Bartonella species, hemoplasmas, and Rickettsia felis DNA in blood and fleas of cats in Bangkok, Thailand. Research in Veterinary Science 93: 1213-1216. Azad, A. F. 1990. Epidemiology of murine typhus. Annu. Rev. Entomol. 35: 553-569. Azad, A. F., J. B. Sacci, Jr., W. M. Nelson, G. A. Dasch, E. T. Schmidtmann, and M. Carl. 1992. Genetic characterization and transovarial transmission of a typhus-like rickettsia found in cat fleas. Proc. Natl. Acad. Sci. U. S. A 89: 43-46. Azad, A. F., and C. B. Beard. 1998. Rickettsial pathogens and their arthropod vectors. Emerg. Infect Dis. 4: 179-186. Azad, S. J. M. a. A. F. 2007. Propagation of arthropod-borne Rickettsia spp. in two mosquito cell lines. Applied and Environmental Microbiology.73 (20): 6637-6643. Barrs V. R., J. A. B., B. J. Wilson, N. Evans, R. Gowan, R. M. Baral, A. E. Lingard, G. Perkovic, J. R. Hawleye and M. R. Lappine. 2010. Prevalence of Bartonella species, Rickettsia felis, haemoplasmas and the Ehrlichia group in the blood of cats and fleas in eastern Australia. Australian Veterinary Journal.88 (5): 160-165. Baum B, C. L. 2008. Drosophila cell lines as model systems and as an experimental tool. Methods in Molecular Biology 420: 391–424. Bayliss, D. B., A. K. Morris, M. C. Horta, M. B. Labruna, S. V. Radecki, J. R. Hawley, M. M. Brewer, and M. R. Lappin. 2009. Prevalence of Rickettsia species antibodies and Rickettsia species DNA in the blood of cats with and without fever. J. Feline. Med. Surg. 11: 266-270. Ben-Zvi I., M. E., Nogueras M., Segura F., and Bank I. 2010. First detection of human infection with Rickettsia felis in Israel. Am J Med Sci. 340(4): 343. Bernabeu-Wittel, M., del Toro, M., Nogueras, M., Muniain, M., Cardenosa, N., Marquez, F., Segura, F., and Pachon, J. 2006. Seroepidemiological study of Rickettsia felis, Rickettsia typhi, and Rickettsia conorii infection among the population of southern Spain. European Journal of Clinical Microbiology & Infectious Diseases. 25(6): 375-381. Bitam, I., P. Parola, K. D. De La Cruz, K. Matsumoto, B. Baziz, J. M. Rolain, M. Belkaid, and D. Raoult. 2006. First molecular detection of Rickettsia felis in fleas from Algeria. Am. J. Trop. Med. Hyg. 74: 532-535. Boone, D. R., R. W. Castenholz, D. H. G. G. M. Bergey, and J. T. Staley. 2001. Bergey's manual of systematic bacteriology , 2 ed., Springer. Boostrom, A., M. S. Beier, J. A. Macaluso, K. R. Macaluso, D. Sprenger, J. Hayes, S. Radulovic, and A. F. Azad. 2002. Geographic association of Rickettsia felis-infected opossums with human murine typhus, Texas. Emerg. Infect. Dis. 8: 549-554. Botelho-Nevers, E. and D. Raoult. 2007. Fever of unknown origin due to Rickettsioses. Infect. Dis. Clinics of North America 21(4): 997-1011. Bouyer, D. H., J. Stenos, P. Crocquet-Valdes, C. G. Moron, V. L. Popov, J. E. Zavala-Velazquez, L. D. Foil, D. R. Stothard, A. F. Azad, and D. H. Walker. 2001. Rickettsia felis: molecular characterization of a new member of the spotted fever group. Int. J. Syst. Evol. Microbiol. 51: 339-347. Brouqui, P., P. Parola, P. E. Fournier, and D. Raoult. 2007. Spotted fever rickettsioses in southern and eastern Europe. FEMS Immunol. Med. Microbiol. 49: 2-12. Case, J. B., B. Chomel, W. Nicholson, and J. E. Foley. 2006. Serological survey of vectorborne zoonotic pathogens in pet cats and cats from animal shelters and feral colonies. J. Feline. Med. Surg. 8: 111-117. Choi Y. J., W. J. J., J. H. Kim, J. S. Ryu, S. H. Lee, K. H. Park, H. S. Paik. Y. S. Koh, M. S. Cho, and I. S. Kim. 2005. Spotted fever group and typhus group rickettsioses in humans, South Korea.Emerging Infectious Diseases 11(2): 237-244. DeSousa, R., P. Edouard-Fournier, M. Santos-Silva, F. Amaro, F. Bacellar, and D. Raoult. 2006. Molecular detection of Rickettsia felis, Rickettsia typhi and two genotypes closely related to Bartonella elizabethae. Am. J. Trop. Med. Hyg. 75: 727-731. Dumler J. S., T. J. P., Walker D. H. 1991. Clinical and laboratory features of murine typhus in South Texas, 1980 through 1987. JAMA. 266 (10): 1365-1370. Dumler, J. S., A. F. Barbet, C. P. Bekker, G. A. Dasch, G. H. Palmer, S. C. Ray, Y. Rikihisa, and F. R. Rurangirwa. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new 45 species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51: 2145-2165. Fang CT, F. W., Hwang JJ, Yu CJ, Chen YC, Wang MH, Chang SC, Hsieh WC. 1997. Life-threatening scrub typhus with meningoencephalitis and acute respiratory distress syndrome. Journal of the Formosan Medical Association 96(3): 213-216. Fournier, P. E., and D. Raoult. 2000. Phylogenetic analysis of members of the genus Rickettsia using the gene encoding the outer membrane protein rOmpB (ompB). Int. J. Syst. Bacteriol. 50: 1449–1455. Galvao, M. A., J. E. Zavala-Velazquez, J. E. Zavala-Castro, C. L. Mafra, S. B. Calic, and D. H. Walker. 2006. Rickettsia felis in the Americas. Ann. N. Y. Acad. Sci. 1078: 156-158. Hidalgo M., V. M., A. Martı’nez, M. Mercado, A. De la Ossa, C. Ve’ lez, G. Estrada, J. E. Pe’ rez, A. A. Faccini-Martı’nez, M. B. Labruna, and G. Valbuena. 2013. Flea-Borne Rickettsioses in the North of Caldas Province, Colombia. Vector-borne and Zoonotic Diseases.13(5): 289-294. Higgins, J. A., S. Radulovic, M. E. Schriefer, and A. F. Azad. 1996. Rickettsia felis: a new species of pathogenic rickettsia isolated from cat fleas. J. Clin. Microbiol. 34: 671-674. Hii Sze-Fui, M. Y. A., Steven R. Kopp, John Stenos,, Robert L. Rees and Rebecca J. Traub. 2013. Seroprevalence and risk factors for Rickettsia felis exposure in dogs from Southeast Queensland and the Northern Territory, Australia. Parasites & Vectors. 6(159) Hii Sze-Fui, S. R. K., Mary F. Thompson, Caroline A. O' Leary, Robert L. Rees and Rebecca J. Traub. 2011. Molecular evidence of Rickettsia felis infection in dogs from northern territory, Australia. Parasites & Vectors. 4(198). Horta, M. C., Marcelo B. Labruna, Edison L. Durigon and Teresinha T. S. Schumaker. 2006. Isolation of Rickettsia felis in the Mosquito Cell Line C6/36. Appl. Environ. Microbiol. 72(2): 1705–1707. Jiang Ju , A. N. M., Darryn L. Knobel, Sarah Cleaveland, Anne Laudisoit, Kabura Wamburu, Eric Ogola, Philippe Parola, Robert F. Breiman, M. Kariuki Njenga, and Allen L. Richards. 2013. Molecular detection of Rickettsia felis and Candidatus Rickettsia Asemboensis in fleas from human habitats, Asembo, Kenya. Vrctor-borne and Zoonotic Diseases. 13(8): 550-558. Kernif T., C. S., K. Wells, M. B. Lakim, S. Inthalad, G. Slesak, N. Boudebouch, J. C. Beaucournu, P. N. Newton, D. Raoult, and P. Parola. 2012. Bartonella and Rickettsia in arthropods from the Lao PDR and from Borneo, Malaysia. Comp Immunol Microbiol. Infect Dis 35(1): 51-57. Kuo, C. C., J. L. Huang, T. E. Lin, H.C. Wang. 2012. Detection of Rickettsia spp. and host and habitat associations of fleas (Siphonaptera) in eastern Taiwan. Med. Vet .Entomol. 26(3): 341-350. La Scola B, L. R., J. B. Ndihokubwayo, S. Vene, and D. Raoult. 2000. Serological differentiation of murine typhus and epidemic typhus using cross-adsorption and western blotting. Clin Diagn Lab Immunol. 7(4): 612-616. Lai C.H., L. L. C., J.N. Lin, K.H. Tsai, Y.C. Hung, L.L. Kuo, H.H. Lin, and Y.H. Chen. 2014. Human spotted fever group rickettsioses are underappreciated in southern Taiwan, particularly for the species closely-related to Rickettsia felis. Plos one. 9(4): e95810. LaScola Bernard, S. M., Florence Fenollar, Jean-Marc Rolain, Ve!ronique Roux and Didier Raoult. 2002. Emended description of Rickettsia felis (Bouyer et al. 2001), a temperature-dependent cultured bacterium. International Journal of Systematic and Evolutionary Microbiology. 52: 2035–2041. Letaief, K. N. 2009. Characterization of rickettsial diseases in a hospital-based population in central tunisia. Ann. N.Y. Acad. Sci. 1166: 167-171. Lim M. Y. , H. B., T. Hambling, K. Sexton, D. Tompkins, and D. Slaney. 2012. Rickettsia felis infections, New Zealand. Emerging Infectious Diseases. 18(1): 167-169. Lindblom A., K. S., and K. Nilsson. 2010. Rickettsia felis infection in Sweden: report of two cases with subacute meningitis and review of the literature. Scandinavian Journal of Infectious Diseases. 42: 906-909. Luce-Fedrow, A., Kevin R. Macaluso, and Allen L. Richards. 2014. Growth of Rickettsia felis in Drosophila melanogaster S2 cells. Vector-borne and Zoonotic Diseases. 14(2): 101-110. Macaluso, K. R., W. Pornwiroon, V. L. Popov, and L. D. Foil. 2008. Identification of Rickettsia felis in the salivary glands of cat fleas. Vector-Borne Zoonotic Dis. 8: 391-396. Maina A. N., D. L. Knobel, J. Jiang, J. Halliday, D. R. Feikin, S. Cleaveland, Z. Nganga, M. Junghae, R. F. Breiman, A. L. Richards, and M. K. Njenga. 2012. Rickettsia felis Infection in febrile patients, Western Kenya, 2007–2010. Emerging Infectious Diseases. 18(2): 328-331. McBride W. J., T. C. Pryor, and J. A, Simpson. 1999. Scrub typhus in north Queensland. The Medical Journal of Australia. 170(7): 318-320. Mediannikov O., F. F., H. Bassene, A. Tall, C. Sokhna, J. F. Trape, amd D. Raoult. 2013. Description of “yaaf”, the vesicular fever caused by acute Rickettsia felis infection in Senegal. Journal of Infection. 66: 536-540. Noden, B. H., S. Radulovic, J.A. Higgins, and A.F. Azad. 1998. Molecular identification of Rickettsia typhi and R. felis in co-infected Ctenocephalides felis (Siphonaptera: Pulicidae). Journal of Med Entomo. 35(4): 410-414. Nogueras M. M., I. P., I. Sanfeliu, M. Sala and F. Segura. 2014. Serosurvey of Rickettsia typhi and Rickettsia felis in HIV-infected patients. Microbiol Immunol 58: 257-259. Nogueras M. M., N. C., I. Sanfeliu, T. Munoz, B. Font, and F. Segura. 2006. Serological evidence of infection with Rickettsia typhi and Rickettsia felis among the human population of Catalonia, in the northeast of Spain. The American journal of tropical medicine and hygiene. 74(1): 123-126. Ogata H., P. R., S. Audic, C. Robert, G. Blanc, P. Fournier, H. Parinello, J. Claverie, D. Raoult. 2005. The Genome Sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite. PLoS Biol. 3(8): e248. Ormsbee, R., M. P., R. Philip, E. Casper, J. Plorde, T. Gabre-Kidan and L. Wright. 1978. Antigenic relationships between the typhus and spotted fever groups of rickettsiae. American Journal of Epidemiology. 108(1): 53-59. Oteo J. A., A. P., S. Santibanez, J. R. Blanco, L. Pe’rez-Martınez, and V. Ibarra. 2006. Cluster of Cases of Human Rickettsia felis Infection from Southern Europe (Spain) Diagnosed by PCR. Journal of Clinical Microbiology. 44(7): 2669–2671. Parker T. M., C. K. M., A. L. Richards, A. Samir, T. Ismail, M. A. Fadeel, J. Jiang, M. O. Wasfy, and G. Pimentel. 2007. Concurrent Infections in Acute Febrile Illness Patients in Egypt. Am. J. Trop. Med. Hyg. 77(2): 390-392. Parola, P. 2003. Scrub typhus and tropical rickettsioses. Current Opinion in Infectious Diseases. 16(5): 429-436. Parola P., C. D. Paddock and D. Raoult. 2005. Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clin Microbiol Rev 18(4): 719-756. Parola P. and D. Raoult. 2001. Ticks and tickbrone bacterial diseases in humans: an emerging infectious threat. Clin Infect Dis. 32(6): 897-928. Parola P., R. S. M., Philip McDaniel, Sam R. Telford, Jean-Marc Rolain, Chansuda Wongsrichanalai, and D. Raoult. 2003. Emerging Rickettsioses of the Thai-Myanmar Border. Emerging Infectious Diseases. 9(5): 592-595. Perez-Arellano J. L., F. F., A. Angel-Moreno, M. Bolanos, M. Hernandez, E. Santana, M. Hemmersbach-Miller, A. M. Martin, and D. Raoult. 2005. Human Rickettsia felis infection, Canary Islands, Spain. Emerging Infectious Diseases. 11(12): 1961-1964. Perez-Osorio, C. E., J. E. Zavala-Velazquez, J. J. A. Leon, and J. E. Zavala-Castro. 2008. Rickettsia felis as emergent global threat for humans. Emerg. Infect. Dis. 14: 1019-1023. Perlman, S. J., M. S. Hunter, and E. Zchori-Fein. 2006. The emerging diversity of Rickettsia. Proc. Biol. Sci. 273: 2097-2106. Phongmany S., J. M. R., R. Phetsouvanh, S. D. Blacksell, V. Soukkhaseum, B. Rasachack, K. Phiasakha, S. Soukkhaseum, K. Frichithavong, V. Chu, V. Keolouangkhot, B. Martinez-Aussel, K. Chang, C. Darasavath, O. Rattanavong, S. Sisouphone, M. Mayxay, S. Vidamaly, P. Parola, C. Thammavong, M. Heuangvongsy, B. Syhavong, D. Raoult, N. J. White, and P. N. Newton. 2006. Rickettsial infections and fever, vientiane, Laos. Emerging Infectious Diseases. 12(2): 256-262. Pornwiroon Walairat, S. S. P., Lane D. Foil, and Kevin R. Macaluso. 2006. Rickettsia felis from cat fleas: isolation and culture in a tick-derived cell line. Applied and Environmental Micorbiology. 72(8): 5589–5595. Radulovic, S., J. A. Higgins, D. C. Jaworski, G. A. Dasc, and A. F. AZAD. 1997. Isolation, Cultivation, and Partial Characterization of the ELB Agent Associated with Cat Fleas. Iinfection and Immunity. 63(12): 4826–4829. Radulovic S., J. A. H., D. C. Jaworski, G. A. Dasch and A. F. Azad. 1995. Isolation, cultivation, and partial characterization of the ELB agent associated with cat fleas. Infect. Immun. 63(12): 4826-4829. Ramirez-Hernandez, A., V. Montoya, A. Martinez , J. E. Perez, M. Mercado, A. de la Ossa, C. Velez, G. Estrada, M.I. Correa, L. Duque, J. S. Ariza, C. Henao, G. Valbuena , and M. Hidalgo. 2013. Molecular detection of Rickettsia felis in different flea species from Caldas, Colombia. Am. J. Tro.p Med. Hyg. 89(3): 453-459. Raoult D. , B. L. S., M. Enea, P. E. Fournier, V. Roux, F. Fenollar, M. A. Galvao, and X. de Lamballerie. 2001. A flea-associated Rickettsia pathogenic for humans. Emerg Infect Dis. 7(1): 73-81. Raoult, D. (1997). Rickettsioses as paradigms of new or emerging infectious diseases. Clin. Microbiol. Rev. 10(4): 694-719. Rault, D. 1997. Laboratory Diagnosis of Rickettsioses: Current Approaches to diagnosis of old and new rickettsial Diseases. Journal of Clinical Microbiology. 35(11): 2715-2727. Regnery, R. L., C. L. Spruill, and B. D. Plikaytis. 1991. Genotypic identification of rickettsiae and estimation of intraspecies sequence divergence for portions of two rickettsial genes. J. Bacteriol. 173: 1576–1589. Reif, K. E., and K. R. Macaluso. 2009. Ecology of Rickettsia felis: a review. J. Med. Entomol. 46: 723-736. Renvoise A., A.-Y. J., and Didier Raoult. 2009. Rickettsia felis Infection in man, France. Emerg Infect Dis. 15(7): 1126-1127. Richards A. L., J. J., S. Omulo, R. Dare, K, Abdirahman, A, Ali, S, K. Sharif, D. R. Feikin, R. F. Breiman, and M. K. Njenga. 2010. Human Infection with Rickettsia felis, Kenya. Emerging Infectious Diseases. 16(7): 1081-1086. Richter J., P.-E. F., J. Petridou, D. Haussinger, and D. Raoult. 2002. Rickettsia felis infection acquired in Europe and documented by polymerase chain reaction. Emerging Infectious Diseases. 8(2): 207-208. Rolain, J. M., L. Stuhl, M. Maurin, and D. Raoult. 2002. Evaluation of antibiotic susceptibilities of three rickettsial species including Rickettsia felis by a quantitative PCR DNA assay. Antimicrob. Agents Chemother. 46: 2747-2751. Rolain, J. M., M. Franc, B. Davoust, and D. Raoult. 2003. Molecular detection of Bartonella quintana, B. koehlerae, B. henselae, B. clarridgeiae, Rickettsia felis, and Wolbachia pipientis in catf Fleas, France. Emerg. Infect. Dis. 9(3): 339-342. Saisongkorh Watcharee, K. E. K., Jean-Yves Patrice, Annick Bernard, Jean-Marc Rolain and Didier Raoult. 2012. Tryptose phosphate broth improves Rickettsia felis replication in mammalian cells. FEMS Immunol Med Microbiol. 64: 111–114. Schriefer M. E. , J. B. S. J., J. S. Dumler, M. G. Bullen and A. F. Azad. 1994. Identification of a novel rickettsial infection in a patient diagnosed with murine typhus. Journal of Clinical Microbiology. 32(4): 949-954. Shimada T., T., L. W., Jr. and Adams, C. T. 1961. Provisional list of medically important fauna of Taiwan (Formosa). Entomology Section, 5th Epidemiological Flight (PACAF) (San Francisco, Calif.). Shyu, M. H., T. C. Hsu, and W. J. Wu. 1993. Seasonal abundance of cat flea, Ctenocephalides felis (Bouche’) (Siphonaptera: Pulicidae), in Taipei city. Chin. J. Entomol. 13: 59-67. Socolovschi C., O. M., C. Sokhna, A. Tall, G. Diatta, H. Bassene, J. F. Trape, and D. Raoult. 2010. Rickettsia felis-associated uneruptive fever, Senegal. Emerging Infectious Diseases. 16(7): 1140-1142. Strickman, G. W. a. D. 1994. Life-Threatening Scrub Typhus in a Traveler Returning from Thailand. Clinical Infectious Diseases. 18(4): 624-626. Sunyakumthorn Piyanate, A. B., Walairat Pornwiroon, Connie David, Steven A. Barker, and Kevin R. Macaluso. 2008. Characterization and growth of polymorphic Rickettsia felis in a tick cell line.' Applied and Environmental Microbiology. 74(10): 3151-3158. Thepparit, C., P. Sunyakumthorn, M. L. Guillotte, V.L. Popov, L. D. Foil, and K. R. Macaluso. 2011. Isolation of a rickettsial pathogen from a non-hematophagousa arthropod. Plos one. 6(1): e16396. Tijsse-Klasen Ellen, M. F., Fedor Gassner, Ard M Nijhof, Emil KE Hovius, Frans Jongejan, Willem Takken, Johan R Reimerink, Paul AM Overgaauw and Hein Sprong. 2011. Absence of zoonotic Bartonella species in questing ticks: First detection of Bartonella clarridgeiae and Rickettsia felis in cat fleas in the Netherlands. Parasites & Vectors 4(61). Tsai, K.-H., Chin-Gi Huang, Chi-Tai Fang, Pei-Yun Shu, and Jyh-Hsiung Huang. 2011. Prevalence of Rickettsia felis and the fFirst iIdentification of Bartonella henselae Fizz/CAL-1 in cat fleas (Siphonaptera: Pulicidae) from Taiwan. Journal of Medical Entomology. 48(2): 445-452. Tsai, K. H., Lu, H. Y., Tsai, J. J., Yu, S. K., Huang, J. H., and Shu,P. Y. 2008. Human case of Rickettsia felis infection, Taiwan. Emerg. Infect Dis. 14(12): 1970–1972. Tsai, K. H., H. C. Wang, C. H. Chen, J. H. Huang, H. Y. Lu, C. L. Su and P. Y. Shu. 2008. Isolation and identification of a novel spotted fever rickettsiae, strain IG-1, from Ixodes granulatus ticks collected on Orchid Island (Lanyu), Taiwan. Am. J. Trop. Med. Hyg. 79: 256-261. Tsui, P. Y., K.H. Tsai, M.H. Weng, Y.W. Hung, Y.T. Liu, K.Y. Hu, J.C. Lien, P.R. Lin, M.F. Shaio, H.C. Wang and D.D. Ji. 2007. Molecular detection and characterization of spotted fever group rickettsiae in Taiwan. Am. J. Trop. Med. Hyg. 77(5): 883-890. Wen-Che Chi, J.-J. H., Junne-Ming Sung, Rong-Rue Lan, Wen-Chien Ko and Fen-Fen Chen. 1997. Scrub typhus associated with Multiorgan Failure: a case report. Scandinavian Journal of Infectious Diseases. 29(6): 634-635. Wiggers R.J., M. C. M., and D. Bouyer. 2005. Rickettsia felis infection rates in an east Texas population. Tex Med.101(2): 56-58. Williams M., L. I., S. R Graves, J. Stenos and J. J. Kelly. 2011. First probable Australian cases of human infection with Rickettsia felis (cat-flea typhus). Med J Aust. 194(1): 41-43. Williams, S. G., J. B. Sacci, Jr., M. E. Schriefer, E. M. Andersen, K. K. Fujioka, F. J. Sorvillo, A. R. Barr, and A. F. Azad. 1992. Typhus and typhuslike rickettsiae associated with opossums and their fleas in Los Angeles County, California. J. Clin. Microbiol. 30: 1758-1762. Zavala-Castro, J. E., M. Small, C. Keng, D. H. Bouyer, J. Zavala-Velazquez, and D. H. Walker. 2005. Transcription of the Rickettsia felis ompA gene in naturally infected fleas' Am. J. Trop. Med. Hyg. 73: 662-666. Zavala-Castroa J., J. Z.-V., D. Walker, J. Perez-Osorioc, and G. Peniche-Lara. 2009. Severe human infection with Rickettsia felis associated with hepatitis in Yucatan, Mexico. International Journal of Medical Microbiology. 299: 529-533. Zavala-Velazquez J. E., J. A. R.-S., R. A. Sanchez-Elias, G. Becerra-Carmona, and D. H. Walker. 2000. Rickettsia felis rickettsiosis in Yucatan. The Lancet. 356(9235): 1079-1080. Zavala-Velazquez J., H. L.-M., J. Zavala-Castro, C. Perez-Osorio, G. Becerra-Carmona, J. A. Ruiz-Sosa, D. H. Bouyer, and D. H. Walker. 2006. Rickettsia felis, the agent of an emerging infectious disease: report of a new case in Mexico. Archives of Medical Research. 37: 419-422. Znazen A., J. M. R., N. Hammami, A. Hammami, M. B. Jemaa, and D. Raoult. 2006. Rickettsia felis infection, Tunisia. Emerging Infectious Dis. 12(1): 138-140. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/55980 | - |
dc.description.abstract | 立克次體病為一常見的不明熱來源。在台灣,本土流行的立克次體病包括恙蟲病以及地方性斑疹傷寒。在過去五年內,每年約有300至400個恙蟲病的個案以及30到40個地方性斑疹傷寒的個案發生。然而,立克次體病的檢出率在近幾年內皆不太高。2008年時,發表了台灣第一個人類感染Rickettsia felis的個案。由於R. felis在臨床上的表徵與其他立克次體病十分相似,包括發燒、頭痛、肌肉痛、關節痛、皮膚紅疹等,造成臨床判斷上的不易。再加上使用血清學方法檢驗時,R. felis和R. typhi會有交叉反應產生,易導致檢驗結果誤判。因此R. felis感染所造成的個案數量可能被低估。為了解台灣蚤傳立克次體病的流行病學,本研究採用於2009年至2010年間由國立臺灣大學附設醫院通報至衛生署疾病管制局疑似為恙蟲病、地方性斑疹傷寒以及Q熱經檢出結果為陰性之血清檢體,共有221個樣本來自127為病人。利用免疫螢光染色法,針對R. felis 、 R. typhi 及 R. japonica 之三種病原進行檢驗。而檢出結果共有23為病人為Rickettsia 感染,其中8位為台灣蚤傳立克次體感染陽性,7位為其他斑點熱群之立克次體感染,另8位因病原之血清學交叉反應而無法確定感染源,須以吸收式西方墨點法(absorb Western blot)再加以確認。另外並針對其中三位為台灣蚤傳立克次體感染之病患進行病例的回顧,三位的臨床症狀包括發燒、皮膚紅疹、腹痛、淋巴結腫大、肝炎、急性腎衰竭而導致休克以及肺炎造成之急性呼吸衰竭而死亡。研究結果顯示了台灣蚤傳立克次體病在北台灣的確是個潛在的病原,而其他斑點熱群立克次體的感染可能也被忽視而需更多的研究及了解。 | zh_TW |
dc.description.abstract | Rickettsioses are common agent as a cause of fever of unknown origin. In Taiwan, endemic rickettsial diseases including scrub typhus and murine typhus which brought about 300 to 400 and 30 to 40 annual cases separately in the past five years. However, positive rate of diagnosis in rickettsial diseases remained low in the past few years. In 2008, first human case of Rickettsia felis was reported in Taiwan. Clinical symptoms of R. felis are similar to other rickettsial diseases including fever, headache, myalgia, and macular rash, which make clinical diagnosis difficult. Also, R. felis may have cross reaction with R. typhi in serologic tests which may lead to misdiagnosis. Human cases of R. felis infection may be underestimated. To realize the epidemiology of R. felis infection in Taiwan, we analyzed 221 serological samples sent from National Taiwan University Hospital to the Centers for Disease Control (Taiwan CDC) for rickettsioses diagnosis during 2009 (86 samples) and 2010 (135 samples) which collected from 127 patients have negative diagnostic results of scrub typhus, murine typhus and Q fever. Three whole cell antigens were tested in immunofluorescence assay including R. felis which isolated from the cat flea, R. typhi and R. japonica. A total of 23 patients were positive for Rickettsia infection, 8 were positive for R. felis infection, 7 were positive for other spotted rickettsiae infection, because of the cross reaction in immunofluorescence assay, source of infection in 8 patients are further examined by absorb Western blot. Medical records of 3 cases are examined, clinical symptoms including fever, skin rash, chills, abdominal dullness, lymphadenopathy, hepatitis, septic shock with acute renal failure, and pneumonia with acute respiratory distress syndrome. The results confirm that R. felis is a potential pathogen in northern Taiwan, and other spotted rickettsiae infection may need further studies. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T05:12:12Z (GMT). No. of bitstreams: 1 ntu-103-R99849007-1.pdf: 1401096 bytes, checksum: 78b75d3e70021f7d5df5a65eb06285c5 (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i ABSTRACT iii 中文摘要 iv CONTENTS v LIST OF FIGURES viii LIST OF TABLES ix Chapter 1 Introduction 10 Chapter 2 Literature Review 11 2.1 General Overview of the Genus Rickettsia 11 2.2 Rickettsioses diseases in Taiwan 14 2.2.1 Scrub typhus 14 2.2.2 Endemic typhus 15 2.3 Characterization of Rickettsia felis 16 2.3.1 Phylogenetics 16 2.3.2 Cultivation 17 2.4 Ecology of Rickettsia felis 21 2.4.1 Infection in Arthropods 21 2.4.2 Mammalian Reservoirs 22 2.4.3 Transmission Routes 22 2.5 Epidemiology of Rickettsia felis 23 2.5.1 Human cases worldwide 23 2.5.2 Clinical symptoms 24 2.5.3 Medication 24 2.6 Detection and Diagnosis of Rickettsia felis Infection 25 2.6.1 Serological Methods 25 2.6.2 Molecular Methods 28 Chapter 3 Materials and Methods 29 3.1 Study Design 29 3.2 Data resources 29 3.3 Isolation of Rickettsia felis from cat flea 30 3.3.1 Fleas and Cats 30 3.3.2 R.felis isolation and incubation 30 3.3.3 DNA isolation 32 3.3.4 Rickettsial Detection and Identification by PCR 33 3.3.5 Immunofluorescence Assay 34 3.4 Diagnosis of Serum from National Taiwan University Hospital 34 3.4.1 Immunofluorescence Assay 34 3.4.2 Western Blot Analysis 35 3.5 Clinical Data Analysis 35 Chapter 4 Results 36 4.1 Isolation of Rikettsia felis from cat flea 36 4.2 Immunofluorescence Assay 37 4.3 Western Blot Analysis 41 4.4 Clinical Records of Patients 42 4.4.1 Case 1 42 4.4.2 Case 2 43 4.4.3 Case 3 44 Chapter 5 Discussion and future directions 47 REFERENCE 50 APPENDIX 64 | |
dc.language.iso | en | |
dc.title | 台灣北部地區蚤傳立克次體病之血清流行病學研究 | zh_TW |
dc.title | Seroepidemiology of Flea-borne Rickettsiosis in Northern Taiwan | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 方啟泰(Chi-Tai Fang) | |
dc.contributor.oralexamcommittee | 舒佩芸(Pei-Yun Shu) | |
dc.subject.keyword | 蚤傳立克次體病,斑點熱群立克次體病,血清流行病學, | zh_TW |
dc.subject.keyword | Rickettsia felis,spotted fever group Rickettsia,Seroepidemiology, | en |
dc.relation.page | 70 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2014-08-19 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 流行病學與預防醫學研究所 | zh_TW |
顯示於系所單位: | 流行病學與預防醫學研究所 |
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