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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/55141完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 曹建和(Jenho Tsao) | |
| dc.contributor.author | Yu-Ting Lin | en |
| dc.contributor.author | 林祐霆 | zh_TW |
| dc.date.accessioned | 2021-06-16T03:48:44Z | - |
| dc.date.available | 2017-03-13 | |
| dc.date.copyright | 2015-03-13 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-01-27 | |
| dc.identifier.citation | [1] A.E. Guedel. Inhalational Anesthesia: A Fundamental Guide. New York, Macmillan,
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/55141 | - |
| dc.description.abstract | 瞬時心跳速率的變化在麻醉深度較深時顯得規律振蕩，在麻醉深度較淺時則顯得較不規律。這個「律動至非律動」現象無法從目前標準麻醉監測儀器上的心電圖波形觀察到。為了探討可能的臨床價值，我提出「可適性諧波分析」模型，此模型符合生理上的特性，並提供足夠的數學條件以進一步定量化這個現象。基於此模型，我們可以使用multitaper Synchrosqueezing transform來實現時變功率頻譜，進而運算定量指標：「非律動至律動」指標(NRR指標)。之後我運用一個臨床資料庫來分析NRR指標的行為，並且將它與其它現行標準麻醉深度指標比較。統計結果顯示NRR指標可以提供額外的臨床資訊反映運動動作的反應，以並行於目前的標準工具。此外我還發現了對於手術傷害性刺激的指標。最後，我提出一個有助於將成果實用化的即時內插方案。 | zh_TW |
| dc.description.abstract | Variations of instantaneous heart rate appears regularly oscillatory in deeper levels of anesthesia and less regular in lighter levels of anesthesia. It is impossible to observe this ``rhythmic-to-non-rhythmic' phenomenon from raw electrocardiography waveform in current standard anesthesia monitors. To explore the possible clinical value, I proposed the adaptive harmonic model, which fits the descriptive property in physiology, and provides adequate mathematical conditions for the quantification. Based on the adaptive harmonic model, multitaper Synchrosqueezing transform was used to provide time-varying power spectrum, which facilitates to compute the quantitative index: ``Non-rhythmic-to-Rhythmic Ratio' index (NRR index). I then used a clinical database to analyze the behavior of NRR index and compare it with other standard indices of anesthetic depth. The positive statistical results suggest that NRR index provides addition clinical information regarding motor reaction, which aligns with current standard tools. Furthermore, the ability to indicates the noxious stimulation is an additional finding. Lastly, I have proposed an real-time interpolation scheme to contribute my study further as a clinical application. | en |
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| dc.description.tableofcontents | 摘要ii
Abstract iii Acknowledgements iv Contents v List of Figures viii List of Tables ix Abbreviations x 1 Introduction 1 1.1 Field of Project . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.2 An Obscure Phenomenon . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.3 Quantification for Depth of Anesthesia . . . . . . . . . . . . . . . . . . . . . 2 1.4 Project Motivation and Goals . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.5 Thesis Outline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2 Background and Previous Work 5 2.1 Historical Background in Anesthesia . . . . . . . . . . . . . . . . . . . . . . 5 2.2 Current View on Anesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2.3 Perspective from Anesthesiology . . . . . . . . . . . . . . . . . . . . . . . . 7 2.4 Anesthesia and Long-Term Mortality . . . . . . . . . . . . . . . . . . . . . . 8 2.5 Perspective from Physiology . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.6 Physiology of Amplitude and Frequency Modulation . . . . . . . . . . . . . 10 2.7 Instantaneous Heart Rate and Heart Rate Variability . . . . . . . . . . . . . 11 2.8 Integration of Multidisciplinary Backgrounds . . . . . . . . . . . . . . . . . 12 3 Theory and Modeling 14 3.1 Proposal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 3.2 Description of Proposed Methodology . . . . . . . . . . . . . . . . . . . . . 14 3.3 Adaptive Harmonic Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 3.4 Non-rhythmic to Rhythmic Ratio . . . . . . . . . . . . . . . . . . . . . . . . 17 3.5 Non-rhythmic Component vs. Stochastic Process . . . . . . . . . . . . . . . 22 3.6 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 4 Time-Frequency Analysis, Reassignment, and Synchrosqueezing 25 4.1 Time-Frequency Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 4.2 Reassignment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 4.3 Synchrosqueezing Transform . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 4.4 Multitaper Estimation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 4.5 Multitaper Synchrosqueezing Spectrogram . . . . . . . . . . . . . . . . . . . 34 4.6 Adaptive Filter and Parametric Estimation . . . . . . . . . . . . . . . . . . 35 4.7 Common Condition in Physiology and Mathematics . . . . . . . . . . . . . 38 5 Performance Evaluation using Clinical Data 39 5.1 Clinical Database . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 5.2 Anesthesia Protocol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 5.3 Data Acquisition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 5.4 Statistical Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 5.5 Serial Prediction Probability Analysis in Predicting Anesthetic Events . . . 44 5.6 Correlations with Sevoflurane Concentration . . . . . . . . . . . . . . . . . . 45 5.7 Algorithm of Serial Prediction Probability (sPK) Analysis . . . . . . . . . . 45 6 Results from Clinical Database 48 6.1 Visual Information in TF Plane . . . . . . . . . . . . . . . . . . . . . . . . . 48 6.2 Multiple Component Phenomenon . . . . . . . . . . . . . . . . . . . . . . . 53 6.3 Ability to Predict Anesthetic Events . . . . . . . . . . . . . . . . . . . . . . 57 6.4 Correlation with Sevoflurane Concentration . . . . . . . . . . . . . . . . . . 58 6.5 Quantitative Results of Noxious Stimulation . . . . . . . . . . . . . . . . . . 60 6.6 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 7 Implications to Anesthesiology and Physiology 66 7.1 Main Findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66 7.2 Genuineness of NRR index . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 7.3 Existing Findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 7.4 Physiologic Interpretation of NRR . . . . . . . . . . . . . . . . . . . . . . . 68 7.5 Clinical Application of the NRR Index . . . . . . . . . . . . . . . . . . . . . 71 7.6 Potential Index in Noxious Stimulation . . . . . . . . . . . . . . . . . . . . . 71 7.7 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 8 Real-time Processing Using the Blending Operator 73 8.1 Real-time Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 8.2 Technique Obstacles for Real-time Processing . . . . . . . . . . . . . . . . . 74 vi Contents 8.3 B-spline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 8.4 Quasi-interpolation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 8.5 Local Interpolation Operator . . . . . . . . . . . . . . . . . . . . . . . . . . 80 8.6 Blending Operator . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 8.7 Real-time tvPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82 9 Conclusion 86 9.1 Research Findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 9.2 Accomplishments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 9.3 Future Directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 9.4 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Bibliography 91 | |
| dc.language.iso | en | |
| dc.subject | 心電圖 | zh_TW |
| dc.subject | 麻醉深度 | zh_TW |
| dc.subject | 時頻域分析 | zh_TW |
| dc.subject | 瞬時心跳速率 | zh_TW |
| dc.subject | electrocardiography | en |
| dc.subject | instantaneous heart rate | en |
| dc.subject | rhythmic-to-non-rhythmic | en |
| dc.subject | Synchrosqueezing transform | en |
| dc.subject | time-frequency analysis | en |
| dc.subject | time-varying power spectrum | en |
| dc.subject | depth of anesthesia | en |
| dc.title | 建模與定量麻醉心電訊號裡的節律與非節律現象 | zh_TW |
| dc.title | The Modeling and Quantification of Rhythmic to Non-rhythmic Phenomenon in Electrocardiography during Anesthesia | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 宋孔彬(Kung-Bin Sung),詹曉龍(Hsiao-Lung Chan),黃念祖(Nien-Tsu Huang),吳浩榳(Hau-tieng Wu) | |
| dc.subject.keyword | 麻醉深度,瞬時心跳速率,時頻域分析,心電圖, | zh_TW |
| dc.subject.keyword | instantaneous heart rate,rhythmic-to-non-rhythmic,Synchrosqueezing transform,time-frequency analysis,time-varying power spectrum,depth of anesthesia,electrocardiography, | en |
| dc.relation.page | 102 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-01-27 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
| 顯示於系所單位： | 生醫電子與資訊學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-104-1.pdf 未授權公開取用 | 10.58 MB | Adobe PDF |
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