請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/54906完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳振中(Chun-Chung Chan) | |
| dc.contributor.author | Meng-Wei Kao | en |
| dc.contributor.author | 高孟煒 | zh_TW |
| dc.date.accessioned | 2021-06-16T03:41:13Z | - |
| dc.date.available | 2025-08-01 | |
| dc.date.copyright | 2020-08-04 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020-08-03 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/54906 | - |
| dc.description.abstract | 當牙本質外露時，如果受到一些外界刺激而引起短暫而劇烈的疼痛，醫學上稱為牙本質敏感症狀。牙本質敏感症狀是長久以來一直困擾許多人的問題，據統計台灣社會大約有84%的成年人深受牙本質敏感影響。牙本質外露有許多原因，通常覆蓋在牙本質表面的牙釉質和牙骨質，會由於磨損或腐蝕而剝落。雖然市面是許多產品都宣稱能有效治療牙本質敏感症狀，但往往沒有立即且持續的療效，所以開發一個能有效治療牙本質敏感症狀的材料是牙科治療的重要任務。本研究利用聚合物延緩磷酸鈣成礦在牙本質小管和用奈米尺寸的磷酸鈣和氟化鈣在牙本質小管中堆積。藉由施加電場的方式，讓牙本質小管能在短時間內被礦物充填，藉此避免外在刺激對牙髓腔內部的神經的影響。這項技術在治療牙本質敏感有極大的潛力。 | zh_TW |
| dc.description.abstract | Dentinal hypersensitivity refers to the pain of exposed dentin, typically in response to thermal, chemical, tactile or osmotic stimuli, as it has long been a troublesome problem in dental care, where more than 80% of adult in Taiwan suffer from it. Dentin may become exposed when the enamel or cementum, which normally covers the dentin surface, is removed or abraded as a result of gradual wear. Although there are many products on the market that claim to be effective against dentinal hypersensitivity, no commercial product has shown immediate and lasting efficacy, and thus, the need to seek an effective treatment is of utmost importance in dentistry. In this work, we proposed to use polymers to delay calcium phosphate precipitation and nano-sized hydroxyapatite or calcium fluoride occlusion in dentinal tubules. By applying an electric field, minerals could be filled in the dentinal tubules in a short time, which can prevent the nerves inside the pulp form suffering from external stimulation. This technique may have great potential for the treatment of dentinal hypersensitivity. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T03:41:13Z (GMT). No. of bitstreams: 1 U0001-0108202011390500.pdf: 12210533 bytes, checksum: 66953d2aaa8b86ab75a5cbe94dbad0da (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 謝誌............................................................................ i 摘要....................................................................... vii Abstract ...................................................................... viii Contents ....................................................................... ix List of Tables .................................................................. xiv List of Figures .......................................................... xv Abbreviations .......................................................... xviii Chapter 1 Introduction .......................................................... 1 1.1 Dentin Hypersensitivity ................................................ 1 1.2 Pathogenic Factors of Dentin Hypersensitivity ................................. 2 1.3 Mechanism of Dentin Hypersensitivity ........................................ 4 1.3.1 Odontoblastic Transduction Theory........................................... 4 1.3.2 Neural Theory ............................................................. 5 1.3.3 Hydrodynamic Theory....................................................... 5 1.4 Dentin Permeability .................................................... 6 1.5 Treatments of Dentin Hypersensitivity ...................................... 10 1.5.1 Chemical Methods .......................................................... 10 1.5.1.1 Inhibition of Inflammatory Response ............................... 10 1.5.1.2 Protein Precipitation................................................. 10 1.5.1.3 Inhibition of Intensification of Sensory Nerves ................ 11 1.5.1.4 Occlusion of Dentinal Tubules.......................................... 12 1.5.2 Physical Methods ..................................................... 15 1.6 Infection of Dentinal Tubules .......................................... 16 1.7 Mesoporous Silica for Dental Treatment ................................ 18 1.8 Motivation ................................................................ 18 Chapter 2 Materials and Method ............................................. 20 2.1 Chemicals and Instruments .............................................. 20 2.2 Physical Methods ........................................................... 23 2.2.1 X-ray Powder Diffraction (XRD) ............................................ 23 2.2.2 Fourier Transform Infrared Spectroscopy (FTIR) ................... 24 2.2.3 Scanning Electron Microscopy (SEM) .................................... 24 2.2.4 Transmission Electron Microscopy (TEM) ............................. 25 2.2.5 Selective Area Electron Diffraction (SAED) ........................... 26 2.2.6 Energy Dispersive X-ray Spectrometer (EDS) ........................ 26 2.2.7 Dynamic Light Scattering (DLS) ............................................. 27 2.2.8 Zeta Potential ........................................................... 28 2.2.9 Inductively Coupled Plasma Mass Spectroscopy (ICPMS)..... 28 2.2.10 Thermogravimetric Analysis (TGA) ........................................ 30 2.2.11 Solid-State Nuclear Magnetic Resonance (ssNMR) ................ 30 2.2.11.1 Cross Polarization (CP)............................................ 32 2.2.11.2 Heteronuclear correlation (HETCOR) .............................. 33 Chapter 3 Background and Methodology ........................................ 34 3.1 Structure of Dentin .................................................... 34 3.2 Polymer-Induced Liquid-Precursor (PILP) ...................................... 37 3.2.1 Calcium Carbonate.......................................................... 37 3.2.2 Calcium Phosphate......................................................... 41 3.3 Application of Calcium Fluoride ......................................... 43 3.4 Particle Delivery ......................................................... 46 3.4.1 Diffusion ............................................................. 46 3.4.2 Sonication ............................................................... 46 3.4.3 Electrophoresis .......................................................... 49 3.5 Matrix for Mineral Particles................................................. 50 3.5.1 Gelatin ................................................................... 50 3.5.2 Agarose ................................................................... 50 Chapter 4 Nano Particles for Dentin Occlusion ................................... 53 4.1 Nano-Sized Calcium Phosphate ...........................................53 4.2 Inhibition of Monetite Precipitation by Polymer ............................. 55 4.2.1 Precipitation Inside Dentinal Tubules ...................................... 60 4.3 Nano-Sized Polymer-Coated Hydroxyapatite .................................. 65 4.3.1 Occlusion of Dentinal Tubules.............................................. 75 4.4 Nano-Sized Calcium Fluoride ................................................. 78 4.4.1 Interaction between Polymer-Coated HAp and CaF2 .............. 85 4.4.2 Occlusion of Dentinal Tubules.............................................. 93 Chapter 5 Occlusion of Dentinal Tubules Assisted by Electric Field............... 95 5.1 Polymer-Coated HAp particles ................................................ 95 5.1.1 Migration Assisted by Electric Field........................................ 95 5.1.2 Occlusion of Dentinal Tubules.............................................. 97 5.2 Polymer-Coated CaF2 Particles ...................................................... 100 5.3 Dentinal Occlusion in Different Electric Field .............................. 105 5.3.1 Sample Preparation ...................................................... 105 5.3.2 Occlusion of Dentinal Tubules........................................... 109 Chapter 6 Conclusion and Outlook .............................................. 115 Reference ....................................................................... 117 Appendix .................................................................. 127 Appendix A .................................................................. 127 Appendix B ..................................................................... 129 | |
| dc.language.iso | en | |
| dc.subject | 電泳 | zh_TW |
| dc.subject | 氟化鈣 | zh_TW |
| dc.subject | 聚合物誘導礦物前驅物 | zh_TW |
| dc.subject | 牙本質敏感症 | zh_TW |
| dc.subject | 磷酸鈣 | zh_TW |
| dc.subject | polymer-induced liquid precursor | en |
| dc.subject | electrophoresis | en |
| dc.subject | calcium fluoride | en |
| dc.subject | calcium phosphate | en |
| dc.subject | dentin hypersensitivity | en |
| dc.title | 以磷酸鈣及氟化鈣礦物封閉牙本質小管 | zh_TW |
| dc.title | Occlusion of Dentinal Tubules by Calcium Phosphate and Calcium Fluoride Minerals | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林俊彬(Chun-Pin Lin),廖尉斯(Wei-Ssu Liao),楊伯康(Po-Kang Yang) | |
| dc.subject.keyword | 牙本質敏感症,磷酸鈣,氟化鈣,聚合物誘導礦物前驅物,電泳, | zh_TW |
| dc.subject.keyword | dentin hypersensitivity,calcium phosphate,calcium fluoride,polymer-induced liquid precursor,electrophoresis, | en |
| dc.relation.page | 131 | |
| dc.identifier.doi | 10.6342/NTU202002194 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2020-08-03 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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