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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蕭浩明(Hao-Ming Hsiao) | |
| dc.contributor.author | Cheng-Han Lin | en |
| dc.contributor.author | 林承翰 | zh_TW |
| dc.date.accessioned | 2021-06-16T02:59:11Z | - |
| dc.date.available | 2020-08-28 | |
| dc.date.copyright | 2015-08-28 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2015-07-05 | |
| dc.identifier.citation | [1] http://health99.hpa.gov.tw/Hot_News/h_NewsDetailN.aspx?TopIcNo=6798
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Denison, 'Nitinol fatigue resistance—a strong function of surface quality,' in Medical Device Materials II: Proceedings of the Materials and Medical Devices Conference, 2004, pp. 205-208. [41] Z. Lin, H. M. Hsiao, D. Mackiewicz, B. Anukhin, and K. Pike, 'Anisotropic Behavior of Radiopaque NiTiPt Hypotube for Biomedical Applications,' Advanced Engineering Materials, vol. 11, pp. B189-B193, 2009. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/54476 | - |
| dc.description.abstract | 微型儲藥槽血管支架已成為未來植入式醫療器材之流行新趨勢，它不僅可以作為傳統塗藥血管支架的另一選項，也可以應用於治療癌症之新藥物載具，具有許多潛在的可能性。微型儲藥槽血管支架的製造，必須於血管支架表面進行雷射鑽孔，加工微型儲藥槽以儲存藥物。其潛在優點包括可攜帶更高藥物劑量、可攜帶多種藥物、可於不同時間點釋放不同藥物、可同時治療兩種以上疾病等可能。然而微型儲藥槽血管支架之結構，通常在加工後會遭到破壞，可能產生臨床性質弱化，而其中以疲勞壽命之影響最巨。
本文提出一項獨特創新之菱形式微型儲藥槽血管支架，其設計概念，乃藉由改變儲藥槽之幾何形狀，將血管支架局部所承受之集中應力，分散導引至應力承載較少區域，使能量重新作更有效分配。由於能量重新分配之故，其疲勞壽命不減反增，甚至高於無任何鑽孔之傳統塗藥血管支架。 文中以有限元素與Goodman方法進行模擬與疲勞安全係數計算，對菱形式微型儲藥槽血管支架進行量化分析，以驗證其抗疲勞強度。由電腦模擬結果顯示，其中一款菱形式微型儲藥槽血管支架最多可將疲勞安全係數提升至傳統塗藥支架的1.7倍、藥物承載量為同尺寸傳統塗藥血管支架之2.7倍，效果十分顯著。在提升上述兩項重要性質時，血管支架並沒有犧牲如徑向支撐力等其他重要臨床性質。此設計概念，對於微型儲藥槽血管支架而言是一大突破，為全球首創，也為其未來市場發展創造了無限的可能。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-16T02:59:11Z (GMT). No. of bitstreams: 1 ntu-103-R01522830-1.pdf: 15247503 bytes, checksum: a0fde264b182ec26104c4e554a36d12b (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 口試委員審定書 i
致謝 ii 摘要 iii ABSTRACT iv 目錄 vi 圖目錄 viii 表目錄 x 第一章 緒論 1 1.1 心腦血管疾病與支架 1 1.2 塗藥血管支架 3 1.3 血管支架的設計與製造 4 1.4 血管支架之疲勞破壞 6 1.5 研究內容與貢獻 7 第二章 血管支架設計 9 2.1 傳統塗藥血管支架設計 9 2.2 傳統微型儲藥槽血管支架設計 11 2.3 創新儲藥槽血管支架設計 13 第三章 有限元素模型分析 17 3.1 有限元素模型 17 3.1.1 鎳鈦合金材料設定 22 3.1.2 網格與接觸設定 24 3.2 Goodman疲勞安全係數分析 29 3.3 支架徑向支撐力分析 31 第四章 模擬結果與討論 33 4.1 菱形儲藥槽血管支架之機械性質分析 33 4.1.1 舒緩應變之成效 33 4.1.2 疲勞安全係數分析 34 4.1.3 儲藥量分析 38 4.1.4 徑向支撐力分析 39 4.2 不同參數之菱形儲藥槽血管支架 40 4.2.1 槽長度對於菱形式儲藥槽血管支架疲勞安全係數之影響 41 4.2.2 槽長度對於菱形式儲藥槽血管支架儲藥量之影響 46 4.2.3 槽長度對於菱形式儲藥槽血管支架徑向支撐力之影響 47 4.2.4 槽寬度對於菱形式儲藥槽血管支架疲勞安全係數之影響 48 4.2.5 槽寬度對於菱形式儲藥槽血管支架儲藥量之影響 49 4.2.6 槽寬度對於菱形式儲藥槽血管支架徑向支撐力之影響 50 4.3 支架設計之評論 51 第五章 結論與未來展望 55 參考文獻 57 | |
| dc.language.iso | zh-TW | |
| dc.subject | 有限元素分析 | zh_TW |
| dc.subject | Goodman疲勞壽命分析 | zh_TW |
| dc.subject | 有限元素分析 | zh_TW |
| dc.subject | 微型儲藥槽血管支架 | zh_TW |
| dc.subject | 心血管疾病 | zh_TW |
| dc.subject | 自動擴張式血管支架 | zh_TW |
| dc.subject | Goodman疲勞壽命分析 | zh_TW |
| dc.subject | 自動擴張式血管支架 | zh_TW |
| dc.subject | 心血管疾病 | zh_TW |
| dc.subject | 微型儲藥槽血管支架 | zh_TW |
| dc.subject | Self-expanding stent | en |
| dc.subject | Goodman fatigue life analysis | en |
| dc.subject | Finite element analysis | en |
| dc.subject | Goodman fatigue life analysis | en |
| dc.subject | Self-expanding stent | en |
| dc.subject | Cardiovascular disease | en |
| dc.subject | Drug-eluting depot stent | en |
| dc.subject | Finite element analysis | en |
| dc.subject | Cardiovascular disease | en |
| dc.subject | Drug-eluting depot stent | en |
| dc.title | 創新菱形式儲藥槽血管支架 | zh_TW |
| dc.title | Novel Rhombus-Shaped Depot Stent with Micro-Sized Drug Reservoirs | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 廖洺漢(Ming-Han Liao),盧彥文(Yen-Wen Lu) | |
| dc.subject.keyword | 自動擴張式血管支架,心血管疾病,微型儲藥槽血管支架,有限元素分析,Goodman疲勞壽命分析, | zh_TW |
| dc.subject.keyword | Self-expanding stent,Cardiovascular disease,Drug-eluting depot stent,Finite element analysis,Goodman fatigue life analysis, | en |
| dc.relation.page | 60 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-07-06 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
| 顯示於系所單位： | 機械工程學系 | |
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| ntu-103-1.pdf 未授權公開取用 | 14.89 MB | Adobe PDF |
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