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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 伍安怡(Betty A. Wu-Hsieh) | |
dc.contributor.author | Juin-Hua Huang | en |
dc.contributor.author | 黃俊樺 | zh_TW |
dc.date.accessioned | 2021-06-16T02:44:15Z | - |
dc.date.available | 2020-09-24 | |
dc.date.copyright | 2015-09-24 | |
dc.date.issued | 2015 | |
dc.date.submitted | 2015-07-20 | |
dc.identifier.citation | Abram, C.L., and Lowell, C.A. (2009). The ins and outs of leukocyte integrin signaling. Annu Rev Immunol 27, 339-362. Ali, T., Kaitha, S., Mahmood, S., Ftesi, A., Stone, J., and Bronze, M.S. (2013). Clinical use of anti-TNF therapy and increased risk of infections. Drug Healthc Patient Saf 5, 79-99. Allendoerfer, R., and Deepe, G.S., Jr. (1997). Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice. Infect Immun 65, 2564-2569. Allendoerfer, R., and Deepe, G.S., Jr. (1998). Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. J Immunol 160, 6072-6082. Allendoerfer, R., and Deepe, G.S., Jr. (2000). Regulation of infection with Histoplasma capsulatum by TNFR1 and -2. J Immunol 165, 2657-2664. Allendorfer, R., Brunner, G.D., and Deepe, G.S., Jr. (1999). Complex requirements for nascent and memory immunity in pulmonary histoplasmosis. J Immunol 162, 7389-7396. Aravalli, R., Hu, S., Woods, J., and Lokensgard, J. (2008). Histoplasma capsulatum yeast phase-specific protein Yps3p induces Toll-like receptor 2 signaling. J Neuroinflammation 5, 30. Arnaout, M.A. (1990). Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 75, 1037-1050. Bain, J.M., Louw, J., Lewis, L.E., Okai, B., Walls, C.A., Ballou, E.R., Walker, L.A., Reid, D., Munro, C.A., Brown, A.J., et al. (2014). Candida albicans hypha formation and mannan masking of beta-glucan inhibit macrophage phagosome maturation. MBio 5, e01874. Brandhorst, T.T., Wuthrich, M., Finkel-Jimenez, B., Warner, T., and Klein, B.S. (2004). Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection. J Immunol 173, 7444-7453. Brown, G.D. (2006). Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 6, 33-43. Brown, G.D. (2011). Innate antifungal immunity: the key role of phagocytes. Annu Rev Immunol 29, 1-21. Brown, G.D., Denning, D.W., and Levitz, S.M. (2012). Tackling human fungal infections. Science 336, 647. Brown, G.D., and Gordon, S. (2001). Immune recognition. A new receptor for beta-glucans. Nature 413, 36-37. Bullock, W.E., and Wright, S.D. (1987). Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages. J Exp Med 165, 195-210. Cenci, E., Mencacci, A., Casagrande, A., Mosci, P., Bistoni, F., and Romani, L. (2001). Impaired antifungal effector activity but not inflammatory cell recruitment in interleukin-6-deficient mice with invasive pulmonary aspergillosis. J Infect Dis 184, 610-617. Cheng, A.M., Rowley, B., Pao, W., Hayday, A., Bolen, J.B., and Pawson, T. (1995). Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378, 303-306. Chow, C.W., Downey, G.P., and Grinstein, S. (2004). Measurements of phagocytosis and phagosomal maturation. Curr Protoc Cell Biol Chapter 15, Unit 15.17. Ciaccio, M.F., Wagner, J.P., Chuu, C.-P., Lauffenburger, D.A., and Jones, R.B. (2010). Systems analysis of EGF receptor signaling dynamics with microwestern arrays. Nat Methods 7, 148-155. Clemons, K.V., Darbonne, W.C., Curnutte, J.T., Sobel, R.A., and Stevens, D.A. (2000). Experimental histoplasmosis in mice treated with anti-murine interferon-gamma antibody and in interferon-gamma gene knockout mice. Microbes Infect 2, 997-1001. Deepe, G.S., Jr., and Buesing, W.R. (2012). Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. J Immnol 188, 334-344. Deepe, G.S., Jr., and Gibbons, R.S. (2006). T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum. J Infect Dis 193, 322-330. Deepe, G.S., Jr., and Gibbons, R.S. (2008). TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. J Immunol 180, 1088-1097. Deepe, G.S., Jr., and Gibbons, R.S. (2009). Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. J Infect Dis 200, 142-151. Dennehy, K.M., and Brown, G.D. (2007). The role of the ß-glucan receptor Dectin-1 in control of fungal infection. J Leukoc Biol 82, 253-258. Dennehy, K.M., Ferwerda, G., Faro-Trindade, I., Pyz, E., Willment, J.A., Taylor, P.R., Kerrigan, A., Tsoni, S.V., Gordon, S., Meyer-Wentrup, F., et al. (2008). Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol 38, 500-506. Dillon, S., Agrawal, S., Banerjee, K., Letterio, J., Denning, T.L., Oswald-Richter, K., Kasprowicz, D.J., Kellar, K., Pare, J., van Dyke, T., et al. (2006). Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest 116, 916-928. Domer, J.E. (1971). Monosaccharide and chitin content of cell walls of Histoplasma capsulatum and Blastomyces dermatitidis. J Bacteriol 107, 870-877. Drummond, R.A., and Brown, G.D. (2011). The role of Dectin-1 in the host defence against fungal infections. Curr Opin Microbiol 14, 392-399. Edwards, J.A., Alore, E.A., and Rappleye, C.A. (2011). The yeast-phase virulence requirement for alpha-glucan synthase differs among Histoplasma capsulatum chemotypes. Eukaryot Cell 10, 87-97. Eissenberg, L.G., Goldman, W.E., and Schlesinger, P.H. (1993). Histoplasma capsulatum modulates the acidification of phagolysosomes. J Exp Med 177, 1605-1611. Ferwerda, B., Ferwerda, G., Plantinga, T.S., Willment, J.A., van Spriel, A.B., Venselaar, H., Elbers, C.C., Johnson, M.D., Cambi, A., Huysamen, C., et al. (2009). Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med 361, 1760-1767. Ferwerda, G., Meyer-Wentrup, F., Kullberg, B.-J., Netea, M.G., and Adema, G.J. (2008). Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages. Cell Microbiol 10, 2058-2066. Gantner, B.N., Simmons, R.M., Canavera, S.J., Akira, S., and Underhill, D.M. (2003). Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 197, 1107-1117. Gantner, B.N., Simmons, R.M., and Underhill, D.M. (2005). Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 24, 1277-1286. Gildea, L.A., Morris, R.E., and Newman, S.L. (2001). Histoplasma capsulatum yeasts are phagocytosed via very late antigen-5, killed, and processed for antigen presentation by human dendritic cells. J Immunol 166, 1049-1056. Gomez, F.J., Pilcher-Roberts, R., Alborzi, A., and Newman, S.L. (2008). Histoplasma capsulatum cyclophilin A mediates attachment to dendritic cell VLA-5. J Imunol 181, 7106-7114. Goodridge, H.S., Reyes, C.N., Becker, C.A., Katsumoto, T.R., Ma, J., Wolf, A.J., Bose, N., Chan, A.S., Magee, A.S., Danielson, M.E., et al. (2011). Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature 472, 471-475. Goodridge, H.S., Shimada, T., Wolf, A.J., Hsu, Y.-M.S., Becker, C.A., Lin, X., and Underhill, D.M. (2009). Differential use of CARD9 by Dectin-1 in macrophages and dendritic cells. J Immunol 182, 1146-1154. Goodridge, H.S., Simmons, R.M., and Underhill, D.M. (2007). Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol 178, 3107-3115. Gow, N.A., Netea, M.G., Munro, C.A., Ferwerda, G., Bates, S., Mora-Montes, H.M., Walker, L., Jansen, T., Jacobs, L., Tsoni, V., et al. (2007). Immune recognition of Candida albicans beta-glucan by dectin-1. J Infect Dis 196, 1565-1571. Gresnigt, M.S., Becker, K.L., Smeekens, S.P., Jacobs, C.W., Joosten, L.A., van der Meer, J.W., Netea, M.G., and van de Veerdonk, F.L. (2013). Aspergillus fumigatus-induced IL-22 is not restricted to a specific Th cell subset and is dependent on complement receptor 3. J Immunol 190, 5629-5639. Gringhuis, S.I., den Dunnen, J., Litjens, M., van der Vlist, M., Wevers, B., Bruijns, S.C.M., and Geijtenbeek, T.B.H. (2009). Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-[kappa]B activation through Raf-1 and Syk. Nat Immunol 10, 203-213. Gross, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T., Peschel, C., Förster, I., and Ruland, J. (2006). Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442, 651-656. Groves, E., Dart, A.E., Covarelli, V., and Caron, E. (2008). Molecular mechanisms of phagocytic uptake in mammalian cells. Cell Mol Life Sci 65, 1957-1976. Guimaraes, A.J., de Cerqueira, M.D., and Nosanchuk, J.D. (2011). Surface architecture of Histoplasma capsulatum. Front Microbiol 2, 225. Hanna, S., and Etzioni, A. (2012). Leukocyte adhesion deficiencies. Ann N Y Acad Sci 1250, 50-55. Harokopakis, E., and Hajishengallis, G. (2005). Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase. Eur J Immunol 35, 1201-1210. Heinsbroek, S.E., Taylor, P.R., Martinez, F.O., Martinez-Pomares, L., Brown, G.D., and Gordon, S. (2008). Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathog 4, e1000218. Hontelez, S., Sanecka, A., Netea, M.G., van Spriel, A.B., and Adema, G.J. (2012). Molecular view on PRR cross-talk in antifungal immunity. Cell Microbiol 14, 467-474. Hovius, J.W.R., de Jong, M.A.W.P., den Dunnen, J., Litjens, M., Fikrig, E., van der Poll, T., Gringhuis, S.I., and Geijtenbeek, T.B.H. (2008). Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog 4, e31. Inoue, M., Moriwaki, Y., Arikawa, T., Chen, Y.H., Oh, Y.J., Oliver, T., and Shinohara, M.L. (2011). Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses. J Immunol 186, 19-23. Inoue, M., and Shinohara, M.L. (2014). Clustering of pattern recognition receptors for fungal detection. PLoS pathog 10, e1003873. Jia, X.M., Tang, B., Zhu, L.L., Liu, Y.H., Zhao, X.Q., Gorjestani, S., Hsu, Y.M., Yang, L., Guan, J.H., Xu, G.T., et al. (2014). CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med 211, 2307-2321. Kauffman, C.A. (2007). Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev 20, 115-132. Keath, E.J., Painter, A.A., Kobayashi, G.S., and Medoff, G. (1989). Variable expression of a yeast-phase-specific gene in Histoplasma capsulatum strains differing in thermotolerance and virulence. Infect Immun 57, 1384-1390. Lane, T.E., Wu-Hsieh, B.A., and Howard, D.H. (1991). Iron limitation and the gamma interferon-mediated antihistoplasma state of murine macrophages. Infect Immun 59, 2274-2278. Lane, T.E., Wu-Hsieh, B.A., and Howard, D.H. (1993). Gamma interferon cooperates with lipopolysaccharide to activate mouse splenic macrophages to an antihistoplasma state. Infect Immun 61, 1468-1473. Lane, T.E., Wu-Hsieh, B.A., and Howard, D.H. (1994). Antihistoplasma effect of activated mouse splenic macrophages involves production of reactive nitrogen intermediates. Infect Immun 62, 1940-1945. Lee, M.S., and Kim, Y.J. (2007). Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76, 447-480. LeibundGut-Landmann, S., Grosz, O., Robinson, M.J., Osorio, F., Slack, E.C., Tsoni, S.V., Schweighoffer, E., Tybulewicz, V., Brown, G.D., Ruland, J., et al. (2007). Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8, 630-638. Leibundgut-Landmann, S., Osorio, F., Brown, G.D., and Reis e Sousa, C. (2008). Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood 112, 4971-4980. Leitinger, B., and Hogg, N. (2002). The involvement of lipid rafts in the regulation of integrin function. J Cell Sci 115, 963-972. Li, B., Allendorf, D.J., Hansen, R., Marroquin, J., Ding, C., Cramer, D.E., and Yan, J. (2006). Yeast β-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Syk-phosphatidylinositol 3-kinase pathway. J Immunol 177, 1661-1669. Li, X., Utomo, A., Cullere, X., Choi, Myunghwan M., Milner Jr, Danny A., Venkatesh, D., Yun, S.-H., and Mayadas, Tanya N. (2011). The β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell Host Microbe 10, 603-615. Lin, J.S., Huang, J.H., Hung, L.Y., Wu, S.Y., and Wu-Hsieh, B.A. (2010). Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast. J Leukoc Biol 88, 95-106. Lin, J.S., and Wu-Hsieh, B.A. (2004). Functional T cells in primary immune response to histoplasmosis. Int Immunol 16, 1663-1673. Lin, J.S., Yang, C.W., Wang, D.W., and Wu-Hsieh, B.A. (2005). Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. J Immunol 174, 6282-6291. Long, K.H., Gomez, F.J., Morris, R.E., and Newman, S.L. (2003). Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. J Immunol 170, 487-494. Marion, C.L., Rappleye, C.A., Engle, J.T., and Goldman, W.E. (2006). An alpha-(1,4)-amylase is essential for alpha-(1,3)-glucan production and virulence in Histoplasma capsulatum. Mol Microbiol 62, 970-983. Marth, T., and Kelsall, B.L. (1997). Regulation of interleukin-12 by complement receptor 3 signaling. J Exp Med 185, 1987-1995. Mayadas, T.N., and Cullere, X. (2005). Neutrophil β2 integrins: moderators of life or death decisions. Trends Immunol 26, 388-395. Mayfield, J.A., and Rine, J. (2007). The genetic basis of variation in susceptibility to infection with Histoplasma capsulatum in the mouse. Genes Immun 8, 468-474. Newman, S.L. (1999). Macrophages in host defense against Histoplasma capsulatum. Trends Microbiol 7, 67-71. Newman, S.L., Bucher, C., Rhodes, J., and Bullock, W.E. (1990). Phagocytosis of Histoplasma capsulatum yeasts and microconidia by human cultured macrophages and alveolar macrophages. Cellular cytoskeleton requirement for attachment and ingestion. J Clin Invest 85, 223-230. Newman, S.L., and Mikus, L.K. (1985). Deposition of C3b and iC3b onto particulate activators of the human complement system. Quantitation with monoclonal antibodies to human C3. J Exp Med 161, 1414-1431. Norambuena, A., and Schwartz, M.A. (2011). Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling. Mol Biol Cell 22, 3456-3464. Palanki, M.S. (2002). Inhibitors of AP-1 and NF-kappa B mediated transcriptional activation: therapeutic potential in autoimmune diseases and structural diversity. Curr Med Chem 9, 219-227. Pande, G. (2000). The role of membrane lipids in regulation of integrin functions. Curr Opin Cell Biol 12, 569-574. Prince, J.E., Brayton, C.F., Fossett, M.C., Durand, J.A., Kaplan, S.L., Smith, C.W., and Ballantyne, C.M. (2001). The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. J Immunol 166, 7362-7369. Rappleye, C.A., Eissenberg, L.G., and Goldman, W.E. (2007). Histoplasma capsulatum α-(1,3)-glucan blocks innate immune recognition by the β-glucan receptor. Proc Nat Acad Sci 104, 1366-1370. Rappleye, C.A., Engle, J.T., and Goldman, W.E. (2004). RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence. Mol Microbiol 53, 153-165. Ratnoff, W.D., Pepple, J.M., and Winkelstein, J.A. (1980). Activation of the alternative complement pathway by Histoplasma capsulatum. Infect Immun 30, 147-149. Rijneveld, A.W., de Vos, A.F., Florquin, S., Verbeek, J.S., and van der Poll, T. (2005). CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia. J Infect Dis 191, 1755-1760. Robinson, M.J., Osorio, F., Rosas, M., Freitas, R.P., Schweighoffer, E., Groß, O., Verbeek, J.S., Ruland, J., Tybulewicz, V., Brown, G.D., et al. (2009). Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med 206, 2037-2051. Romani, L. (2004). Immunity to fungal infections. Nat Rev Immunol 4, 11-24. Romani, L., Mencacci, A., Cenci, E., Spaccapelo, R., Toniatti, C., Puccetti, P., Bistoni, F., and Poli, V. (1996). Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. J Exp Med 183, 1345-1355. Saijo, S., Fujikado, N., Furuta, T., Chung, S.H., Kotaki, H., Seki, K., Sudo, K., Akira, S., Adachi, Y., Ohno, N., et al. (2007). Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol 8, 39-46. Saijo, S., and Iwakura, Y. (2011). Dectin-1 and Dectin-2 in innate immunity against fungi. Int Immunol 23, 467-472. Shaulian, E., and Karin, M. (2002). AP-1 as a regulator of cell life and death. Nat Cell Biol 4, E131-136. Smith, J.G., Magee, D.M., Williams, D.M., and Graybill, J.R. (1990). Tumor necrosis factor-alpha plays a role in host defense against Histoplasma capsulatum. J Infect Dis 162, 1349-1353. Smits, G.J., Kapteyn, J.C., van den Ende, H., and Klis, F.M. (1999). Cell wall dynamics in yeast. Curr Opin Microbiol 2, 348-352. Soloviev, D.A., Jawhara, S., and Fonzi, W.A. (2011). Regulation of innate immune response to Candida albicans infections by alphaMbeta2-Pra1p interaction. Infect Immun 79, 1546-1558. Subramanian Vignesh, K., Landero Figueroa, J.A., Porollo, A., Caruso, J.A., and Deepe, G.S., Jr. (2013). Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity 39, 697-710. Takahara, K., Tokieda, S., Nagaoka, K., Takeda, T., Kimura, Y., and Inaba, K. (2011). C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1. Eur J Immunol 41, 1435-1444. Tassi, I., Cella, M., Castro, I., Gilfillan, S., Khan, W.N., and Colonna, M. (2009). Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization. Eur J Immunol 39, 1369-1378. Taylor, P.R., Tsoni, S.V., Willment, J.A., Dennehy, K.M., Rosas, M., Findon, H., Haynes, K., Steele, C., Botto, M., Gordon, S., et al. (2007). Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 8, 31-38. Toyotome, T., Adachi, Y., Watanabe, A., Ochiai, E., Ohno, N., and Kamei, K. (2008). Activator protein 1 is triggered by Aspergillus fumigatus beta-glucans surface-exposed during specific growth stages. Microb Pathog 44, 141-150. Trinchieri, G., and Sher, A. (2007). Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 7, 179-190. Underhill, D.M., and Ozinsky, A. (2002). Phagocytosis of microbes: complexity in action. Annu Rev Immunol 20, 825-852. Underhill, D.M., Rossnagle, E., Lowell, C.A., and Simmons, R.M. (2005). Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106, 2543-2550. van de Veerdonk, F.L., Marijnissen, R.J., Kullberg, B.J., Koenen, H.J.P.M., Cheng, S.-C., Joosten, I., van den Berg, W.B., Williams, D.L., van der Meer, J.W.M., Joosten, L.A.B., et al. (2009). The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe 5, 329-340. Vetvicka, V., Thornton, B.P., and Ross, G.D. (1996). Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells. J Clin Invest 98, 50-61. Werner, J.L., Metz, A.E., Horn, D., Schoeb, T.R., Hewitt, M.M., Schwiebert, L.M., Faro-Trindade, I., Brown, G.D., and Steele, C. (2009). Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol 182, 4938-4946. Wu-Hsieh, B.A., and Howard, D.H. (1987). Inhibition of the intracellular growth of Histoplasma capsulatum by recombinant murine gamma interferon. Infect Immun 55, 1014-1016. Wu-Hsieh, B.A., Lee, G.S., Franco, M., and Hofman, F.M. (1992). Early activation of splenic macrophages by tumor necrosis factor alpha is important in determining the outcome of experimental histoplasmosis in mice. Infect Immun 60, 4230-4238. Wu, S.Y., Yu, J.S., Liu, F.T., Miaw, S.C., and Wu-Hsieh, B.A. (2013). Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum. J Immunol 190, 3427-3437. Xu, S., Huo, J., Gunawan, M., Su, I.-H., and Lam, K.-P. (2009a). Activated Dectin-1 localizes to lipid raft microdomains for signaling and activation of phagocytosis and cytokine production in dendritic cells. J Biol Chem 284, 22005-22011. Xu, S., Huo, J., Lee, K.-G., Kurosaki, T., and Lam, K.-P. (2009f). Phospholipase Cγ2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J Biol Chem 284, 7038-7046. Yanagi, S., Inatome, R., Ding, J., Kitaguchi, H., Tybulewicz, V.L.J., and Yamamura, H. (2001). Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice. Blood 98, 2869-2871. Ye, N., Ding, Y., Wild, C., Shen, Q., and Zhou, J. (2014). Small molecule inhibitors targeting activator protein 1 (AP-1). J Mrd Chem 57, 6930-6948. Zhou, P., Miller, G., and Seder, R.A. (1998). Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma. J Immunol 160, 1359-1368. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/54197 | - |
dc.description.abstract | 真菌感染的發生率在過去近幾十年來不斷地增加,且威脅患者的生命。更進一步地了解真菌病原體與宿主細胞之間的交互作用,將有助於抗真菌治療新策略的開發。不同種類的模式辨識受體的合作作用引起的免疫反應之協同作用對於宿主抵禦入侵的病原體是很重要的。第三型補體受體及Dectin-1是先天性免疫細胞上主要用來辨識真菌的模式辨識受體,然而這兩個受體在抵禦真菌的免疫反應上的合作機制還尚未被釐清。在此研究中,我們利用組織胞漿菌能同時與第三型補體受體和Dectin-1交互作用的特性,以及利用專一性的顆粒性配體來探討第三型補體受體與Dectin-1在巨噬細胞細胞激素反應上的合作機制。經由使用高通量的微西方陣列技術(Micro-Western Array)、基因改造策略以及藥物抑制劑,我們證明第三型補體受體與Dectin-1能共同合作引起巨噬細胞產生腫瘤壞死因子及介白素-6反應,且此合作作用是透過匯集第三型補體受體與Dectin-1的下游訊息傳遞於Syk激酶,進而增強Syk-JNK-AP-1訊息途徑的活化所致。當巨噬細胞受到組織胞漿菌的刺激,第三型補體受體與Dectin-1會被召集到細胞膜上的脂筏形成聚集,並將脂筏當作平台促進第三型補體受體與Dectin-1引起的訊息活化及細胞激素反應的合作作用。此外,我們也利用小鼠全身性感染組織胞漿菌之實驗模式來研究第三型補體受體與Dectin-1在體內感染的合作現象。實驗結果顯示第三型補體受體與Dectin-1合作參與宿主抵禦組織胞漿菌感染,並且共同影響抗真菌之後天性免疫反應。我們的研究結果提供了第三型補體受體與Dectin-1兩種模式辨識受體間如何合作之分子機制,並證明第三型補體受體與Dectin-1的合作作用對於宿主抵禦真菌的重要性。 | zh_TW |
dc.description.abstract | The incidence of life-threatening fungal infections are increasing during the last decades. A better understanding of the interactions between fungal pathogen and its host cell is important to the development of new therapeutic strategies against fungal infections. Collaboration between heterogeneous pattern recognition receptors (PRRs) leading to synergistic coordination of immune response is important for the host to fight against invading pathogens. Complement receptor 3 (CR3) and Dectin-1 are major PRRs to detect fungi. However, crosstalk between these two receptors in antifungal immunity is largely undefined. Here we took advantage of Histoplasma capsulatum which is known to interact with both CR3 and Dectin-1 and specific particulate ligands to study the collaboration of CR3 and Dectin-1 in macrophage cytokine response. By employing Micro-Western Array (MWA), genetic approach, and pharmacological inhibitors, we demonstrated that CR3 and Dectin-1 act collaboratively to trigger macrophage TNF and IL-6 response through signaling integration at Syk kinase, allowing subsequent enhanced activation of Syk-JNK-AP-1 pathway. Upon engagement, CR3 and Dectin-1 colocalize and form clusters on lipid raft microdomains which serve as a platform facilitating their cooperation in signaling activation and cytokine production. Furthermore, in vivo studies showed that CR3 and Dectin-1 cooperatively participate in host defense against disseminated histoplasmosis and instruct adaptive immune response. Taken together, our findings define the molecular mechanisms underlying receptor crosstalk between CR3 and Dectin-1 and demonstrate the importance of their collaboration in host defense against fungal infection. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T02:44:15Z (GMT). No. of bitstreams: 1 ntu-104-F96449004-1.pdf: 5319398 bytes, checksum: c62e249f38f534eab0f726e1a519915d (MD5) Previous issue date: 2015 | en |
dc.description.tableofcontents | Abstract i Abstract (Chinese) ii Abbreviations iii Tables of Contents iv Chapter I. Introduction 1 I. Crosstalk between fungal pattern recognition receptors (PRRs) 2 II. PRRs recognize Histoplasma capsulatum 4 III. Signaling and immune response mediated by CR3 and Dectin-1 6 IV. Role of protective cytokines in histoplasmosis 9 Chapter II. Aims of Study 12 I. To characterize the collaboration between CR3 and Dectin-1 in macrophage cytokine response 13 II. To study the role of lipid rafts in the interaction and collaboration between CR3 and Dectin-1 13 III. To delineate the signaling pathways downstream of CR3 and Dectin-1 that collaboratively regulate macrophage cytokine response 14 IV. To investigate the roles of CR3 and Dectin-1 in host defense against H. capsulatum infection. 14 Chapter III. Materials and Methods 16 Part I. Materials 17 1. Mice and ethics statement 17 2. Antibodies 17 3. Solutions 21 4. Chemicals and reagents 25 5. Equipments 29 6. Software 30 Part II. Methods 30 1. Fungus and cell wall glucan staining 30 2. Cells 31 3. Stimulation with fungus and particulate ligands 32 4. Cytokine assays 32 5. Western blotting 32 6. Preparation of FITC-labeled H. capsulatum 33 7. Phagocytosis assay 33 8. Replication time of intracellular H. capsulatum 34 9. LDH assay 34 10. Isolation of lipid raft fractions 34 11. Immunofluorescence staining and confocal microscopy 35 12. Micro-Western Arrays (MWAs) 35 13. siRNA transfection of macrophages 36 14. RNA isolation and quantitative analysis of mRNA by real-time q-PCR 36 15. H. capsulatum infection, fungal burden and leukocyte populations in spleen 37 16. Ex vivo cytokine production and intracellular cytokine staining 37 17. Statistics 38 Chapter IV. Results 39 Part I. CR3 and Dectin-1 collaborate to activate Syk in macrophage cytokine response 40 1. H. capsulatum strain 505 lacks -glucan with -glucan exposed 40 2. CR3 and Dectin-1 collaborate in macrophage cytokine response to H. capsulatum 40 3. Signals from CR3 and Dectin-1 integrate in Syk kinase to mediate the subsequent cytokine response 41 Part II. Association of CR3 and Dectin-1 on lipid rafts facilitates their collaboration 43 1. CR3 and Dectin-1 form cluster on lipid rafts where they activate Syk upon engagement by H. capsulatum 43 2. The role of lipid rafts in H. caspualtum-induced macrophage responses 43 Part III. The molecular mechanism underlying the collaboration between CR3 and Dectin-1 44 1. Micro-Western Array analysis reveals the signaling pathways activated by H. capsulatum 44 2. JNK is involved in the collaboration between CR3 and Dectin-1 45 3. Transcription factors that mediate the collaborative cytokine response upon CR3 and Dectin-1 engagement 46 4. CR3 and Dectin-1 in dendritic cell responses to H. capsulatum 47 Part IV. CR3 and Dectin-1 work in concert in host defense against H. capsulatum infection 48 1. CR3 and Dectin-1 control disseminated histoplasmosis by facilitating the differentiation of IFN--producing T cells 48 2. CR3 and Dectin-1 cooperatively protect host from H. capsulatum-induced mortality 49 3. Role of CR3 and Dectin-1 in pulmonary histoplasmosis 50 Chapter V. Discussion 52 1. PRR recognition of H. capsulatum 53 2. Molecular mechanisms underlying crosstalk between CR3 and Dectin-1 55 3. Clustering of PRRs for fungal detection 57 4. Signaling molecules activated in H. capsulatum-stimulated macrophages 58 5. The role of CR3 and Dectin-1 in histoplasmosis 60 6. Summary 62 References 64 Figures 79 Table 134 Appendix 136 | |
dc.language.iso | en | |
dc.title | CR3與Dectin-1透過與脂筏連結及活化Syk-JNK-AP-1訊息傳遞路徑機制共同合作引起巨噬細胞的細胞激素反應 | zh_TW |
dc.title | CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway | en |
dc.type | Thesis | |
dc.date.schoolyear | 103-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 賴明宗(Ming-Zong Lai),林錫賢(Hsi-Hsien Lin),朱清良(Ching-Liang Chu),徐立中(Li-Chung Hsu) | |
dc.subject.keyword | 真菌感染,受體合作,C型凝集素受體,Dectin-1,第三型補體受體,巨噬細胞,組織胞漿菌,訊號交互作用,先天性抗真菌免疫,促發炎細胞激素,脂筏,受體聚集,後天性抗真菌免疫, | zh_TW |
dc.subject.keyword | fungal infection,receptor collaboration,C-type lectin,Dectin-1,complement receptor 3,macrophage,Histoplasma capsulatum,signaling crosstalk,innate antifungal immunity,pro-inflammatory cytokine,lipid raft,receptor clustering,adaptive antifungal immunity, | en |
dc.relation.page | 137 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2015-07-20 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 免疫學研究所 | zh_TW |
顯示於系所單位: | 免疫學研究所 |
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