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標題: | 應用潛在交互作用探討黴菌毒素對坦尚尼亞孩童成長情形之影響 Applying Latent Interactions to Investigate the Association between Child Growth and Mycotoxins Exposure in Tanzania |
作者: | Jia-Chun He 何佳純 |
指導教授: | 杜裕康(Yu-Kang Tu) |
關鍵字: | 黴菌毒素,成長不良,坦尚尼亞孩童,測量誤差,潛在交互作用模式, Mycotoxins,Growth impairment,Tanzanian children,Measurement error,Structural Equation Models of Latent Interaction, |
出版年 : | 2015 |
學位: | 碩士 |
摘要: | 背景與目的 黃麴黴毒素、伏馬毒素和脫氧雪腐鐮刀菌烯醇(或稱嘔吐毒素)三種黴菌毒素為食物中的有毒汙染物,被認為與坦尚尼亞孩童成長不良的問題有關。關於黃麴黴毒 素和伏馬毒素的暴露與坦尚尼亞孩童成長之關係,Shirima 等學者(2015)已作探討, 但是針對這兩種黴菌毒素之間的交互作用,她們是以傳統線性迴歸作分析,此作法未考慮黴菌毒素暴露值的變動程度,將造成迴歸係數估計值不準確及統計檢定力下降的問題。為了解決此問題,我們以結構方程模式作分析,並進一步探討黃麴黴毒素、伏馬毒素和嘔吐毒素與坦尚尼亞孩童成長情形的關係。 材料與方法 總共有166位年齡介於6至14個月的坦尚尼亞孩童參加這項研究。被招募的孩童首次接受測量時為玉米收成的季節,之後他們需再接受兩次的追蹤,分別是6個月後(此時為玉米儲藏時期)和12個月後(此時為新的玉米收成時期)。每次收案,研究人員都會記錄孩童的飲食狀況、成長情形(包含體重、身高和成長指標)和體內黃麴黴毒素、伏馬毒素和嘔吐毒素之暴露資料。我們以結構方程模式進行分析,應用潛在變數的交互作用模式分析兩兩黴菌毒素之間的交互作用與孩童成長情形的關係。 結果 單一黴菌毒素的結果顯示,伏馬毒素對於孩童一年內身高及身高對年齡的 Z分數之成長斜率有負面影響(β=-0.098,p=0.01;β=-0.025,p=0.05)。潛在變數的交互作用模式下,黃麴黴毒素與嘔吐毒素的交互作用對於孩童一年內體重、體重對身高的Z分數、體重對年齡的Z分數和BMI對年齡的Z分數的估計成長斜率有負面影響(β=-0.062,p=0.023;β=-0.1,p=0.021;β=-0.069,p=0.014;β=-0.013,p=0.015)。 結論 單一黴菌毒素,如伏馬毒素,可能與孩童成長不良有關。黃麴黴毒素與嘔吐毒素之間的交互作用效果,可能會加劇影響孩童成長不良的問題。 Background and Objective Aflatoxin, fumonisin and deoxynivalenol (also known as Vomitoxin) are toxic contaminants in food. These three mycotoxins may have a negative impact on child growth in Tanzania. Shirima et al. (2015) investigated the association between child growth and aflatoxin and fumonisin exposure in Tanzania. Ordinary least squares method was used but measurement error of mycotoxins exposure was not considered in the model. This causes bias in parameter estimation and a loss of power for detecting relationship among variables. One way to solve these problems is to use structural equation modeling, which controls for measurement error of mycotoxins exposure through the specification of a measurement model. Then, the relationship between child growth and aflatoxin, fumonisin and vomitoxin in Tanzania could be estimated. Materials and Methods There are 166 Tanzanian children whose ages between 6 and 14 months were enrolled in the study. The children were recruited during maize harvest season and followed up twice; after 6 months during the season when stored maize was consumed and after 12 months which was another harvest season for maize. During each of the three sampling times, the child’s diet and growth data (body weight, height and growth indices) and three mycotoxins exposures (aflatoxin, fumonisin and vomitoxin) were collected by trained researchers. Structural equation models of latent interaction are used to investigate the association between child growth and mycotoxins exposures. Results Fumonisin concentrations were associated inversely with child’s height and height for age z-scores (β=-0.098, p=0.01;β=-0.025, p=0.05). The estimated interaction effect between aflatoxin and vomitoxin were significantly and negatively related to the slope of child’s weight, weight-for-height z-scores, weight-for-age z-scores and bmi-for-age z-scores (β=-0.062, p=0.023;β=-0.1, p=0.021;β=-0.069, p=0.014;β=-0.013, p= 0.015, respectively). Conclusion In the study, exposure to fumonisin alone may contribute to child growth impairment. The joint effects of aflatoxin and vomitoxin will exacerbate child growth impairment. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/53820 |
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顯示於系所單位: | 流行病學與預防醫學研究所 |
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