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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 鄭謙仁(Chian-Ren Jeng) | |
dc.contributor.author | Yu-Hsuan Wu | en |
dc.contributor.author | 吳雨軒 | zh_TW |
dc.date.accessioned | 2021-05-15T17:56:28Z | - |
dc.date.available | 2016-07-08 | |
dc.date.available | 2021-05-15T17:56:28Z | - |
dc.date.copyright | 2014-07-08 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-06-26 | |
dc.identifier.citation | Allan, G. M. and J. A. Ellis (2000). Porcine circoviruses: a review. J Vet Diagn Invest 12(1): 3-14.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5345 | - |
dc.description.abstract | 兔化豬瘟疫苗(Lapinized Philippines Coronel, LPC)為豬瘟病毒(Classical Swine Fever Virus, CSFV)的減毒株,目前已有研究指出第二型豬環狀病毒 (Porcine Circovirus type 2, PCV2)的感染會減少LPC疫苗的保護效力,為了探討PCV2影響LPC疫苗的可能機制,本研究使用單核球來源之樹突細胞(Monocyte-derived dendritic cells, MoDCs)進行活體外的相關分析,以探討PCV2和豬瘟疫苗毒株(LPC Virus, LPCV)之間的交互作用。結果顯示,當PCV2和LPCV共同感染時,在早期可檢測到IL-1、IL-6、IL-8、IL-10、IFN-α和TNF-α有較高的mRNA表現量,在蛋白質層次也檢測到IL-8、IL-12p40和INF-γ有較高的表現量,另外也發現PCV2的感染會使MoDCs的存活率減低,凋亡率和壞死率升高。從本研究的實驗結果推論PCV2所誘導的免疫反應,特別是高表現的量的INF-γ以及誘導MoDCs的凋亡或許可以解釋PCV2影響LPC疫苗效價的部分原因。 | zh_TW |
dc.description.abstract | The Lapinized Philippines Coronel (LPC) vaccine, an attenuated strain of classical swine fever virus (CSFV), it has been noted that porcine circovirus type 2 (PCV2) infection adversely affects the protective efficacy of LPC vaccine. In order to investigate the possible mechanisms of the PCV2-derived interference, an in vitro model was established to study the interaction of LPC virus (LPCV) and PCV2 in Monocyte-derived dendritic cells (MoDCs). The results showed that IL-1, IL-6, IL-8, IL-10, IFN-α and TNF-α mRNA expression can be detected in early stage of PCV2 and LPCV co-infection in MoDCs. In addition, higher protein level of IL-8, IL-12p40 and INF-γ was also compatible present. Finally, apoptosis and low surviral rate can be induced by PCV2 and PCV2/LPCV in the late stage culture of MoDCs. The results of the present study may partially explain how PCV2 infection interferes with the efficacy of LPC vaccine. | en |
dc.description.provenance | Made available in DSpace on 2021-05-15T17:56:28Z (GMT). No. of bitstreams: 1 ntu-103-R01644005-1.pdf: 3998560 bytes, checksum: fac83e0c06b686ae2dc91c0d657aca3a (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 中文摘要i
英文摘要ii 目錄iii 表次v 圖次vi 第一章 序言1 第二章 文獻回顧2 第一節豬瘟病毒 1-1病毒學分類2 1-2歷史背景與流行病學3 1-3豬瘟病毒的傳播方式4 1-4臨床症狀與病理變化5 1-5致病機轉6 1-6豬瘟病毒的標的細胞與免疫調控6 1-7兔化豬瘟疫苗與次單位豬瘟疫苗8 第二節 豬第二型環狀病毒 2-1病毒學分類9 2-2歷史背景與流行病學10 2-3豬環狀病毒傳播方式11 2-4臨床症狀與離乳後多系統性消耗症侯群11 2-5豬環狀病毒標的細胞與免疫調控12 第三節 豬相關病毒共同感染之免疫干擾 3-1豬第二型環狀病毒與相關病毒共同感染13 3-2豬第二型環狀病毒影響兔化豬瘟疫苗之效價16 第四節 豬單核球來源之樹突細胞研究模式 4-1豬單核球來源樹突細胞簡介19 第三章 材料與方法22 第一節 實驗設計 1-1實驗設計與流程圖22 第二節 實驗材料 2-1實驗動物23 2-2血球分離相關藥品23 2-3細胞培養液和試劑24 2-4豬第二型環狀病毒與兔化豬瘟疫苗病毒株25 2-5核酸萃取及聚合酶鍊鎖反應之藥品25 2-6流式細胞儀相關藥品25 2-7酵素連結免疫分析法26 2-8免疫螢光染色相關試劑27 2-9儀器27 第三節 實驗方法 3-1細胞分離與培養27 3-1.1豬周邊血液單核細胞的分離與純化27 3-1.2 MACS磁珠系統分選SWC3+細胞與培養28 3-2豬第二型環狀病毒對兔化豬瘟疫苗在樹突細胞的影響29 3-2.1以免疫螢光染色法檢測病毒對樹突細胞的感染率29 3-2.2以流式細胞儀檢測細胞表面抗原30 3-2.3以AV-FITC/PI染色檢測細胞凋亡和壞死率31 3-2.4 S. aureus-FITC檢測細胞攝取顆粒性抗原的能力32 3-2.5 DQTM-OVA檢測細胞攝取可溶性抗原的能力32 3-2.6以酵素連結免疫分析法檢測細胞激素蛋白表現量33 3-2.7以Real-time PCR偵測細胞激素mRNA表現量34 3-3統計分析35 第四章 結果 第一節 細胞純化37 第二節 豬第二型環狀病毒對兔化豬瘟疫苗在單核球來源樹突細胞的影響 2-1病毒對單核球來源之樹突細胞感染率37 2-2單核球來源之樹突細胞相關細胞表面抗原表現結果38 2-3感染病毒後細胞之存活率、死亡率與凋亡率38 2-4細胞攝取抗原之能力41 2-5單核球來源之樹突細胞相關細胞激素蛋白質的表現量42 2-6單核球來源之樹突細胞相關細胞激素mRNA的表現量44 第五章 討論54 第六章 參考資料63 | |
dc.language.iso | zh-TW | |
dc.title | 活體外第二型豬的環狀病毒和豬瘟疫苗毒對單核球來源樹突細胞的影響 | zh_TW |
dc.title | The Effects of Porcine Circovirus type 2 (PCV2) and Lapinized Philippines Coronel Virus (LPCV) on Monocyte-Derived Dendritic Cells (MoDCs) in vitro | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 龐飛(Victor Fei Pang) | |
dc.contributor.oralexamcommittee | 張志成(Chih-Cheng Chang),劉涓(Jiuan Liu),黃有良(Yu-Liang Huang),張惠雯(Hui-Wen Chang) | |
dc.subject.keyword | 豬瘟病毒,兔化豬瘟疫苗,豬第二型環狀病毒,豬單核球來源樹突細胞,體外培養, | zh_TW |
dc.subject.keyword | classical swine fever virus,porcine circovirus type 2,Lapinized Philippine Coronel vaccine,monocyte-derived dendritic cells,in vitro, | en |
dc.relation.page | 75 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2014-06-27 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 分子暨比較病理生物學研究所 | zh_TW |
顯示於系所單位: | 分子暨比較病理生物學研究所 |
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