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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/53178完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 杜裕康 | |
| dc.contributor.author | Liang-Ko Lin | en |
| dc.contributor.author | 林良珂 | zh_TW |
| dc.date.accessioned | 2021-06-15T16:49:11Z | - |
| dc.date.available | 2020-10-16 | |
| dc.date.copyright | 2015-10-16 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-07 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/53178 | - |
| dc.description.abstract | Background Periodontal disease is a common dental problem. In Taiwan, about ninety percent of adults suffer from various forms of periodontal diseases. Early periodontal diseases may not have symptoms; when people start to develop signs or symptoms, they may have already suffer moderate or advanced periodontal diseases, resulting in subsequent tooth loss. Therefore, effective control and treatment for periodontal diseases is an important public health issue in many countries. Clinically, the extent of periodontal disease are usually measured by clinical attachment level (CAL) and probing pocket depths (PPD). Periodontal surgery is the main treatment for severe periodontal disease. There are two types of periodontal surgeries; one is traditional flap operation (FO), and the other is periodontal regeneration surgery. The most common periodontal regeneration surgeries are enamel matrix derivative (EMD) and guided tissue regeneration (GTR). Objectives As the cost of periodontal regeneration surgery is much greater than flap operation. Previous meta-analyses only compared one-year results after the periodontal surgeries. Therefore, the objectives of this study are: 1. To use longitudinal meta-analysis to compare the difference in the long-term treatment benefits between various periodontal regeneration surgeries and traditional flap surgery. 2. To investigate whether there is difference in the long-term effect of two common periodontal regeneration therapies, enamel matrix derivative and guided tissue regeneration surgery. Material and methods We conduct a systematic review to search for studies that compared the difference in PPD and CAL between periodontal regeneration surgeries. In addition, longitudinal meta-analysis and restricted cubic spline function are used to investigate the difference in clinical outcomes between the two periodontal surgeries. Results 1. The long-term results of clinical attachment level and probing pocket depth in each comparison displays the effect of periodontal regeneration surgeries are better than that of flap surgery. These additional effects last for more than five years, and maintain in 1 mm to 1.5 mm. 2. The difference between enamel matrix derivative and guided tissue regeneration is not significant either in clinical attachment level or probing pocket depth. 3. The trajectory of each comparison group shows small changes by assuming different correlations between outcomes reported at different time points Conclusion We used longitudinal meta-analysis and restricted cubic spline to investigate the differences in trajectory of the effect of periodontal surgeries. The long-term effects of periodontal regeneration surgeries are better than the those of flap surgery in long-term. In addition, there is no significant difference between enamel matrix derivative and guided tissue regeneration. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T16:49:11Z (GMT). No. of bitstreams: 1 ntu-104-R02849015-1.pdf: 1800890 bytes, checksum: bdfbf535194ba939abbc951b08fc45a9 (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 口試委員會審定書 誌謝 i 摘要 ii Abstract iv 目錄 vii 圖表目錄 ix 第一章 前言 1 1.1研究背景 1 1.2 研究目的 6 第二章材料與方法 7 2.1 資料來源 7 2.2 搜尋文獻 7 2.3 搜尋文獻標準 7 2.4 資料萃取與反應變數 8 2.5品質評估 8 2.6研究方法 8 2.6.1縱貫性統合分析-所有時間點一次統合 8 2.6.2縱貫性統合分析-各個時間點分別統合 10 2.6.3限制性三次方樣條（Restricted cubic splines） 10 2.7 使用軟體 12 第三章 結果 14 3.1不同牙周病手術的系統性回顧之結果 14 3.2 資料描述 14 3.3 結點的選擇 15 3.4 縱貫性統合分析之結果 15 3.4.1各組臨床附著高度差異比較之結果 15 3.4.2各組牙周囊袋深度差異比較之結果 17 第四章 討論 20 4.1 研究結果 20 4.2 研究貢獻 21 4.3 研究限制 21 第五章 結論 23 附錄 44 參考文獻 46 圖表目錄 圖 一 資料萃取流程圖 25 圖 二 牙釉基質衍生物（EMD）與翻瓣手術（FO）在臨床附著高度的比較結果 36 圖 三 牙釉基質衍生物（EMD）與引導組織再生手術（GTR）在臨床附著高度的比較結果 37 圖 四 引導組織再生手術（GTR）與翻瓣手術（FO）在臨床附著高度的比較結果 38 圖 五 含骨粉的引導再生手術（GTR+BG）與翻瓣手術（FO）在臨床附著高度的比較結果 39 圖 六 牙釉基質衍生物（EMD）與翻瓣手術（FO）在牙周囊袋深度的比較結果 40 圖 七 牙釉基質衍生物（EMD）與引導組織再生手術（GTR）在牙周囊袋深度的比較結果 41 圖 八 引導組織再生手術（GTR）與翻瓣手術（FO）在牙周囊袋深度的比較結果 42 圖 九 含骨粉的引導組織再生手術（GTR+BG）與翻瓣手術（FO）在PPD的比較結果 43 表 一 限制性三次方樣條不同個數的結點對應的結點位置 24 表 二 各個時間點下所有治療於臨床附著高度的治療效果 26 表 三 各個時間點下所有治療於牙周囊袋深度的治療效果 30 表 四 各組比較分別在臨床附著高度與牙周囊袋深度的文獻個數 33 表 五 不同牙周病治療比較下各個時間的資料個數表 34 表 六 不同治療比較的結點位置 （單位：年） 35 | |
| dc.language.iso | zh-TW | |
| dc.subject | 縱貫性統合分析 | zh_TW |
| dc.subject | 牙周再生手術 | zh_TW |
| dc.subject | 一般化最小平方法 | zh_TW |
| dc.subject | Longitudinal meta-analysis | en |
| dc.subject | periodontal regeneration surgeries | en |
| dc.subject | generalized least square | en |
| dc.title | 縱貫性統合分析：各種牙周再生手術的長期效果 | zh_TW |
| dc.title | Longitudinal meta-analysis: Long-term effects of various periodontal regeneration surgeries. | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 簡國龍,呂炫? | |
| dc.subject.keyword | 縱貫性統合分析,牙周再生手術,一般化最小平方法, | zh_TW |
| dc.subject.keyword | Longitudinal meta-analysis,periodontal regeneration surgeries,generalized least square, | en |
| dc.relation.page | 51 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-08-07 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學與預防醫學研究所 | zh_TW |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
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