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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 梁庚辰(Keng-Chen Liang) | |
| dc.contributor.author | Pin-Wu Liu | en |
| dc.contributor.author | 劉品吾 | zh_TW |
| dc.date.accessioned | 2021-06-15T16:25:07Z | - |
| dc.date.available | 2015-08-20 | |
| dc.date.copyright | 2015-08-20 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-14 | |
| dc.identifier.citation | Anderson, & Jeffery, K. J. (2003). Heterogeneous modulation of place cell firing by changes in context. The Journal of Neuroscience, 23(26), 8827-8835.
Anderson, & Phelps, E. A. (2000). Expression without recognition: Contributions of the human amygdala to emotional communication. Psychological Science, 11(2), 106-111. Bahar, A., Samuel, A., Hazvi, S., & Dudai, Y. (2003). The amygdalar circuit that acquires taste aversion memory differs from the circuit that extinguishes it. European Journal of Neuroscience, 17(7), 1527-1530. Baldi, E., Ambrogi Lorenzini, C., Sacchetti, B., Tassoni, G., & Bucherelli, C. (2000). Effects of coupled perirhinal cortex and medial septal area, fimbria-fornix, entorhinal cortex tetrodotoxin inactivations on passive avoidance consolidation in the rat. Neuroscience Letters, 280(2), 91-94. Berlau, D. J., & McGaugh, J. L. (2006). Enhancement of extinction memory consolidation: the role of the noradrenergic and GABAergic systems within the basolateral amygdala. Neurobiology of Learning and Memory, 86(2), 123-132. Burgos-Robles, A., Vidal-Gonzalez, I., Santini, E., & Quirk, G. J. (2007). Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron, 53(6), 871-880. Chang, S. D., Chen, D. Y., & Liang, K. C. (2008). Infusion of lidocaine into the dorsal hippocampus before or after the shock training phase impaired conditioned freezing in a two-phase training task of contextual fear conditioning. Neurobiology of Learning and Memory, 89(2), 95-105. Chang, S. D., & Liang, K. C. (2012). Roles of hippocampal GABAa and muscarinic receptors in consolidation of context memory and context-shock association in contextual fear conditioning: a double dissociation study. Neurobiology of Learning and Memory, 98(1), 17-24. Corcoran, Desmond, T. J., Frey, K. A., & Maren, S. (2005). Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction. The Journal of Neuroscience, 25(39), 8978-8987. Corcoran, & Quirk, G. J. (2007). Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears. The Journal of Neuroscience, 27(4), 840-844. Courtin, J., Bienvenu, T. C., Einarsson, E. O., & Herry, C. (2013). Medial prefrontal cortex neuronal circuits in fear behavior. Neuroscience, 240, 219-242. Delgado, M. R., Nearing, K. I., LeDoux, J. E., & Phelps, E. A. (2008). Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron, 59(5), 829-838. Doron, N. N., & Ledoux, J. E. (1999). Organization of projections to the lateral amygdala from auditory and visual areas of the thalamus in the rat. Journal of Comparative Neurology, 412(3), 383-409. Eichenbaum, H., Stewart, C., & Morris, R. G. (1990). Hippocampal representation in place learning. The Journal of Neuroscience, 10(11), 3531-3542. Etkin, A., Egner, T., & Kalisch, R. (2011). Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Sciences, 15(2), 85-93. Fanselow, M. S. (1982). The postshock activity burst. Animal Learning & Behavior, 10(4), 448-454. Fanselow, M. S. (1990). Factors governing one-trial contextual conditioning. Animal Learning & Behavior, 18(3), 264-270. Feltenstein, M. W., & See, R. E. (2007). NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapse. Neurobiology of Learning and Memory, 88(4), 435-444. Frankland, P. W., Bontempi, B., Talton, L. E., Kaczmarek, L., & Silva, A. J. (2004). The involvement of the anterior cingulate cortex in remote contextual fear memory. Science, 304(5672), 881-883. Frey, U., & Morris, R. G. (1997). Synaptic tagging and long-term potentiation. Nature, 385(6616), 533-536. Gamiz, F., & Gallo, M. (2011). Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats. Learning & Memory, 18(8), 529-533. Hales, J. B., Ocampo, A. C., Broadbent, N. J., & Clark, R. E. (2015). Hippocampal infusion of zeta inhibitory peptide impairs recent, but not remote, recognition memory in rats. Neural Plasticity, 501, 847136. Hasler, G., Fromm, S., Alvarez, R. P., Luckenbaugh, D. A., Drevets, W. C., & Grillon, C. (2007). Cerebral blood flow in immediate and sustained anxiety. The Journal of Neuroscience, 27(23), 6313-6319. He, Y. Y., Xue, Y. X., Wang, J. S., Fang, Q., Liu, J. F., Xue, L. F., & Lu, L. (2011). PKMzeta maintains drug reward and aversion memory in the basolateral amygdala and extinction memory in the infralimbic cortex. Neuropsychopharmacology, 36(10), 1972-1981. Heidbreder, C. A., & Groenewegen, H. J. (2003). The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neuroscience and Biobehavioral Reviews, 27(6), 555-579. Jarrard, L. E. (1993). On the role of the hippocampus in learning and memory in the rat. Behavioral Neural Biology, 60(1), 9-26. Kalisch, R., Korenfeld, E., Stephan, K. E., Weiskopf, N., Seymour, B., & Dolan, R. J. (2006). Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. The Journal of Neuroscience, 26(37), 9503-9511. Kim, J. J., & Fanselow, M. S. (1992). Modality-specific retrograde amnesia of fear. Science, 256(5057), 675-677. Klüver, H., & Bucy, P. (1937). ' Psychic blindness' and other symptoms following bilateral temporal lobectomy in Rhesus monkeys. American Journal of Physiology, 119, 352-353. Kuriyama, K., Soshi, T., Fujii, T., & Kim, Y. (2010). Emotional memory persists longer than event memory. Learning & Memory, 17(3), 130-133. Kwapis, J. L., & Helmstetter, F. J. (2014). Does PKMzeta maintain memory? Brain Research Bulletin, 105, 36-45. Kwapis, J. L., Jarome, T. J., Gilmartin, M. R., & Helmstetter, F. J. (2012). Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory. Neurobiology of Learning and Memory, 98(2), 148-153. Kwapis, J. L., Jarome, T. J., Lonergan, M. E., & Helmstetter, F. J. (2009). Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. Behavioral Neuroscience, 123(4), 844-850. LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998). Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron, 20(5), 937-945. Lacroix, L., Spinelli, S., Heidbreder, C. A., & Feldon, J. (2000). Differential role of the medial and lateral prefrontal cortices in fear and anxiety. Behavioral Neuroscience, 114(6), 1119-1130. Lang, S., Kroll, A., Lipinski, S. J., Wessa, M., Ridder, S., Christmann, C., . . . Flor, H. (2009). Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex. European Journal of Neuroscience, 29(4), 823-832. LeDoux, J. E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155-184. LeDoux, J. E., Iwata, J., Cicchetti, P., & Reis, D. J. (1988). Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. The Journal of Neuroscience, 8(7), 2517-2529. Lesburguères, E., Gobbo, O. L., Alaux-Cantin, S., Hambucken, A., Trifilieff, P., & Bontempi, B. (2011). Early tagging of cortical networks is required for the formation of enduring associative memory. Science, 331(6019), 924-928. Liang, K. C. (2009). Involvement of the amygdala and its connected structures in formation and expression of inhibitory avoidance memory: issues and implications. Chinese Journal of Physiology, 52(4), 196-214. Liang, K. C., Hu, S. J., & Chang, S. C. (1995). Formation and retrieval of inhibitory avoidance memory: differential roles of glutamate receptors in the amygdala and medial prefrontal cortex. The Chinese journal of physiology, 39(3), 155-166. Liang, K. C., McGaugh, J. L., Martinez, J. L., Jr., Jensen, R. A., Vasquez, B. J., & Messing, R. B. (1982). Post-training amygdaloid lesions impair retention of an inhibitory avoidance response. Behavioral Brain Research, 4(3), 237-249. Lu, K. T., Walker, D. L., & Davis, M. (2001). Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle. The Journal of Neuroscience, 21(16), RC162. Madronal, N., Gruart, A., Sacktor, T. C., & Delgado-Garcia, J. M. (2010). PKMzeta inhibition reverses learning-induced increases in hippocampal synaptic strength and memory during trace eyeblink conditioning. PLOS one, 5(4), e10400. Malin, E. L., & McGaugh, J. L. (2006). Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock. Proceedings of the National Academy of Sciences, 103(6), 1959-1963. Maren, S., Aharonov, G., Stote, D. L., & Fanselow, M. S. (1996). N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats. Behavioral Neuroscience, 110(6), 1365-1374. Maren, S., & Fanselow, M. S. (1995). Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. The Journal of Neuroscience, 15(11), 7548-7564. Martınez, I. Q., G. L.; Dıaz-Cintra, S.; Quiroz, C.; Prado-Alcala, R. A. (2002). Effects of lesions of hippocampal fields CA1 and CA3 on acquisition of inhibitory avoidance. Neuropsychobiology, 46, 97-103. McGaugh, J. L. (2000). Memory-a century of consolidation. Science, 287(5451), 248-251. McGaugh, J. L. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annual Review of Neuroscience, 27, 1-28. McGaugh, J. L., Cahill, L., & Roozendaal, B. (1996). Involvement of the amygdala in memory storage: interaction with other brain systems. Proceedings of the National Academy of Sciences, 93(24), 13508-13514. McGaugh, J. L., McIntyre, C. K., & Power, A. E. (2002). Amygdala modulation of memory consolidation: interaction with other brain systems. Neurobiology of Learning and Memory, 78(3), 539-552. Migues, P. V., Hardt, O., Wu, D. C., Gamache, K., Sacktor, T. C., Wang, Y. T., & Nader, K. (2010). PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nature Neuroscience, 13(5), 630-U147. Milad, M. R., & Quirk, G. J. (2012). Fear extinction as a model for translational neuroscience: ten years of progress. Annual Review of Psychology, 63, 129-151. Mitchell, D. G. V. (2011). The nexus between decision making and emotion regulation: A review of convergent neurocognitive substrates. Behavioural Brain Research, 217(1), 215-231. Moita, M. A., Rosis, S., Zhou, Y., LeDoux, J. E., & Blair, H. T. (2004). Putting fear in its place: remapping of hippocampal place cells during fear conditioning. The Journal of Neuroscience, 24(31), 7015-7023. Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993). Extinction of emotional learning: contribution of medial prefrontal cortex. Neuroscience Letters, 163(1), 109-113. Morris, R. G., Garrud, P., Rawlins, J. N., & O'Keefe, J. (1982). Place navigation impaired in rats with hippocampal lesions. Nature, 297(5868), 681-683. Nadel, L., Samsonovich, A., Ryan, L., & Moscovitch, M. (2000). Multiple trace theory of human memory: computational, neuroimaging, and neuropsychological results. Hippocampus, 10(4), 352-368. O'Keefe, J. (1976). Place units in the hippocampus of the freely moving rat. Experimental Neurology, 51(1), 78-109. Parsons, R. G., & Davis, M. (2011). Temporary disruption of fear-potentiated startle following PKMzeta inhibition in the amygdala. Nature Neuroscience, 14(3), 295-296. Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006). Storage of spatial information by the maintenance mechanism of LTP. Science, 313(5790), 1141-1144. Paxinos, G., & Watson, C. (2007). The rat brain in stereotaxic coordinates. (6th Ed.). SanDiego, CA: Academic Press. Phelps, E. A. (2006). Emotion and cognition: insights from studies of the human amygdala. Annual Review of Psychology, 57, 27-53. Roesler, R., Schroder, N., Vianna, M. R., Quevedo, J., Bromberg, E., Kapczinski, F., & Ferreira, M. B. (2003). Differential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in rats. Brain Research, 975(1-2), 207-213. Romanski, L. M., & LeDoux, J. E. (1992). Equipotentiality of thalamo-amygdala and thalamo-cortico-amygdala circuits in auditory fear conditioning. The Journal of Neuroscience, 12(11), 4501-4509. Roozendaal, B., McReynolds, J. R., Van der Zee, E. A., Lee, S., McGaugh, J. L., & McIntyre, C. K. (2009). Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala. The Journal of Neuroscience, 29(45), 14299-14308. Rudy, J. W., & O'Reilly, R. C. (2001). Conjunctive representations, the hippocampus, and contextual fear conditioning. Cognitive, Affective, & Behavioral Neuroscience, 1(1), 66-82. Sacchetti, B., Baldi, E., Lorenzini, C. A., & Bucherelli, C. (2002). Differential contribution of some cortical sites to the formation of memory traces supporting fear conditioning. Experimental Brain Research, 146(2), 223-232. Sacchetti, B., Baldi, E., Lorenzini, C. A., & Bucherelli, C. (2003). Role of the neocortex in consolidation of fear conditioning memories in rats. Experimental Brain Research, 152(3), 323-328. Sacktor, T. C. (2011). How does PKMzeta maintain long-term memory? Nature Reviews Neuroscience, 12(1), 9-15. Sajikumar, S., & Korte, M. (2011). Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mζ (PKMζ). Proceedings of the National Academy of Sciences, 108(6), 2551-2556. Sajikumar, S., Navakkode, S., Sacktor, T. C., & Frey, J. U. (2005). Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression. The Journal of Neuroscience, 25(24), 5750-5756. Santini, E., Ge, H., Ren, K., Pena de Ortiz, S., & Quirk, G. J. (2004). Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. The Journal of Neuroscience, 24(25), 5704-5710. Schoenbaum, G., Chiba, A. A., & Gallagher, M. (1999). Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. The Journal of Neuroscience, 19(5), 1876-1884. Scoville, W. B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery, and Psychiatry, 20(1), 11-21. Serrano, P., Friedman, E. L., Kenney, J., Taubenfeld, S. M., Zimmerman, J. M., Hanna, J., . . . Fenton, A. A. (2008). PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories. PLOS biology, 6(12), 2698-2706. Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011). Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology, 36(2), 529-538. Smith, D. M., & Mizumori, S. J. (2006). Learning-related development of context-specific neuronal responses to places and events: the hippocampal role in context processing. The Journal of Neuroscience, 26(12), 3154-3163. Sotres-Bayon, F., & Quirk, G. J. (2010). Prefrontal control of fear: more than just extinction. Current Opinion in Neurobiology, 20(2), 231-235. Souza, T. M. E., Vianna, M., Rodrigues, C., Quevedo, J., Moleta, B., & Izquierdo, I. (2000). Involvement of the medial precentral prefrontal cortex in memory consolidation for inhibitory avoidance learning in rats. Pharmacology Biochemistry and Behavior, 66(3), 615-622. Squire, L. R., & Alvarez, P. (1995). Retrograde amnesia and memory consolidation: a neurobiological perspective. Current Opinion in Neurobiology, 5(2), 169-177. Sul, J. H., Kim, H., Huh, N., Lee, D., & Jung, M. W. (2010). Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making. Neuron, 66(3), 449-460. Tinsley, M. R., Quinn, J. J., & Fanselow, M. S. (2004). The role of muscarinic and nicotinic cholinergic neurotransmission in aversive conditioning: comparing pavlovian fear conditioning and inhibitory avoidance. Learning & Memory, 11(1), 35-42. Tully, K., & Bolshakov, V. Y. (2010). Emotional enhancement of memory: how norepinephrine enables synaptic plasticity. Molecular brain, 3(1), 15. Uwano, T., Nishijo, H., Ono, T., & Tamura, R. (1995). Neuronal responsiveness to various sensory stimuli, and associative learning in the rat amygdala. Neuroscience, 68(2), 339-361. Vazdarjanova, A., & McGaugh, J. L. (1999). Basolateral amygdala is involved in modulating consolidation of memory for classical fear conditioning. The Journal of Neuroscience, 19(15), 6615-6622. Weiskrantz, L. (1956). Behavioral changes associated with ablation of the amygdaloid complex in monkeys. Journal of Comparative and Physiological Psychology, 49(4), 381-391. White, N. M., & McDonald, R. J. (1993). Acquisition of a Spatial Conditioned Place Preference Is Impaired by Amygdala Lesions and Improved by Fornix Lesions. Behavioural Brain Research, 55(2), 269-281. Wilensky, A. E., Schafe, G. E., & LeDoux, J. E. (2000). The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning. The Journal of Neuroscience, 20(18), 7059-7066. Yang, F. C., & Liang, K. C. (2014). Interactions of the dorsal hippocampus, medial prefrontal cortex and nucleus accumbens in formation of fear memory: difference in inhibitory avoidance learning and contextual fear conditioning. Neurobiology of Learning and Memory, 112, 186-194. Zald, D. H. (2003). The human amygdala and the emotional evaluation of sensory stimuli. Brain Research Reviews, 41(1), 88-123. Zelinski, E. L., Hong, N. S., Tyndall, A. V., Halsall, B., & McDonald, R. J. (2010). Prefrontal cortical contributions during discriminative fear conditioning, extinction, and spontaneous recovery in rats. Experimental Brain Research, 203(2), 285-297. Zhang, Y., Fukushima, H., & Kida, S. (2011). Induction and requirement of gene expression in the anterior cingulate cortex and medial prefrontal cortex for the consolidation of inhibitory avoidance memory. Molecular Brain, 4(4), 4. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52730 | - |
| dc.description.abstract | 記憶理論指出，新近形成的長期記憶會進一步穩固成永久記憶，新近記憶(recent memory)的神經表徵如何轉化成久遠記憶(remote memory)，是生理心理學家關切的議題。過去研究發現，杏仁核、海馬與前額葉皮質在許多恐懼相關學習作業中扮演重要角色。然而，這些腦區在新近與久遠記憶有無不同的角色並不清楚。由於新近與久遠記憶的轉化是在保存時距內進行，探討這問題需要能夠在記憶已經儲存後操弄記憶的神經痕跡。近期研究發現protein kinase M zeta (PKMz)為神經細胞內保持記憶儲存(memory storage)的重要蛋白質。本論文的研究為檢驗上述腦區在儲存情緒記憶的角色，於大白鼠習得抑制型躲避作業(inhibitory avoidance task, IA)或情境恐懼制約作業(contextual fear conditioning, CFC)後一天或二十天，於杏仁核、背側海馬與前額葉內側皮質注射PKMz特定抑制劑myristolated PKC zeta pseudosubstrate (ZIP)，以削弱存好的恐懼記憶。實驗結果發現，ZIP注入上述杏仁核與海馬僅損害抑制型躲避作業的新近記憶，不損害久遠記憶；ZIP在新近記憶形成後，注射在前額葉內側皮質對當時的記憶測試表現沒有影響，但在久遠記憶測試時出現損害。相對地，杏仁核內注射ZIP損害情境恐懼制約作業的新近記憶，不影響久遠記憶，前額葉內側皮質注射ZIP不影響任何記憶。上述結果顯示大白鼠自不同的學習作業所獲得的恐懼記憶，會根據學習內涵不同而有不同神經機制，PKMz在內涵互異的記憶歷程中具有不同的參與程度。 | zh_TW |
| dc.description.abstract | This study aims to understand the neural mechanisms underlying storage of fear memory and its update over time. The neural mechanism subserving consolidation of fear memory has been well documented, but little is known for storage maintenance of it. Previous evidence showed that inhibition of protein kinase M zeta (PKMz), which is proposed to support cellular changes for memory storage within the amygdala, dorsal hippocampus (DH) or medial prefrontal cortex (mPFC), impaired tasks involving fear, space or drug related information respectively. The inhibitory avoidance (IA) task and contextual fear conditioning (CFC) task are two different types of fear learning that respectively engaged instrumental or classical conditioning. However, the role of PKMz within these three areas in memory storage of the IA and CFC tasks remains unknown. To address this question, male Wistar rats with cannulae implanted in one of these areas were trained on either one-trial step-through IA task or two-phase training paradigm of CFC task. They were randomly assigned to receive a PKMz inhibitor - ZIP (10 nmole/ul) or vehicle infusion in different time points. The results showed that for IA task, intra-amygdala, -DH, or -mPFC infusion of ZIP one day after training impaired fear memory. For treatments in the amygdala and DH, the effect was apparent in the recent memory tests, but that in the mPFC was not apparent until the remote memory test. On the other hand, for the CFC task infusion of ZIP into the amygdala impaired recent memory, however, there was no such effect on memory when intra-mPFC infusion of ZIP. These findings suggest that fear memory would store in different brain regions according to different types of learning tasks. Further, PKMz may have different roles in different kinds of memory processes. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T16:25:07Z (GMT). No. of bitstreams: 1 ntu-104-R01227107-1.pdf: 2174829 bytes, checksum: 4163aa2b80fe22446dfa8d77ea505429 (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 第一章 緒論…………………………………………………………………………..1
記憶的穩固與儲存………………………………………………………………2 PKMz…………………………………………………………………………….5 情緒記憶的神經機制……………………………………………………………9 情境恐懼制約作業與抑制型躲避學習作業…………………………………..18 研究目的………………………………………………………………………..28 第二章 實驗材料與方法……………………………………………………………31 受試者………………...………………………………………………………...31 顱內埋管手術…………………………………………………………………..31 藥品、顱內藥物注射程序與時間安排…………………………………………33 抑制型躲避學習作業(Inhibitory avoidance task) ……………………………..35 情境恐懼制約作業(Contextual fear conditioning) ……………………………38 灌流………………...…………………………………………………………...40 組織切片……………………………..…………………………………………40 統計分析………………………………………………………………………..41 第三章 實驗結果……………………………………………………………………43 實驗一：在抑制型躲避學習作業中，PKMz在底側杏仁核、背側海馬與前額葉內側皮質扮演之角色………………………………………………………..43 實驗二：底側杏仁核與前額葉內側皮質PKMz在情境恐懼制約作業之角色………………………………………………………………………………..61 第四章 綜合討論……………………………………………………………………73 在抑制型躲避學習作業中，海馬需要在環境探索及電擊訓練後兩階段的ZIP注射，才會影響記憶表現………………………………………………………75 前額葉內側皮質PKMz參與維持抑制型躲避學習作業記憶儲存，但不參與情境恐懼制約作業之記憶儲存…………………………………………………..78 杏仁核PKMz在兩個作業中維持新近記憶儲存的角色……………………...79 海馬及前額葉內側皮質PKMz在兩個作業中維持新近及久遠記憶的角色...81 結論與後續研究………………………………………………………………..84 第五章 參考文獻……………………………………………………………………87 附錄…………………………………………………………………………………105 | |
| dc.language.iso | zh-TW | |
| dc.title | 杏仁核、背側海馬與前額葉內側皮質在新近與久遠記憶的角色：PKMz與恐懼記憶的儲存 | zh_TW |
| dc.title | Roles of the Amygdala, Hippocampus and Medial Prefrontal Cortex in Recent and Remote Memory: PKMz and Storage of Fear Experience | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 游一龍(Lung Yu),李季湜(Jay-Shake Li),葉俊毅(Chun-I Yeh),呂國棟(Kwok-Tung Lu) | |
| dc.subject.keyword | 情緒,記憶儲存,系統穩固,抑制型躲避學習作業,情境恐懼制約作業, | zh_TW |
| dc.subject.keyword | emotion,memory storage,system consolidation,contextual fear conditioning,inhibitory avoidance task, | en |
| dc.relation.page | 107 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-08-14 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 心理學研究所 | zh_TW |
| 顯示於系所單位： | 心理學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-104-1.pdf 目前未授權公開取用 | 2.12 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。