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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張建成(Chien-Cheng Chang) | |
| dc.contributor.author | Yu-Hong Chen | en |
| dc.contributor.author | 陳昱宏 | zh_TW |
| dc.date.accessioned | 2021-06-15T16:15:09Z | - |
| dc.date.available | 2015-08-19 | |
| dc.date.copyright | 2015-08-19 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-17 | |
| dc.identifier.citation | Agata, K. (2003). Regeneration and gene regulation in planarians. Current opinion in genetics & development, 13, 492-496.
Baguna, J., and Slack, J.M.W. (1981). Planarian eoblasts. Nature, 290, 14-15. Baguna, J., Salo, E., and Auladell, C. (1989). Regeneration and pattern formation in planarians iii evidence that neoblasts are totipotent stem cells and the source of blastema cells. Development, 107, 77-86. Beane, W.S., Morokuma, J., Lemire, J.M., and Levin, M. (2013). Bioelectric signaling regulates head and organ size during planarian regeneration. Development, 140, 313-322. Becker, A.J., McCulloch, E.A. and Till, J.E. (1963). Cytological demonstration of the clonal nature of spleen olonies derived from transplanted mouse marrow cells. Nature, 197 (4866): 452. Chiba, S.and Tanno, N. (1991). Backscattering Optical Heterodyne Tomography. prepared for the 14th Laser Sensing Symposium Dufour, M. L., Lamouche, G., Detalle, V., Gauthier, B. and Sammut, P. (2004). Low-Coherence Interferometry, an Advanced Technique for Optical Metrology in Industry. Industrial Materials Institute, National Research Council (Canada). Fercher, A. F., Hitzenberger, C. K., Drexler, W., Kamp, G., and Sattmann, H. (1993). In Vivo Optical Coherence Tomography. American Journal of Ophthalmology, vol. 116, no. 1, pp. 113-114 Fercher, A. F., Hitzenberger, C. K., Sticker, M., Moreno, E. B., Leitgeb, R., Drexler, W. and H. Sattmann. (2000). A thermal light source technique for optical coherence tomography. Optics Communications, vol. 185, 57-64. Fercher, A. F. (1990). Ophthalmic interferometry. Proceedings of the International Conference on Optics in Life Sciences, Garmisch-Partenkirchen, Germany, 12–16 August 1990. Ed. G. von Bally and S. Khanna, pp. 221-228. Gentile, L., Cebria, F., and Bartscherer, K. (2011). The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Disease models & mechanisms, 4, 12-19. Gerry, C., Knight, P. (2005). Introductory Quantum Optics. Cambridge University Press, Cambridge. Haralick, R.M., Shanmugam, K. and Dinstein I.H. (1973). Textural Features for Image Classification. IEEE Transactions on Systems, Man and Cybernetics ,4, 610-621. Hart and Wall. (2004). UK population dose from medical X-ray examinations. European Journal of Radiology, 50, 285-291. Kwong, K.F., Yankelevich, D., Chu, K.C., Heritage, J.P., and Dienes, A. (1993) 400-Hz mechanical scanning optical delay line, Optics Letters, 18, 558-560. Lin, Y.-S., Chu, C.-C., Lin, J.-J., Chang, C.-C., Wang, C.-Y. and Tsui, P.-H. (2014). Optical coherence tomography: A new strategy to image planarian regenertation. Scientific Reports, 4, e0613; doi:10.1038/srep06316. Lobo, D., Beane, W.S., and Levin, M. (2012). Modeling planarian regeneration: a primer for reverse-engineering the worm. PLoS computational biology, 8, e1002481. Morgan, T.H. (1898). Experimental studies of the regeneration of Planaria maculata. Archiv für Entwickelungsmechanik der Organismen, 7, 364-397. Morganer, U., Drexler, W., Kartner, F.X., Li, X.D., Pitris, C., Ippen, E.P. and Fuijimoto, J.G. (2000). Spectroscopic optical coherence tomography. Optics Letters, 25, 111-113. Rayleigh, L. (1896). On the theory of optical images with special reference to the microscope. Philosophical Magazine, 5(42), 167–195. Reddien, P.W., and Sanchez Alvarado, A. (2004). Fundamentals of planarian regeneration. Annual review of cell and developmental biology, 20, 725-757. Sampson, D.D. (2004). Trends and prospects for optical coherence tomography. Proceedings of SPIE, Bellingham, WA. in 2nd European Workshop on Optical Fiber Sensors, edited by J. M. Lopez-Higuera, B. Culshaw , Vol. 5502, pp. 51-58. Tsai, M.T. (2008). Effective indicators for diagnosis of oral cancer using optical coherence tomography, Optics express. Tanno, N, Ichikawa, T.and Saeki, A. (1990). Lightwave Reflection Measurement. Japanese Patent, 2010042. Wilson, B.C. and Jacques, S.L. (1990). Optical reflectance and transmittance of tissues: principles and applications. IEEE J. Quan. Electro, vol. 26, 2186-2199. 李冠卿(1988)。近代光學。聯經出版事業有限公司。 楊博年(2008)。以光學同調斷層攝影術評估果蠅的心臟功能。國立臺灣師範大學，臺北市。 林裕昇(2014)。光學同調斷層影像應用於小動物生理發展評估之研究。國立臺灣大學，臺北市。 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52450 | - |
| dc.description.abstract | 光學同調斷層掃描系統具有非侵入式、無輻射汙染以及成像結果迅速等優勢，成為近代成熟發展之醫學影像系統之一。本文即是利用光學同調斷層掃描系統作為主要的研究工具，並針對具有發展再生醫學研究潛力之渦蟲做為一動物模型來進行研究。為了達到這個目的，實驗內容將比較切割前之渦蟲組織與切割後之渦蟲組織。控制變因為渦蟲之不同位置以及切割後所經過的時間。希望能完整的以光學同調斷層掃描結果描述渦蟲的再生。
研究所使用的分析方法為紋理統計分析。由光學斷層掃描系統所截取之B-Scan影像中選取一個感興趣之位置範圍，並建立其空間灰階相關矩陣。再由該矩陣進行運算得到各項紋理特徵參數，包括對比度、相關性、能量、同質性以及熵。再分別就不同時間、不同位置之各項紋理特徵參數進行比較。 在實驗的分析結果中可明顯的發現，紋理分析特徵參數可以有效的描述渦蟲在光學同調斷層掃描系統所拍攝之B-Scan影像之影像特性。對比度、相關性以及能量在特定範圍間，可以表示該選取位置區域之影像具有較高濃度之高灰階值粒子聚集。而相關性的大小可以評估該高灰階值粒子在各個方向上的排列是否具有高度的方向性。而同質性與亂度可以表示所得之訊號中雜訊對關心區域影像之影響。因此能夠以量化方式描述渦蟲的再生，希望能建立一套量化標準，去評估渦蟲的再生狀況，減少人為判斷之誤差，以提供再生醫學研究一種之輔助判準。 | zh_TW |
| dc.description.abstract | Optical coherence tomography (OCT) is an established medical imaging technique. The key benefit of optical coherence tomography is non-invasive and instant imaging of live tissues without ionizing radiation. This study used OCT to investigate the planarian as a model for regenerative medicine. This experiment compares the tissue of the planarian before cutting and after cutting. Variables are the planarian’s different locations and the time elapsed after cutting. Hoping to completely describe the planarian regeneration with OCT.
The statistical method used for describing tissue is texture features analysis. First, select a region of interest (ROIs) in the B-Scan image by OCT to establish its spatial gray level dependence matrices. Then calculate the texture features properties, including contrast, correlation, energy, homogeneity and entropy. Lastly, compare the different times and locations of the texture properties. The result showed that texture feature properties can effectively describe the B-Scan images of the planarian by OCT. Contrast, correlation and energy in the specific value can represent the high concentration of high gray level value particles gathering. Furthermore, the scale of correlation can also be assessed high gray level value particles are highly directional arrangement. The homogeneity and entropy can be expressed the impact of noise in the ROIs. It is possible to quantify the regeneration of planarian, hoping to establish a quantitative criteria to assess the state of regeneration and reduce errors of human judgment, in order to provide an auxiliary method in regenerative medicine studies. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T16:15:09Z (GMT). No. of bitstreams: 1 ntu-104-R02543030-1.pdf: 3908215 bytes, checksum: 7a341c38e34bc4ade0af3a42668fee4c (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 第一章 緒論 1
1.1 前言 1 1.2 研究背景 3 1.3 文獻回顧 7 1.3.1 光學同調斷層掃描 7 1.3.2 幹細胞與渦蟲 10 1.4 研究目的 15 1.5 論文架構 16 第二章 理論基礎 17 2.1 干涉理論 17 2.2 同調性 23 2.3 Wiener–Khinchin定理 31 2.4 空間解析度 35 2.4.1 縱向解析度 35 2.4.2 橫向解析度 37 2.5 吸收與散射 40 第三章 實驗材料與方法 43 3.1 實驗儀器與系統架構 43 3.1.1 光學同調斷層掃描系統 43 3.1.2 軟體介面 47 3.2 實驗樣本 50 3.2.1 樣本簡介及來源 50 3.2.2 樣本處理與活體測量 51 3.3 實驗流程 52 3.4 影像分析方法 54 3.4.1 空間灰階相關矩陣 55 3.4.2 紋理特徵參數 58 第四章 實驗結果與討論 62 4.1 切割前不同位置之實驗結果 62 4.1.1 切割前縱剖面不同位置之結果 62 4.1.2 切割前橫剖面不同位置之結果 68 4.2 切割後各位置於不同時間之實驗結果 74 4.2.1 切割後各位置於不同時間之縱剖面結果 74 4.2.2 切割後各位至於不同時間之橫剖面結果 83 4.3 感興趣範圍選取大小對結果影響之討論 93 4.4 紋理特徵參數與渦蟲再生情形之關係討論 98 第五章 結論與未來展望 101 5.1 結論 101 5.2 未來展望 103 參考資料 104 | |
| dc.language.iso | zh-TW | |
| dc.subject | 空間灰階矩陣 | zh_TW |
| dc.subject | 光學同調斷層掃描系統 | zh_TW |
| dc.subject | 渦蟲再生 | zh_TW |
| dc.subject | 紋理分析 | zh_TW |
| dc.subject | planarian regeneration | en |
| dc.subject | texture features analysis | en |
| dc.subject | Optical coherence tomography (OCT) | en |
| dc.title | 以統計紋理方法分析光學同調斷層掃描儀觀測渦蟲之再生 | zh_TW |
| dc.title | Observation of Planarian Regeneration by Optical Coherence Tomography with Statistical Tissue Analysis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 崔博翔(Po-Hsiang Tsui) | |
| dc.contributor.oralexamcommittee | 朱錦洲(Chin-Chou Chu),朱家瑩(Chia-Ying Chu) | |
| dc.subject.keyword | 光學同調斷層掃描系統,渦蟲再生,空間灰階矩陣,紋理分析, | zh_TW |
| dc.subject.keyword | Optical coherence tomography (OCT),planarian regeneration,texture features analysis, | en |
| dc.relation.page | 106 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-08-18 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 應用力學研究所 | zh_TW |
| 顯示於系所單位： | 應用力學研究所 | |
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