中藥小青龍湯的使用能降低小兒氣喘的住院率

Abstract

Background: Several animal studies have shown the therapeutic effect of Xiao Qing Long Tang (XQLT) in asthma. However, However, there is still no large clinical trial to prove the effect of XQLT in children with asthma. The purpose of this study was to investigate the association between XQLT use and asthma in children. Methods: We conducted a population-based cohort study by using the Taiwan National Health Insurance Research Database. A total of 21 415 children with asthma were included as the study cohort. A Cox proportional hazard regression was performed to evaluate the association between XQLT use and asthma admission risk. Results: The patients who recorded as XQLT users and nonusers were 2 281 and 19 134 in the unmatched cohort. In the matched cohort, a total of 2 197 users and 8 788 nonusers were included. After adjusted for the age, gender, severity, Allergic rhinitis, Atopic dermatitis, and urbanization, XQLT was independently associated with the decreased risk of admission for asthma with dose-response relationship. In the unmatched cohort, the hazard ratio(HRs) were 0.54 (95% confidence interval (CI) 0.36-0.81) in children who used XQLT 28 days or less and 0.34 (95% CI 0.21-0.55) in children who used XQLT more than 28 days, and were 0.53 (95% CI 0.34-0.82) and 0.34 (95% CI 0.21-0.56) in children who used XQLT 28 days or less and children who used XQLT more than 28 days in the matched cohort. Conclusion: In conclusion, XQLT use was associated with lower incidence of asthma admission in children with asthma. It may show the possible therapeutic application of XQLT in children with asthma. Further large-scale clinical study is needed.