光碟微流道晶片在流體黏滯係數量測之研究

Abstract

黏滯係數(Viscosity)是生醫檢驗上的一個重要指標，它代表了檢體的黏稠度，與心血管等疾病有著絕對關聯。量測黏滯係數的儀器稱為黏度計(Viscometer)，傳統黏度計設計大多利用機械力來驅動流體，但傳統器材需要過多的檢體與耗時的檢驗。本研究欲利用光碟式微流道系統達成黏滯係數分析，光碟微流道系統不僅擁有微流道的各種優點，還能利用碟片轉動所帶來的力學效應驅動流體，藉由轉速和轉向的控制調節各力間的平衡，控制流體的流動。光碟式微流道同時也是快速檢測、低成本的檢測系統，並能達成床邊檢驗功能。 研究從流體模擬方面著手，調整不同注入槽位置及流道尺寸，尋找所需的流道參數。並由不同流體的流動情形，建立與黏滯係數關聯性，發現在光碟式微流道黏度計中，流動距離與黏滯係數的反比有著線性關係，不同流體的相對流動狀況與光碟轉速無關，這些情況可以應用在0.8 ~ 16m Pa-s黏滯係數區段，做為臨床醫學上的量測工作。

Viscosity is an important marker in biological industry and medical predictions. It corresponds to the “thickness” of sample fluid and plays an important role in cardiovascular disease. The device used to measure the viscosity is viscometer. The traditional viscometers utilize mechanical forces for pumping and control sample fluid. In this study, we design a disc-shape centrifugal microfluidic device in order to measure the fluidic viscosity. There are many benefits of disc-shape microfluidic devices as the same with other ordinary microfluidic devices. Furthermore, it is possible and easier to manipulate the flow conditions by controlling the rotational speed. In this study, we use computer simulations to develop the relationship between sample viscosities with their flow conditions and manufacture the microfluidic device. Viscosity is inversely proportion to the flow distance regardless of rotational speed within 0.8 ~ 16m Pa-s.