請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5160完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蔡坤憲,方?泰 | |
| dc.contributor.author | Tsen-Ju Shiu | en |
| dc.contributor.author | 許岑竹 | zh_TW |
| dc.date.accessioned | 2021-05-15T17:52:46Z | - |
| dc.date.available | 2016-10-20 | |
| dc.date.available | 2021-05-15T17:52:46Z | - |
| dc.date.copyright | 2014-10-20 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-08 | |
| dc.identifier.citation | 參考文獻
1. Tseng LF, Chang WC, Ferreira MC, Wu CH, Rampao HS, Lien JC: Rapid control of malaria by means of indoor residual spraying of alphacypermethrin in the Democratic Republic of Sao Tome and Principe. Am J Trop Med Hyg 2008, 78:248-250. 2. Hempelmann E, Krafts K: Bad air, amulets and mosquitoes: 2,000 years of changing perspectives on malaria. Malar J 2013, 12:232. 3. Cox FE: History of the discovery of the malaria parasites and their vectors. Parasit Vectors 2010, 3:5. 4. Garcia LS: Malaria. Clin Lab Med 2010, 30:93-129. 5. Aikawa M, Iseki M, Barnwell JW, Taylor D, Oo MM, Howard RJ: The pathology of human cerebral malaria. Am J Trop Med Hyg 1990, 43:30-37. 6. Martinez-Salazar E, Tobon-Castano A, Blair S: Natural Plasmodium knowlesi malaria infections in humans. Biomedica 2012, 32 Suppl 1:121-130. 7. Jongwutiwes S, Putaporntip C, Iwasaki T, Sata T, Kanbara H: Naturally acquired Plasmodium knowlesi malaria in human, Thailand. Emerg Infect Dis 2004, 10:2211-2213. 8. Singh B, Kim Sung L, Matusop A, Radhakrishnan A, Shamsul SS, Cox-Singh J, Thomas A, Conway DJ: A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet 2004, 363:1017-1024. 9. Ta TH, Hisam S, Lanza M, Jiram AI, Ismail N, Rubio JM: First case of a naturally acquired human infection with Plasmodium cynomolgi. Malar J 2014, 13:68. 10. Pinto J, Sousa CA, Gil V, Goncalves L, Lopes D, do Rosario VE, Charlwood JD: Mixed-species malaria infections in the human population of Sao Tome island, west Africa. Trans R Soc Trop Med Hyg 2000, 94:256-257. 11. CDC: http://www.cdc.gov/malaria/about/biology/. 12. Cruz I, Mody V, Callender C, Hosten A: Malaria infection in transplant recipient. J Natl Med Assoc 1978, 70:105-107. 13. Richet, Griffin WB: The treatment of malaria and malaria coma by intravenous injection of quinine urethane. Br Med J 1917, 1:190-191. 14. Baird JK: Effectiveness of antimalarial drugs. N Engl J Med 2005, 352:1565-1577. 15. Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler EA, Sinden RE, Leroy D: The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med 2012, 9:e1001169. 16. Qinghaosu Antimalaria Coordinating Research group: Antimalaria studies on Qinghaosu. Chin Med J (Engl) 1979, 92:811-816. 17. Dondorp A, Nosten F, Stepniewska K, Day N, White N: Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet 2005, 366:717-725. 18. Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, Bojang K, Olaosebikan R, Anunobi N, Maitland K, et al: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet 2010, 376:1647-1657. 19. Wongsrichanalai C, Pickard AL, Wernsdorfer WH, Meshnick SR: Epidemiology of drug-resistant malaria. Lancet Infect Dis 2002, 2:209-218. 20. White N: Antimalarial drug resistance and combination chemotherapy. Philos Trans R Soc Lond B Biol Sci 1999, 354:739-749. 21. Gil VS, Ferreira MC, d'Alva FS, d'Abreu JA, Will IM, Gomes ML, Castelli F, Taylor WR, Olliaro P, D'Alessandro U: Efficacy of artesunate plus chloroquine for uncomplicated malaria in children in Sao Tome and Principe: a double-blind, randomized, controlled trial. Trans R Soc Trop Med Hyg 2003, 97:703-706. 22. WHO: World Malaria Report. 2013. 23. Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, Collins F, Doumbo OK, Greenwood B, Hall BF, Levine MM, et al: A research agenda to underpin malaria eradication. PLoS Med 2011, 8:e1000406. 24. Mendis K, Rietveld A, Warsame M, Bosman A, Greenwood B, Wernsdorfer WH: From malaria control to eradication: The WHO perspective. Trop Med Int Health 2009, 14:802-809. 25. Breeveld FJ, Vreden SG, Grobusch MP: History of malaria research and its contribution to the malaria control success in Suriname: a review. Malar J 2012, 11:95. 26. Pinto J, Sousa CA, Gil V, Ferreira C, Goncalves L, Lopes D, Petrarca V, Charlwood JD, do Rosario VE: Malaria in Sao Tome and Principe: parasite prevalences and vector densities. Acta Trop 2000, 76:185-193. 27. Lee PW, Liu CT, do Rosario VE, de Sousa B, Rampao HS, Shaio MF: Potential threat of malaria epidemics in a low transmission area, as exemplified by Sao Tome and Principe. Malar J 2010, 9:264. 28. Lee PW, Liu CT, Rampao HS, do Rosario VE, Shaio MF: Pre-elimination of malaria on the island of Principe. Malar J 2010, 9:26. 29. Ulrich JN, Naranjo DP, Alimi TO, Muller GC, Beier JC: How much vector control is needed to achieve malaria elimination? Trends Parasitol 2013, 29:104-109. 30. Aidoo M: Factoring quality laboratory diagnosis into the malaria control agenda for sub-saharan Africa. Am J Trop Med Hyg 2013, 89:403-406. 31. Moody A: Rapid diagnostic tests for malaria parasites. Clin Microbiol Rev 2002, 15:66-78. 32. Brown AE, Kain KC, Pipithkul J, Webster HK: Demonstration by the polymerase chain reaction of mixed Plasmodium falciparum and P. vivax infections undetected by conventional microscopy. Trans R Soc Trop Med Hyg 1992, 86:609-612. 33. Gunasekera WMdAW, Abeyasinghe RR, Premawansa S, Fernando SD: Usefulness of polymerase chain reaction to supplement field microscopy in a pre-selected population with a high probability of malaria infections. Am J Trop Med Hyg 2011, 85:6-11. 34. The malERA Consultative Group on Diagnoses and Diagnostics: A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med 2011, 8:e1000396. 35. Wooden J, Kyes S, Sibley CH: PCR and strain identification in Plasmodium falciparum. Parasitol Today 1993, 9:303-305. 36. Al-Hamidhi S, Mahdy MA, Al-Hashami Z, Al-Farsi H, Al-Mekhlafi AM, Idris MA, Beja-Pereira A, Babiker HA: Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen. Malar J 2013, 12:244. 37. Rodger AJ, Cooke GS, Ord R, Sutherland CJ, Pasvol G: Cluster of falciparum malaria cases in UK airport. Emerg Infect Dis 2008, 14:1284-1286. 38. Zhong D, Afrane Y, Githeko A, Yang Z, Cui L, Menge DM, Temu EA, Yan G: Plasmodium falciparum genetic diversity in western Kenya highlands. Am J Trop Med Hyg 2007, 77:1043-1050. 39. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN: High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 1993, 61:315-320. 40. Israelsson E, Vafa M, Maiga B, Lysen A, Iriemenam NC, Dolo A, Doumbo OK, Troye-Blomberg M, Berzins K: Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali. Malar J 2008, 7:175. 41. Mangold KA, Manson RU, Koay ES, Stephens L, Regner M, Thomson RB, Jr., Peterson LR, Kaul KL: Real-time PCR for detection and identification of Plasmodium spp. J Clin Microbiol 2005, 43:2435-2440. 42. NCBI: http://blast.ncbi.nlm.nih.gov/Blast.cgi. 43. Cotter C, Sturrock HJ, Hsiang MS, Liu J, Phillips AA, Hwang J, Gueye CS, Fullman N, Gosling RD, Feachem RG: The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet 2013, 382:900-911. 44. Mohapatra PK, Prakash A, Taison K, Negmu K, Gohain AC, Namchoom NS, Wange D, Bhattacharyya DR, Goswami BK, Borgohain BK, Mahanta J: Evaluation of chloroquine (CQ) and sulphadoxine/pyrimethamine (SP) therapy in uncomplicated falciparum malaria in Indo-Myanmar border areas. Trop Med Int Health 2005, 10:478-483. 45. Zhou X, Huang JL, Njuabe MT, Li SG, Chen JH, Zhou XN: A molecular survey of febrile cases in malaria-endemic areas along China-Myanmar border in Yunnan province, People's Republic of China. Parasite 2014, 21:27. 46. Hagmann R, Charlwood JD, Gil V, Ferreira C, do Rosario V, Smith TA: Malaria and its possible control on the island of Principe. Malar J 2003, 2:15. 47. Snounou G, Pinheiro L, Antunes AM, Ferreira C, do Rosario VE: Non-immune patients in the Democratic Republic of Sao Tome e Principe reveal a high level of transmission of P. ovale and P. vivax despite low frequency in immune patients. Acta Trop 1998, 70:197-203. 48. McKenzie FE, Sirichaisinthop J, Miller RS, Gasser RA, Jr., Wongsrichanalai C: Dependence of malaria detection and species diagnosis by microscopy on parasite density. Am J Trop Med Hyg 2003, 69:372-376. 49. Nkrumah B, Agyekum A, Acquah SE, May J, Tannich E, Brattig N, Nguah SB, von Thien H, Adu-Sarkodie Y, Huenger F: Comparison of the novel Partec rapid malaria test to the conventional Giemsa stain and the gold standard real-time PCR. J Clin Microbiol 2010, 48:2925-2928. 50. Reller ME, Chen WH, Dalton J, Lichay MA, Dumler JS: Multiplex 5' Nuclease Quantitative Real-Time PCR for Clinical Diagnosis of Malaria and Species-Level Identification and Epidemiologic Evaluation of Malaria-Causing Parasites, Including Plasmodium knowlesi. J Clin Microbiol 2013, 51:2931-2938. 51. Lee MA, Tan CH, Aw LT, Tang CS, Singh M, Lee SH, Chia HP, Yap EP: Real-time fluorescence-based PCR for detection of malaria parasites. J Clin Microbiol 2002, 40:4343-4345. 52. Lee PW, Ji DD, Liu CT, Rampao HS, do Rosario VE, Lin IF, Shaio MF: Application of loop-mediated isothermal amplification for malaria diagnosis during a follow-up study in Sao Tome. Malar J 2012, 11:408. 53. Kuesap J, Chaijaroenkul W, Ketprathum K, Tattiyapong P, Na-Bangchang K: Evolution of genetic polymorphisms of Plasmodium falciparum merozoite surface protein (PfMSP) in Thailand. Korean J Parasitol 2014, 52:105-109. 54. Ogouyemi-Hounto A, Gazard DK, Ndam N, Topanou E, Garba O, Elegbe P, Hountohotegbe T, Massougbodji A: Genetic polymorphism of merozoite surface protein-1 and merozoite surface protein-2 in Plasmodium falciparum isolates from children in South of Benin. Parasite 2013, 20:37. 55. Atroosh WM, Al-Mekhlafi HM, Mahdy MA, Saif-Ali R, Al-Mekhlafi AM, Surin J: Genetic diversity of Plasmodium falciparum isolates from Pahang, Malaysia based on MSP-1 and MSP-2 genes. Parasit Vectors 2011, 4:233. 56. Hamid MM, Mohammed SB, El Hassan IM: Genetic diversity of Plasmodium falciparum field isolates in central Sudan inferred by PCR genotyping of merozoite surface protein 1 and 2. N Am J Med Sci 2013, 5:95-101. 57. Lindblade KA, Steinhardt L, Samuels A, Kachur SP, Slutsker L: The silent threat: asymptomatic parasitemia and malaria transmission. Expert Rev Anti Infect Ther 2013, 11:623-639. 58. Cravo P, Figueiredo S, Nogueira F, Lopes D, Ferreira ID, Ferreira C, Gil JP, do Rosario VE: High frequency of the genetic polymorphisms associated with sulfadoxine-pyrimethamine resistance, among Plasmodium falciparum isolates from Sao Tome and Principe, West Africa. Ann Trop Med Parasitol 2004, 98:293-296. 59. Lopes D, Nogueira F, Gil JP, Ferreira C, do Rosario VE, Cravo P: pfcrt and pfmdr1 mutations and chloroquine resistance in Plasmodium falciparum from Sao Tome and Principe, West Africa. Ann Trop Med Parasitol 2002, 96:831-834. 60. Ferreira ID, Lopes D, Martinelli A, Ferreira C, do Rosario VE, Cravo P: In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from Sao Tome and Principe. Trop Med Int Health 2007, 12:353-362. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5160 | - |
| dc.description.abstract | 瘧疾過去在聖多美普林西比民主共和國 (以下簡稱聖多美) 造成極大的威脅，在各種防治措施介入後，疾病發生率和盛行率都有顯著的下降。本研究藉由分析聖多美流行病學資料，驗證當地是否進入瘧疾清除前期。透過定量即時聚合酶鏈鎖反應和巢式聚合酶鏈鎖反應，比較分生檢驗與鏡檢結果差異。此外，將聚合酶鏈鎖反應陽性檢體進行瘧原蟲裂殖體表面蛋白第一型 (MSP1)和瘧原蟲裂殖體表面蛋白第二型 (MSP2) 基因定序，分析聖多美不同年代、地區、寄生蟲等級檢體中所帶惡性瘧原蟲流行株趨勢。研究蒐集西元2000年起聖多美13年發燒與瘧疾確診人數，以及2010年瘧疾陽性病人 (n=28)、2011年至2013年間低寄生蟲血症病人 (n=377)、不明發燒病人 (n=605) 與普林西比島全島篩檢 (n=6855) 之資料與血片，結果顯示僅有Lemba省和Principe自治區達到世界衛生組織訂立瘧疾清除前期標準。在鏡檢為瘧疾陰性的461位門診發燒病人中，有15人 (3.3%) 經PCR判定為感染瘧原蟲；普林西比島篩檢則分生檢驗與鏡檢結果一致。分析PCR陽性檢體之親緣關係發現，聖多美惡性瘧原蟲流行株大致可分為三大群，是否源自不同國家傳入其他型別則需進一步分析。藉由分子流行病學資料顯示，聖多美目前已逐漸進入瘧疾清除階段，本研究結果將提供聖多美瘧疾治療與疫苗發展的相關資訊，對未來瘧疾防治能做更適宜的政策規劃與準備。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-05-15T17:52:46Z (GMT). No. of bitstreams: 1 ntu-103-R01849026-1.pdf: 803869 bytes, checksum: 571e6f672a56924ac809b4998807e2f3 (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 目 錄
口試委員會審定書………………………….…………………………………..............i 致謝………………………………………………………………………….............….ii 中文摘要……………………………………………………………………………......iii 英文摘要…………………………………………………………………………..........iv 研究流程圖…………………………………………………………………….…….....vi 目錄…………………………………………………………………………….............vii 圖目錄……………………………………………………………………...................viii 表目錄……………………………………………………………………………..........ix 第一章 前言.....................................................................................................................1 第一節 聖多美普林西比背景介紹.........................................................................1 第二節 瘧疾概述.....................................................................................................2 第三節 檢驗策略.....................................................................................................6 第四節 瘧原蟲親緣關係比較.................................................................................8 第五節 研究目的.....................................................................................................9 第二章 材料與方法.......................................................................................................10 第一節 聖多美基礎流行病學分析.......................................................................10 第二節 聖多美分生檢驗.......................................................................................11 第三節 瘧原蟲親緣關係比較...............................................................................16 第三章 結果………………………………………………………...............................19 第一節 聖多美基礎流行病學分析...............……………………….……...........19 第二節 聖多美分生檢驗…...………………………………………....................20 第三節 瘧原蟲親緣關係比較...……………………………………....................23 第四章 討論………………………………………………………...............................25 參考文獻……………………………………………………….....................................28 | |
| dc.language.iso | zh-TW | |
| dc.subject | 親緣關係 | zh_TW |
| dc.subject | 聖多美普林西比民主共和國 | zh_TW |
| dc.subject | 瘧疾 | zh_TW |
| dc.subject | 惡性瘧原蟲 | zh_TW |
| dc.subject | 定量即時聚合?鏈鎖反應 | zh_TW |
| dc.subject | 巢式聚合?鏈鎖反應 | zh_TW |
| dc.subject | Plasmodium falciparum | en |
| dc.subject | Phylogeny | en |
| dc.subject | Nested PCR | en |
| dc.subject | Quantitative real-time PCR | en |
| dc.subject | Democratic Republic of Sao Tome and Principe | en |
| dc.subject | Malaria | en |
| dc.title | 聖多美普林西比民主共和國瘧疾分子流行病學研究 | zh_TW |
| dc.title | Molecular epidemiological study of malaria in the Democratic Republic of Sao Tome and Principe | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 嵇達德 | |
| dc.subject.keyword | 聖多美普林西比民主共和國,瘧疾,惡性瘧原蟲,定量即時聚合?鏈鎖反應,巢式聚合?鏈鎖反應,親緣關係, | zh_TW |
| dc.subject.keyword | Democratic Republic of Sao Tome and Principe,Malaria,Plasmodium falciparum,Quantitative real-time PCR,Nested PCR,Phylogeny, | en |
| dc.relation.page | 48 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2014-08-08 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學與預防醫學研究所 | zh_TW |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-103-1.pdf | 785.03 kB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。