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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 花茂棽(Mau-Sun Hua) | |
| dc.contributor.author | Hsin-Te Chang | en |
| dc.contributor.author | 張馨德 | zh_TW |
| dc.date.accessioned | 2021-06-15T13:38:15Z | - |
| dc.date.available | 2019-02-15 | |
| dc.date.copyright | 2016-02-15 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-01-22 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/51544 | - |
| dc.description.abstract | 針對阿茲海默病之神經病理研究指出語意記憶缺損在病程演進中可能早於事件記憶，近期許多研究於失憶型輕度認知缺損患者中發現語意記憶缺損；然而，研究對於語意記憶缺損對於日後轉變為阿茲海默型失智症之預測能力看法不一，此外，目前尚無研究探討主觀記憶缺損個體之語意記憶。本研究目標為探討失憶型輕度認知缺損患者語意記憶缺損之不同面向並提供這些面向對於轉變為阿茲海默型失智症之預測效果，另外，本研究亦探討主觀記憶缺損個體記憶中之語意面向。主觀記憶缺損個體及單一領域失憶型輕度認知缺損患者在費力、策略性語意記憶提取歷程明顯受損，而多重領域失憶型輕度認知缺損患者在費力及自動性語意記憶提取歷程皆受損；由單一領域失憶型輕度認知缺損轉變為阿茲海默型失智症受到費力性語意記憶提取缺損所預測，相反的，由多重領域失憶型輕度認知缺損轉變為阿茲海默型失智症受到自動性語意記憶提取缺損所預測。這些發現顯示失憶型輕度認知缺損患者及具有主觀記憶缺損個體在語意記憶缺損上呈現特有型態，此類缺損型態具有預測失憶型輕度認知缺損患者後續認知退化之效果。 | zh_TW |
| dc.description.abstract | Neuropathological evidence suggests that semantic memory deterioration can occur earlier than episodic memory in the disease progression of Alzheimer’s disease (AD). Increasing evidence has suggested marked semantic memory impairment in patients with amnestic mild cognitive impairment (aMCI-sd). However, the predicative power of semantic memory on conversion from aMCI to dementia of the Alzheimer’s type (DAT) has remained inconsistent. In addition, no studies have directly investigated semantic memory among individuals with subjective memory decline (SMD). This study aimed to investigate various aspects of semantic memory decline among aMCI patients, to evaluate the predictive values of these aspects of semantic memory on conversion to DAT, and to examine the semantic aspect of memory among SMD individuals. Individuals with SMD and patients with aMCI-single domain (aMCI-sd) suffered from disproportionately impaired performance on effortful and strategic retrieval of semantic memory, whereas those with aMCI-multiple domain (aMCI-md) suffered from deficits in both effortful and automatic retrieval of semantic memory. The conversion from aMCI-sd to DAT was predicted by poor performance in effortful retrieval of semantic memory. In contrast, conversion from aMCI-md to DAT was predicted by poor performance on automatic retrieval. These findings suggest distinctive patterns and predictive values of semantic memory deterioration among individuals in the earliest stages of AD. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T13:38:15Z (GMT). No. of bitstreams: 1 ntu-105-D99227205-1.pdf: 4120116 bytes, checksum: 9b3c74e058c876a85bf5be08f430c909 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 摘要 I
Abstract II Abbreviations IX Chapter 1: Overview 1 Chapter 2: Introduction 5 2-1. Dementia of the Alzheimer’s type (DAT) 5 2-1-1. Clinical presentations 5 2-1-2. Neuropathology 6 2-2. Amnestic mild cognitive impairment (aMCI) 12 2-2-1. Clinical presentations 13 2-2-2. Neuropathology 15 2-3. Subjective memory decline (SMD) 16 2-3-1. Conceptual framework 16 2-3-2. Controversy 20 2-4. Semantic memory 22 2-4-1. Semantic memory and types of memory 22 2-4-2. Semantic memory deterioration in DAT 25 2-4-3. Neural substrates of semantic memory 36 2-5. Semantic memory deterioration in prodromal and preclinical AD 51 2-5-1. aMCI 51 2-5-2. SMD 54 2-5-3. The utility of semantic fluency 56 2-6. Aims of the present study 58 Chapter 3: Study 1-Patterns of semantic memory deterioration among aMCI patients 61 3-1. Introduction 61 3-2. Methods 63 3-2-1. Participants 63 3-2-2. Background neuropsychological functions 64 3-2-3. Semantic memory 66 3-2-4. Data analysis 68 3-3. Results 69 3-3-1. Demographic and clinical characteristics 69 3-3-2. Background neuropsychological functions 70 3-3-3. Semantic memory 71 3-3-4. Follow-up 75 3-4. Discussion 77 3-4-1. Patterns of semantic memory impairment among patients with aMCI subtypes 79 3-4-2. Predictive values of semantic memory among patients with aMCI subtypes 80 3-4-3. Future studies 81 Chapter 4: Study 2-Patterns of semantic fluency deterioration among aMCI patients 83 4-1. Introduction 83 4-2. Methods 85 4-2-1. Participants 85 4-2-2. Background neuropsychological functions 86 4-2-3. Semantic fluency 86 4-2-4. Data analysis 88 4-3. Results 89 4-3-1. Demographic and clinical characteristics 90 4-3-2. Background neuropsychological functions 90 4-3-3. Semantic fluency across the categories 92 4-3-4. SI 93 4-3-5. Follow-up 96 4-4. Discussion 99 4-4-1. Category-specific deterioration in semantic memory among aMCI patients 99 4-4-2. Retrieval mechanisms in different epochs of semantic fluency 101 4-4-3. Predictive values of category-specific semantic memory deterioration among aMCI patients 102 4-4-4. Future studies 103 Chapter 5: Study 3-Changes in semantic networks among aMCI patients 105 5-1. Introduction 105 5-2. Methods 107 5-2-1. Participants 107 5-2-2. Networks in semantic fluency 107 5-2-3. Data analysis 110 5-3. Results 112 5-3-1. Demographic and clinical characteristics 113 5-3-2. Background neuropsychological functions 113 5-3-3. Structures in the clustering of semantic fluency 114 5-4. Discussion 125 5-4-1. Changes in semantic networks among patients with aMCI 127 5-4-2. Predictive values of semantic networks among patients with aMCI 130 5-4-3. Future studies 131 Chapter 6: Study 4-Arbitrary and semantic forms of association among individuals with SMD 133 6-1. Introduction 133 6-2. Methods 136 6-2-1. Participants 136 6-2-2. Background neuropsychological functions 137 6-2-3. Memory tasks 138 6-2-4. Data analysis 139 6-3. Results 140 6-3-1. Demographics and clinical characteristics 140 6-3-2. Memory tests 142 6-4. Discussion 144 6-4-1. Sensitivity of verbal list learning task in detection cognitive changes in early stages of AD 144 6-4-2. Arbitrary forms of association among individuals with SMD 147 Chapter 7: General Discussion 151 7-1. Summary of findings 151 7-2. Mechanisms of semantic memory decline and their predictive values in early stages of AD 152 7-2-1. Effortful allocation of attention in semantic memory retrieval 153 7-2-2. Praxis and action 156 7-2-3. Arbitrary association of semantic memory 159 7-3. Limitations and directions of future research 160 7-3-1. Roles of frontal lobes in different semantic memory retrieval processes 161 7-3-2. Early detection using sensitive memory task 162 7-3-3. Components of specific representations in encoding and retrieval 162 7-3-4. Different mechanisms to achieve semantic fluency and semantic memory retrieval 163 7-3-5. Predictive values in SMD 164 7-3-6. Impacts of personal experience on processes of semantic memory retrieval 164 7-3-7. Emotional symptoms and SMD 165 7-4. Conclusion 165 References 167 Appendix 219 | |
| dc.language.iso | en | |
| dc.subject | 費力型提取 | zh_TW |
| dc.subject | 阿茲海默病 | zh_TW |
| dc.subject | 失憶型輕度認知缺損 | zh_TW |
| dc.subject | 主觀記憶缺損 | zh_TW |
| dc.subject | 語意記憶 | zh_TW |
| dc.subject | semantic memory | en |
| dc.subject | effortful retrieval | en |
| dc.subject | subjective memory decline | en |
| dc.subject | amnestic mild cognitive impairment | en |
| dc.title | 前驅期阿茲海默病個體語意記憶缺損之型態與預測認知退化能力 | zh_TW |
| dc.title | Distinct patterns and predictive values of semantic memory deterioration among individuals with prodromal Alzheimer's disease | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 賴德仁(Te-Jen Lai),王培寧(Pei-Ning Wang),林克能(Ker-Neng Lin),邱銘章(Ming-Jang Chiu),郭乃文(Nai-Wen Guo) | |
| dc.subject.keyword | 阿茲海默病,失憶型輕度認知缺損,主觀記憶缺損,語意記憶,費力型提取, | zh_TW |
| dc.subject.keyword | amnestic mild cognitive impairment,subjective memory decline,semantic memory,effortful retrieval, | en |
| dc.relation.page | 222 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-01-25 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 心理學研究所 | zh_TW |
| 顯示於系所單位： | 心理學系 | |
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