請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5141
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林文澧 | |
dc.contributor.author | Tsu-Wei Liu | en |
dc.contributor.author | 劉子維 | zh_TW |
dc.date.accessioned | 2021-05-15T17:52:29Z | - |
dc.date.available | 2016-08-17 | |
dc.date.available | 2021-05-15T17:52:29Z | - |
dc.date.copyright | 2014-08-17 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-08-11 | |
dc.identifier.citation | 1. Archambeau, J O, Pezner, R., and Wasserman, T. (1995). Pathophysiology of irradiated skin and breast. Int J Radiat Oncol Biol Phys, 31(5), 1171-1185. doi: 10.1016/0360-3016(94)00423-i
2. Baum, B J, Zheng, C, Cotrim, A P, Goldsmith, C M, Atkinson, J C, Brahim, J S, . . . Illei, G G (2006). Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction. Biochim Biophys Acta, 1758(8), 1071-1077. doi: 10.1016/j.bbamem.2005.11.006 3. Bezdek, J C (1981). Pattern Recognition with Fuzzy Objective Function Algorithms. New York: Plenum Press. 4. Citrin, D., Cotrim, A P, Hyodo, F, Baum, B J, Krishna, M C, & Mitchell, J B (2010). Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist, 15(4), 360-371. doi: 10.1634/theoncologist.2009-S104 5. Cooper, J S, Fu, K, Marks, J, and Silverman, S (1995). Late effects of radiation therapy in the head and neck region. Int J Radiat Oncol Biol Phys, 31(5), 1141-1164. doi: 10.1016/0360-3016(94)00421-g 6. Cotrim, A P, Hyodo, F, Matsumoto, K, Sowers, A L, Cook, J A, Baum, B J, . . . Mitchell, J B (2007). Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clin Cancer Res, 13(16), 4928-4933. doi: 10.1158/1078-0432.ccr-07-0662 7. Dorr, W, and Hendry, J H (2001). Consequential late effects in normal tissues. Radiother Oncol, 61(3), 223-231. 8. Dunn, J C (1974). A fuzzy relative of the isodata process and its use in detecting compact well separated clusters. Journal of Cybernetics, 3(3), 32-57. 9. Dvorak, H F (1986). Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med, 315(26), 1650-1659. doi: 10.1056/nejm198612253152606 10. Fajardo, L F (1982). Pathology of radiation injury. New York: Masson. 11. Fowler, J F (1984). The first James Kirk memorial lecture. What next in fractionated radiotherapy? Br J Cancer Suppl, 6, 285-300. 12. Greis, C (2011). Quantitative evaluation of microvascular blood flow by contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc, 49(1-4), 137-149. doi: 10.3233/ch-2011-1464 13. Hadi, A M, Mouchaers, K T, Schalij, I, Grunberg, K, Meijer, G A, Vonk-Noordegraaf, A, . . . Belien, J A (2011). Rapid quantification of myocardial fibrosis: a new macro-based automated analysis. Cell Oncol (Dordr), 34(4), 343-354. doi: 10.1007/s13402-011-0035-7 14. Laug, W E, DeClerck, Y A, and Jones, P A (1983). Degradation of the subendothelial matrix by tumor cells. Cancer Res, 43(4), 1827-1834. 15. Siegal, T, and Pfeffer, M R (1995). Radiation-induced changes in the profile of spinal cord serotonin, prostaglandin synthesis, and vascular permeability. Int J Radiat Oncol Biol Phys, 31(1), 57-64. doi: 10.1016/0360-3016(94)e0305-4 16. Stamenkovic, I (2000). Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol, 10(6), 415-433. doi: 10.1006/scbi.2000.0379 17. Szabo, T L (2004). Diagnostic Ultrasound Imaging: Inside Out. CH8-10. 18. Thames, H D, Jr, Withers, H R, Peters, L J, and Fletcher, G H (1982). Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships. Int J Radiat Oncol Biol Phys, 8(2), 219-226. 19. van Leeuwen-Segarceanu, E M, Dorresteijn, L D, Pillen, S, Biesma, D H, Vogels, O J, and van Alfen, N (2012). Progressive muscle atrophy and weakness after treatment by mantle field radiotherapy in Hodgkin lymphoma survivors. Int J Radiat Oncol Biol Phys, 82(2), 612-618. doi: 10.1016/j.ijrobp.2010.11.064 20. Woolley, D E (1984). Collagenolytic mechanisms in tumor cell invasion. Cancer Metastasis Rev, 3(4), 361-372. 21. Yang, Y, and Huang, S Y (2007). Image segmentation by fuzzy c-means clustering algorithm with a novel penalty term. Computing and Informatics, 26(1), 17-31. 22. Yang, Y, Zheng, C, and Lin, P (2005). Fuzzy c-means clustering algorithm with a novel penalty term for image segmentation. Opto-Electronics Review, 13(4), 309-315. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5141 | - |
dc.description.abstract | 本研究主要的目的為量化胸鎖乳突肌(Sternocleidomastoid, SCM)肌肉中所含的肌肉纖維比例,以利於臨床醫師評估患者經放射線照射後的患者肌肉所受傷害程度,並在患者主觀感到不適之前,及早發現肌肉組織的惡化,提供切入治療時間的判斷依據。
使用的影像來源為36位臨床頭頸部腫瘤患者經放射治療後的胸鎖乳突肌之B型(Brightness mode)超音波影像,包含腫瘤側及非腫瘤側的影像,經由MATLAB為基底撰寫的影像分析系統,並結合Fuzzy c-means clustering與自行開發的Size criterion運算法,來分析肌肉纖維與肌肉細胞成分,並統計所占的面積及比例,以得到該影像中的肌肉纖維面積、肌肉細胞面積及肌肉纖維比例等數值,達到量化肌肉纖維的目的。利用3位正常人的手臂肌肉超音波影像,在不同超音波參數,如Total gain等做實驗校正,作為Size criterion的理論依據。另外使用蛋白仿體做量化的實驗驗證,證明本系統的準確性及有效性,最後以患者影像來做分析並以單一患者及多患者分別統計作圖。 由蛋白仿體實驗可以驗證實際的燒灼面積比例與經本系統處理之超音波影像所得之燒灼面積比例成正比關係。在患者超音波影像分析上,統計結果顯示,放射治療後腫瘤附近的肌肉會有腫脹現象,而在3個月之後有較明顯的肌肉纖維化,另外在腫瘤側的肌肉纖維化會比非腫瘤側來的嚴重許多。 本研發系統能有效量化單一患者的肌肉纖維化隨時間演進與位多患者的肌肉纖維化普遍趨勢,可提供臨床醫師一個客觀且穩定的標準來評估肌肉組織在放射治療後的傷害程度與判斷患部在復健療程的恢復程度。 | zh_TW |
dc.description.abstract | The purpose of this study is to develop a quantitative method for estimating muscular fiber of Sternocleidomastoid (SCM) muscle to help doctors evaluate the damage of SCM muscle after radiotherapy.
The raw data of the study are ultrasound B-mode images of SCM muscle for 36 patients with head and neck cancer before and after radiotherapy. These images include tumor side and non-tumor side. The analysis system is based on MATLAB with fuzzy c-means clustering and size criterion algorithm. Muscular fiber and muscle cell are divided by the developed system and then their areas are calculated. After processing, muscular fiber area, muscle cell area and fiber ratio are displayed. Due to different sonography parameters, such as total gain for each image, calibration is considered for the biceps of 3 normal people and phantom experiment is further studied to prove the accuracy of the system. Finally, the ultrasound images of 36 patients are analyzed by the system and the results are plotted. From the result of phantom experiment, it shows that the lesion in ultrasound images is proportional to optical picture. The result of patient images shows that as time goes on, SCM muscle near tumor gets swelling and then gets fibrotic 3 months after radiotherapy. Furthermore, fibrosis of SCM muscle in tumor side gets worse than non-tumor side. The analysis system has ability to quantitatively estimate the fibrosis of SCM muscle as time goes on for each patient and fibrosis trend for all patients. It provides clinical doctors an objective and stable way to analyze the condition of SCM muscle after radiotherapy and it may be used to evaluate the treatment result for rehabilitation. | en |
dc.description.provenance | Made available in DSpace on 2021-05-15T17:52:29Z (GMT). No. of bitstreams: 1 ntu-103-R01548016-1.pdf: 7987951 bytes, checksum: 225acc6871cf6f1798063e98c40b7ae4 (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | 誌謝 I
摘要 II Abstract III 目錄 IV 圖目錄 V 表目錄 VII 第1章 緒論 1 1.1 超音波應用簡述 1 1.2 肌肉組織之生理構造 2 1.3 研究動機 5 1.4 放射治療後周邊正常組織之生理病理現象 10 1.5 先前技術回顧 15 1.6 研究目的 20 第2章 材料與影像來源 21 2.1 超音波成像原理說明 21 2.2 影像來源及取得方法 22 2.3 蛋白仿體實驗材料與流程 29 第3章 系統與方法 36 3.1 系統架構說明 36 3.2 系統功能介紹 39 3.3 影像處理演算法介紹 47 第4章 結果與討論 54 4.1 變數討論 54 4.2 仿體實驗結果與討論 64 4.3 病患超音波影像分析與討論 67 第5章 結論及未來展望 74 參考文獻 75 附錄一 78 附錄二 87 | |
dc.language.iso | zh-TW | |
dc.title | 應用於放射線所造成肌肉組織傷害之超音波影像分析方法 | zh_TW |
dc.title | Analytical Methods of Sonography for Radiation-induced uscular Tissue Injury | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳景欣,陳永耀,周呈霙 | |
dc.subject.keyword | 超音波影像,放射治療後正常組織,Fuzzy c-means clustering,Size criterion, | zh_TW |
dc.subject.keyword | ultrasound image,normal tissue,Fuzzy c-means clustering,Size criterion, | en |
dc.relation.page | 106 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2014-08-11 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-103-1.pdf | 7.8 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。