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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈雅敬(Ya-Ching Shen) | |
| dc.contributor.author | Chan-Han Hsieh | en |
| dc.contributor.author | 謝承翰 | zh_TW |
| dc.date.accessioned | 2021-06-15T13:30:52Z | - |
| dc.date.available | 2021-02-26 | |
| dc.date.copyright | 2016-02-26 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-02-03 | |
| dc.identifier.citation | 1. 臺灣中藥典. (行政院衛生署中醫藥委員會, 2013).
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/51335 | - |
| dc.description.abstract | 本論文主要研究台灣產阿里山五味子(Schisandra arisanensis Hayata)藤莖含有之降三萜類化合物。阿里山五味子藤莖乙醇萃取物經過液液分配層析、管柱層析、高效液相層析等分離流程，並進一步分析鑑定所含之降三萜類成分。
實驗共分離得到二十二個五味子降三萜類化合物，其中包含八個新的化合物。新化合物依據碳骨架排列方式的不同，可進一步分類為四種類型: 14(13→12)16(17→13)–diabeoschiartane–type (1–3)、wuweiziartane–type (4、5)、lancischiartane–type (6、7)、preschisanartane–type (8)。其餘十四個已知化合物分別是schisarisanlactone A (9)、arisanlactone A (10)、arisanlactone C (11)、preschisanartanins A–B (12、13)、schilancidilactone W (14)、micrandilactone G (15)、lancifodilactones B–D, N (16–18、20)、henridilactone C (19)、schicagenin A (21)以及propindilactone K (22)。 以上化合物之結構鑑定主要是依據一維核磁共振光譜(1H–NMR, 13C–NMR, DEPT–135, DEPT–90)及二維核磁共振圖譜(COSY, HSQC, HMBC, NOESY, ROESY)，輔以高解析電灑式質譜、紅外線光譜、紫外線光譜、圖二色光譜以及比旋光度，除了實驗室過去相關化合物的數據分析，並利用化學資料庫Reaxys以及資料庫Web of science搜尋比對相關文獻。 | zh_TW |
| dc.description.abstract | This thesis focuses on the chemical investigation of triterpenoids from the stems of Schisandra arisanensis Hayata, an endemic schisandraceae species of Taiwan. The ethanol extract was fractionated by liquid–liquid partition and column chromatography. Fractions were further analyzed for their triterpenoid components by application of reverse phase high–performance liquid chromatography.
Twenty two triterpenoids including eight new compounds (1–8) were identified as schinortriterpenoids which can be exclusively found in Schisandraceae family. The new compounds can be classified into four types according to their carbon skeleton patterns: 14(13→12)16(17→13)–diabeoschiartane–type (1–3), wuweiziartane–type (4 and 5), lancischiartane–type (6 and 7) and preschisanartane–type (8) . Other fourteen known compounds are schisarisanlactone A (9), arisanlactone A (10), arisanlactone C (11), preschisanartanins A–B (12, 13), schilancidilactone W (14), micrandilactone G (15), lancifodilactones B–D, N (16–18, 20), henridilactone C (19), schicagenin A (21) and propindilactone K (22). Structural elucidation of the schinortriterpenoids is mainly based on one–dimension NMR (1H–NMR, 13C–NMR, DEPT–135, DEPT–90) and two–dimension NMR ( COSY, HSQC, HMBC, NOESY, ROESY), together with high resolution ESI mass, infrared, UV, circular dichroism and specific optical rotation. The experimental data of related compounds were also examined and obtained from previous lab results. Other analytical reports were further reached by searching chemical data bases Reaxys and Web of science. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T13:30:52Z (GMT). No. of bitstreams: 1 ntu-105-R02423004-1.pdf: 14061482 bytes, checksum: b2852141d6c8440468ef25fe243d3f4e (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 中文摘要 i
Abstract iii 目錄 v 圖目錄 vii 表目錄 xiii 第一章 序論 1 第一節 前言 1 第二節 研究動機 2 第三節 五味子科植物三萜類成分之文獻回顧 3 第二章 材料及方法 47 第一節 材料介紹 47 第二節 實驗儀器 49 第三節 實驗溶劑及矽膠 51 第四節 分離流程 52 第三章 實驗結果 60 第一節 化合物1之結構解析 60 第二節 化合物2之結構解析 74 第三節 化合物3之結構解析 87 第四節 化合物4之結構解析 100 第五節 化合物5之結構解析 114 第六節 化合物6之結構解析 126 第七節 化合物7之結構解析 138 第八節 化合物8之結構解析 150 第九節 化合物9之結構 162 第十節 化合物10之結構 165 第十一節 化合物11之結構 168 第十二節 化合物12之結構 171 第十三節 化合物13之結構 174 第十四節 化合物14之結構 177 第十五節 化合物15之結構 180 第十六節 化合物16之結構 183 第十七節 化合物17之結構 186 第十八節 化合物18之結構 189 第十九節 化合物19之結構 192 第二十節 化合物20之結構 195 第二十一節 化合物21之結構 198 第二十二節 化合物22之結構 201 第四章 結果與討論 204 第五章 參考文獻 215 附錄 : X–ray 數據 231 | |
| dc.language.iso | zh-TW | |
| dc.subject | 五味子降三?類 | zh_TW |
| dc.subject | 阿里山五味子 | zh_TW |
| dc.subject | 五味子降三?類 | zh_TW |
| dc.subject | 阿里山五味子 | zh_TW |
| dc.subject | Schisandra arisanensis | en |
| dc.subject | Schisandra arisanensis | en |
| dc.subject | triterpenoids | en |
| dc.subject | triterpenoids | en |
| dc.title | 阿里山五味子藤莖之降三萜類成分研究 | zh_TW |
| dc.title | Studies on the Nortriterpenoids from the Stems of
Schisandra arisanensis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭曜豪(Yao-Haur Kuo),鄭源斌(Cheng Yuan-Bin) | |
| dc.subject.keyword | 阿里山五味子,五味子降三?類, | zh_TW |
| dc.subject.keyword | Schisandra arisanensis,triterpenoids, | en |
| dc.relation.page | 248 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-02-03 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥學研究所 | zh_TW |
| 顯示於系所單位： | 藥學系 | |
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