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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5111完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張雅君(Ya-Chun Chang) | |
| dc.contributor.author | Pei-ying Li | en |
| dc.contributor.author | 李佩穎 | zh_TW |
| dc.date.accessioned | 2021-05-15T17:52:03Z | - |
| dc.date.available | 2016-08-17 | |
| dc.date.available | 2021-05-15T17:52:03Z | - |
| dc.date.copyright | 2014-08-17 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-13 | |
| dc.identifier.citation | 王生荣，朱克恭。2002。植物系统获得抗病性研究进展。中国生态农业学报 10(2), 32-35。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/5111 | - |
| dc.description.abstract | 病毒於感染植物之後，常造成植株無法復原的傷害，而穩定有效的病毒防治策略仍有待發展。Histone deacetylases (HDACs) 在細胞中負責調控 histone 修飾行為，藉以影響基因的表現。過去研究顯示 Brome mosaic virus, Tomato bushy stunt virus 此兩種 RNA 病毒在 HDACs 基因功能缺失的酵母菌中，其病毒的累積會受到影響而下降，且 Histone deacetylase inhibitors (HDACi) 更被發現在 HCV replicon cell OR6上對C型肝炎病毒的複製有顯著的抑制效果，但這類物質的作用卻缺乏植物病毒方面的探討，因此本實驗選用sodium butyrate (HDACi 中的一種) 在易感病圓葉菸草進行菸草嵌紋病毒抗性測試。實驗結果顯示 sodium butyrate 雖無法阻止病毒系統性感染植株，但可延遲病株的病程發展並減緩外部病徵，且在抗性蛋白的時程表現上，有測得水楊酸抗性途徑之標記基因 PR-1a 的生成，推測其可能的調控與水楊酸路徑相關，且其在系統葉上的表現量較處理葉為多，但相反地水楊酸處理的植株，其處理葉上的 PR-1a 其表現量比系統葉來得多，顯示sodium butyrate誘導系統性抗性較水楊酸為佳，但局部抗性誘導以水楊酸為佳，因此將水楊酸和 sodium butyrate 合併塗抹於葉片上，實驗結果顯示，合併使用其抗性有加成效果。另外在活性氧物質的測定上，1 mM 的sodium butyrate單獨使用處理也會造成系統葉上過氧化氫的累積。因此 sodium butyrate 的誘導系統性抗病能力應為未來可應用之方法，期為植物病毒病害防治提供新的方向。 | zh_TW |
| dc.description.abstract | Viruses cause serious damage to crops; however, effective plant antiviral disease managements remain largely to be explored. Histone deacetylases (HDACs) are genes involved in histone regulation, and modulate the expression of genes. Previous studies demonstrated that in histone deacetylases (HDACs) single-gene-knockout yeasts the accumulation of Brome mosaic virus and Tomato bushy stunt virus decreased, and application of histone deacetylase inhibitors (HDACi) to HCV replicon cell OR6 showed suppressive effect on Hepatitis C virus. However, whether HDACi can be applied for plant viral disease management remained to be resolved. In this study, we first treated sodium butyrate (one kind of HDACi) to Nicotiana benthamiana, a susceptible host, to Tobacco mosaic virus (TMV). The data indicated that plants pretreated with sodium butyrate showed more vigorously growth and delayed in symptom expression than untreated plants after TMV inoculation. In addition, our RT-PCR revealed that the application of sodium butyrate induced the expression of PR-1a, suggested that sodium butyrate participated in the salicylic acids (SA) related plant defense pathway. Furthermore, in contrast to SA-treated plants the expression of PR-1a is stronger in treated leaves than systemic leaves; sodium butyrate-treated leaf shows stronger PR-1a induction in systemic leaves. The production of ROS showed obviously increase in the systemic leaf of sodium butyrate-treated N. benthamiana. It indicated that SA may trigger stronger local defense and sodium butyrate trigger stronger systemic defense. Thus, we applied both SA and sodium butyrate solutions on the leaves of N. benthamiana, and enhanced resistance was observed on the mixed solutions-treated plants. It revealed that sodium butyrate has the potential to be applied in development of effective systemic antiviral disease managements. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-15T17:52:03Z (GMT). No. of bitstreams: 1 ntu-103-R01633006-1.pdf: 7787579 bytes, checksum: 8f12f30cffa23df41f544510e3af8717 (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 目錄
口試委員審定書 i 致謝 ii 中文摘要 iii Abstract iv Contents vi Figure contents vii Table contents x Appendix contents xi Introduction 1 Materials and Methods 7 Results 12 Dicussion 18 References 24 Figures 33 Tables 58 Appendix 62 Figure contents Fig. 1 Symptoms of Nicotiana benthamiana infected with freeze-dried TMV at different concentrations five days pi 34 Fig. 2 Disease index for measuring the symptoms of TMV-infected Nicotiana benthamian 35 Fig. 3 Phenotypes of Nicotiana benthamiana drenched with different chemicals 36 Fig. 4 Phenotypes of Nicotiana benthamiana drenched with different concentrations of sodium butyrate 38 Fig. 5 Phenotypes of Nicotiana benthamiana drenched with different concentrations of sodium butyrate 40 Fig. 6 Phenotypes of Nicotiana benthamiana with leaves applied with chemicals 41 Fig. 7 Leaves appearance of Nicotiana benthamiana with leaves applied with chemicals 42 Fig. 8 Symptoms of Nicotiana benthamiana pre-drenched with chemicals then inoculated with TMV ten days pi 43 Fig. 9 Symptoms of Nicotiana benthamiana pretreated with chemicals on leaves then inoculated with TMV ten days pi 45 Fig. 10 Symptoms of Nicotiana benthamiana pretreated with chemicals on leaves then inoculated with TMV ten days pi 47 Fig. 11 Detection of PR1a expression in different chemical-treated Nicotiana benthamiana in 7-day time course 48 Fig. 12 Quantification of the symptom reduction of Nicotiana benthamiana pretreated with single or mixed chemicals and then inoculated with TMV 49 Fig. 13 Hydrogen peroxide accumulation was detected via DAB staining in different chemical-treated Nicotiana benthamiana one day after treatment 50 Fig. 14 Quantification of hydrogen peroxide accumulation in different chemical-treated Nicotiana benthamiana via DAB staining one day after treatment 51 Fig. 15 Quantification of hydrogen peroxide on Nicotiana benthamiana applied with different chemicals seven days after treatment 52 Fig. 16 Lesion numbers and whole leaf phenotype of Nicotiana glutinosa pre-drenched with chemicals and then inoculated with TMV five days pi 53 Fig. 17 Lesion numbers and whole leaf phenotype of Nicotiana glutinosa pretreated with chemicals and inoculated with TMV five days pi 55 Fig. 18 Phenotypes of Nicotiana tabacum Xanthi-nc treated with different solutions four days after treatment 56 Table contents Table 1. Primers used for RT-PCR analysis in Nicotiana benthamiana 59 Table 2. Reported concentration of chemicals used for plant treatment 60 Table 3. The expression pattern of PR1a derived from repeated experiments 61 Appendix contents Appendix Fig. 1 Symptoms of Nicotiana benthamiana pretreated with chemicals then inoculated with TMV-30B-GFP 63 Appendix Fig. 2 Symptoms of Nicotiana benthamiana infected by TMV-U1 on plants pretreated with chemicals 64 Appendix Table 1. The accumulation of hydrogen peroxide on leaves of different chemical-treated Nicotiana benthamiana 65 | |
| dc.language.iso | en | |
| dc.subject | 圓葉菸草 | zh_TW |
| dc.subject | histone deacetylases (HDACs) | zh_TW |
| dc.subject | histone deacetylase inhibitors (HDACi) | zh_TW |
| dc.subject | sodium butyrate | zh_TW |
| dc.subject | 菸草嵌紋病毒 | zh_TW |
| dc.subject | histone deacetylase inhibitors (HDACi) | en |
| dc.subject | Nicotiana benthamiana | en |
| dc.subject | TMV | en |
| dc.subject | sodium butyrate | en |
| dc.subject | histone deacetylases (HDACs) | en |
| dc.title | 探討 sodium butyrate 在病毒防治之利用與機轉 | zh_TW |
| dc.title | Investigation of the effect of sodium butyrate on plant virus prevention and its mechanism | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 葉信宏(Hsin-Hung Yeh) | |
| dc.contributor.oralexamcommittee | 洪挺軒(Ting-Hsuan Hung),柯文雄(Wen-Hsiung Ko) | |
| dc.subject.keyword | histone deacetylases (HDACs),histone deacetylase inhibitors (HDACi),sodium butyrate,菸草嵌紋病毒,圓葉菸草, | zh_TW |
| dc.subject.keyword | histone deacetylases (HDACs),histone deacetylase inhibitors (HDACi),sodium butyrate,TMV,Nicotiana benthamiana, | en |
| dc.relation.page | 65 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2014-08-13 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 植物病理與微生物學研究所 | zh_TW |
| 顯示於系所單位： | 植物病理與微生物學系 | |
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