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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 潘子明 | |
dc.contributor.author | Po-An Chen | en |
dc.contributor.author | 陳柏安 | zh_TW |
dc.date.accessioned | 2021-06-15T12:38:40Z | - |
dc.date.available | 2018-08-03 | |
dc.date.copyright | 2016-08-03 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-07-28 | |
dc.identifier.citation | 行政院衛生福利部。2014。民國 102 年與民國 92 年十大死因分析。
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/50386 | - |
dc.description.abstract | 腦中風再灌流 (cerebral stroke reperfusion) 所導致腦部傷害包括腦中產生大量自由基所造成氧化壓力傷害、能量不平衡、發炎反應以及細胞凋亡。先前多篇文獻指出乳酸菌具有降低氧化壓力、發炎反應等功效,另外近年也有文獻提到益生菌透過菌腦腸軸線 (brain-gut-microbiota axis) 間接影響腦部認知功能。本研究探討 Lactobacillus paracasei subsp. paracasei NTU 101 原末菌粉對腦中風大鼠是否具有改善學習記憶能力及降低腦中發炎反應的效果。腦中風的動物誘導模式使用八週齡大之 Sparque-Dawley (SD) 雄性大鼠進行雙側總動脈斷流再灌流 (bilateral common carotid artery occliusion-reperfusion, BCCAO) 手術。此誘導模式會造成大鼠學習記憶能力大幅下降、腦部嚴重發炎,而餵食 NTU 101原末菌粉對大鼠學習記憶能力具有明顯的改善效果,可抑制神經膠質細胞 (neuroglial cell) 中星形膠質細胞 (astrocyte) 及微膠細胞 (microglia) 的活化,並降低腦中發炎細胞激素 TNF (tumor necrosis factor)-α、IL (interleukin)-6和 IL-1β及一氧化氮 (nitric oxide) 濃度,顯著降低發炎相關蛋白 iNOS (inducible nitric oxide synthase)、NF-κB以及MAPK路徑蛋白之表現量。綜合以上結果,餵食 NTU 101原末菌粉可透過減輕發炎反應,改善腦中風再灌流所造成的學習記憶損傷。 | zh_TW |
dc.description.abstract | Cerebral stroke reperfusion caused brain injury including a large number of free radicals generated in the brain caused by oxidative stress damage, energy imbalance, inflammation and apoptosis. Many papers previously mentioned that lactic acid bacteria (LAB) can reduce oxidative stress, inflammation and other effects. On the other hand, in recent years, probiotics affecting cognitive function of the brain through the brain-gut axis indirectly have been reported. This study investigated whether the Lactobacillus paracasei subsp. paracasei NTU 101 improves learning and memory and reduces brain inflammation in stroke rat. In this research, all male Sprague-Dawley rats accept bilateral common carotid artery occlusion-reperfusion (BCCAO) operation to induce memory and learning ability impairment of stroke. This animal model leaded to learning and memory impairment and a serious inflammation of the brain, while NTU 101 administration improved cognitive impairment. Additionally, NTU 101 inhibited astrocytes and microglia activation, therefore reduced proinflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β and nitric oxide (NO). Moreover, the expression of inflammatory-related proteins inducible nitric oxide synthase (iNOS), NF-κB and protein of MAPKs signaling pathway were decreased in NTU 101-treated groups. In summary, administration of NTU 101 can against the impairment of memory and learning ability induced by stroke via ameliorating inflammation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T12:38:40Z (GMT). No. of bitstreams: 1 ntu-105-R03b22025-1.pdf: 4623175 bytes, checksum: ef29c292e47c69ed988698947392f193 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 縮寫表……………………………………………………………… Ⅰ
中文摘要………………………………………………………… Ⅲ 英文摘要………………………………………………………… Ⅳ 目錄…………………………………………………………………… Ⅴ 圖目錄……………………………………………………………… Ⅸ 表目錄……………………………………………………………… XII 第一章 文獻回顧…………………………………………………1 ㄧ、腦中風………………………………………………………………1 (一) 腦中風之簡介……………………………………………1 (二) 腦中風之分類……………………………………………1 1.缺血性腦中風………………………………………………………1 2.出血性腦中風………………………………………………………4 (三) 腦中風之危險因子……………………………………4 (四) 腦中風之臨床症狀……………………………………6 (五) 腦中風之病理機轉……………………………………7 (六) 腦中風之治療方式及藥物………………………11 (七) 腦中風之動物模式建立………………………………15 二、乳酸菌 (lactic acid bacteria)…………………18 (ㄧ) 乳酸菌之簡介………………………………………………18 (二) 乳酸菌之功效………………………………………………19 (三) 副乾酪乳酸桿菌副乾酪亞種 NTU 101 (Lactobacillus paracasei subsp. paracasei NTU 101)…………25 第二章 研究動機與研究架構………………………………28 ㄧ、研究動機………………………………………………………………28 二、研究架構………………………………………………………………29 第三章 材料與方法…………………………………………………32 ㄧ、實驗材料………………………………………………………………32 (ㄧ) 儀器…………………………………………………………………32 (二) 藥品…………………………………………………………………32 (三) 菌株…………………………………………………………………33 二、實驗方法………………………………………………………………33 (ㄧ) 實驗動物……………………………………………………………33 1.實驗動物與飼養………………………………………………………33 2.腦血管再灌流手術誘導…………………………………………34 3.實驗試驗組別與日程………………………………………………34 4.被動迴避實驗……………………………………………………….…40 5.Morris 水迷宮試驗………………………………………………40 6.實驗動物犧牲……………………………………………….…………44 7.抽血法……………………………………………………….………………45 8.腦及臟器收取……………………………………………….…………45 (二) 生化與生理分析…………………………………………………45 1.組織病理切片染色……………………………………………….…45 2.免疫組織化學染色……………………………………………….…45 3.腦組織蛋白質抽取與定量………………………………………46 4.促發炎細胞激素測定………………………………………….……46 5.一氧化氮 (nitric oxide, NO) 濃度測定……………48 6.MDA 濃度測定……………………………………………….………….49 7.乙醯膽鹼酯酶 (acetylcholinesterase, AChE) 活性測定…………49 8.西方點墨法 (Western blot assay) ……………49 9.生物統計分析方法………………………………………….…………50 第四章 結果與討論…………………………………………………………51 第一部分:NTU 101 原末菌粉對腦缺血再灌流誘導腦中風大鼠之學習記憶能力改善情形………………………………….…………...…...51 一、實驗動物之飼養及體重變化量……………………………51 二、雙側總頸動脈斷流再灌流誘導腦中風………………51 三、被動迴避試驗………………………………………………………………51 四、Morris 水迷宮試驗…………………………………………………54 1.參考記憶試驗……………………...……………………...…………54 2.空間性探測試驗………………………………...…………...……55 3.工作記憶試驗…………...………………….……………...………58 第二部分:NTU 101 原末菌粉對腦缺血再灌流誘導腦中風大鼠之發炎反應改善情形……………………………………….…………...…...…...61 一、膠質原纖維酸性蛋白 (glial fibrillary acidic protein, GFAP) 之表現量…………61 二、離子化鈣結合分子 ( ionized calcium-binding adapter molecule 1, Iba1) 之表現量……………………………………64 三、促發炎細胞激素 (TNF-α, IL-1β, IL-6) 含量………….64 四、誘導型一氧化氮合成酶 (inducible nitric oxide synthase, iNOS) 蛋白表現量…...67 五、一氧化氮 (nitric oxide, NO) 含量…………..73 六、丙二醛 (malondialdehyde, MDA) 含量…………73 第三部分: NTU 101 原末菌粉對腦缺血再灌流誘導腦中風大鼠之發炎反應相關機轉之探討……………………………….…………...…...….76 一、核因子活化B細胞κ輕鏈增強子 (nuclear factor kappa-light-chain-enhancer of activated B cells, NF-κB)………………76 二、促分裂原活化蛋白激酶 (Mitogen-activated protein kinases, MAPKs)…...…76 1.p38 MAPK…………………….……...…..…... .. .. .. 76 2.JNK……………………………………………...…...…...…...…...80 3.ERK……………………………………….…………...…...…...…...…80 第四部分: NTU 101 原末菌粉對腦缺血再灌流誘導腦中風大鼠相關因子之探討...82 一、乙醯膽鹼酯酶 (Acetylcholinesterase, AChE) 活性……82 二、安全性評估…...…...…...…...….…...….…...…85 第五部分: NTU 101 原末菌粉對腦缺血再灌流誘導腦中風大鼠綜合整理……….85 第伍章 結論…………………………………………………………………………….89 第陸章 參考文獻………………………………………………………………………92 | |
dc.language.iso | zh-TW | |
dc.title | Lactobacillus paracasei subsp. paracasei NTU 101 乳酸菌菌粉對經由雙側總頸動脈斷流再灌流手術誘導之腦中風大鼠學習記憶能力改善效果 | zh_TW |
dc.title | Effect of Lactobacillus paracasei subsp. paracasei NTU 101 powder to improve memory and learning ability on stroke rats induced by bilateral common carotid artery occlusion-reperfusion | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 周正俊,廖啟成,蔡宗佑,蔣慎思 | |
dc.subject.keyword | Lactobacillus paracasei subsp. paracasei NTU 101,腦中風,雙側總頸動脈斷流再灌流,學習記憶能力,發炎反應, | zh_TW |
dc.subject.keyword | Lactobacillus paracasei subsp. paracasei NTU 101,stroke,bilateral common carotid artery occlusion-reperfusion,memory and learning,inflammation, | en |
dc.relation.page | 107 | |
dc.identifier.doi | 10.6342/NTU201601535 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2016-07-29 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 生化科技學系 | zh_TW |
顯示於系所單位: | 生化科技學系 |
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