請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/50171
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 廖秀娟(Vivian Hsiu-Chuan Liao) | |
dc.contributor.author | Chun Ming How | en |
dc.contributor.author | 侯俊銘 | zh_TW |
dc.date.accessioned | 2021-06-15T12:31:32Z | - |
dc.date.available | 2019-08-24 | |
dc.date.copyright | 2016-08-24 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-08-03 | |
dc.identifier.citation | An, J.H., and Blackwell, T.K. (2003). SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 17, 1882-1893.
Anderson, G.L., Cole, R.D., and Williams, P.L. (2004). Assessing behavioral toxicity with Caenorhabditis elegans. Environ Toxicol Chem 23, 1235-1240. Ayyadevara, S., Engle, M.R., Singh, S.P., Dandapat, A., Lichti, C.F., Benes, H., Shmookler Reis, R.J., Liebau, E., and Zimniak, P. (2005). Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Aging Cell 4, 257-271. Bansal, A., Zhu, L.J., Yen, K., and Tissenbaum, H.A. (2015). Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci USA 112, E277-286. Biebricher, A.S., Heller, I., Roijmans, R.F., Hoekstra, T.P., Peterman, E.J., and Wuite, G.J. (2015). The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics. Nat Commun 6, 7304. Blackwell, T.K., Steinbaugh, M.J., Hourihan, J.M., Ewald, C.Y., and Isik, M. (2015). SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med 88, 290-301. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. CalEPA (2000). Toxicology data review summary for triadimenol (55219-65-3). (California Environmental Protection Agency, Department of Pesticide Regulation). Chase, D.L., and Koelle, M.R. (2007). Biogenic amine neurotransmitters in C. elegans. WormBook, 1-15. Chu, S.H., Liao, P.H., and Chen, P.J. (2016). Developmental exposures to an azole fungicide triadimenol at environmentally relevant concentrations cause reproductive dysfunction in females of medaka fish. Chemosphere 152, 181-189. Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., Matthijssens, F., Araiz, C., Mandel, A., Vlachos, M. (2013). Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol 11, e1001613. Collins, J.J., Huang, C., Hughes, S., and Kornfeld, K. (2008). The measurement and analysis of age-related changes in Caenorhabditis elegans. WormBook, 1-21. Corsi, A.K., Wightman, B., and Chalfie, M. (2015). A Transparent window into biology: A primer on Caenorhabditis elegans. WormBook, 1-31. Cowen, L.E., and Steinbach, W.J. (2008). Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot Cell 7, 747-764. Crofton, K.M., Boncek, V.M., and Reiter, L.W. (1988). Hyperactivity induced by triadimefon, a triazole fungicide. Fundam Appl Toxicol 10, 459-465. Darr, D., and Fridovich, I. (1995). Adaptation to oxidative stress in young, but not in mature or old, Caenorhabditis elegans. Free Radic Biol Med 18, 195-201. Davalli, P., Mitic, T., Caporali, A., Lauriola, A., and D'Arca, D. (2016). ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases. Oxid Med Cell Longev 2016, 3565127. Di Renzo, F., Bacchetta, R., Sangiorgio, L., Bizzo, A., and Menegola, E. (2011a). The agrochemical fungicide triadimefon induces abnormalities in Xenopus laevis embryos. Reprod Toxicol 31, 486-493. Di Renzo, F., Broccia, M.L., Giavini, E., and Menegola, E. (2011b). Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse. Reprod Toxicol 31, 194-199. Doonan, R., McElwee, J.J., Matthijssens, F., Walker, G.A., Houthoofd, K., Back, P., Matscheski, A., Vanfleteren, J.R., and Gems, D. (2008). Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev 22, 3236-3241. Drummen, G.P., van Liebergen, L.C., Op den Kamp, J.A., and Post, J.A. (2002). C11-BODIPY581/591, an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology. Free Radic Biol Med 33, 473-490. Dubus, I.G., Hollis, J.M., and Brown, C.D. (2000). Pesticides in rainfall in Europe. Environ Pollut 110, 331-344. Dues, D.J., Andrews, E.K., Schaar, C.E., Bergsma, A.L., Senchuk, M.M., and Van Raamsdonk, J.M. (2016). Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways. Aging (Albany NY) 8, 777-795. Elskus, A.A. (2014). Toxicity, sublethal effects, and potential modes of action of select fungicides on freshwater fish and invertebrates (ver. 1.1, November 2014): U.S. Geological Survey Open-File Report 2012–1213. Everett, C.J., and Thompson, O.M. (2012). Associations of dioxins, furans and dioxin-like PCBs with diabetes and pre-diabetes: is the toxic equivalency approach useful? Environ Res 118, 107-111. FAO, and WHO (2011). FAO specification and evaluations for triadimenol (Food and Agricultural Organizations, United Nations). Ferguson, L.R., and Denny, W.A. (2007). Genotoxicity of non-covalent interactions: DNA intercalators. Mutation research 623, 14-23. Finch, C.E., and Ruvkun, G. (2001). The genetics of aging. Annu Rev Genomics Hum Genet 2, 435-462. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E., and Mello, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811. Friedman, D.B., and Johnson, T.E. (1988). Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J Gerontol 43, B102-109. Garrison, A.W., Avants, J.K., and Jones, W.J. (2011). Microbial transformation of triadimefon to triadimenol in soils: selective production rates of triadimenol stereoisomers affect exposure and risk. Environ Sci Technol 45, 2186-2193. Gems, D., and Doonan, R. (2009). Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong? Cell Cycle 8, 1681-1687. Gerstbrein, B., Stamatas, G., Kollias, N., and Driscoll, M. (2005). In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell 4, 127-137. Ghannoum, M.A., and Rice, L.B. (1999). Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev 12, 501-517. Glenn, C.F., Chow, D.K., David, L., Cooke, C.A., Gami, M.S., Iser, W.B., Hanselman, K.B., Goldberg, I.G., and Wolkow, C.A. (2004). Behavioral deficits during early stages of aging in Caenorhabditis elegans result from locomotory deficits possibly linked to muscle frailty. J Gerontol A Biol Sci Med Sci 59, 1251-1260. Goetz, A.K., and Dix, D.J. (2009). Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals. Toxicol Sci 110, 449-462. Gomes, A., Fernandes, E., and Lima, J.L. (2005). Fluorescence probes used for detection of reactive oxygen species. J Biochem Biophys Methods 65, 45-80. Groppelli, S., Pennati, R., De Bernardi, F., Menegola, E., Giavini, E., and Sotgia, C. (2005). Teratogenic effects of two antifungal triazoles, triadimefon and triadimenol, on Xenopus laevis development: craniofacial defects. Aquat Toxicol 73, 370-381. Gruber, J., Chen, C.B., Fong, S., Ng, L.F., Teo, E., and Halliwell, B. (2015). Caenorhabditis elegans: what we can and cannot learn from aging worms. Antioxid Redox Sign 23, 256-279. Haigis, M.C., and Yankner, B.A. (2010). The aging stress response. Molecular cell 40, 333-344. Halliwell, B. (2006). Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Plant Physiol 141, 312-322. Halliwell, B. (2007). Biochemistry of oxidative stress. Biochem Soc Trans 35, 1147-1150. Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. J Gerontol 11, 298-300. Hayden, K.M., Norton, M.C., Darcey, D., Ostbye, T., Zandi, P.P., Breitner, J.C., Welsh-Bohmer, K.A., and Cache County Study, I. (2010). Occupational exposure to pesticides increases the risk of incident AD: the Cache County study. Neurology 74, 1524-1530. Henderson, S.T., and Johnson, T.E. (2005). daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 15, 690-690. Herndon, L.A., Schmeissner, P.J., Dudaronek, J.M., Brown, P.A., Listner, K.M., Sakano, Y., Paupard, M.C., Hall, D.H., and Driscoll, M. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814. Heusinkveld, H.J., Molendijk, J., van den Berg, M., and Westerink, R.H. (2013). Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. Toxicol Sci 134, 374-381. Hohn, A., and Grune, T. (2013). Lipofuscin: formation, effects and role of macroautophagy. Redox Biol 1, 140-144. Hohn, A., Konig, J., and Grune, T. (2013). Protein oxidation in aging and the removal of oxidized proteins. J Proteomics 92, 132-159. Honda, Y., Tanaka, M., and Honda, S. (2010). Redox regulation, gene expression and longevity. Geriatr Gerontol Int 10, S59-S69. Hosokawa, H., Ishii, N., Ishida, H., Ichimori, K., Nakazawa, H., and Suzuki, K. (1994). Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans. Mech Ageing Dev 74, 161-170. HSDB (2009). Triadimenol. Date acquired: 6/26/2016. Retrieved from: http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@DOCNO+7733 Huang, C., Xiong, C., and Kornfeld, K. (2004). Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc Natl Acad Sci USA 101, 8084-8089. JMPR (2004). Triadimenol and triadimefon. 325-386. Kaletta, T., and Hengartner, M.O. (2006). Finding function in novel targets: C. elegans as a model organism. Nat Rev Drug Discov 5, 387-398. Kenyon, C. (2005). The plasticity of aging: insights from long-lived mutants. Cell 120, 449-460. Kenyon, C., Chang, J., Gensch, E., Rudner, A., and Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild-type. Nature 366, 461-464. Keowkase, R., Aboukhatwa, M., and Luo, Y. (2010). Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59, 358-365. Khurana, S., and Oberdoerffer, P. (2015). Replication Stress: A lifetime of epigenetic change. Genes (Basel) 6, 858-877. Klass, M.R. (1983). A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev 22, 279-286. Kong, Z., Li, M., Chen, J., Gui, Y., Bao, Y., Fan, B., Jian, Q., Francis, F., and Dai, X. (2016). Behavior of field-applied triadimefon, malathion, dichlorvos, and their main metabolites during barley storage and beer processing. Food Chem 211, 679-686. Kourtis, N., and Tavernarakis, N. (2011). Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J 30, 2520-2531. Kreuger, J. (1998). Pesticides in stream water within an agricultural catchment in southern Sweden, 1990-1996. Sci Total Environ 216, 227-251. Lai, C.H., Chou, C.Y., Ch'ang, L.Y., Liu, C.S., and Lin, W. (2000). Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res 10, 703-713. Li, W.H., Chang, C.H., Huang, C.W., Wei, C.C., and Liao, V.H. (2014a). Selenite enhances immune response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans. PLoS One 9, e105810. Li, W.H., Ju, Y.R., Liao, C.M., and Liao, V.H. (2014b). Assessment of selenium toxicity on the life cycle of Caenorhabditis elegans. Ecotoxicology 23, 1245-1253. Liang, H., Li, L., Qiu, J., Li, W., Yang, S., Zhou, Z., and Qiu, L. (2013). Stereoselective transformation of triadimefon to metabolite triadimenol in wheat and soil under field conditions. J Hazard Mater 260, 929-936. Liao, V.H., Yu, C.W., Chu, Y.J., Li, W.H., Hsieh, Y.C., and Wang, T.T. (2011). Curcumin-mediated lifespan extension in Caenorhabditis elegans. Mech Ageing Dev 132, 480-487. Liu, J., Zhang, B., Lei, H., Feng, Z., Liu, J., Hsu, A.L., and Xu, X.Z. (2013). Functional aging in the nervous system contributes to age-dependent motor activity decline in C. elegans. Cell Metab 18, 392-402. Liu, S.Y., Jin, Q., Huang, X.H., and Zhu, G.N. (2014). Disruption of zebrafish (Danio rerio) sexual development after full life-cycle exposure to environmental levels of triadimefon. Environ Toxicol Pharmacol 37, 468-475. Lopez-Otin, C., Blasco, M.A., Partridge, L., Serrano, M., and Kroemer, G. (2013). The hallmarks of aging. Cell 153, 1194-1217. Maniere, X., Krisko, A., Pellay, F.X., Di Meglio, J.M., Hersen, P., and Matic, I. (2014). High transcript levels of heat-shock genes are associated with shorter lifespan of Caenorhabditis elegans. Exp Gerontol 60, 12-17. Martins, R., Lithgow, G.J., and Link, W. (2015). Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell 15, 196-207. Mazouzi, A., Velimezi, G., and Loizou, J.I. (2014). DNA replication stress: causes, resolution and disease. Exp Cell Res 329, 85-93. McCallum, K.C., Liu, B., Fierro-Gonzalez, J.C., Swoboda, P., Arur, S., Miranda-Vizuete, A., and Garsin, D.A. (2016). TRX-1 regulates SKN-1 nuclear localization cell non-autonomously in Caenorhabditis elegans. Genetics 203, 387-402. Menegola, E., Broccia, M.L., Di Renzo, F., Prati, M., and Giavini, E. (2000). In vitro teratogenic potential of two antifungal triazoles: triadimefon and triadimenol. In Vitro Cell Dev Biol Anim 36, 88-95. Mitteldorf, J. (2010). Aging is not a process of wear and tear. Rejuvenation Res 13, 322-326. Miyazawa, M., Ishii, T., Yasuda, K., Noda, S., Onouchi, H., Hartman, P.S., and Ishii, N. (2009). The role of mitochondrial superoxide anion (O2‒) on physiological aging in C57BL/6J mice. J Radiat Res 50, 73-83. Moore, B.T., Jordan, J.M., and Baugh, L.R. (2013). WormSizer: high-throughput analysis of nematode size and shape. PLoS One 8, e57142. Mostafalou, S., and Abdollahi, M. (2013). Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. Toxicol Appl Pharmacol 268, 157-177. Murakami, S., and Johnson, T.E. (1996). A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143, 1207-1218. Murphy, C.T. (2006). The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Exp Gerontol 41, 910-921. Murphy, C.T., and Hu, P.J. (2013). Insulin/insulin-like growth factor signaling in C. elegans. WormBook, 1-43. Murphy, C.T., McCarroll, S.A., Bargmann, C.I., Fraser, A., Kamath, R.S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283. Nesnow, S., Ward, W., Moore, T., Ren, H., and Hester, S.D. (2009). Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression. Toxicol Sci 110, 68-83. Ogawa, T., Kodera, Y., Hirata, D., Blackwell, T.K., and Mizunuma, M. (2016). Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Scientific reports 6, 21611. Olahova, M., Taylor, S.R., Khazaipoul, S., Wang, J., Morgan, B.A., Matsumoto, K., Blackwell, T.K., and Veal, E.A. (2008). A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci USA 105, 19839-19844. Papp, D., Csermely, P., and Soti, C. (2012). A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans. PLoS Pathog 8, e1002673. Pawelec, G., Goldeck, D., and Derhovanessian, E. (2014). Inflammation, ageing and chronic disease. Curr Opin Immunol 29, 23-28. Petriv, O.I., and Rachubinski, R.A. (2004). Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. J Biol Chem 279, 19996-20001. Pierce-Shimomura, J.T., Chen, B.L., Mun, J.J., Ho, R., Sarkis, R., and McIntire, S.L. (2008). Genetic analysis of crawling and swimming locomotory patterns in C. elegans. Proc Natl Acad Sci USA 105, 20982-20987. Pincus, Z., Mazer, T.C., and Slack, F.J. (2016). Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green. Aging (Albany NY) 8, 889-898. Pinton, P., Giorgi, C., Siviero, R., Zecchini, E., and Rizzuto, R. (2008). Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene 27, 6407-6418. Poljsak, B., Suput, D., and Milisav, I. (2013). Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants. Oxid Med Cell Longev. Pose-Juan, E., Sanchez-Martin, M.J., Andrades, M.S., Rodriguez-Cruz, M.S., and Herrero-Hernandez, E. (2015). Pesticide residues in vineyard soils from Spain: Spatial and temporal distributions. Sci Total Environ 514, 351-358. Prasanth, M.I., Santoshram, G.S., Bhaskar, J.P., and Balamurugan, K. (2016). Ultraviolet-A triggers photoaging in model nematode Caenorhabditis elegans in a DAF-16 dependent pathway. Age (Dordr) 38, 27. Przybysz, A.J., Choe, K.P., Roberts, L.J., and Strange, K. (2009). Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Mech Ageing Dev 130, 357-369. Reeves, R., Thiruchelvam, M., Richfield, E.K., and Cory-Slechta, D.A. (2004). The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood. Toxicol Appl Pharmacol 200, 54-63. Riddle, D.L., Swanson, M.M., and Albert, P.S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-671. Samu, F., and Vollrath, F. (1992). Spider orb web as bioassay for pesticide side-effects. Entomol Exp Appl 62, 117-124. Saul, N., Baberschke, N., Chakrabarti, S., Sturzenbaum, S.R., Lieke, T., Menzel, R., Jonas, A., and Steinberg, C.E. (2014). Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans. Environ Sci Pollut Res Int 21, 10419-10431. Schaible, R., Sussman, M., and Kramer, B.H. (2014). Aging and potential for self-renewal: hydra living in the age of aging - a mini-review. Gerontology 60, 548-556. Schieber, M., and Chandel, N.S. (2014). ROS function in redox signaling and oxidative stress. Curr Biol 24, R453-462. Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B. (2012). Fiji: an open-source platform for biological-image analysis. Nat Methods 9, 676-682. Seehafer, S.S., and Pearce, D.A. (2006). You say lipofuscin, we say ceroid: defining autofluorescent storage material. Neurobiol Aging 27, 576-588. Shaye, D.D., and Greenwald, I. (2011). OrthoList: a compendium of C. elegans genes with human orthologs. PLoS One 6, e20085. Shi, Y.C., Yu, C.W., Liao, V.H., and Pan, T.M. (2012). Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. PLoS One 7, e39515. Siddle, K. (2011). Signalling by insulin and IGF receptors: supporting acts and new players. J Mol Endocrinol 47, R1-10. Singh, N. (2005). Factors affecting triadimefon degradation in soils. J Agric Food Chem 53, 70-75. Singh, S.P., Niemczyk, M., Zimniak, L., and Zimniak, P. (2009). Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). Aging (Albany NY) 1, 68-80. Sorrentino, J.A., Krishnamurthy, J., Tilley, S., Alb, J.G., Jr., Burd, C.E., and Sharpless, N.E. (2014a). p16INK4a reporter mice reveal age-promoting effects of environmental toxicants. J Clin Invest 124, 169-173. Sorrentino, J.A., Sanoff, H.K., and Sharpless, N.E. (2014b). Defining the toxicology of aging. Trends Mol Med 20, 375-384. Soukas, A.A., Carr, C.E., and Ruvkun, G. (2013). Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet 9, e1003908. Sugawara, S., Honma, T., Ito, J., Kijima, R., and Tsuduki, T. (2013). Fish oil changes the lifespan of Caenorhabditis elegans via lipid peroxidation. J Clin Biochem Nutr 52, 139-145. Tan, L., Wang, S., Wang, Y., He, M., and Liu, D. (2015). Bisphenol A exposure accelerated the aging process in the nematode Caenorhabditis elegans. Toxicol Lett 235, 75-83. Tang, L.L., Dodd, W., and Choe, K. (2016). Isolation of a hypomorphic skn-1 allele that does not require a balancer for maintenance. G3-Genes Genom Genet 6, 551-558. Tanner, C.M., Kamel, F., Ross, G.W., Hoppin, J.A., Goldman, S.M., Korell, M., Marras, C., Bhudhikanok, G.S., Kasten, M., Chade, A.R., et al. (2011). Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect 119, 866-872. Tissenbaum, H.A. (2012). Genetics, life span, health span, and the aging process in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 67, 503-510. Tseng, I.L., Yang, Y.F., Yu, C.W., Li, W.H., and Liao, V.H. (2013). Phthalates induce neurotoxicity affecting locomotor and thermotactic behaviors and AFD neurons through oxidative stress in Caenorhabditis elegans. PLoS One 8, e82657. USEPA (2006). Triadimefon reregistration eligibility decision (RED) and triadimenol tolerance reassessment and risk management decision (TRED) fact sheet (U.S. Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances). Voss, P., and Siems, W. (2006). Clinical oxidation parameters of aging. Free Radic Res 40, 1339-1349. Walker, Q.D., and Mailman, R.B. (1996). Triadimefon and triadimenol: effects on monoamine uptake and release. Toxicol Appl Pharmacol 139, 227-233. Wang, X.X., Cook, L.F., Grasso, L.M., Cao, M., and Dong, Y.Q. (2015). Royal jelly-mediated prolongevity and stress resistance in Caenorhabditis elegans is possibly modulated by the interplays of DAF-16, SIR-2.1, HCF-1, and 14-3-3 proteins. J Gerontol a-Biol 70, 827-838. Warrilow, A.G., Parker, J.E., Kelly, D.E., and Kelly, S.L. (2013). Azole affinity of sterol 14alpha-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother 57, 1352-1360. Wei, C.C., Yu, C.W., Yen, P.L., Lin, H.Y., Chang, S.T., Hsu, F.L., and Liao, V.H. (2014). Antioxidant activity, delayed aging, and reduced amyloid-beta toxicity of methanol extracts of tea seed pomace from Camellia tenuifolia. J Agric Food Chem 62, 10701-10707. Wu, H., and Roks, A.J. (2014). Genomic instability and vascular aging: a focus on nucleotide excision repair. Trends Cardiovasc Med 24, 61-68. Wu, J.Z., Huang, J.H., Khanabdali, R., Kalionis, B., Xia, S.J., and Cai, W.J. (2016). Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans. Exp Gerontol 80, 43-50. Xi, J., Yang, Z., Zeng, C., Hu, X., and Wang, J. (2012). Suppressive effect of triadimefon, a triazole fungicide, on spatial learning and reference memory in rats. Behav Pharmacol 23, 727-734. Xu, T., Li, P., Wu, S., Li, D., Wu, J., Raley-Susman, K.M., and He, D. (2016). Chronic exposure to perfluorooctane sulfonate reduces lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling. Bull Environ Contam Toxicol. Yasuda, K., Adachi, H., Fujiwara, Y., and Ishii, N. (1999). Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 54, B47-51; discussion B52-43. Yu, C.W., How, C.M., and Liao, V.H. (2016). Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans. Chemosphere 150, 632-638. Yu, C.W., and Liao, V.H. (2014). Arsenite induces neurotoxic effects on AFD neurons via oxidative stress in Caenorhabditis elegans. Metallomics 6, 1824-1831. Yu, C.W., Wei, C.C., and Liao, V.H. (2014). Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. Free Radic Res 48, 371-379. Yu, S., Rui, Q., Cai, T., Wu, Q., Li, Y., and Wang, D. (2011). Close association of intestinal autofluorescence with the formation of severe oxidative damage in intestine of nematodes chronically exposed to Al2O3-nanoparticle. Environ Toxicol Pharmacol 32, 233-241. Zhang, Y., Zhang, G., Fu, P., Ma, Y., and Zhou, J. (2012). Study on the interaction of triadimenol with calf thymus DNA by multispectroscopic methods and molecular modeling. Spectrochim Acta A Mol Biomol Spectrosc 96, 1012-1019. Zhao, Y., Yang, R., Rui, Q., and Wang, D. (2016). Intestinal insulin signaling encodes two different molecular mechanisms for the shortened longevity induced by graphene oxide in Caenorhabditis elegans. Scientific reports 6, 24024. Zhuang, Z., Zhao, Y., Wu, Q., Li, M., Liu, H., Sun, L., Gao, W., and Wang, D. (2014). Adverse effects from clenbuterol and ractopamine on nematode Caenorhabditis elegans and the underlying mechanism. PLoS One 9, e85482. 農委會 (2004). 三泰隆 (Triadimenol). Date acquired: 6/26/2016. Retrieved from: http://www.tactri.gov.tw/wSite/htdocs/intro/pcd/pcdfile/Cate/book06/017.pdf | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/50171 | - |
dc.description.abstract | Triadimenol (三泰隆) 是農業上廣為使用的廣效型抗真菌劑,因為性質穩定不易分解,容易殘留於環境與食物中造成長期暴露風險。Triadimenol可造成基因體不穩定及干擾細胞許多轉錄因子的功能,然而,鮮少研究探討長期暴露triadimenol是否加速生物老化。本研究以C. elegans探討環境相關濃度的triadimenol的老化相關毒性及機制。研究結果發現0.1 % ETOH (酒精) 的溶劑控制組並不會顯著影響C. elegans的移動行為 (locomotive behaviors) ,而且也不會對C. elegans的繁殖與生長造成不良影響,因此所有實驗皆以0.1 % ETOH作為控制組。 Triadimenol在環境相關濃度 (3、30、300 μg/L) 的暴露顯著影響C. elegans在第0天成蟲的體長,在30 與300 μg/L暴露下顯著減少C. elegans的繁殖能力;並且在3、30、300 μg/L顯著抑制C. elegans的身體彎曲次數 (body bends) 與頭部擺動頻率 (head thrashes),而且毒性呈劑量-反應關係。結果顯示暴露於最有效應濃度300 μg/L triadimenol的C. elegans的平均壽命、壽命中位數與最大壽命由控制組的17.3、18、29天分別縮短為15、15、25天。綜合觀察C. elegans的老化相關行為如咽喉部收縮 (pumping rate) 與排泄週期 (defecation cycle),發現長期暴露triadimenol (300 μg/L) 顯著加速了以上兩種行為的退化,證明triadimenol加速了C. elegans的生理老化。此外,triadimenol (300 μg/L) 顯著增加第4、8天成蟲的脂褐素累積量,但是在第0、4天成蟲沒有顯著改變脂質過氧化物的累積量,只有第8天成蟲才顯著增加脂質過氧化程度。進一步量測生物體內氧化壓力如H2O2與O2•‒指標,發現在第0、4天成蟲皆無顯著差異,而在第8天成蟲triadimenol顯著增加氧化活性物質的累積量,與脂質過氧化物累積的變化趨勢相似。本研究更進一步利用轉基因C. elegans發現長期的triadimenol (300 μg/L) 暴露造成C. elegans體內DAF-16 (DAuer Formation) 的去磷酸化轉移入核,顯示triadimenol的暴露對C. elegans造成了氧化壓力;但是SKN-1 (SKiNhead) 並未對triadimenol暴露有所反應,顯示SKN-1與triadimenol造成之毒性效應無直接關係。綜合結果,本研究發現長期暴露於環境相關濃度的triadimenol可對C. elegans造成氧化壓力,並透過DAF-16調控機制加速C. elegans的老化。 | zh_TW |
dc.description.abstract | Triadimenol is a widely used agricultural antifungal which is commonly detected in the environment due to its stable property. Triadimenol is able to disrupt genomic stability and modulate function of several transcription factors, yet the prolonged exposure of triadimenol and its age-related toxicity effects remain elucidated. This study utilized Caenorhabditis elegans (C. elegans) to study the toxicity of triadimenol on aging and the underlying mechanisms. The results showed that 0.1 % ETOH (ethanol) as solvent control did not affect the locomotive behaviors, reproduction, and growth in C. elegans. Therefore, 0.1 % ETOH was used as control throughout this study. Triadimenol at environmentally relevant concentrations (3, 30, 300 μg/L) significantly affected worm’s growth, and reduced the total brood size at 30 and 300 μg/L. Additionally, prolonged exposure to 3, 30, 300 μg/L triadimenol significantly inhibited locomotive behaviors of C. elegans in a dose-dependent manner. Moreover, under the most effective concentration, 300 μg/L triadimenol reduced C. elegans mean (17.3 days), median (18 days), and maximum (29 days) lifespan at 15, 15, 25 days, respectively. Further evidence showed that triadimenol (300 μg/L) accelerated the decline in pharyngeal pumping rate and the increase in defecation cycles, implying physiological aging. In addition, triadimenol (300 μg/L) significantly increased lipofuscin accumulation in day- 4, 8 adulthood, but did not significantly increase lipid peroxidation until day 8 adulthood. Similarly, triadimenol (300 μg/L) did not significantly elevate internal ROS (reactive oxidative species) levels such as H2O2 and O2•‒ until day 8 adulthood. By using the transgenic GFP strains, we found that triadimenol (300 μg/L) triggered DAF-16 translocation from cytosol into nucleus in C. elegans, suggesting that triadimenol exerted oxidative stress on C. elegans. In contrast, triadimenol did not affect SKN-1 translocation, suggesting that triadimenol toxicity in C. elegans is not SKN-1 mediated. In conclusion, this study demonstrated that prolonged exposure to triadimenol at environmentally relevant concentration resulted in oxidative stress and accelerated aging process in C. elegans via DAF-16. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T12:31:32Z (GMT). No. of bitstreams: 1 ntu-105-R03622039-1.pdf: 2705858 bytes, checksum: 771e2e191361ac2606af8f338e0eaedd (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 口試委員會審定書 i
誌謝 ii 摘要 iii Abstract v Graphic Abstract vii Highlights viii 目錄 ix 圖次 xii 表次 xiii 縮寫表 xiv 1. 研究動機 1 2. 文獻回顧 3 2.1 三唑類 (triazole) 化合物 3 2.2 三泰隆 (Triadimenol) 4 2.3 Triadimenol之生物毒理性質 7 2.3.1 Triadimenol之吸收、分佈、代謝與排除 7 2.3.2 In vitro毒性 7 2.3.3 In vivo毒性 8 2.4 以秀麗隱桿線蟲 (Caenorhabditis elegans, C. elegans) 探討triadimenol之長期毒性 10 2.4.1 秀麗隱桿線蟲 10 2.4.2 利用C. elegans探討老化現象 11 2.4.3 MAPK、SKN-1/Nrf、老化與環境毒物 13 2.4.4 IIS、DAF-16/FOXO、老化與環境毒物 14 2.4.5 Triadimenol對C. elegans可能造成老化相關毒性 15 2.5 研究目的 16 3. 材料與方法 18 3.1 實驗架構流程圖 18 3.2實驗藥品 18 3.3 C. elegans培養 19 3.4 Triadimenol對C. elegans生長與繁殖毒性測試 20 3.5 Triadimenol對C. elegans locomotive behaviors之毒性測試 20 3.6 Triadimenol對C. elegans壽命之毒性測試 21 3.7 Triadimenol對C. elegans的pharyngeal pumping rate與defecation cycle之毒性測試 21 3.8 Triadimenol對C. elegans體內累積脂褐素 (lipofuscin) 之測試 22 3.9 Triadimenol對C. elegans脂質過氧化 (lipid peroxidation) 之測試 22 3.10 Triadimenol對C. elegans體內ROS之測試 23 3.11 C. elegans SKN-1入核現象觀察 23 3.12 C. elegans DAF-16入核現象觀察 24 3.13 數據處理 24 4. 結果與討論 25 4.1 Triadimenol對C. elegans成長與繁殖之影響 25 4.2 Triadimenol對C. elegans locomotive behaviors行為之影響 29 4.3 長期暴露triadimenol對C. elegans壽命之影響 31 4.4 長期暴露triadimenol對C. elegans老化相關行為之改變 34 4.5 長期暴露triadimenol對C. elegans老化相關指標之影響 37 4.6 長期暴露triadimenol對C. elegans體內ROS累積量之影響 41 4.7 Triadimenol對C. elegans SKN-1入核反應之影響 44 4.8 Triadimenol對C. elegans DAF-16入核反應之影響 47 5. 結論 51 6. 建議 52 7. 參考文獻 53 8. 附錄 65 | |
dc.language.iso | zh-TW | |
dc.title | 長期暴露環境相關濃度的三泰隆透過DAF-16加速秀麗隱桿線蟲的老化過程 | zh_TW |
dc.title | Prolonged exposure to triadimenol at environmentally relevant concentration accelerates aging process in Caenorhabditis elegans via DAF-16 | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 廖中明(Chung-Min Liao),張俊哲(Chun-Che Chang),陳佩貞(Pei-Jen Chen) | |
dc.subject.keyword | Triadimenol,秀麗隱桿線蟲,環境相關濃度,長期暴露,老化,DAF-16,氧化壓力, | zh_TW |
dc.subject.keyword | Triadimenol,Caenorhabditis elegans,environmentally relevant concentration,prolonged exposure,aging,DAF-16,oxidative stress, | en |
dc.relation.page | 88 | |
dc.identifier.doi | 10.6342/NTU201601898 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2016-08-04 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 生物環境系統工程學研究所 | zh_TW |
顯示於系所單位: | 生物環境系統工程學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-105-1.pdf 目前未授權公開取用 | 2.64 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。