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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳小梨 | |
| dc.contributor.author | Wei-Chen Liu | en |
| dc.contributor.author | 劉未辰 | zh_TW |
| dc.date.accessioned | 2021-05-15T17:50:50Z | - |
| dc.date.available | 2014-10-09 | |
| dc.date.available | 2021-05-15T17:50:50Z | - |
| dc.date.copyright | 2014-10-09 | |
| dc.date.issued | 2014 | |
| dc.date.submitted | 2014-08-19 | |
| dc.identifier.citation | 1. zur Hausen H (2009) Papillomaviruses in the causation of human cancers - a brief historical account. Virology 384: 260-265.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/4997 | - |
| dc.description.abstract | 人類乳突瘤病毒(Human papillomavirus,HPV)的E2蛋白對病毒生命週期有著重要的影響。E2蛋白會影響病毒的複製，轉錄和segregation。之前大量研究表明E2蛋白在細胞分裂時鏈接病毒DNA與宿主染色體，使病毒DNA可以均勻分佈到兩顆細胞。根據前人研究得知人類乳突瘤病毒8型E2蛋白的S253位置的磷酸化會消失會導致E2蛋白在宿主細胞細胞分裂時不能與染色體鏈接。其中一個人類乳突瘤病毒16型E2蛋白上的磷酸化位置S243。其磷酸化的消失會使大部分E2蛋白在細胞分裂時從染色體脫落。並且其影響E2蛋白與染色體鏈接的能力是通過（Bromodomain-containing protein 4 ）Brd4實現的。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-05-15T17:50:50Z (GMT). No. of bitstreams: 1 ntu-103-R00445129-1.pdf: 1862245 bytes, checksum: 1a45131f9120632578792eabd940a37f (MD5) Previous issue date: 2014 | en |
| dc.description.tableofcontents | 口試委員會審定書
序言 I 中文摘要 II ABSTRACT III 第一章 緒論 1 第二章 材料和方法 4 第三章 試驗結果 6 第四章 討論 9 參考文獻 12 表格圖片 17 附錄 22 | |
| dc.language.iso | zh-TW | |
| dc.subject | 磷酸化 | zh_TW |
| dc.subject | 人類乳突瘤病毒 | zh_TW |
| dc.subject | 染色體 | zh_TW |
| dc.subject | Brd4 | en |
| dc.subject | phosphorylation | en |
| dc.subject | segregation | en |
| dc.subject | HPV16 | en |
| dc.title | 人類乳突瘤病毒16型 通過E2蛋白質S243磷酸化修飾調節與Brd4及宿主染色體連接 | zh_TW |
| dc.title | Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 102-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳美如,詹迺立 | |
| dc.subject.keyword | 人類乳突瘤病毒,磷酸化,染色體, | zh_TW |
| dc.subject.keyword | HPV16,Brd4,phosphorylation,segregation, | en |
| dc.relation.page | 23 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2014-08-19 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 微生物學研究所 | zh_TW |
| 顯示於系所單位： | 微生物學科所 | |
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