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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張芳嘉 | |
| dc.contributor.author | Yi-Jou Wu | en |
| dc.contributor.author | 吳宜柔 | zh_TW |
| dc.date.accessioned | 2021-06-15T12:26:09Z | - |
| dc.date.available | 2017-08-24 | |
| dc.date.copyright | 2016-08-24 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-08-10 | |
| dc.identifier.citation | 1. Morin CM, and Barlow DH. Insomnia: Psychological assessment and management. Guilford Press New York, 1993.
2. Akil H, Mayer DJ, and Liebeskind JC. Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist. Science 191: 961-962, 1976. 3. Albus K, and Herz A. Inhibition of behavioural and EEG activation induced by morphine acting on lower brain-stem structures. Electroencephalography and clinical neurophysiology 33: 579-590, 1972. 4. Andersen ML, and Tufik S. Sleep patterns over 21-day period in rats with chronic constriction of sciatic nerve. Brain research 984: 84-92, 2003. 5. Andresen MC, and Kunze DL. Nucleus tractus solitarius-gateway to neural circulatory control. Annual Review of Physiology 56: 93-116, 1994. 6. Anis N, Berry S, Burton N, and Lodge D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate. British journal of pharmacology 79: 565-575, 1983. 7. Apkarian AV, Bushnell MC, Treede RD, and Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. European journal of pain 9: 463-463, 2005. 8. Bronstein DM, Day NC, Gutstein HB, Trujillo KA, and Akil H. Pre‐and Posttranslational Regulation of β‐Endorphin Biosynthesis in the CNS: Effects of Chronic Naltrexone Treatment. Journal of neurochemistry 60: 40-49, 1993. 9. Campbell I, and Feinberg I. Comparison of MK-801 and sleep deprivation effects on NREM, REM, and waking spectra in the rat. Sleep 22: 423-432, 1999. 10. Chang F-C, Tsai H-Y, Yu M-C, Yi P-L, and Lin J-G. The central serotonergic system mediates the analgesic effect of electroacupuncture onZusanli (ST36) acupoints. Journal of biomedical science 11: 179-185, 2004. 11. Cheng C-H, Yi P-L, Lin J-G, and Chang F-C. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats. Evidence-Based Complementary and Alternative Medicine 2011: 2011. 12. Critchley HD. Neural mechanisms of autonomic, affective, and cognitive integration. Journal of Comparative Neurology 493: 154-166, 2005. 13. de Andrés I, and Corpas I. Morphine effects in brainstem-transected cats: II. Behavior and sleep of the decerebrate cat. Behavioural brain research 44: 21-26, 1991. 14. Dikeos D, and Georgantopoulos G. Medical comorbidity of sleep disorders. Current opinion in psychiatry 24: 346-354, 2011. 15. Dimsdale JE, Norman D, DeJardin D, and Wallace MS. The effect of opioids on sleep architecture. J Clin Sleep Med 3: 33-36, 2007. 16. Dixon W. The up-and-down method for small samples. Journal of the American Statistical Association 60: 967-978, 1965. 17. Dixon WJ, and Mood AM. A method for obtaining and analyzing sensitivity data. Journal of the American Statistical Association 43: 109-126, 1948. 18. Feinberg I, and Campbell I. Stimulation of NREM delta EEG by ketamine administration during waking: demonstration of dose dependence. Neuropsychopharmacology 12: 89-90, 1995. 19. Feinberg I, and Campbell IG. Ketamine administration during waking increases delta EEG intensity in rat sleep. Neuropsychopharmacology 9: 41-48, 1993. 20. Finan PH, Goodin BR, and Smith MT. The association of sleep and pain: an update and a path forward. The Journal of Pain 14: 1539-1552, 2013. 21. First MB. Diagnostic and statistical manual of mental disorders. DSM IV-4th edition APA 1994, 1994. 22. Foo H, and Mason P. Brainstem modulation of pain during sleep and waking. Sleep medicine reviews 7: 145-154, 2003. 23. Fuller PM, Gooley JJ, and Saper CB. Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback. Journal of biological rhythms 21: 482-493, 2006. 24. Glass J, Lanctôt KL, Herrmann N, Sproule BA, and Busto UE. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. Bmj 331: 1169, 2005. 25. Han J-S. Acupuncture and endorphins. Neuroscience letters 361: 258-261, 2004. 26. Han J-S. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends in neurosciences 26: 17-22, 2003. 27. Holbrook AM, Crowther R, Lotter A, Cheng C, and King D. Meta-analysis of benzodiazepine use in the treatment of insomnia. Canadian Medical Association Journal 162: 225-233, 2000. 28. Ji-sheng H, Guo-xi X, Zhong-fu Z, Folkesson R, and Terenius L. Acupuncture mechanisms in rabbits studied with microinjection of antibodies against β-endorphin, enkephalin and substance P. Neuropharmacology 23: 1-5, 1984. 29. Keifer JC, Baghdoyan H, and Lydic R. Sleep disruption and increased apneas after pontine microinjection of morphine. Anesthesiology 77: 973-982, 1992. 30. Kong J, Ma L, Gollub RL, Wei J, Yang X, Li D, Weng X, Jia F, Wang C, and Li F. A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods. The Journal of Alternative & Complementary Medicine 8: 411-419, 2002. 31. Landis C, Levine J, and Robinson C. Decreased slow-wave and paradoxical sleep in a rat chronic pain model. Sleep 12: 167-177, 1989. 32. Lautenbacher S, Kundermann B, and Krieg J-C. Sleep deprivation and pain perception. Sleep medicine reviews 10: 357-369, 2006. 33. Leys LJ, Chu KL, Xu J, Pai M, Yang HS, Robb HM, Jarvis MF, Radek RJ, and McGaraughty S. Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats. PAIN® 154: 1092-1102, 2013. 34. Lin J-G, and Chen W-L. Acupuncture analgesia: a review of its mechanisms of actions. The American journal of Chinese medicine 36: 635-645, 2008. 35. Liu K, Gao X-Y, Li L, Ben H, Qin Q-G, Zhao Y-X, and Zhu B. Neurons in the nucleus tractus solitarius mediate the acupuncture analgesia in visceral pain rats. Autonomic Neuroscience 186: 91-94, 2014. 36. Longo LP, and Johnson B. Addiction: Part I. Benzodiazepines-side effects, abuse risk and alternatives. American family physician 61: 2121-2128, 2000. 37. Marker CL, and Pomonis JD. The monosodium iodoacetate model of osteoarthritis pain in the rat. Pain Research: Methods and Protocols 239-248, 2012. 38. Moldofsky H. Sleep and pain. Sleep medicine reviews 5: 385-396, 2001. 39. Mor D, Bembrick A, Austin P, Wyllie P, Creber N, Denyer G, and Keay K. Anatomically specific patterns of glial activation in the periaqueductal gray of the sub-population of rats showing pain and disability following chronic constriction injury of the sciatic nerve. Neuroscience 166: 1167-1184, 2010. 40. Mor D, Bembrick AL, Austin PJ, and Keay KA. Evidence for cellular injury in the midbrain of rats following chronic constriction injury of the sciatic nerve. Journal of chemical neuroanatomy 41: 158-169, 2011. 41. Napadow V, Makris N, Liu J, Kettner NW, Kwong KK, and Hui KK. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Human brain mapping 24: 193-205, 2005. 42. Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep medicine reviews 6: 97-111, 2002. 43. Ohayon MM. Relationship between chronic painful physical condition and insomnia. Journal of psychiatric research 39: 151-159, 2005. 44. Onen SH, Onen F, Courpron P, and Dubray C. How pain and analgesics disturb sleep. The Clinical journal of pain 21: 422-431, 2005. 45. Reinoso-Barbero F, and de Andrés I. Effects of opioid microinjections in the nucleus of the solitary tract on the sleep-wakefulness cycle states in cats. The Journal of the American Society of Anesthesiologists 82: 144-152, 1995. 46. Smith M, Edwards R, and McCann U. The effects of sleep de-privation on pain inhibition and spontaneous pain in women. Sleep (New York, NY) 30: 494-505, 2007. 47. Sutton BC, and Opp MR. Musculoskeletal sensitization and sleep: chronic muscle pain fragments sleep of mice without altering its duration. Sleep 37: 505, 2014. 48. Terman GW, Shavit Y, Lewis JW, Cannon JT, and Liebeskind JC. Intrinsic mechanisms of pain inhibition: activation by stress. Science 226: 1270-1277, 1984. 49. Tiede W, Magerl W, Baumgärtner U, Durrer B, Ehlert U, and Treede R-D. Sleep restriction attenuates amplitudes and attentional modulation of pain-related evoked potentials, but augments pain ratings in healthy volunteers. Pain 148: 36-42, 2010. 50. Tsui P, and Leung MC. Comparison of the effectiveness between manual acupuncture and electro-acupuncture on patients with tennis elbow. Acupuncture & electro-therapeutics research 27: 107-117, 2002. 51. Ulett GA, Han S, and Han J-s. Electroacupuncture: mechanisms and clinical application. Biological psychiatry 44: 129-138, 1998. 52. Usichenko TI, Kuchling S, Witstruck T, Pavlovic D, Zach M, Hofer A, Merk H, Lehmann C, and Wendt M. Auricular acupuncture for pain relief after ambulatory knee surgery: a randomized trial. Canadian Medical Association Journal 176: 179-183, 2007. 53. Wu YM, Pietrone R, Cashmere JD, Begley A, Miewald JM, Germain A, and Buysse DJ. EEG power during waking and NREM sleep in primary insomnia. Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine 9: 1031-1037, 2013. 54. Yi P-L, Tsai C-H, Lin J-G, Liu H-J, and Chang F-C. Effects of electroacupuncture at ‘Anmian (Extra)’acupoints on sleep activities in rats: the implication of the caudal nucleus tractus solitarius. Journal of biomedical science 11: 579-590, 2004. 55. Zhang B, and Wing Y. Sex differences in insomnia: a meta-analysis. SLEEP-NEW YORK THEN WESTCHESTER- 29: 85, 2006. 56. Zhao Z-Q. Neural mechanism underlying acupuncture analgesia. Progress in neurobiology 85: 355-375, 2008. 57. 李辞蓉, and 宋大鲁. 小鼠常用针灸穴位. 实验动物与动物实验 85-87, 1992. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/49917 | - |
| dc.description.abstract | 針灸足三里穴於臨床上經常被利用來治療失眠，但其缺少科學證據；本實驗證實連續30分鐘針刺足三里穴兩天後，可以增加非快速動眼期與快速動眼期睡眠。而先前實驗室研究已證實電針刺激安眠穴時，藉由刺激交感神經促使孤獨徑核釋放內生性鴉片，使非快速動眼期睡眠增加，因此，我們同樣於孤獨徑核顯微注射鴉片類受器拮抗劑後，發現針刺足三里穴之安眠效果被抑制，進而得知針刺足三里穴可藉由刺激孤獨徑核中鴉片類物質釋放而達到安眠效果。
疼痛與睡眠之間互相影響，患有長期疼痛的病人經常同時存在著睡眠失調之情形；足三里穴除了安眠之外，亦是一止痛效果顯著之穴位，因此，我們進一步探討針刺足三里穴是否能夠改善因疼痛引起之睡眠失調，結果顯示原本因疼痛而造成之非快速動眼期與快速動眼期睡眠下降的情形，在接受針刺治療以後獲得改善。 | zh_TW |
| dc.description.abstract | Sleep disorders and chronic pain are often comorbid conditions and patients with primary insomnia also report chronic pain at the rate over 50%. Clinical studies show that pain-induced sleep disturbance may be improved by relief of pain. In clinic, ST-36 (Zusanli) is one of commonly used acupoints for the treatment of insomnia, but there is no scientific evidence. Therefore, the goal of this study was to investigate whether manual acupuncture at ST-36 can improve sleep and the underlying mechanisms. Therefore, this study also investigated the effects of acupuncture at ST-36 on pain-induced sleep disturbance. Our results indicated that acupuncture at ST-36 per se increased spontaneous NREMS and REMS via endogenous opioid system in NT. Moreover, acupuncture of ST-36 exhibits analgesic effects and improves pain-induced sleep disturbance. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T12:26:09Z (GMT). No. of bitstreams: 1 ntu-105-R03629017-1.pdf: 2352723 bytes, checksum: 5bdca6a11faa9bed39c9ee2de7951f41 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 目錄
論文口試委員審定書………………………………………………………………….i 致謝…...………………………………………………………………………….…....ii 中文摘要……………………………………………………………………..……….iii Abstract……………………………………………………………...………….…....iv 壹、 研究目的與背景 1 一、 睡眠與失眠 1 1. 簡介 1 2. 失眠定義與原因 1 3. 失眠治療 2 4. 疼痛與睡眠 2 5. 疼痛引起睡眠失調之動物模式 3 二、 針灸與疼痛之間的關係 4 1. 簡介 4 2. 針灸止痛 4 3. 孤獨徑核 (nucleus tractus solitarius, NTS) 與針灸止痛之關聯 5 三、 針灸與睡眠之間的關係 6 1. 簡介 6 2. 針灸安眠機制 6 3. 內源性鴉片物質與睡眠之關係 7 四、 研究目的 7 貳、 材料與方法 8 一、 實驗動物 8 二、 實驗方法 ─ 針刺足三里穴組 8 1. 手術 8 2. 實驗流程 10 三、 實驗方法 ─ 探討鴉片類受器在針刺足三里穴中扮演之角色 12 1. 手術 12 2. 實驗用藥 13 3. 實驗流程 13 四、 實驗方法 — 疼痛組 15 1. 手術 15 2. 實驗用藥 15 3. 實驗流程 15 4. 50 %縮腳閾值之測量與計算 15 五、 實驗方法 — 針刺足三里對於疼痛引之睡眠失調的影響 17 1. 手術 17 2. 實驗用藥 17 3. 實驗流程 17 六、 EEG紀錄與分析 18 1. 紀錄 18 2. 分析 18 七、 數據統計 19 參、 結果 20 一、 針刺足三里之安眠效果 20 1. 非快速動眼期 (NREM) 睡眠 20 2. 快速動眼期 (REM) 睡眠 23 二、 於孤獨徑核顯微注射鴉片類受器拮抗劑對於針刺足三里穴產生之安眠效果的影響 25 1. 非快速動眼期與快速動眼期睡眠 25 三、 於右後掌皮下注射CFA引發之疼痛對於50% 縮腳閾值以及睡眠的影響 ………………………………………………………………………27 1. 50% 縮腳閾值 27 2. 疼痛對於睡眠之影響 27 四、 針刺足三里對於疼痛引起睡眠失調之影響 31 1. 50% 縮腳閾值 31 2. 於睡眠失調之影響 31 肆、 討論 34 伍、 結論 40 參考資料……………………………………………………………………………..42 圖目錄 Fig. 1. 植入EEG紀錄電極位置圖 9 Fig. 2. Sham組所選用之不具穴位之位置 11 Fig. 3. 測試針刺足三里對於睡眠影響之實驗流程 11 Fig. 4. EEG電極以及single guide cannula植入位置圖 12 Fig. 5. 探討鴉片類受器在針刺足三里穴中所扮演角色之流程圖 14 Fig. 6. 針刺第一天24小時內非快速動眼期 (NREM) 之睡眠變化 21 Fig. 7. 針刺第二天24小時內非快速動眼期 (NREM) 之睡眠變化 21 Fig. 8. 針刺二天後隔天24小時內非快速動眼期 (NREM) 之睡眠變化 22 Fig. 9. 針刺第一天24小時內快速動眼期 (REM) 之睡眠變化 23 Fig. 10. 針刺第二天24小時內快速動眼期 (REM) 之睡眠變化 24 Fig. 12. 針刺二天以及分別顯微注射PFS (白點) 、naloxone (黑點)以後，24小時內非快速動眼期 (NREM) 之睡眠變化 25 Fig. 13. 針刺二天以及分別顯微注射PFS (白點) 、naloxone (黑點)以後，24小時內快速動眼期 (REM) 之睡眠變化 26 Fig. 14. 疼痛第一天 (黑色) 、疼痛第二天 (深灰色) 、疼痛第三天 (淺灰) 與baseline (白色) 之間50%縮腳閾值之變化 28 Fig. 15. 疼痛第一天24小時內非快速動眼期 (NREM) 之睡眠變化 28 Fig. 17. 疼痛第一天24小時內快速動眼期 (REM) 之睡眠變化 29 Fig. 18. 疼痛第二天24小時內快速動眼期 (REM) 之睡眠變化 30 Fig. 19. 疼痛組 (淺灰色) 、針刺治療組 (深灰色) 與baseline (黑色) 之50%縮腳閾值之變化 31 Fig. 20. 針刺足三里穴後，疼痛第二天24小時內非快速動眼期 (NREM) 之睡眠變化 32 | |
| dc.language.iso | zh-TW | |
| dc.title | 探討針刺足三里穴對疼痛引起之睡眠失調的影響 | zh_TW |
| dc.title | Effects of acupuncture at ST-36 (Zusanli) on pain-induced sleep disturbance | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林昭庚,徐崇堯,陳易宏,尹珮璐 | |
| dc.subject.keyword | 足三里穴,孤獨徑核,內生性鴉片類物質,疼痛,睡眠失調, | zh_TW |
| dc.subject.keyword | ST-36,manual acupuncture,NTS,endogenous opioid system,pain,sleep disturbance, | en |
| dc.relation.page | 46 | |
| dc.identifier.doi | 10.6342/NTU201602229 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-08-10 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
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