Please use this identifier to cite or link to this item:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48582Full metadata record
| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 簡國龍 | |
| dc.contributor.author | Shu-Ching Tai | en |
| dc.contributor.author | 戴淑卿 | zh_TW |
| dc.date.accessioned | 2021-06-15T07:03:09Z | - |
| dc.date.available | 2021-12-31 | |
| dc.date.copyright | 2011-03-03 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2011-01-11 | |
| dc.identifier.citation | 1. Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases: Part i: General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104:2746-2753
2. Levenson JW, Skerrett PJ, Gaziano JM. Reducing the global burden of cardiovascular disease: The role of risk factors. Preventive Cardiology. 2002;5:188-199 3. Department of Health EY, R.O.C., Taiwan. 2009 statistics of causes of death 2010 4. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH. Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 american heart association scientific statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism. Circulation. 2006;113:898-918 5. Balkau B CM. Comment on the provisional report from the who consultation. European group for the study of insulin resistance (egir). Diabetic Medicine. 1999;16:442-443 6. E. S. Ford WHGaWHD. Third report of the national cholesterol education program (ncep) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel iii) final report. Circulation. 2002;106:3143- 7. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Jr, Spertus JA, Costa F. Diagnosis and management of the metabolic syndrome: An american heart association/national heart, lung, and blood institute scientific statement. Circulation. 2005;112:2735-2752 8. Enkhmaa B, Shiwaku K, Anuurad E, Nogi A, Kitajima K, Yamasaki M, Oyunsuren T, Yamane Y. Prevalence of the metabolic syndrome using the third report of the national cholesterol educational program expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (atp iii) and the modified atp iii definitions for japanese and mongolians. Clin Chim Acta. 2005;352:105-113 9. Shah T, Jonnalagadda SS, Kicklighter JR, Diwan S, Hopkins BL. Prevalence of metabolic syndrome risk factors among young adult asian indians. J Immigr Health. 2005;7:117-126 10. Shiwaku K, Nogi A, Kitajima K, Anuurad E, Enkhmaa B, Yamasaki M, Kim JM, Kim IS, Lee SK, Oyunsuren T, Yamane Y. Prevalence of the metabolic syndrome using the modified atp iii definitions for workers in japan, korea and mongolia. J Occup Health. 2005;47:126-135 11. Choi SH, Ahn CW, Cha BS, Chung YS, Lee KW, Lee HC, Huh KB, Kim DJ. The prevalence of the metabolic syndrome in korean adults: Comparison of who and ncep criteria. Yonsei Med J. 2005;46:198-205 12. Matsuzawa Y. New criteria for 'obesity disease' in japan. Circ J. 2002;66:987-992 13. Obesity and overweight. 2003;2010 14. Lin Y-C, Yen L-L, Chen S-Y, Kao M-D, Tzeng M-S, Huang P-C, Pan W-H. Prevalence of overweight and obesity and its associated factors: Findings from national nutrition and health survey in taiwan, 1993-1996. Preventive Medicine. 2003;37:233-241 15. Hwang LC, Bai CH, Chen CJ. Prevalence of obesity and metabolic syndrome in taiwan. J Formos Med Assoc. 2006;105:626-635 16. Taiwanese survey on prevalence of hyperglycemia, hyperlipidemia and hypertension (twshhh). 2002 17. Frank B. Hu e. Measurements of adiposity and body composition. In: Hu FB, ed. Obesity epidemiology Oxford University Press, 2008; 2008:53-83. 18. Reaven G. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607 19. Alberti K, Zimmet P. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a who consultation. Diabetic Medicine. 1998;15:539-553 20. Definition, diagnosis and classification of diabetes mellitus and its complications: Report of a who consultation. Part 1: Diagnosis and classification of diabetes mellitus. 1999 21. Einhorn D, Reaven GM, Cobin RH, Ford E, Ganda OP, Handelsman Y, Hellman R, Jellinger PS, Kendall D, Krauss RM, Neufeld ND, Petak SM, Rodbard HW, Seibel JA, Smith DA, Wilson PW. American college of endocrinology position statement on the insulin resistance syndrome. Endocr Pract. 2003;9:237-252 22. Alberti KGMM, Zimmet P, Shaw J. The metabolic syndrome--a new worldwide definition. The Lancet. 2005;366:1059-1062 23. The criteria of metabolic syndrome. 2007 24. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults--the evidence report. National institutes of health. Obes Res. 1998;6 Suppl 2:51S-209S 25. The criteria of metabolic syndrome. 2004;2010 26. Eggen DA, Strong JP, McGill HC, Jr. Calcification in the abdominal aorta; relationship to race, sex, and coronary atherosclerosis. Arch Pathol. 1964;78:575-583 27. Hyman JB, Epstein FH. A study of the correlation between roentgenographic and post-mortem calcification of the aorta. Am Heart J. 1954;48:540-543 28. Witteman JC, Kok FJ, van Saase JL, Valkenburg HA. Aortic calcification as a predictor of cardiovascular mortality. Lancet. 1986;2:1120-1122 29. Wilson PWF, Kauppila LI, O'Donnell CJ, Kiel DP, Hannan M, Polak JM, Cupples LA. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation. 2001;103:1529-1534 30. Kawaguchi Y, Kubo H, Yamamoto H, Nakayama M, Yokoyama K, Shigematsu T, Sakai O. Is atherosclerosis accelerated by capd? Peritoneal Dialysis International. 1996;16 31. Jie KSG, Bots ML, Vermeer C, Witteman JCM, Grobbee DE. Vitamin k status and bone mass in women with and without aortic atherosclerosis: A population-based study. Calcified Tissue International. 1996;59:352-356 32. Kauppila LI, Joseph FP, Cupples LA, Marian TH, Douglas PK, Peter WFW. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: A 25-year follow-up study. Atherosclerosis. 1997;132:245-250 33. Tanko LB, Bagger YZ, Alexandersen P, Larsen PJ, Christiansen C, for the PERF study group. Central and peripheral fat mass have contrasting effect on the progression of aortic calcification in postmenopausal women. Eur Heart J. 2003;24:1531-1537 34. Alexandersen P, Tanko LB, Bagger YZ, Jespersen J, Skouby SO, Christiansen C. Associations between aortic calcification and components of body composition in elderly men[ast]. Obesity. 2006;14:1571-1578 35. Kimura K, Saika Y, Otani H, Fujii R, Mune M, Yukawa S. Factors associated with calcification of the abdominal aorta in hemodialysis patients. Kidney Int Suppl. 1999;71:S238-241 36. Matsushita M, Nishikimi N, Sakurai T, Nimura Y. Relationship between aortic calcification and atherosclerotic disease in patients with abdominal aortic aneurysm. International Angiology. 2000;19:276-279 37. Reaven PD, Sacks J. Reduced coronary artery and abdominal aortic calcification in hispanics with type 2 diabetes. Diabetes Care. 2004;27:1115-1120 38. Bowden DJ, Aitken SR, Wilkinson IB, Dixon AK. Interobserver variability in the measurement of abdominal aortic calcification using unenhanced ct. Br J Radiol. 2009;82:69-72 39. Golledge J, Jayalath R, Oliver L, Parr A, Schurgers L, Clancy P. Relationship between ct anthropometric measurements, adipokines and abdominal aortic calcification. Atherosclerosis. 2008;197:428-434 40. Narumi H, Yoshida K, Hashimoto N, Umehara I, Funabashi N, Yoshida S, Komuro I. Increased subcutaneous fat accumulation has a protective role against subclinical atherosclerosis in asymptomatic subjects undergoing general health screening. Int J Cardiol. 2009;135:150-155 41. Fox CS, Hwang SJ, Massaro JM, Lieb K, Vasan RS, O'Donnell CJ, Hoffmann U. Relation of subcutaneous and visceral adipose tissue to coronary and abdominal aortic calcium (from the framingham heart study). Am J Cardiol. 2009;104:543-547 42. Hoffmann U, Massaro JM, Fox CS, Manders E, O'Donnell CJ. Defining normal distributions of coronary artery calcium in women and men (from the framingham heart study). Am J Cardiol. 2008;102:1136-1141, 1141 e1131 43. Seidell JC, Bakker CJ, van der Kooy K. Imaging techniques for measuring adipose-tissue distribution--a comparison between computed tomography and 1.5-t magnetic resonance. Am J Clin Nutr. 1990;51:953-957 44. Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S. A novel technique for the determination of body fat by computed tomography. Int J Obes. 1983;7:437-445 45. Measurement of waist circumference. 2005 46. Yoshizumi T, Nakamura T, Yamane M, Waliul Islam AHM, Menju M, Yamasaki K, Arai T, Kotani K, Funahashi T, Yamashita S, Matsuzawa Y. Abdominal fat: Standardized technique for measurement at ct. Radiology. 1999;211:283-286 47. Borkan GA, Gerzof SG, Robbins AH, Hults DE, Silbert CK, Silbert JE. Assessment of abdominal fat content by computed tomography. Am J Clin Nutr. 1982;36:172-177 48. Weits T, van der Beek EJ, Wedel M, Ter Haar Romeny BM. Computed tomography measurement of abdominal fat deposition in relation to anthropometry. Int J Obes. 1988;12:217-225 49. Agatston A, Janowitz W, Hildner F, Zusmer N, Viamonte M, Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-832 50. Jayalath RW, Mangan SH, Golledge J. Aortic calcification. European Journal of Vascular and Endovascular Surgery. 2005;30:476-488 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48582 | - |
| dc.description.abstract | 研究背景和目的：腹部肥胖會增加發生代謝症候群的風險，代謝症候群的發生又會提高將來發生動脈硬化、心血管疾病的風險。本研究的目的為研究腹部脂肪分佈與腹主動脈鈣化之相關性。
材料與方法：本研究為一橫斷性研究，調查於 2009年9月至2010年1月，在某家區域醫院接受腹部電腦斷層檢查之門診及健康檢查病人，為其測量身高、體重、腰圍，利用病歷回顧的方式，收集參與者之基本資料及臨床檢驗結果。我們採用2005年AHA/NHLBI所修訂的標準做為診斷代謝症候群的依據，腰圍則是採用亞洲人的標準。利用腹部電腦斷層資料分析所有參與者之內臟脂肪面積及皮下脂肪面積，及腹主動脈分叉往上4.5公分內的鈣化積分。 結果：我們一共收集了200位參與者腹部電腦斷層的資料，其平均年齡為50.8歲，其中47%為女性，40% 參與者有代謝症候群； 42.5% 參與者有腹主動脈鈣化的情形。而檢定內臟脂肪面積分層(三層)和腹主動脈鈣化之相關性，其勝算比(OR)分別為2.1及4.2(95%信賴區間為：1.0-4.5; 2.0-8.7; trend test, p <0.001)，在加入相關危險因子校正後，第三組比起第一組的勝算比為1.5 (95%信賴區間為0.6-3.6; trend test, p=0.33)，；而以Receiver operating characteristic (ROC) 曲線分析求得內臟脂肪面積診斷腹主動脈鈣化的切點為81.5cm2(敏感性為75.3%，特異性為51.3%)，所對應之腰圍分別為女性84cm，男性88cm。 結論：內臟脂肪面積與腹主動脈鈣化之相關性只有在單因子分析時存在，在校正相關危險因子後，此相關性即不具統計顯著意義。 | zh_TW |
| dc.description.abstract | Objectives: The relationship between visceral fat and abdominal aortic calcification among Taiwanese was still unclear. We investigated the association between visceral fat and abdominal aortic calcification in Taiwanese.
Material and Methods: We conducted a cross-sectional study of 200 adult participants in a regional hospital during September 2009 to January 2010. Subcutaneous and visceral fat areas were measured on one cross-sectional abdominal CT scan and the calcium score of abdominal aorta were measured within a 4.5cm cylindrical section of abdominal aorta just above aortic bifurcation. Results: The mean age was 50.8 (standard deviation, 14.4) years and 47% were women; 40% had metabolic syndrome and 42.5% had abdominal aortic calcification. The odds ratios (ORs) of abdominal aortic calcification according to tertiles of visceral fat area were 2.1 and 4.2 (95% confidence interval (CI), 1.0-4.5, 2.0-8.7;trend test, p <0.001). After adjusting for age, gender, body mass index (BMI), the OR comparing the participants in the 3rd tertile of visceral fat area with those in the first tertile was 1.5 (95%CI, 0.6-3.6; trend test, p=0.33). We plotted the Receiver Operating Characteristic (ROC) curve of different fat measurements with association of abdominal aortic calcification. The cut-off point for visceral fat area to diagnose aortic calcification was 81.5cm2(sensitivity 75.3%，specificity 51.3%), and the corresponding waist circumference is 84cm in women and 88cm in men. Conclusions: The association between visceral fat area and abdominal aortic calcification were found only in univariate analysis, this association attenuated after multivariate adjustment. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T07:03:09Z (GMT). No. of bitstreams: 1 ntu-99-R97846009-1.pdf: 2267385 bytes, checksum: 31579372cc17c085eb0c415e0bb7d144 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 摘要 I
Abstract II 內容綱要(Table of Contents) III 表目錄 VII 圖目錄 IX 第一章前言 1 第一節 研究背景及研究動機 1 第二節文獻回顧 2 1.2.1 身體組成(Body composition)的評估 2 1.2.2代謝症候群的診斷標準 6 1.2.3 腹主動脈鈣化和心血管疾病的相關性 10 1.2.4. 腹主動脈鈣化的評估 11 1.2.5 內臟脂肪與腹主動脈鈣化相關性之文獻回顧 12 第四節 討論 15 第二章目標/假說 16 第一節與過去研究的差異(Gap) 16 第二節研究目的 16 第三章 研究方法 17 第一節研究對象 17 第二節 基本測量 17 第三節電腦斷層的測量： 18 3.3.1腹部脂肪的測量： 18 3.3.2腹主動脈鈣化的測量： 19 3.3.3測量再現性(Reproducibility of Measurement) 19 第四節研究對象之病歷回顧 19 第五節資料分析方法 20 3.5.1 代謝症候群的診斷標準 20 3.5.2 樣本數(Sample size)計算 20 3.5.3資料變項準備及整理 20 3.5.4測量再現性(Reproducibility of Measurement) 21 3.5.5 描述性資料分析 21 3.5.6相關係數分析 21 3.5.7推論統計 22 3.5.8 趨勢檢定(test for trend) 22 3.5.9 ROC曲線 22 3.5.10 交互作用檢定 23 第四章結果 24 第一節 研究對象基本資料 24 第二節測量再現性(Reproducibility of Measurement) 24 第三節代謝症候群與基本資料之相關性 25 第四節 內臟型肥胖與基本資料之相關性 26 第五節 相關係數 26 第六節內臟脂肪面積分層 27 4.6.1內臟脂肪面積分層與基本資料之相關性 27 4.6.2 內臟脂肪面積分層與代謝症候群之相關性 29 4.6.3內臟脂肪面積分層與腹主動脈鈣化之相關性 29 4.6.4依年齡分層的次群體分析 30 第七節 皮下脂肪面積分層 30 4.7.1皮下脂肪面積分層與腹主動脈鈣化之相關性 31 4.7.2依年齡分層的次群體分析 31 第八節ROC曲線及診斷切點 32 4.8.1診斷代謝症候群之ROC曲線及診斷切點 32 4.8.2診斷腹主動脈鈣化之ROC曲線及診斷切點 32 4.8.3以內臟脂肪面積推估腰圍 33 第九節 檢定交互作用 33 第五章討論 34 第一節 內臟脂肪面積與腹主動脈鈣化的相關性 34 第二節 皮下脂肪面積與腹主動脈鈣化的相關性 35 第三節 腰圍標準 36 第四節 研究優點與限制 36 第五節結論與未來展望 37 參考文獻 38 | |
| dc.language.iso | zh-TW | |
| dc.subject | 主動脈鈣化 | zh_TW |
| dc.subject | 皮下脂肪面積 | zh_TW |
| dc.subject | 內臟脂肪面積 | zh_TW |
| dc.subject | 腹部肥胖 | zh_TW |
| dc.subject | 代謝症候群 | zh_TW |
| dc.subject | visceral obesity | en |
| dc.subject | visceral fat area | en |
| dc.subject | abdominal aortic calcification | en |
| dc.title | 腹部脂肪分佈與代謝症候群及腹主動脈鈣化之相關 | zh_TW |
| dc.title | Association between Abdominal Fat Distribution and Metabolic Syndrome and Abdominal Aortic Calcification | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 程蘊菁,黃國晉,黃耀祥,李文正 | |
| dc.subject.keyword | 腹部肥胖,內臟脂肪面積,皮下脂肪面積,主動脈鈣化,代謝症候群, | zh_TW |
| dc.subject.keyword | visceral obesity,visceral fat area,abdominal aortic calcification, | en |
| dc.relation.page | 67 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-01-11 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學與預防醫學研究所 | zh_TW |
| Appears in Collections: | 流行病學與預防醫學研究所 | |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| ntu-99-1.pdf Restricted Access | 2.21 MB | Adobe PDF |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.