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標題: | 華中五味子之果實成分研究 Studies on the Constituents of Fruits from Schisandra sphenanthera Rehd. et Wils |
作者: | Khongorzul Mendbayar 蒙貝佳 |
指導教授: | 沈雅敬(Ya-Ching Shen) |
關鍵字: | 華中五味子, Schisandra sphenanthera,sesquiterpenes,lignans,DPP-4 inhibition assay, |
出版年 : | 2011 |
學位: | 碩士 |
摘要: | Phytochemical investigation of Schisandra sphenanthera (Schisandraceae) from dichloromethane partition of the acetone extracts led to the isolation of four new sesquiterpenes called schisansphenins A, B, C and D (1, 2, 3, 4) and eleven known compounds such as macelignan (5), 1-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-2,3-dimethylbutane (6), chicanine (7), meso-dimethyl dihydroguaraeitic acid (8), schisantherin D (9), 6-O-benzoylgomisin O (10), erythro-austrobailignan-6 (11), gomisin B (12), schisantherin A (13), gomisin G (14) and gomisin C (15).
Structural elucidations for the found compounds were based on spectroscopic analyses such as 1H- and 13C-NMR, including 2D NMR (1H-1H COSY, HMQC, HMBC and NOESY) experiments, and by comparison of their spectroscopic data with those of related metabolites. The isolated compounds had been tested by dipeptidyl peptidase-4 (DPP-4) inhibition assay. Except erythro-austrobailignan-6 (11), the rest isolated compounds did not show any significant inhibition. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/48576 |
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顯示於系所單位: | 藥學系 |
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