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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林璧鳳(Bi-Fong Lin) | |
| dc.contributor.author | Tse-Yu Lu | en |
| dc.contributor.author | 盧則豫 | zh_TW |
| dc.date.accessioned | 2021-06-15T06:12:11Z | - |
| dc.date.available | 2010-08-19 | |
| dc.date.copyright | 2010-08-19 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-08-12 | |
| dc.identifier.citation | 第五章 參考文獻
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/47678 | - |
| dc.description.abstract | 已知靈芝的三萜類成分具有多種生理活性，故台灣GMP機能性食品認證將靈芝三萜類品質列入審查標準。本研究欲探討在高油飲食誘發肥胖的小鼠模式中，松杉靈芝三萜類 (GT-TRE) 對代謝症候群危險因子及發炎狀況的影響。
本研究以RAW264.7和3T3-L1細胞株評估GT-TRE對促發炎細胞激素分泌量的影響。在動物模式下，飲食誘發肥胖的C57BL/6J公鼠給予高油飲食並分別補充GT-TRE、降血糖藥物Rosiglitazone與具有降血糖作用的山苦瓜，每兩週測定血糖和血脂，餵食十四週後進行OGTT (oral glucose tolerance test)。餵食十六週後犧牲小鼠，分析血糖、血脂以及血清中的發炎介質含量，並分析脂肪組織中發炎相關基因的表現量。 在細胞實驗中發現GT-TRE可降低RAW264.7、3T3-L1細胞株和初代腹腔細胞分泌促發炎細胞激素的含量，如TNF-a和IL-6。因此推測GT-TRE可藉由抑制發炎反應改善胰島素抗性，降低禁食血糖。而動物實驗中，給予各樣品十六週後， Rosiglitazone和山苦瓜顯著降低高油飲食下的禁食血糖，也有顯著較低的胰島素抗性指標 (HOMA-IR index)。而GT-TRE調控禁食血糖的效果不明顯，但HOMA-IR index有較低的趨勢。GT-TRE可顯著降低血清中三酸甘油酯，非酯化游離脂肪酸也有較低的趨勢；另外，也顯著降低肝臟中三酸甘油酯、膽固醇和非酯化游離脂肪酸含量。在發炎反應的指標方面，GT-TRE顯著降低血清中leptin和MCP-1濃度，而脂肪組織的IL-10 mRNA表現量有較低的趨勢，但不影響脂肪組織中促發炎介質和巨噬細胞指標的表現量。 本研究顯示GT-TRE對抑制組織發炎反應的作用不明顯，而較低的IL-10 mRNA表現量和血清leptin、MCP-1濃度可能反映體內有較控制組輕微的發炎反應。HOMA-IR index在較高劑量的TRE40x組有較低的趨勢，推測提高GT-TRE餵食的劑量能有更顯著的降血糖效果；另外，GT-TRE顯著降低血脂和肝脂的含量，可能是透過活化LXR改善脂質的代謝狀況，值得後續探討。 綜合以上結果，GT-TRE應可抑制促發炎介質的生成，改善高血糖現象，甚至促進脂質代謝的恆定。高油飲食下補充GT-TRE可減少代謝症候群的危險因子，也可能具有改善胰島素抗性的潛力。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-15T06:12:11Z (GMT). No. of bitstreams: 1 ntu-99-R97b47301-1.pdf: 2564285 bytes, checksum: e17be56a32f333e55210478dac21572e (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 總目錄
目錄 i 表目錄 vi 圖目錄 viii 中文摘要 x 英文摘要 xi 縮寫對照表 xiii 第一章、緒論 第一節 文獻回顧 1 一、 前言 1 二、 胰島素抗性 2 三、 肥胖引起的發炎反應 3 (一) 脂肪細胞肥大 3 (二) 游離脂肪酸的作用 4 (三) 內質網壓力 4 四、 發炎反應與胰島素抗性 5 (一) 胰島素訊息傳遞途徑 6 (二) 促發炎介質對胰島素訊息傳遞的負向調控 6 五、 白色脂肪組織 6 (一) Adipocyte / Preadipocyte 6 (二) Adipose tissue macrophage (ATM) 7 六、 靈芝 8 (一) 靈芝之抑制發炎功能 8 (二) 靈芝之調控血糖功能 8 七、 苦瓜 9 八、 Thiazolidinedione 9 第二節 研究動機 10 第三節 研究架構 11 第二章、以細胞培養模式評估GT-TRE對促發炎介質的影響 第一節 前言 12 第二節 材料與方法 12 一、 樣品前處理 12 二、 RAW264.7細胞培養 13 三、 3T3-L1細胞培養 14 四、 細胞存活分析 15 五、 腹腔細胞取得與培養 16 六、 細胞激素含量分析 17 七、 統計分析 19 第三節 結果 19 一、 RAW264.7細胞株 19 二、 3T3L-L1細胞株 20 三、 初代腹腔細胞株 20 第四節 討論 24 一、 藥物的抗發炎效果 24 二、 靈芝三萜類的抗發炎作用 24 三、 苦瓜萃物的抗發炎作用 25 四、 動物劑量推估 25 第三章、GT-TRE對高油飲食C57BL/6J小鼠血糖及發炎狀況的影響 第一節 前言 27 第二節 材料與方法 27 一、 實驗設計 27 二、 飼料配製 30 三、 動物飼養 31 四、 樣品收集 32 五、 口服葡萄糖耐受性試驗 32 六、 血糖分析 33 七、 血脂質分析 33 八、 血清胰島素分析 35 九、 胰島素抗性指標HOMA-IR index 計算 36 十、 腹腔細胞取得與培養 36 十一、脾臟細胞分離與培養 36 十二、脾臟細胞增生測定 37 十三、吞噬細胞活性測定 38 十四、自然殺手細胞活性分析 39 十五、Real-time PCR法分析腹部脂肪組織細胞激素及巨噬細胞marker相 關基因 39 十六、肝臟脂質分析 42 十七、TNF-a、IL-6、MCP-1、adiponectin、leptin含量測定 43 十八、CRP 含量測定 44 十九、統計分析 44 第三節 結果 45 一、 體重變化及攝食量 45 二、 組織器官重量 45 三、 血清葡萄糖和血脂的分析結果 45 四、 肝臟脂質分析 46 五、 口服葡萄糖耐受性試驗 46 六、 胰島素抗性指標 47 七、 脂肪組織中mRNA的表現量 47 八、 血清adipokines及促發炎介質分析 48 九、 腹腔細胞之細胞激素分泌情形 48 十、 脾臟細胞之細胞激素分泌情形 48 十一、脾臟細胞增生反應 49 十二、自然免疫反應指標分析 49 第四節 討論 69 一、 高油飲食誘發胰島素抗性與發炎狀況 69 二、 GT-TRE對高油飲食小鼠胰島素抗性及發炎狀況的影響 70 三、 Rosiglitazone對高油飲食小鼠胰島素抗性和發炎狀況的影響 71 四、 苦瓜對高油飲食小鼠胰島素抗性及發炎狀況的影響 72 第四章、綜合討論與總結 第一節 綜合討論 76 一、 降血糖藥物Rosiglitazone對血糖和發炎反應的影響 76 二、 山苦瓜對血糖和發炎反應的影響 76 三、 動物實驗各指標間之相關性 77 (一) 與體重之相關性 77 (二) 與血糖之相關性 78 (三) 與leptin的相關性 78 四、 松杉靈芝三萜類對脂質代謝的影響 79 (一) 血清中脂質含量 79 (二) 肝臟中脂質含量 79 第二節 總結 82 第五章、參考文獻 83 | |
| dc.language.iso | zh-TW | |
| dc.subject | 胰島素抗性 | zh_TW |
| dc.subject | 肥胖 | zh_TW |
| dc.subject | 脂質 | zh_TW |
| dc.subject | 血糖 | zh_TW |
| dc.subject | GT-TRE | zh_TW |
| dc.subject | 發炎 | zh_TW |
| dc.subject | insulin resistance | en |
| dc.subject | GT-TRE | en |
| dc.subject | obesity | en |
| dc.subject | inflammation | en |
| dc.subject | hyperglycemic | en |
| dc.subject | lipid | en |
| dc.title | 松杉靈芝三萜類對高油飲食小鼠代謝症候群指標與發炎介質的影響 | zh_TW |
| dc.title | Effects of triterpenoid-rich extracts of Ganoderma tsugae on metabolic syndrome and inflammatory factors in mice fed high-fat diet | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 黃青真(Ching-jang Huang),許瑞祥(Ruey-Shyang Hseu),江伯倫(Bor-Leun Chiang),陳妙齡(Miaw-Ling Chen) | |
| dc.subject.keyword | 肥胖,發炎,GT-TRE,血糖,脂質,胰島素抗性, | zh_TW |
| dc.subject.keyword | obesity,inflammation,GT-TRE,hyperglycemic,lipid,insulin resistance, | en |
| dc.relation.page | 95 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-08-13 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 微生物與生化學研究所 | zh_TW |
| 顯示於系所單位： | 微生物學科所 | |
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