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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 潘子明 | |
dc.contributor.author | Hui-Hsuan Wang | en |
dc.contributor.author | 王惠宣 | zh_TW |
dc.date.accessioned | 2021-06-15T05:54:28Z | - |
dc.date.available | 2010-08-19 | |
dc.date.copyright | 2010-08-19 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-17 | |
dc.identifier.citation | 王俐婷、宋賢一、張珍田,1999。基隆山藥塊莖多酚氧化之純化及性質研究。中國農業化學會誌。37:141-151。
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/47309 | - |
dc.description.abstract | 紅麴發酵產物在亞洲應用於膳食已經有千年以上歷史。本研究以人類和小鼠大腸癌細胞株評估紅麴山藥酒精萃取物對大腸癌細胞之細胞增生、細胞轉移及細胞週期之影響。紅麴山藥酒萃物對大腸癌細胞HCT116、HT29、SW480、SW620與CT26皆有顯著的毒殺能力,對於CT26及SW480更可抑制其轉移作用,並透過抑制細胞週期停滯於sub-G1 phase,誘發大腸癌細胞走向細胞凋亡。此外,本研究利用誘導BALB/c小鼠產生腫瘤,分別建立全身性和局部性大腸癌動物模式,評估紅麴山藥對於大腸癌治療之功效。在局部性動物模式中,首先在小鼠後腿以皮下注射方式植入大腸癌細胞CT26,當腫瘤生長至150 ± 10 mm3 後,每天餵食不同濃度的紅麴山藥,並於四週後犧牲動物。全身性動物模式中,以脾臟注射的方式植入小鼠大腸癌細胞CT26,模擬臨床上大腸癌發生肝臟轉移的症狀,並於隔天摘除脾臟,同時開始每天餵食不同濃度紅麴山藥,持續四週,並分別在一到四週犧牲動物。研究結果顯示,不論是局部性或全身性之大腸癌動物模式,餵食紅麴山藥的實驗組其腫瘤嚴重程度都較控制組來的低,不但抑制腫瘤生長,更有抑制癌細胞轉移至其他器官的能力。因此,在大腸癌治療過程中,紅麴山藥具有相當潛力可以應用為一輔助治療劑。 | zh_TW |
dc.description.abstract | Red mold fermented products have been applied to food for over centuries in Asia. In the present study, ethanol extract of red mold dioscorea (RMDE) was selected for investigating the effects on cell proliferation, cell migration and cell cycle in human and mouse colon cancer cells. The results showed that RMDE decreased cellular proliferation in HCT116, HT29, SW480, SW620 human colon cancer cells and CT26 mouse colon cancer cells. RMDE also decreased cellular migration in CT26 and SW480. RMDE inhibited cell cycle arrest at sub-G1 phase with further apoptosis induced. In the animal model, in order to evaluate the effect of RMDE on colon cancer, we established local and systemic colon cancer model in BALB/c by injecting CT26 mouse colon cancer cells. In local model, CT26 were injected subcutaneously. When tumor size reached 150 ± 10 mm3, mice were gavaged with different dose of RMDE daily and sacrificed after 4 weeks. In systemic model, intrasplenic injection of CT26 was performed to simulate the clinical liver metastasis of colon cancer. Different dose of RMDE daily gavage began at the next day for 4 weeks and mouse were sacrificed in 1, 2, 3, 4 weeks, respectively. Regardless of local or systemic model, the results showed that the tumor size and degree were reduced by RMDE. Cell proliferation and migration were inhibited by RMDE, indicating the potential of red mold dioscorea in cure treatment or adjuvant for colon cancer therapy. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T05:54:28Z (GMT). No. of bitstreams: 1 ntu-99-R97b47113-1.pdf: 8519284 bytes, checksum: 8fe87ced59e1685f938be265d3e42c32 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 摘要………………………………………………………………………………… III
第一章 前言…………………………………………………………………………1 一、大腸癌……………………………………………………………………………1 二、紅麴菌………………………………………………………………………… 5 三、山藥之背景與簡介………………………………………………… 25 四、細胞週期與細胞凋亡的關係……………………………… 34 五、大腸癌動物模式的建立……………………………………………………… 37 第二章 研究動機與目的……………………………………………………………39 第三章 材料與方法…………………………………………………………………42 一、實驗材料…………………………………………………………………………42 二、實驗方法…………………………………………………………………………43 第四章 結果與討論…………………………………………………………………53 一、體外試驗…………………………………………………………………………53 (一) 紅麴山藥酒萃物對大腸癌細胞之細胞存活率影響………………………53 (二) 紅麴山藥酒萃物對大腸癌細胞之移行作用影響……………………………57 (三) 紅麴山藥酒萃物對大腸癌細胞之細胞週期影響…………………………59 (四) 各種純物質對大腸癌細胞之細胞存活率影響………………………………63 (五) 體外試驗綜合討論……………………………………………………………74 二、體內試驗…………………………………………………………………………74 (一) 紅麴山藥酒萃物降低局部性腫瘤之大小與體積…………………………73 (二) 紅麴山藥酒萃物降低轉移至肝臟生長之腫瘤數量及大小………………82 (三) 體內試驗綜合討論…………………………………………………………89 第五章 綜合討論……………………………………………………………………90 第六章 參考文獻……………………………………………………………………93 | |
dc.language.iso | zh-TW | |
dc.title | 紅麴山藥酒精萃取物對於大腸癌細胞
生長及轉移治療效果之研究 | zh_TW |
dc.title | Effect of Red Mold Dioscorea Ethanol Extract
On Proliferation and Metastasis of Colon Cancer Cell | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蘇遠志,黃健雄,張金堅,吳耀銘 | |
dc.subject.keyword | 紅麴發酵產物,紅麴山藥,大腸癌, | zh_TW |
dc.subject.keyword | Monascus-fermented products,red mold dioscorea,colon cancer,intrasplenic injection,subcutaneous injection, | en |
dc.relation.page | 103 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-08-18 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 微生物與生化學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
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