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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張惠婷(Hui-Ting Chang) | |
| dc.contributor.author | Yann-Ru Lou | en |
| dc.contributor.author | 駱彥如 | zh_TW |
| dc.date.accessioned | 2021-06-15T05:52:40Z | - |
| dc.date.available | 2015-08-20 | |
| dc.date.copyright | 2010-08-20 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-08-17 | |
| dc.identifier.citation | 應紹舜（1996）台灣高等植物彩色圖誌 第一卷。台北。pp. 79-80。
鄭森松、張惠婷、古惠菁、古喬云、張上鎮（2006）黑心柳杉造林木精油及其成分之抗真菌活性。中華林學季刊 39:557-574. 李文馨（2008）柳杉樹皮抗細菌及抗氧化活性成分之研究，國立臺灣大學生農學院森林環境暨資源學研究所。 Adams, R.P. (1991) Cedar wood oil: Analyses and properties. In H.F Linksens and J.F. Jackson (Eds.), Modern Methods of Plant Analysis, New Series: Essential Oils and Waxes. Springer Verlag: Berlin. pp. 159-171. Adams, R.P. (2007) Identification of Essential Oil Components by Gas Chromatography/ Mass Spectroscopy (4th ed.). Allured Publishing Corp.: Carol Stream IL. pp. 489-608, 761-785. Arihara, S., A. Umeyama, S. Bando, S. Imoto, M. Ono, M. Tani and K. Yoshikawa (2004) A new abietane and two dimeric abietane diterpenes from the black heartwood of Cryptomeria japonica. Chemical & Pharmaceutical Bulletin 52:354-358. Ashitani, T., M. Ujike, S. Nagahama, T. Ueno and K. Sakai (2001) Characterization of sugi (Cryptomeria japonica) bark extracts. Journal of Japan Wood Research Society 47:276-281. Baiker, A. (1999) Supercritical fluids in heterogeneous catalysis. Chemical Reviews 99:453-474. Bakkali, F., S. Averbeck, D. Averbeck and M. Idaomar (2008) Biological effects of essential oils - a review. Food and Chemical Toxicology 46:446-475. Bartley, J.P. and P. Foley (1994) Supercritical fluid extraction of Australian-grown ginger (Zingiber officinale). Journal of the Science of Food and Agriculture 66:365-371. Bauer, K., D. Garbe and H. Surburg H (Eds.) (1990) Common Fragrance and Flavor Materials. Wiley-VCH Verlag: Weinheim. pp. 1-5. Bispo de Jesus, M., W.F. Zambuzzi, R.R. Ruela de Sousa, C. Areche, A.C. Santos de Souza, H. Aoyama, G. Schmeda-Hirschmann, J.A. Rodriguez, A.R. Monteiro de Souza Brito and M.P. Peppelenbosch (2008) Ferruginol suppresses survival signaling pathways in androgen-independent human prostate cancer cells. Biochimie 90:843-854. Brunner, G. (1994) Gas extraction: An introduction to fundamentals of supercritical fluids and the application to separation processes; In H. Baumgürtel, E.U. Franck and W. Grünbein (Eds.), Topic in Physical Chemistry. Springer Verlag: New York. pp. 59-73. Burt, S. (2004) Essential oils: Their antibacterial properties and potential applications in foods - a review. International Journal of Food Microbiology 94:223-253. Cagniard de LaTour, C. (1822) Supercritical fluids. Annales de Chimie Physic 21:127-132. Cha, J.D., M.R. Jeong, S.I. Jeong, S.E. Moon, B.S. Kil, S.I. Yun, K.Y. Lee and Y.H. Song (2007) Chemical composition and antimicrobial activity of the essential oil of Cryptomeria japonica. Phytotherapy Research 21:295-299. Chaillou, L.L. and M.A. Nazareno (2006) New method to determine antioxidant activity of polyphenols. Journal of Agricultural and Food Chemistry 54:8397-8402. Cavalcanti, E.S.B., S.M. Morais, M.A.A. Lima and E.W.P. Santana (2004) Larvicidal activity of essential oils from brazilian plants against Aedes aegypti. Memorias do Instituto Oswaldo Cruz 99:541-544. Chen, X., J. Ding, Y.M. Ye and J.S. Zhang (2002) Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis. Journal of Natural Products 65:1016-1020. Cheng, S.S., H.T. Chang, S.T. Chang, K.H. Tsai and W.J. Chen (2003) Bioactivity of selected plant essential oils against the yellow fever mosquito Aedes aegypti larvae. Bioresource Technology 89:99-102. Cheng, S.S., J.Y. Liu, K.H. Tsai, W.J. Chen and S.T. Chang (2004) Chemical composition and mosquito larvicidal activity of essential oils from leaves of different Cinnamomum osmophloeum provenances. Journal of Agricultural and Food Chemistry 52:4395-4400. Cheng, S.S., H.Y. Lin and S.T. Chang (2005) Chemical composition and antifungal activity of essential oils from different tissues of Japanese cedar (Cryptomeria japonica). Journal of Agricultural and Food Chemistry 53:614-619. Cheng, S.S., C.G. Huang, W.J. Chen, Y.H. Kuo and S.T. Chang (2008) Larvicidal activity of tectoquinone isolated from red heartwood-type Cryptomeria japonica against two mosquito species. Bioresource Technology 99:3617-3622. Cheng, S.S., H.T. Chang, C.Y. Lin, P.S. Chen, C.G. Huang, W.J. Chen and S.T. Chang (2009) Insecticidal activities of leaf and twig essential oils from Clausena excavate against Aedes aegypti and Aedes albopictus larvae. Pest Management Science 65:339-343. Choi, Y.H., J. Kim, M.J. Noh, E.S. Choi and K.P. Yoo (1997) Comparison of supercritical carbon dioxide extraction with solvent extraction of nonacosan-10-ol, a-amyrin acetate, squalene and stigmasterol from medicinal plants. Phytochemical Analysis 8:233-237. Choi, Y.H., J. Kim, S.H. Jeon, K.P. Yoo and H.K. Lee (1998) Optimum SFE condition for lignans of Schisandra chinensis fruits. Chromatographia 48:695-699. Chun, M.K., H.W. Shin, Η. Lee and J.R. Liu (1994) Supercritical fluid extraction of taxol and baccatin ü from needles of Taxus cuspidata. Biotechnology Techniques 8:547-550. Clevenger, J.F. (1928) Apparatus for determination of essential oils. Journal of America Pharmacology Association 17:346-349. Da Costa, C.T., S.A. Margolis, B.A. Benner Jr and D. Horton (1999) Comparison of methods for extraction of flavanones and xanthones from the root bark of the osage orange tree using liquid chromatography. Journal of Chromatography A 831:167-178. Del Valle, J.M., C. Godoy, M. Asencio and J.M. Aguilera (2004) Recovery of antioxidants from boldo (Peumus boldus M.) by conventional and supercritical CO2 extraction. Food Research International 37:695-702. Del Valle, J.M., T. Rogalinski, C. Zetzl and G. Brunner (2005) Extraction of boldo (Peumus boldus M.) leaves with supercritical CO2 and hot pressurized water Food Research International 38:203-213. Dev, S. (1989) Terpenoids. In J.W. Rowe (Ed.), Natural Products of Woody Plants Ⅱ. Springer Verlag: Berlin. pp. 691-807. Dobbs, J.M., J.M. Wong, R.J. Lahiere and K.P. Johnston (1987) Modification of supercritical fluid phase behavior using polar cosolvents. Industrial & Engineering Chemistry Research 26:56-65. Dung, N.X., P. Van Khien, H.T. Chien and P.A. Leclercq (1993) The essential oil of Cinnamomum camphora (L.) Sieb. var. linaloolifera from Vietnam. Journal of Essential Oil research 5:451-453. Ebrahimzadeh, H., Y. Yamini, F. Sefidkon, M. Chaloosi and S.M. Pourmortazavi (2003) Chemical composition of the essential oil and supercritical CO2 extracts of Zataria multiflora boiss. Food Chemistry 83:357-361. Ellington, E., J. Bastida, F. Viladomat and C. Codina (2003) Supercritical carbon dioxide extraction of colchicine and related alkaloids from seeds of Colchicum autumnale L. Phytochemical Analysis 14:164-169. Evans, G.B., R.H. Furneaux, M.B. Gravestock, G.P Lynch and G.K. Scott (1999) The synthesis and antibacterial activity of totarol derivatives. Part 1: Modifications of ring-c and pro-drugs. Bioorganic & Medicinal Chemistry 7:1953-1964. Fadel, H., F. Marx, A. El-Sawy and A. El-Ghorab (1999) Effect of extraction techniques on the chemical composition and antioxidant activity of Eucalyptus camaldulensis var. brevirostris leaf oils. Zeitschrift für Lebensmitteluntersuchung und Forschung A 208:212-216. Fraga, B.M., C.E. Diaz, A. Guadano and A. Gonzalez-Coloma (2005) Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity. Journal of Agricultural and Food Chemistry 53:5200-5206. Fukumoto, L.R. and G. Mazza (2000) Assessing antioxidant and prooxidant activities of phenolic compounds. Journal of Agricultural and Food Chemistry 48:3597-3604. Gu, H.J., S.S. Cheng, C.G. Huang, W.J. Chen and S.T. Chang (2009) Mosquito larvicidal activities of extractives from black heartwood-type Cryptomeria japonica. Parasitology research 105:1455-1458. Guenther, E. (1948) The Essential Oils. D. van Nostrand Inc.: New York. pp. 17-83. Guenther, E., K. Kulka and J.A. Rogers Jr (1959) Essential oils. Analytical Chemistry 31:679-687. Guerrero, I.C., L.S. Andres, L.G. Leon, R.P. Machin, J.M. Padron, J.G. Luis and J. Delgadillo (2006) Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines. Journal of Natural Products 69:1803-1805. Halliwell, B. (1997) Antioxidants and human disease: A general introduction. Nutrition Reviews 55:S44-S49. Hamburger, M., D. Baumann and S. Adler (2004) Supercritical carbon dioxide extraction of selected medicinal plants-effects of high pressure and added ethanol on yield of extracted substances. Phytochemical Analysis 15:46-54. Hanson, J.R. (1998) Diterpenoids. Natural Product Reports 15:93-106. Heaton, D.M., K.D. Bartle, C.M. Rayner and A.A. Clifford (1993) Application of supercritical fluid extraction and supercritical fluid chromatography to the production of taxanes as anti-cancer drugs. Journal of High Resolution Chromatography 16:666-670. Henning, J.A., R.J. Core and J.L. Gardea-Torresdey (1994) Extracting volatile compounds from single plants using supercritical fluid extraction. Crop Science 34:1120-1122. Herrero, M., A. Cifuentes and E. Ibañez (2006) Sub-and supercritical fluid extraction of functional ingredients from different natural sources: Plants, food-by-products, algae and microalgae: A review. Food Chemistry 98:136-148. Illes, V., H.G. Daood, S. Perneczki, L. Szokonya and M. Then (2000) Extraction of coriander seed oil by CO2 and propane at super-and subcritical conditions. The Journal of Supercritical Fluids 17:177-186. Imdorf, A., S. Bogdanov, R.I. Ochoa and N.W. Calderone (1999) Use of essential oils for the control of Varroa jacobsoni Oud. in honey bee colonies. Apidologie 30:209-228. Jantan, I. and S.H. Goh (1992) Essential oils of Cinnamomum species from peninsular Malaysia. Journal of Essential Oil research 4:161-171. Jublot, L., R.S.T. Linforth and A.J. Taylor (2004) Direct coupling of supercritical fluid extraction to a gas phase atmospheric pressure chemical ionisation source ion trap mass spectrometer for fast extraction and analysis of food components. Journal of Chromatography A 1056:27-33. Kabouche, A., Z. Kabouche, M. Öztürk, U. Kolak and G.I. Topçu (2007) Antioxidant abietane diterpenoids from Salvia barrelieri. Food Chemistry 102:1281-1287. Kaufmann, P.B., L.J. Cseke, S. Warber S, J.A. Duke and H.L. Brielmann (Eds.) (1999) Natural Products from Plants. CRC Press: United States of America. pp. 9-17. Kerrola, K.M. and H.P. Kallio (1994) Extraction of volatile compounds of angelica (Angelica archangelica L.) root by liquid carbon dioxide. Journal of Agricultural and Food Chemistry 42:2235-2245. Khajeh, M., Y. Yamini, N. Bahramifar, F. Sefidkon and M. Reza Pirmoradei (2005) Comparison of essential oils compositions of Ferula assa-foetida obtained by supercritical carbon dioxide extraction and hydrodistillation methods. Food Chemistry 91:639-644. King-Dìaz, B., P.A. Castelo-Branco, F.J.L. dos Santos, M.M.M. Rubinger, D.L. Ferreira-Alves, D. Pilu-Veloso and B. Lotina-Hennsen (2009) Furanoditerpene ester and thiocarbonyldioxy derivatives inhibit photosynthesis. Pesticide Biochemistry and Physiology 3:119-126. Kofujita, H., Y. Fujino, T. Sasaki, M. Hasebe, M. Ota and K. Suzuki (2001) Antifungal activity of the bark of Cryptomeria japonica and its relevant components. Mokuzai Gakkaishi 47:479-486. Kofujita, H., M. Ota, K. Takahashi, Y. Kawai and Y. Hayashi (2002) A diterpene quinone from the bark of Cryptomeria japonica. Phytochemistry 61:895-898. Kofujita, H., Y. Fujino, M. Ota and K. Takahashi (2006) Antifungal diterpenes from the bark of Cryptomeria japonica D. Don. Holzforschung 60:20-23. Krebs, H.C. and H. Ramiarantsoa (1997) Clerodane diterpenes of Croton hovarum. Phytochemistry 45:379-381. Kuo, P.M., F.H. Chu, S.T. Chang, W.F. Hsiao and S.Y. Wang (2007) Insecticidal activity of essential oil from Chamaecyparis formosensis. Holzforschung 61:595-599. Lang, Q. and C.M. Wai (2001) Supercritical fluid extraction in herbal and natural product studies - practical review. Talanta 53:771-782. Le Floch, F., M.T. Tena, A. Rios and M. Valcarcel (1998) Supercritical fluid extraction of phenol compounds from olive leaves. Talanta 46:1123-1130. Li, W.H., S.T. Chang, S.C. Chang and H.T. Chang (2008) Isolation of antibacterial diterpenoids from Cryptomeria japonica bark. Natural Product Research 22:1085-1093. Lin, F.M., C.H. Tsai, Y.C. Yang, W.C. Tu, L.R. Chen, Y.S. Liang, S.Y. Wang, L.F. Shyur, S.C. Chien and T.L. Cha (2008) A novel diterpene suppresses cwr22rv1 tumor growth in vivo through antiproliferation and proapoptosis. Cancer Research 68:6634-6642. Liu, J., R. Ando, K. Shimizu, K. Hashida, R. Makino, S. Ohara and R. Kondo (2008) Steroid 5-reductase inhibitory activity of condensed tannins from woody plants. Journal of Wood Science 54:68-75. MacDonald-Wicks, L.K., L.G. Wood and M.L. Garg (2006) Methodology for the determination of biological antioxidant capacity in vitro: A review. Journal of the Science of Food and Agriculture 86:2046-2056. MacMillan, J. and M.H. Beale (1999) Diterpene biosynthesis. Comprehensive Natural Products Chemistry 2:217-243. Martinez, J.L. (Ed.) (2007) Supercritical Fluid Extraction of Nutraceuticals and Bioactive Compounds. CRC Press: Boca Raton FL. pp.220-222. Masella, R., R. Di Benedetto, R. Varì, C. Filesi and C. Giovannini (2005) Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes. The Journal of Nutritional Biochemistry 16:577-586. Matsushita, Y., Y.H. Hwang, K. Sugamoto and T. Matsui (2006) Antimicrobial activity of heartwood components of sugi (Cryptomeria japonica) against several fungi and bacteria. Journal of Wood Science 52:552-556. Mendiola, J.A., M. Herrero, A. Cifuentes and E. Ib•Òez (2007) Use of compressed fluids for sample preparation: Food applications. Journal of Chromatography A 1152:234-246. Mikhaeil, B.R., G.T. Maatooq, F.A. Badria and M.M.A. Amer (2003) Chemistry and immunomodulatory activity of frankincense oil. Zeitschrift für Naturforschung (Journal of Biosciences) 58:230-238. Miller, N.J. and C.A. Rice-Evans (1997) Factors influencing the antioxidant activity determined by the ABTS+ radical cation assay. Free Radical Research 26:195-199. Milner, C.P., R.D. Trengove, C.M. Bignell and P.J. Dunlop (1997) Supercritical CO2 extraction of the essential oils of eucalypts: A comparison with other methods. In H.F. Linskens and J.F. Jackson (Eds.), Plant Volatile Analysis. Springer Verlag: New York. pp. 141-154. Muhammad, I., J. Mossa and F. El-Feraly (1992) Antibacterial diterpenes from the leaves and seeds of Juniperus excelsa M. Bieb. Phytotherapy Research 6:261-264. Nakajima, K., T. Yoshimoto and T. Fukuzumi T (1980) Substance inhibiting growth of Shiitaka mycelium in sugi wood (Cryptomeria japonica D. Don). Mokuzai Gakkaishi 26:698-702. Narita, H. and M. Yatagai (2006) Terpenes from bogwood of Cryptomeria japonica D.Don and characterization of its ash. Organic Geochemistry 37:818-826. Nicolson, K., G. Evans and P.W. O'Toole (1999) Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes. FEMS Microbiology Letters 179:233-239. Otto, A., H. Walther and W. Püttmann (1997) Sesqui- and diterpenoid biomarkers preserved in Taxodium-rich Oligocene oxbow lake clays, Weisselster basin, Germany. Organic Geochemistry 26:105-115. Piggott, M.J., E.L. Ghisalberti and R.D. Trengove (1998) Western Australian sandalwood oil: Extraction by different techniques and variations of the major components in different sections of a single tree. Flavour and Fragrance Journal 12:43-46. Pourmortazavi, S.M., P. Baghaee and M.A. Mirhosseini (2004) Extraction of volatile compounds from Juniperus communis L. leaves with supercritical fluid carbon dioxide: Comparison with hydrodistillation. Flavour and Fragrance Journal 19:417-420. Pourmortazavi, S.M. and S.S. Hajimirsadeghi (2007) Supercritical fluid extraction in plant essential and volatile oil analysis. Journal of Chromatography A 1163:2-24. Rao, M.V., A.H. Al-Marzouqi, F.S. Kaneez, S.S. Ashraf and A. Adem (2007) Comparative evaluation of SFE and solvent extraction methods on the yield and composition of black seeds (Nigella sativa). Journal of Liquid Chromatography & Related Technologies 30:2545-2555. Raynie, D.E. (2006) Modern extraction techniques. Analytical Chemistry 78:3997-4004 Re, R., N. Pellegrini, A. Proteggente, A. Pannala, M. Yang and C. Rice-Evans (1999) Antioxidant activity applying an improved ABTS+ radical cation decolorization assay. Free Radical Biology and Medicine 26:1231-1237. Reverchon, E. and F. Senatore (1992) Isolation of rosemary oil: Comparison between hydrodistillation and supercritical CO2 extraction. Flavour and Fragrance Journal 7:227-230. Reverchon, E., G. Della Porta and D. Gorgoglione (1997) Supercritical CO2 extraction of volatile oil from rose concrete. Flavour and Fragrance Journal 12:37-41. Reverchon, E. and I. De Marco (2006) Supercritical fluid extraction and fractionation of natural matter. The Journal of Supercritical Fluids 38:146-166. Sanchez-Moreno, C. (2002) Review: Methods used to evaluate the free radical scavenging activity in foods and biological systems. Food Science and Technology International 8:121-137. Sargenti, S.R. and F.M. LanÁas FM (1997) Supercritical fluid extraction of Peumus boldus (molina). Journal of High Resolution Chromatography 20:511-515. Sewram, V., M.W. Raynor, D.M. Raidoo and D.A. Mulholland (1998) Coupling SFE to uterotonic bioassay: An on-line approach to analysing medicinal plants. Journal of Pharmaceutical and Biomedical Analysis 18:305-318. Sewram, V., M.W. Raynor, D.A. Mulholland and D.M. Raidoo (2000) The uterotonic activity of compounds isolated from the supercritical fluid extract of Ekebergia capensis. Journal of Pharmaceutical and Biomedical Analysis 24:133-145. Shimada, K., K. Fujikawa, K. Yahara and T. Nakamura (1992) Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. Journal of Agricultural and Food Chemistry 40:945-948. Shyur, L.F., C.C. Huang, C.P. Lo, C.Y. Chiu, Y.P. Chen, S.Y. Wang and S.T. Chang (2008) Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators. Phytochemistry 69:1348-1358. Simo, C., E. Ibanez, F.J. Senorans, C. Barbas, G. Reglero and A. Cifuentes (2002) Analysis of antioxidants from orange juice obtained by countercurrent supercritical fluid extraction, using micellar electrokinetic chromatography and reverse-phase liquid chromatography. Journal of Agricultural and Food Chemistry 50:6648-6652. Sjödin, K., M. Persson, A.K. Borg-Karlson and T. Norin (1996) Enantiomeric compositions of monoterpene hydrocarbons in different tissues of four individuals of Pinus sylvestris. Phytochemistry 41:439-445. Solano, F., S. Briganti, M. Picardo and G. Ghanem (2006) Hypopigmenting agents: An updated review on biological, chemical and clinical aspects. Pigment Cell Researchs 19:550-571. Son, K.H., H.M. Oh, S.K. Choi, D.C. Han and B.M. Kwon (2005) Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens. Bioorganic & Medicinal Chemistry Letters 15:2019-2021. Song, K.M., S.W. Park, W.H. Hong, H. Lee, S.S. Kwak and J.R. Liu (2008) Isolation of vindoline from Catharanthus roseus by supercritical fluid extraction. Biotechnology Progress 8:583-586. Stashenko, E.E., B.E. Jaramillo and J.R. MartÌnez (2004) Comparison of different extraction methods for the analysis of volatile secondary metabolites of Lippia alba (Mill.) N.E. Brown, grown in Colombia, and evaluation of its in vitro antioxidant activity. Journal of Chromatography A 1025:93-103. Su, W.C., J.M. Fang and Y.S. Cheng (1994) Abietanes and kauranes from leaves of Cryptomeria japonica. Phytochemistry 35:1279-1284. Sun, T. and C.T. Ho (2005) Antioxidant activities of buckwheat extracts. Food Chemistry 90:743-749. Takei, M., A. Umeyama, N. Shoji and T. Hashimoto (2008) Diterpene, 16-phyllocladanol enhances Th1 polarization induced by LPS-primed DC, but not TNF-α-primed DC. Biochemical and Biophysical Research Communications 370:6-10. Taylor, L.T. (1996) Supercritical Fluid Extraction. John Wiley & Sons: New York. pp.2-7. Topçu, G. and A.C. Gören (2007) Biological activity of diterpenoids isolated from Anatolian Lamiaceae plants. Records of Natural Products 1:1-16. Tsuda, T., K. Mizuno, K. Ohshima, S. Kawakishi and T. Osawa T (1995) Supercritical carbon dioxide extraction of antioxidative components from tamarind (Tamarindus indica L.) seed coat. Journal of Agricultural and Food Chemistry 43:2803-2806. Tsutsumi, Y., A. Shimada, A. Miyano, T. Nishida and T. Mitsunaga (1998) In vitro screening of angiotensin i-converting enzyme inhibitors from Japanese cedar (Cryptomeria japonica). Journal of Wood Science 44:463-468. Tu, W.C., S.Y. Wang, S.C. Chien, F.M. Lin, L.R. Chen, C.Y. Chiu and P.W. Hsiao (2007) Diterpenes from Cryptomeria japonica inhibit androgen receptor transcriptional activity in prostate cancer cells. Planta Medica 73:1407-1409. Tuley de Silva, K. (1996) A manual on the essential oil industry. United Nations Industrial Development Organization, Vienna. pp. 1-13. Van de Braak, S. and G. Leijten (1999) Essential oils and oleoresins: A survey in the Netherlands and other major markets in the European Union. CBI, Centre for the Promotion of Imports from Developing Countries, Rotterdam. pp. 116. Wang, L. and C.L. Weller (2006) Recent advances in extraction of nutraceuticals from plants. Trends in Food Science & Technology 17:300-312. Wang, S.Y., J.H. Wu, L.F. Shyur, Y.H. Kuo and S.T. Chang (2002) Antioxidant activity of abietane-type diterpenes from heartwood of Taiwania cryptomerioides Hayata. Holzforschung 56:487-492. Wang. S.Y., W.C. Lai, F.H. Chu, C.T. Lin, S.Y. Shen and S.T. Chang (2006) Essential oil from the leaves of Cryptomeria japonica acts as a silverfish (Lepisma saccharina) repellent and insecticide. Journal of Wood Science 52:522-526. Wang, Z., M. Ashraf-Khorassani and L.T. Taylor (2005) Feasibility study of online supercriticalfluid extraction - liquid chromatography - UV absorbance – mass spectrometry for the determination of proanthocyanidins in grape seeds. Journal of Chromatographic Science 43:109-115. Wani, M.C., H.L. Taylor, M.E. Wall, P. Coggon and A.T. McPhail (1971) Plant antitumor agents. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. Journal of the American Chemical Society 93:2325-2327. Yang, C., Y.R. Xu and W.X. Yao (2002) Extraction of pharmaceutical components from Ginkgo biloba leaves using supercritical carbon dioxide. Journal of Agricultural and Food Chemistry 50:846-849. Yang, Z., Y. Kitano, K. Chiba, N. Shibata, H. Kurokawa, Y. Doi, Y. Arakawa and M. Tada (2001) Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE. Bioorganic and Medicinal Chemistry 9:347-356. Yatagai, M., H. Makihara and K. Oba (2002) Volatile components of Japanese cedar cultivars as repellents related to resistance to Cryptomeria bark borer. Journal of Wood Science 48:51-55. Yoshikawa, K., T. Tanaka, A. Umeyama and S. Arihara (2006) Three abietane diterpenes and two diterpenes incorporated sesquiterpenes from the bark of Cryptomeria japonica. Chemical & Pharmaceutical Bulletin 54:315-319. Zosel K (1981) Process for the decaffeination of coffee. US Patent 4260639. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/47260 | - |
| dc.description.abstract | 柳杉（Cryptomeria japonica D. Don）分佈於東亞，廣泛地用為建築及家具材料。傳統木材加工業普遍無法有效利用柳杉之樹皮，因此開發樹皮的應用，非常值得研究。本研究使用超臨界流體萃取法及水蒸餾萃取法萃取柳杉樹皮，並利用氣相層析質譜和核磁共振光譜鑑定成分，並評估超臨界萃取物的生物活性。
結果顯示，在不同壓力及溫度下超臨界流體萃取物的收率，約為水蒸餾法精油收率的 2-4 倍。進一步比較超臨界流體萃取及水蒸餾精油之化學成分則可以發現，超臨界萃取物所含之雙ᑒ類化合物比率高於水蒸餾精油。水蒸餾法萃取所得之精油主要成分為 Cubebol、γ-Eudesmol、β-Eudesmol、15-Kaurene、Phyllocladan-16α-ol 和 Ferruginol；而超臨界萃取物的主要成分則是 Cubebol、Phyllocladan-16α-ol、Ferruginol、6,7-Dehydroferruginol、Cryptojaponol、Isopimaric acid 和 Sugiol。綜合而言，柳杉樹皮的超臨界萃取物，除了收率較高，也較水蒸餾法精油含有較高量的含氧雙帖類化合物。 生物活性評估顯示，柳杉樹皮超臨界流體萃取物與精油清除 DPPH 自由基與TEAC 總抗氧化的效果相近。超臨界流體萃取物於抑制 β-胡蘿蔔素脫色之效果則有優於精油的表現。超臨界萃取物與精油對於酪胺酶的抑制效果均不顯著。抗病媒蚊幼蟲活性方面，超臨界流體萃取物擁有優異的活性，對埃及斑蚊和白線斑蚊幼蟲具有良好的毒殺活性。評估超臨界流體萃取物中的 5 種雙帖化合物的抗病媒蚊活性，以 Cryptojaponol 對病媒蚊幼蟲的毒殺效果最佳，優於正對照組的魚藤精。 綜合試驗結果顯示柳杉樹皮萃取物與 Cryptojaponol 相當具有開發為天然抗病媒蚊幼蟲藥劑之潛力。 | zh_TW |
| dc.description.abstract | Cryptomeria japonica D. Don (Japanese cedar; sugi), a traditional constructural material, is a conifer tree distributed in East Asia. Despite the popular usage of sugi
wood, the utilization of sugi bark is limited in the lumber industry. Recently, researchers have suggested that the usage of extracts may be a promosing method for bark utilization. Supercritical CO2 fluid extraction and hydrodistillation were used to extract C. japonica bark in this study. Chemical constituents of supercritical extract (SFE) and essential oil (EO) of sugi bark were identified by GC-MS and NMR analyses. Bioactivities of the extracts were also evaluated. Results showed that supercritical extraction yields under different temperatures and pressures were all much higher than that of EO obtained by hydrodistillation. Further comparison of the chemical composition between SFE and EO showed that SFE was composed of more diterpenoids than that of EO. The main constituents of EO were cubebol, γ-eudesmol, β-eudesmol, 15-kaurene, phyllocladan-16α-ol and ferruginol. As for SFE, cubebol, phyllocladan-16α-ol, 6,7-dehydroferruginol, ferruginol, isopimaric acid, cryptojaponol and sugiol were the major constituents. SFE of sugi bark showed a higher content of oxygenated diterpenes. Comparison of the bioactivities of these extracts showed that, although SFE has low inhibitory activity against the DPPH radical and ABTS˙+ radical (TEAC assay), it could effectively reduce β-carotene bleaching. EO, however, did not show significant antioxidation activities in these 3 in vitro tests. Tyrosinase inhibitory activities of these extracts were insignificant. SFE showed high mosquito larvicidal activity, LC50 of SFE against Aedes aegypti and Ae. albopictus larvae were both lower than the LC50 of positive control, rotenone. Five diterpene compounds were isolated from SFE and further tested; cryptojaponol presented the highest inhibitory performance among the compounds, and showed better activity than the positive control. Results indicated that supercritical fluid extracts from C. japonica bark and cryptojaponol possess high larvicidal activity, and are highly potent to be used as natural pesticides. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T05:52:40Z (GMT). No. of bitstreams: 1 ntu-99-R97625004-1.pdf: 4683064 bytes, checksum: 845cd7863862d76aab0624cc9d78ea28 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 中文摘要……………………………………………………………………………. Ⅰ
Abstract…………………………………………………………………………….. Ⅱ 目錄………………………………………………………………………………… Ⅲ 圖目錄……………………………………………………………………………… Ⅶ 表目錄……………………………………………………………………………… XII 壹、前言…………………………………………………………………………….. 1 貳、文獻回顧……………………………………………………………………….. 2 一、植物之ᑒ類天然物…………………………………………………………….. 2 （一）、單ᑒ類化合物……………………………………………………….. 3 （二）、倍半ᑒ類化合物…………………………………………………….. 5 （三）、雙ᑒ類化合物……………………………………………………….. 7 二、植物天然物之萃取…………………………………………………………… 10 （一）、水蒸餾萃取法……………………………………………………… 10 （二）、有機溶劑萃取法…………………………………………………… 11 （三）、超臨界流體萃取法………………………………………………… 12 1. 超臨界流體萃取法之方法…………………………………………….... 14 2. 超臨界流體萃取法之特色與優點……………………………………… 15 (1) 可以較佳之效率獲得較高的收率 …………………………………. 15 (2) 可以進行微樣品萃取 ………………………………………………. 16 (3) 超臨界流體萃取具有較高的選擇性 ………………………………. 17 (4) 無溶劑殘留問題 ……………………………………………………. 19 (5) 可以獲得較符合真實的精油成分 …………………………………. 20 (6) 可以串連分析儀器進行線上偵測 …………………………………. 20 (7) 對環境破壞較小 ……………………………………………………. 21 3. 超臨界流體萃取與傳統萃取之成分差異……………………………… 21 三、柳杉樹皮之成分分析與生物活性…………………………………………… 25 （一）、柳杉樹皮之成分分析……………………………………………….25 （二）、柳杉樹皮及抽出成分之生物活性………………………………….29 1. 抗真菌活性………………………………………………………………29 2. 抗細菌活性………………………………………………………………30 3. 抗病媒蚊活性……………………………………………………………32 4. 抗癌活性…………………………………………………………………33 5. 降血脂活性………………………………………………………………35 6. 抗氧化活性………………………………………………………………36 8. 抑制雄性禿頭活性………………………………………………………36 參、材料與方法…………………………………………………………………… 39 一、試驗材料……………………………………………………………………… 39 （一）、柳杉樹皮…………………………………………………………… 39 （二）、試驗藥品與溶劑…………………………………………………… 39 1. 藥品…………………………………………………………………….... 39 2. 溶劑…………………………………………………………………….... 39 二、試驗方法……………………………………………………………………… 40 （一）、柳杉樹皮水蒸餾法精油之製備…………………………………… 40 （二）、柳杉樹皮超臨界萃取物之製備…………………………………… 40 （三）、柳杉樹皮超臨界萃取物成分之分析……………………………… 40 1. 氣相層析儀串連質譜分析儀……………………………………………40 2. 高效能液相層析儀………………………………………………………41 3. 化合物結構之鑑定………………………………………………………41 （四）、抗氧化活性試驗…………………………………………………… 42 1. DPPH 自由基清除試驗………………………………………………… 42 2. 抑制 β-胡蘿蔔素脫色試驗……………………………………………... 42 3. 總抗氧化能力……………………………………………………………43 （五）、抑制酪胺酸ઽ活性………………………………………………….44 1. 使用多巴作為受質的抑制催化能力試驗 ……………………………...44 2. 使用酪胺酸作為受質的抑制催化能力試驗 ………………………….. 45 （六）、抗病媒蚊幼蟲試驗………………………………………………… 45 （七）、統計分析…………………………………………………………… 45 肆、結果與討論…………………………………………………………………… 46 一、超臨界流體萃取物與精油之成分分析……………………………………… 46 （一）、超臨界流體萃取物之成分分析…………………………………… 46 （二）、壓力對超臨界流體萃取之影響…………………………………… 50 1. 壓力對超臨界流體萃取之收率影響………………………………….. 50 2. 壓力對超臨界流體萃取物之成分影響……………………………….. 51 （三）、溫度對超臨界流體萃取之影響…………………………………… 54 1. 溫度對超臨界流體萃取之收率影響………………………………….. 54 2. 溫度對超臨界流體萃取物之成分影響……………………………….. 55 （四）、輔助溶劑的添加對超臨界流體萃取之影響……………………… 58 1. 添加輔助溶劑對超臨界流體萃取之收率影響……………………….. 58 2. 添加輔助溶劑對超臨界流體萃取物之成分影響…………………….. 60 （五）、超臨界流體萃取物與水蒸餾精油之比較………………………… 63 1. 超臨界流體萃取物與水蒸餾精油之收率比較……………………….. 63 2. 超臨界流體萃取物與水蒸餾精油之抽出成分比較………………….. 63 二、柳杉樹皮超臨界流體萃取化合物之分離與鑑定…………………………… 67 （一）、主要化合物之分離與鑑定………………………………………… 67 1. 化合物 Ferruginol 之分離與鑑定 ………………………………………67 2. 化合物 6,7-Dehydroferruginol 之分離與鑑定…………………………..69 3. 化合物 Cryptojaponol 之分離與鑑定………………………………….. 71 4. 化合物 Isopimaric acid 之分離與鑑定………………………………….73 5. 化合物 Phyllocladan-16α-ol 之分離與鑑定…………………………….75 （二）、其他化合物之鑑定………………………………………………… 77 三、 柳杉樹皮超臨界流體萃取之生物活性探討…………………………..…… 84 （一）、抗氧化活性評估…………………………………………………… 84 1. DPPH 自由基捕捉活性………………………………………………… 84 2. 抑制 β-胡蘿蔔素脫色能力………………………………………………86 3. TEAC 總抗氧化活性…………………………………………………… 87 （二）、抑制酪胺酸ઽ活性…………………………………………………. 88 （三）、抗病媒蚊幼蟲活性…………………………………………………. 89 1. 埃及斑蚊幼蟲毒殺效果………………………………………………… 89 2. 白線斑蚊幼蟲毒殺效果………………………………………………… 92 3. 化合物之抗病媒蚊幼蟲活性評估……………………………………… 96 伍、結論……………………………………………………………………………. 98 陸、參考文獻………………………………………………………………………100 | |
| dc.language.iso | zh-TW | |
| dc.subject | 樹皮 | zh_TW |
| dc.subject | Cryptojaponol | zh_TW |
| dc.subject | 柳杉 | zh_TW |
| dc.subject | 抗病媒蚊幼蟲活性 | zh_TW |
| dc.subject | 超臨界流體萃取 | zh_TW |
| dc.subject | Cryptomeria japonica D. Don | en |
| dc.subject | Crytojaponol | en |
| dc.subject | Mosquito larvicidal activity | en |
| dc.title | 柳杉樹皮超臨界流體萃取物之成分與生物活性研究 | zh_TW |
| dc.title | Studies on the Constituents and Bioactivities of Supercritical Fluid Extracts from Cryptomeria japonica Bark | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張上鎮(Shang-Tzen Chang),王升陽(Sheng-Yang Wang),謝瑞忠(Jui-Chung Shieh),鄭森松(Sen-Sung Cheng) | |
| dc.subject.keyword | Cryptojaponol,柳杉,樹皮,抗病媒蚊幼蟲活性,超臨界流體萃取, | zh_TW |
| dc.subject.keyword | Crytojaponol,Cryptomeria japonica D. Don,Mosquito larvicidal activity, | en |
| dc.relation.page | 110 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-08-18 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 森林環境暨資源學研究所 | zh_TW |
| 顯示於系所單位： | 森林環境暨資源學系 | |
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