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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳羿貞(Yi-Jane Chen) | |
dc.contributor.author | Kuan-Yen Peng | en |
dc.contributor.author | 彭冠諺 | zh_TW |
dc.date.accessioned | 2021-06-15T05:48:53Z | - |
dc.date.available | 2011-09-09 | |
dc.date.copyright | 2010-09-09 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-19 | |
dc.identifier.citation | Aichelmann-Reidy ME, Yukna RA, Evans GH, Nasr HF, Mayer ET. 2001. Clinical evaluation of acellular allograft dermis for the treatment of human gingival recession. J Periodontol 72: 998-1005.
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A classification of marginal tissue recession. Int J Periodontics Restorative Dent 5: 8-13. Modica F, Del Pizzo M, Roccuzzo M, Romagnoli R. 2000. Coronally advanced flap for the treatment of buccal gingival recessions with and without enamel matrix derivative. A split-mouth study. J Periodontol 71: 1693-1698. Nagata MJ, Bosco AF, Leite CM, Melo LG, Sundefeld ML. 2005. Healing of dehiscence defects following root surface demineralization with tetracycline: a histologic study in monkeys. J Periodontol 76: 908-914. Niknejad H, Peirovi H, Jorjani M, Ahmadiani A, Ghanavi J, Seifalian AM. 2008. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cell Mater 15: 88-99. Okuda K, Momose M, Miyazaki A, Murata M, Yokoyama S, Yonezawa Y, Wolff LF, Yoshie H. 2000. Enamel matrix derivative in the treatment of human intrabony osseous defects. J Periodontol 71: 1821-1828. Pitaru S, Tal H, Soldinger M, Grosskopf A, Noff M. 1988. 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Homogenous amniotic membrane as a biological dressing for oral mucositis in rats: histomorphometric analysis. Arch Oral Biol 53: 1163-1171. Weinberg MA, Bral M. 1999. Laboratory animal models in periodontology. J Clin Periodontol 26: 335-340. Weng D, Hurzeler MB, Quinones CR, Pechstadt B, Mota L, Caffesse RG. 1998. Healing patterns in recession defects treated with ePTFE membranes and with free connective tissue grafts. A histologic and histometric study in the beagle dog. J Clin Periodontol 25: 238-245. Wennstrom JL. 1987. Lack of association between width of attached gingiva and development of soft tissue recession. A 5-year longitudinal study. J Clin Periodontol 14: 181-184. Wilderman MN, Wentz FM. 1965. Repair of a Dentogingival Defect with a Pedicle Flap. J Periodontol 36: 218-231. Yang L, Shirakata Y, Shudou M, Dai X, Tokumaru S, Hirakawa S, Sayama K, Hamuro J, Hashimoto K. 2006. New skin-equivalent model from de-epithelialized amnion membrane. Cell Tissue Res 326: 69-77. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/47145 | - |
dc.description.abstract | 固定式矯正裝置改善咬合不正的治療過程中,有時牙齒會發生有不可逆的牙齦萎縮的現象發生。牙齦萎縮可能引起不美觀或者牙根敏感症狀,以牙根覆蓋術式覆蓋暴露牙根是解決上述問題的最佳選擇。羊膜為胎膜的最內層,除了含有許多生長因子,其胞外間質之中含有大量的膠原蛋白基質。因此羊膜適用於組織生長支架材料及傷口敷料,且被證實可以加速傷口癒合及重建受損的器官。本研究之目的為評估羊膜應用於牙根覆蓋之可能性,特別是羊膜對於組織傷口癒合的影響及對牙周組織再生的作用。
本實驗以三隻小獵犬的上下顎第三門齒、上下顎第二、第三、第四小臼齒及上顎第一小臼齒為實驗對象,在實驗牙齒上切除部份牙周組織製造5毫米之骨缺損及牙齦萎縮,一個月後進行牙根覆蓋手術。進行牙根覆蓋手術時,以實驗動物右側上下顎牙齒為實驗組,於牙根覆蓋手術多覆蓋一層羊膜;而左側同名牙齒則為對照組,雖執行牙根覆蓋手術但未加放羊膜。之後,依據實驗組不同,於牙根覆蓋手術之後的第三天、兩星期、一個月、兩個月、六個月,將動物犧牲並進行組織切片觀察。臨床評估包括牙周囊袋深度、牙齦萎縮量及邊緣牙齦發炎程度。組織切片形態分析及量化則包括牙周組織再生情況、牙齦覆蓋高度、上皮高度及厚度等等。 本研究結果發現:羊膜於傷口初期癒合時,具有降低發炎反應、增加牙根覆蓋後傷口區域的血管數量及促進組織癒合之作用,且同時有利於牙齦邊緣的表皮細胞往牙冠部移行生長。因此,組織學形態觀察顯示羊膜應用於牙根覆蓋時,應仍具有促進牙周組織再生的優勢。於牙周組織再生、牙齦覆蓋高度、上皮高度及厚度等量化分析方面,實驗組的牙周組織再生量、牙齦覆蓋量、上皮厚度等組織形態測量較未貼附羊膜的對照組為多,但二組之差異未達統計顯著性。 | zh_TW |
dc.description.abstract | Gingival recession is the most common mucogingival deformity in adult orthodontic patients. Treatment of gingival recession has been an important therapeutic issue due to increasing cosmetic demand. The exposed roots could be covered by various surgical procedures including connective tissue graft, free gingival grafts, coronally positioned flaps, and the use of barrier membranes. The amniotic membrane, the innermost layer of the fetal membrane, contains growth factors and large amount of collagen matrix. Therefore, amniotic membrane has been successfully used as a scaffold for cell growth and as a physiological wound dressing. The aim of this study was to assess the effect of applying de-epithelialized amniotic membrane in root coverage surgery to promote tissue regeneration. In a split-mouth design, the maxillary and mandibular third incisors, canines, second premolars, third premolars, and maxillary first premolars of 3 adult mongrel dogs were used. The buccal osseous dehiscence and gingival recession were surgically created 1 month prior to root coverage surgery, and refined immediately before the surgery. The exposed root surfaces were covered with de-epithelialized human amniotic membrane, and followed by the coronally positioned flap (experimental group). On the contralateral side, the coronally positioned flap was conducted without coverage of amniotic membrane (control group). The clinical parameters assessed during the experimental period included the probing depth and the amount of gingival recession (n =4~5). The observation time points were the 3 days, 2 weeks, 1 months, 2 months, and 6 months after root coverage. After the animals were sacrificed, the specimens of dento-periodontal complex were processed for paraffin sections and stained with haematoxylin-eosin. Histomorphometric evaluations were conducted by analyzing the parameters including the amount of new cementum formation, new bone formation, connective tissue regeneration, root coverage, epithelium thickness and height. Our results revealed that the amniotic membrane may inhibit tissue inflammation and promote rapid epithelialization at the initial healing of the gingival wound. The histomorphometric analysis showed that the periodontal tissue regeneration and root coverage in the experimental group were better than those in the control group. However, the group differences were not statistically significant. Further studies of higher sample size are needed to clearly assess the beneficial effect of applying amniotic membrane in the periodontal surgical procedures for root coverage. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T05:48:53Z (GMT). No. of bitstreams: 1 ntu-99-R96422025-1.pdf: 1437619 bytes, checksum: 5a3e1ec62d3ce8c2028dafc11a72a8ab (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 第一章 文獻回顧…………………………………………….……………………….1
1.1 矯正治療過程中發生牙齦萎縮成因………………………………………….1 1.2 牙根覆蓋…………………………………………....…..………………...……2 1.2.1 牙根覆蓋的術式…..…………………………………………..………..2 1.2.2 牙根覆蓋的組織學觀察……….…………….……….…… …………3 1.2.3 應用於牙根覆蓋的材料……………………………….……………….4 (1) 牙根處理劑…………………………………………..…….….…...5 (2) 牙釉基質衍物…………………………………………..…..……...5 (3) 牙周再生膜…..……………...……………………………...……...6 (4) 無細胞真皮基質移植體…….……………………………..............8 1.3羊膜……………………………………………………………………………..9 1.3.1 羊膜基本結構……………………………….………………………...9 1.3.2 羊膜生物特性………………………………….……………………...9 1.3.3 羊膜機械性質…...…………………………………...………...…….10 1.3.4羊膜的處理………………………………………...…………………10 1.3.5 羊膜應用於口腔的相關文獻…………………….………………….11 第二章 實驗目的……………………………………………………………………13 第三章 實驗材料與方法……………………………………………………………14 3.1 實驗設計..…………………………………………………………………...14 3.2 實驗步驟………..…………………………………………………………...16 3.2.1 動物麻醉..............................................................................................16 3.2.2 實驗流程...…………………………………………………………...17 (1)製造牙齦萎縮及骨缺損………………………………………….17 (2)牙根覆蓋術……………………………………………………….18 (3)動物犧牲………………………………………………………….19 (4)組織切片製作……………………………………….……………20 3.3 統計分析……………………………………………………..……………...21 第四章 結果…………………………………………………………………………22 4.1 重複測量誤差…………………………….……………………………...…...22 4.2 臨床檢查………………...…………………………………….……………...22 4.2.1 牙周囊袋探測結果……………………………………………….…...22 4.2.2 臨床照片描述…………………………………………………….…...23 (1) 6個月組(牙根覆蓋手術至動物犧牲間隔6個月)……………….23 (2) 2個月組(牙根覆蓋手術至動物犧牲間隔2個月)……………….24 (3) 1個月組(牙根覆蓋手術至動物犧牲間隔1個月)……………….25 (4) 2星期組(牙根覆蓋手術至動物犧牲間隔2星期)……………….26 (5) 3天組(牙根覆蓋手術至動物犧牲間隔3 天)……………………26 4.3 組織學檢查…….……………………………………………………...……...27 4.3.1 組織切片描述…..…………………………………………….…….... 27 (1) 6個月組(牙根覆蓋手術至動物犧牲間隔6個月)…….……..… .27 (2) 2個月組(牙根覆蓋手術至動物犧牲間隔2個月)…….….…. ….29 (3) 1個月組(牙根覆蓋手術至動物犧牲間隔1個月)………..…. ….31 (4) 2星期組(牙根覆蓋手術至動物犧牲間隔2星期)………....…….33 (5) 3天組(牙根覆蓋手術至動物犧牲間隔3 天)………..….….……34 4.3.2 組織型態分析…………………………………………………… …...36 (1) 6個月組(牙根覆蓋手術至動物犧牲間隔6個月)………. .….….36 (2) 2個月組(牙根覆蓋手術至動物犧牲間隔2個月)………. .….….38 (3) 1個月組(牙根覆蓋手術至動物犧牲間隔1個月)……….. ….….39 第五章 討論…………………………………………………………………………40 5.1 動物模型的選擇及實驗方法探討….…………………… ………………...40 5.1.1 動物模型的選擇……………..………………… …………………...40 5.1.2 牙根覆蓋量…………………..…………………………… ………...40 5.1.3 牙根覆蓋術式的選擇………...……………………………………...41 5.1.4 實驗牙齒的選擇….………………………..………………………...41 5.1.5 切片製作過程探討…………………………...……………………...42 5.2 牙根覆蓋後之組織及臨床上的短期變化…..……………………………...43 5.3 牙根覆蓋後之組織及臨床上的長期變化…………………..……………...45 第六章 結論…………………………………………………………………………49 | |
dc.language.iso | zh-TW | |
dc.title | 應用人類羊膜輔助牙根覆蓋之動物實驗模式研究 | zh_TW |
dc.title | An animal study of applying amniotic membrane matrix for root coverage surgery | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 章浩宏(Hao-Hueng Chang),呂炫?(Hsein-Kun Lu) | |
dc.subject.keyword | 牙根覆蓋,羊膜,牙周再生, | zh_TW |
dc.subject.keyword | root coverage,amniotic membrane,periodontal tissue regeneration, | en |
dc.relation.page | 56 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-08-19 | |
dc.contributor.author-college | 牙醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
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