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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李百祺 | |
dc.contributor.author | Wan-Ya Chen | en |
dc.contributor.author | 陳婉雅 | zh_TW |
dc.date.accessioned | 2021-06-15T05:44:32Z | - |
dc.date.available | 2010-08-20 | |
dc.date.copyright | 2010-08-20 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-19 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/46979 | - |
dc.description.abstract | 由於老鼠與人類在基因和構造上的相似性,老鼠被廣泛的用做心血管疾病的研究模型。而超音波具有非侵入式和即時的成像特性,適合對心臟構造和血液功能做連續和長時間的觀測。但一般的醫用超音波不適用於快速搏動(約300-600bpm)和尺寸微小(小於10mm)的老鼠心臟,必須應用空間解析度達100μm以下的高頻超音波進行成像。現行的商用高頻超音波系統仍以單一探頭做機械式掃描為主,限制了成像的每秒影格數(frame rate)在30-60fps或更低。本研究應用心電圖訊號來觸發心臟超音波影像的擷取,再進行回溯式的影像重建,可等效的提升每秒影格數至數百至數千張,以對快速搏動的老鼠心臟進行高時間解析度的造影。
在實驗室之前的研究中,對心搏率300-400bpm的麻醉中老鼠,以發射中心頻率25MHz, 脈波間隔頻率(PRF)2kHz的高頻超音波,進行心電圖觸發的心臟B-mode影像重建,等效每秒影格數可達2000fps. 而本研究希望在心電圖觸發的B-mode成像基礎上,發展血液流速成像(Color Doppler mode). 首先以低頻探頭(3.5MHz), 脈波間隔頻率1kHz對血流仿體環境進行模擬心電圖訊號觸發的成像,重建出符合血流輸出波形變化的流速圖。接著進一步將此功能實現在實驗室開發的單一探頭高頻系統上。以高頻探頭(30MHz), 脈波間隔頻率5-10kHz再次進行仿體實驗。並對照PW Doppler取得的流速對時間變化,比較出重建的color Doppler影像在時序上是與PW Doppler相吻合的,但速度的量值普遍較PW Doppler低。 仿體實驗證實了,心電圖訊號觸發的回溯式血流成像,在血流速度呈現穩定的週期性變化下,可重建出等效每秒影格數達5000-10000fps的一系列color Doppler影像。而活體中的心電圖變異、紊亂的心臟血流等變因造成的影響,還需要實驗來探討。 | zh_TW |
dc.description.abstract | Ultrasound has been used to image murine models noninvasively and longitudinally in real-time for cardiovascular disorder studies. To improve spatial resolution to 100μm or higher, high frequency ultrasound (>20MHz) has to be used. Because of the frame rate limitation due to the fact that mechanical scanning on single element transducers need to be applied, the temporal resolution up to hundreds fps is hard to achieve. ECG gating strategies which synchronize the image acquisition with the cardiac cycle, can retrospectively reconstruct a series of images at equivalent high frame rate and thus is of interest in this study.
In previous research, B-mode in vivo images were retrospectively reconstructed, with the center frequency of 25MHz and the pulse repetition frequency at 2kHz, and the frame rate is equivalently raised to 2000frames/second. The current study is extended from ECG gated/triggered B-mode imaging to Color Doppler imaging. Firstly, phantom experiments under the center frequency of 3.5MHz and the pulse repetition frequency at 1kHz were performed. The series of Color Doppler images corresponding to an output flow cycle were reconstructed with emulated ECG output that gates data acquisition. Phantom experiments were conducted again on a single element transducer high frequency system, under the frequency of 30MHz and the pulse repetition frequency at 5kHz~10kHz. The reconstructed Color Doppler images were compared to PW Doppler velocity profile quantitatively. The two are temporally matched and the spatial information is provided only by the former, but the velocity in the former is lower than that in the latter. ECG gating/triggering Color Doppler is suitable for retrospective flow imaging, taking the frame rate up to 5000-10000fps equivalently. In vivo tests with ECG and flow turbulence are on-going. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T05:44:32Z (GMT). No. of bitstreams: 1 ntu-99-R97945006-1.pdf: 8537017 bytes, checksum: ed1dc7df556a2d5c32223ca6f7b5e417 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 口試委員會審定書 i
誌謝 ii 中文摘要 iii Abstract iv 第一章 緒論 1 1.1 超音波老鼠心臟影像 1 1.2 高頻超音波的優點與限制 4 1.3 同步心電圖訊號及影像擷取的時間閘方式 8 1.4 高頻超音波下的二維血流影像 11 1.5 研究動機與目標 12 1.6 論文架構 14 第二章 ECG triggering and gating 15 2.1 成像方法[28] 15 2.2 Color Doppler 18 2.2.1 原理與自相關運算法 18 2.2.2 影像訊號處理流程 23 2.3 B-mode and Color Doppler mode比較 25 2.3.1 發射與接收方式[28] 25 2.3.2 心電圖觸發模式下的彩色都卜勒 27 2.3.3 心電圖時間閘模式下的彩色都卜勒 27 2.4 回溯式的血液流速計算 28 2.4.1 心電圖時間閘模式 28 2.4.2 心電圖觸發模式 29 2.4.3 掃掠式掃描產生的影響 30 第三章 仿體實驗與結果 33 3.1 超音波成像環境架設 33 3.2 血流仿體環境 34 3.3 心電圖時間閘模式下的資料擷取與影像重組 37 3.4 實驗結果與討論 39 第四章 高頻超音波單一探頭系統 44 4.1 系統架構簡述 44 4.2 數位訊號處理器(DSP)[46][47][48][49] 45 4.3 軟硬體控制流程[50][51] 47 4.4 仿體實驗結果與討論 50 第五章 結論與未來工作 75 第六章 參考文獻 76 | |
dc.language.iso | zh-TW | |
dc.title | 使用心電圖信號作觸發的高頻超音波小動物心臟血流成像 | zh_TW |
dc.title | ECG Triggering and Gating for Ultrasonic Small Animal Cardiac Flow Imaging | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 江惠華,沈哲州,王士豪,郭柏齡 | |
dc.subject.keyword | 高頻超音波,回溯式成像,心電圖時間閘,高速成像,彩色都卜勒成像,心電圖, | zh_TW |
dc.subject.keyword | High-frequency ultrasound,Retrospective imaging,ECG gating,High frame rate imaging,Color Doppler imaging,Electrocardiogram, | en |
dc.relation.page | 80 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-08-19 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
顯示於系所單位: | 生醫電子與資訊學研究所 |
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