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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蘇璧伶(Biling su) | |
| dc.contributor.author | Yi Ta Chen | en |
| dc.contributor.author | 陳依妲 | zh_TW |
| dc.date.accessioned | 2021-06-15T05:44:25Z | - |
| dc.date.available | 2011-08-20 | |
| dc.date.copyright | 2010-08-20 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-08-19 | |
| dc.identifier.citation | References
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Bissot T., Servet E., Stephanie V.,Deboise M., Sergheraert R., Egron G., Hugonnard M., Heath S.E., Biourge V., German A.J.,2010. Novel dietary strategies can improve the outcome of weight loss programmes in obese client owned cats. J Feline Med Surg.,12, 104-112. 11. Dall’Olio G., Dorizzi R.M., 2000. Diagnosis of diabetes mellitus at the Hospital of Venice in 1863. Clinica Chinica Acta,297,17-27. 12. Elliott D.A., Nelson R.W., Reusch C.E., Feldman E.C., Neal A., 1999. Comparison of serum fructosamine and blood glycosylated hemoglobin concentrations for assessment of glycemic control in cats with diabetic mellitus. J Am Vet Med Assoc,15, 1794-1798. 13. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, 2003. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Daibetes Care, 26, 3160-3167. 14. Feldhahn J.R., Rand J.S., Martin G., 1999. Insulin sensitivity in normal and diabetic cats. J Feline Med Surg., 1,107-115. 15. Gielding S.V., Robinson ., Lowe S., 1994. Validation of the low dose insulin tolerance test for evaluation of insulin sensitivity. Clin Endocrinol (Oxf), 40, 611-615. 16. Goossen M.M., Nelson R.W., Feldman E.C., Griffey S.M., 1998. Response to insulin treatment and survival in 104 cats with diabetes mellitus (1985-1995), J Vet Intern Med, 12,1-6. 17. Hoenig M., Hall G., Ferguson D., Jordan K., Henson M., Johnson K., O’Brien T.D., 2000. A feline model of experimentally induced islet amyloidosis. Am J Pathol,157,2143-2150. 18. Hiddinga H.J. and Eberhardt N.L. 1999. Intracellular amyloidogenesis by human islet amyloid polypeptide induces apoptosis in COS-1 cells. Am J Pathol, 154, 1077-1088. 19. Hoenig M., Ferguson D.C., 1988. Impairment of glucose tolerance in hyperthyroid cats. J Endocrinol, 121, 249-251. 20. Hoenig M. Peterson M.E., Ferguson D.C., 1992. Glucose tolerance and insulin secretion in spontaneously hyperthyroid cats. Res Vet Sci, 53, 338-341. 21. Hoenig M., Thomason K., Waldron M., Ferguson D.C., 2006. Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss. Am J Physiol Regul Inter Comp Physio, 292, 227-234. 22. Hoenig M., Thomaseth K., Brandao J., Waldron M., Ferguson D.C., 2005.Assessment and mathematical modeling of glucose turnover and insulin sensitivity in lean and obese cats. Domest Anim Endocrinol, 31, 373-389. 23. Hoenig M., Thomaseth K., Waldron M., Ferguson D.C., 2007. Fatty acid turnover, substrate oxidation, and heat production in lean and obese cats during the euglycemic hyperinsulinemic clamp. Domest Anim Endocrinol,32,329-338. 24. Hoenig M., Alerander S., Holson J., Ferguson D.C., 2002. Influence of glucose dosage on interpretation of intravenous glucose tolerance tests in lean and obese cats. J Vet Intern Med, 16, 529-532. 25. Harper E.J., Stack D.M., Watson T.D., Moxham G., 2001. Effectd of feeding regimes on body weight, composition and condition score in cats following ovariohysterectomy. J Small Anim Pract, 42, 433-438. 26. Hoenig M., Thomaseth K., Waldron M., Ferguson D.C., 2007. Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss. Am J Physiol Regulatory Intergrative Comp Phsiol, 292, 227-234. 27. Johnson K.H., O’ Brien T.D., Westermark, P.,1986. Animal model of human disease: spontaneous diabetes mellitus-islet amyloid complex in adult cats. Am. J. Pathol. 125,416-419. 28. Johnson K.H., 1988. Islet amyloid, islet amyloid polypeptide and diabetes mellitus. N. Engl J. Med,321, 513-518. 29. Knowler W.C., Barrett-Connor E., Fowler S.E., Hamman R.F., Lachin J.M., Walker E.A., Nathan D.M., Diabetes prevention program, 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med, 346, 393-403. 30. Lederer R., Rand J.S., Hughes I, Fleeman L.M. 2003. Chronic or recurring medical problems, dental disease, repeated corticosteroid treatment and low physical activity are associated with diabetes in Burmese cats. J Vet Intern Med,17,433. 31. Little C.J. and Gettinby G., 2008. Heart failure is common in diabetic cats: findings from a retrospective case-controlled study in first-opinion practice. J Small Anim Pract,49,17-25. 32. Link K.R., Rand J.S., Hendrikz J.K., 1997. Evaluation of a simplified intravenous glucose tolerance test and a reflectance glucose meter for use in cats. Vet Rec.140, 253-256. 33. Link K.R., Rand J.S., 1998. Reference values for glucose tolerance and glucose tolerance status in cats. J Am Vet Med Assoc, 213, 492-496. 34. Lorenzo A., Razzaboni B., Weir G.C., Yankner B.A., 1994. Pacreatic islet cell toxicity of amylin associated with type 2 diabetes mellitus, Nature, 368, 756-760. 35. Lutz T.A., Rand J.S.,1996. Plasma amylin and insulin concentrations in normoglycemic and hyperglycemic cats. Can Vet J, 37, 27-34. 36. Nelson R.W., Griffey S.M., Feldman E.C., Ford S.L., 1998. Transient clinical diabetes mellitus in cats: 10 cases (1989-1991). J Vet Intern Med, 13, 28-35. 37. Nelson R.W., Himsel C.A., Feldman E.C., Bottoms G.D., 1990. Glucose tolerance and insulin response in normal-weight and obese cats. J Vet Res, 51, 1357-1362. 38. O’Brien T.D., Butler P.C., KreutterD.K., Kane L.A., Eberhardt N. L., 1995. Human islet amyloid polypeptide expression in COS-1 cells. A model of intracellular amyloidogenesis. Am J Pathol, 147, 609-616. 39. Panciera D.L., Thomas C.B., Eicker S.W., Atkins C.E., 1990: Epizootiologic patterns of diabetes mellitus in cats: 333 cases (1980-1986). J Am Vet Med Assoc,197,1504-1508. 40. Petrus D.J., Jackson M.W., Kemnitz J.W., 1998. Assessing insulin sensitivity in the cats: evaluation of the hyperinsulinemic euglycemia clamp and the minimal model analysis. Res Vet Sci, 65, 179-181. 41. Prahl A., Guptill L., Glickman N.W., Tetrick M., Glickman L.T., 2007. Time trends and risk factors for diabetes mellitus in cats presented to veterinary teching hospitals. J Feline Med Surg., 9, 351-358. 42. Rossetti L., 1990. Glucose toxicity. Diabetic Care, 13, 610-621. 43. Scarlet J.M., Donoghue S., Saidla J., Wills J., 1994. Overweight cats: prevalence and risk factors. International Journal of obesity and related metabolic disorders, 18, S22-S28. 44. Unger R.H., Grundy S., 1985. Hyperglycemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia, 28, 119-121. 45. Vincent B., Nelson R.W., Feldman E.C., Willits N.H., Morris J.G., Gogers Q.R., 1997. Effect of weight gain and subsequent weight loss on glucose tolerance and insulin response in healthy cats. J Vet Intern Med, 11, 86-91. 46. Westermark et al., 1987. Islet amyloid poplyppeptide-like immunoreactivity in the islet B cells of type 2 (non-insulin-dependent) diabetic and nondiabetic individuals. Diabetologia, 30, 887-892. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/46974 | - |
| dc.description.abstract | 現今貓隻血糖恆定之評估主要仍需依賴靜脈葡萄糖耐受性試驗之結果(Intravenous glucose tolerance test, IVGTT)，由於此試驗需要麻醉及住院，因此在臨床上的實用性非常低。本研究目的在於建立臨床可行之修正簡化型靜脈葡萄糖耐受性試驗 (modified simplified intravenous glucose tolerance test, MSIVGTT)及簡化胰島素敏感指數(Homeostasis model assessment, HOMA)，進而篩選出葡萄糖耐受性異常( Impaired glucose intolerance)之貓隻。38隻家貓參與本研究，修正簡化型靜脈葡萄糖耐受性試驗過程包括畜主陪同、以延長之蝴蝶針重複採血以及提供軟墊及毛巾供緊張貓隻遮蔽，試驗時間共計三個小時。所有貓隻依據貓身體質量指數 (Feline body mass index)分為肥胖及體態正常兩組。38隻貓中，32隻貓隻(84%)完成修正簡化型靜脈葡萄糖耐受試驗，試驗結果在肥胖貓組顯示其葡萄糖排除率(Glucose disposal rate)較體態正常貓組緩慢及在第二時期胰島素分泌過量，兩組結果的不同皆達統計上顯著差異。在32隻貓中，篩選出3隻貓葡萄糖耐受性異常。此外，全部38隻貓所進行HOMA試驗結果顯示在肥胖貓有較高之數值，且達統計上顯著之差異，同時與貓隻肥胖程度呈現正相關結果。總結，本研究成功的建立臨床上可應用的修正簡化型靜脈葡萄糖耐受性試驗及HOMA試驗，並且藉此之試驗篩選出葡萄糖耐受性異常之貓隻。 | zh_TW |
| dc.description.abstract | Intravenous glucose tolerance test is a suggested method to evaluate the glucose homeostasis in cats. However, anesthesia and hospitalization required in performing the test hamper its clinical application. In order to establish a clinical applicable test, 34 client-owned cats were enrolled in this study. A modified simplified intravenous glucose tolerance test (MSIVGTT), a simple indice of insulin sensitivity homeostasis model assessment (HOMA) were evaluated for their applicability in the detection of glucose intolerant patients. The modifications include accompany of the pet owner, application of winged infusion set connected with the catheter for repeatable blood sampling, lay of the examined cats upon a soft pet bed and covered with a towel, as well as shorten the examined procedure to 3 hours. All cats were divided into obese and lean groups based on the feline body mass index (FBMI). Complete evaluation was achieved from 32 out of 38 cats (84%) using MSIVGTT and the results showed statistical differences between obese and lean cats with slower glucose disposal rate in glucose response and exaggerated insulin secretion in the 2nd phase of insulin response in the obese cats. Moreover, the test also screens out 3 impaired glucose tolerant cats from the 32 cats. The HOMA showed significant difference between two groups and had a positive correlation with the obese condition of the 38 cats. In conclusion, MSIVGTT and HOMA were established for clinical usage evaluation of glucose homeostasis. Application of these 2 assays can be used to screen out impaired glucose tolerant cats in clinical practice. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T05:44:25Z (GMT). No. of bitstreams: 1 ntu-99-R97643009-1.pdf: 525597 bytes, checksum: 1550b3668c33a951a810369abb1567a4 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | Table of contents………………………………………………… i
List of tables and figures………………………………………iv 誌謝……………………………………………………………………v Abstract………………………………………………………………vii 中文摘要………………………………………………………………viii Chapter I: Literatures reviews.……………………………… 1 Section I: Background of diabetic mellitus………………1 Section II: Introduction of diabetic mellitus (DM)……2 2.1 Classification and etiology………………………… 2 2.1.1 In humans…………………………………………… 2 2.1.1.1 Type 1 diabetes……………………………… 3 2.1.1.2 Type 2 diabetes…………………………………3 2.1.2 In cats……………………………………………… 3 2.1.2.1 Insulin-dependent diabetic mellitus (IDDM) …………………………………………………… 4 2.1.2.2 Non-insulin-dependent diabetic mellitus (NIDDM)……………………………………………5 2.1.2.3 Transient diabetic mellitus in cats………6 Section III: Preventive medicine in diabetes mellitus…8 3.1 In human…………………………………………………… 8 3.1.1 The screening tests in pre-diabetic humans… 8 3.1.1.1 The fasting plasma glucose (FPG)……………8 3.1.1.2 The glucose tolerance test (GTT)……………9 3.1.1.3 Simplified insulin indexes……………………9 3.1.2 Risk factors in pre-diabetic humans……………10 3.2 In cats………………………………………………………11 3.2.1Screening tests for pre-diabetic cats………… 11 3.2.1.1 Intravenous glucose tolerance test (IVGTT) ………………………………………………………11 3.2.1.2 Insulin sensitivity test (IST)………………13 3.2.1.3 Insulin tolerance test (ITT)…………………14 3.2.1.4 Simplified insulin indexes……………………15 3.2.2 The risk factors in pre-diabetic cats…………16 3.2.2.1 Obesity…………………………………………… 16 3.2.2.2 Diet…………………………………………………17 3.2.2.3 Age, gender and genetic factors…………… 17 3.2.2.4 Environmental factors………………………… 18 3.2.2.5 Concurrent illness and drugs…………………18 Section IV Aims……………………………………………………19 Chapter II Introduction………………………………………… 21 Chapter III: Material and Methods………………………………23 Section I Animals……………………………………………… 23 Section II Assessments of bodyweight and body mass index …………………………………………………………23 Section III Modified simplified intravenous glucose tolerance (MSIVGTT)………………………………24 Section IV Data analysis……………………………………… 25 Section V Statistic analysis………………………………… 26 Chapter IV: Results…………………………………………………27 Section I Questionnaire…………………………………………28 Section II Modified simplified intravenous glucose tolerance test (MSIVGTT)………………………… 28 Section III Impaired glucose tolerant cats……………… 30 Section IV homeostasis of model assessment (HOMA)………31 Chapter V: Discussions……………………………………………………………32 Tables………………………………………………………………… 41 Figures…………………………………………………………………43 Appedix……………………………………………….……………… 48 Reference………………………………………………………………52 | |
| dc.language.iso | en | |
| dc.subject | 試驗 | zh_TW |
| dc.subject | 改良式 | zh_TW |
| dc.subject | 簡易型 | zh_TW |
| dc.subject | 靜脈 | zh_TW |
| dc.subject | 葡萄糖 | zh_TW |
| dc.subject | 耐受性 | zh_TW |
| dc.subject | modified | en |
| dc.subject | test | en |
| dc.subject | tolerance | en |
| dc.subject | glucose | en |
| dc.subject | intravenous | en |
| dc.subject | simplified | en |
| dc.title | 改良式簡易型靜脈葡萄糖耐受性試驗及胰島素敏感性試驗(HOMA)臨床應用之評估 | zh_TW |
| dc.title | Clinical applications of modified simplified intravenous glucose tolerance test (MSIVGTT) and homeostasis model assessment (HOMA) in client-owned healthy obese and lean cats | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林中天,闕玲玲,周濟眾 | |
| dc.subject.keyword | 改良式,簡易型,靜脈,葡萄糖,耐受性,試驗, | zh_TW |
| dc.subject.keyword | modified,simplified,intravenous,glucose,tolerance,test, | en |
| dc.relation.page | 54 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-08-19 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
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