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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 翁祖輝(Tzuu-Huei Ueng) | |
| dc.contributor.author | Huei-Chieh Yu | en |
| dc.contributor.author | 俞惠潔 | zh_TW |
| dc.date.accessioned | 2021-06-15T05:17:26Z | - |
| dc.date.available | 2010-09-09 | |
| dc.date.copyright | 2010-09-09 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-07-21 | |
| dc.identifier.citation | 1. Ballester, F., Estarlich, M., Iniguez, C., Llop, S., Ramon, R., Esplugues, A., Lacasana, M., and Rebagliato, M. (2010) Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain, Environ Health 9, 6.
2. Bandiera, F. C., Arheart, K. L., Caban-Martinez, A. J., Fleming, L. E., McCollister, K., Dietz, N. A., Leblanc, W. G., Davila, E. P., Lewis, J. E., Serdar, B., and Lee, D. J. (2010) Secondhand smoke exposure and depressive symptoms, Psychosom Med 72, 68-72. 3. Bellinger, D. C. (2001) Future directions for neurobehavioral studies of environmental neurotoxicants, Neurotoxicology 22, 645-656. 4. Berg, K. A., Harvey, J. A., Spampinato, U., and Clarke, W. P. (2008) Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression, Prog Brain Res 172, 287-305. 5. Berton, O., and Nestler, E. J. (2006) New approaches to antidepressant drug discovery: beyond monoamines, Nat Rev Neurosci 7, 137-151. 6. Block, M. L., Wu, X., Pei, Z., Li, G., Wang, T., Qin, L., Wilson, B., Yang, J., Hong, J. S., and Veronesi, B. (2004) Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase, FASEB J 18, 1618-1620. 7. Broadwell, D. K., Darcey, D. J., Hudnell, H. K., Otto, D. A., and Boyes, W. K. (1995) Work-site clinical and neurobehavioral assessment of solvent-exposed microelectronics workers, Am J Ind Med 27, 677-698. 8. Brook, R. D., Rajagopalan, S., Pope, C. A., 3rd, Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., Peters, A., Siscovick, D., Smith, S. C., Jr., Whitsel, L., and Kaufman, J. D. (2010) Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association, Circulation 121, 2331-2378. 9. Brouwer, D. H., de Pater, N. A., Zomer, C., Lurvink, M. W., and van Hemmen, J. J. (2005) An experimental study to investigate the feasibility to classify paints according to neurotoxicological risks: occupational air requirement (OAR) and indoor use of alkyd paints, Ann Occup Hyg 49, 443-451. 10. Bueno, O. F., De Windt, L. J., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T. E., Jones, S. P., Lefer, D. J., Peng, C. F., Kitsis, R. N., and Molkentin, J. D. (2000) The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice, EMBO J 19, 6341-6350. 11. Bueno, O. F., and Molkentin, J. D. (2002) Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death, Circ Res 91, 776-781. 12. Bujak, M., and Frangogiannis, N. G. (2009) The role of IL-1 in the pathogenesis of heart disease, Arch Immunol Ther Exp (Warsz) 57, 165-176. 13. Bunio, A., Szygula, R., Tubek, S., and Krasowski, G. (2010) The content of elements in rainwater and its relation to the frequency of hospitalization for diabetes and obesity in opole voivodship, poland, during 2000-2002, Biol Trace Elem Res 136, 149-156. 14. Chang, C. C., Hwang, J. S., Chan, C. C., Wang, P. Y., Hu, T. H., and Cheng, T. J. (2005) Effects of concentrated ambient particles on heart rate variability in spontaneously hypertensive rats, J Occup Health 47, 471-480. 15. Chen, C.H. (2009) Effects of motorcycle exhaust on heart and reproductive development toxicity in rats, National Taiwan University Master Thesis. 16. Cintra, A., Aguirre, J. A., Andbjer, B., Finnman, U. B., Hagman, M., Agnati, L. F., Hoglund, C., Moller, A., and Fuxe, K. (1999) Subchronic toluene exposure in low concentrations produces signs of reduced dysfunction in the 6-hydroxydopamine lesioned nigrostriatal dopaminergic system of the rat, Neurosci Lett 274, 5-8. 17. Clancy, L., Goodman, P., Sinclair, H., and Dockery, D. W. (2002) Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study, Lancet 360, 1210-1214. 18. Clougherty, J. E. (2010) A growing role for gender analysis in air pollution epidemiology, Environ Health Perspect 118, 167-176. 19. Croute, F., Poinsot, J., Gaubin, Y., Beau, B., Simon, V., Murat, J. C., and Soleilhavoup, J. P. (2002) Volatile organic compounds cytotoxicity and expression of HSP72, HSP90 and GRP78 stress proteins in cultured human cells, Biochim Biophys Acta 1591, 147-155. 20. Deakin, J. F., and Dostrovsky, J. O. (1978) Involvement of the periaqueductal grey matter and spinal 5-hydroxytryptaminergic pathways in morphine analgesia: effcts of lesions and 5-hydroxytryptamine depletion, Br J Pharmacol 63, 159-165. 21. Desimone, R. (1992) The physiology of memory: recordings of things past, Science 258, 245-246. 22. Dominici, F., Peng, R. D., Bell, M. L., Pham, L., McDermott, A., Zeger, S. L., and Samet, J. M. (2006) Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases, JAMA 295, 1127-1134. 23. Drevets, W. C. (2001) Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders, Curr Opin Neurobiol 11, 240-249. 24. Ellman, G. L., Courtney, K. D., Andres, V., Jr., and Feather-Stone, R. M. (1961) A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem Pharmacol 7, 88-95. 25. Forkman, B. A., Ljungberg, T., Johnson, A. C., Nylen, P., Stahle, L., Hoglund, G., and Ungerstedt, U. (1991) Long-term effects of toluene inhalation on rat behavior, Neurotoxicol Teratol 13, 475-481. 26. Frey, N., and Olson, E. N. (2003) Cardiac hypertrophy: the good, the bad, and the ugly, Annu Rev Physiol 65, 45-79. 27. Gillespie-Brown, J., Fuller, S. J., Bogoyevitch, M. A., Cowley, S., and Sugden, P. H. (1995) The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes, J Biol Chem 270, 28092-28096. 28. Gordon, J. A., and Hen, R. (2004) Genetic approaches to the study of anxiety, Annu Rev Neurosci 27, 193-222. 29. Habig, W. H., Pabst, M. J., and Jakoby, W. B. (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation, J Biol Chem 249, 7130-7139. 30. Halfon, N., and Newacheck, P. W. (1999) Prevalence and impact of parent-reported disabling mental health conditions among U.S. children, J Am Acad Child Adolesc Psychiatry 38, 600-609; discussion 610-603. 31. Herculiani, P. P., Pires-Neto, R. C., Bueno, H. M., Zorzetto, J. C., Silva, L. C., Santos, A. B., Garcia, R. C., Yonamine, M., Detregiachi, C. R., Saldiva, P. H., and Mauad, T. (2009) Effects of chronic exposure to crack cocaine on the respiratory tract of mice, Toxicol Pathol 37, 324-332. 32. Hertzman, C., Wiens, M., Bowering, D., Snow, B., and Calne, D. (1990) Parkinson's disease: a case-control study of occupational and environmental risk factors, Am J Ind Med 17, 349-355. 33. Huang, J. Y., Liao, J. W., Liu, Y. C., Lu, S. Y., Chou, C. P., Chan, W. H., Chen, S. U., and Ueng, T. H. (2008) Motorcycle exhaust induces reproductive toxicity and testicular interleukin-6 in male rats, Toxicol Sci 103, 137-148. 34. Jurewicz, J., Hanke, W., Radwan, M., and Bonde, J. P. (2009) Environmental factors and semen quality, Int J Occup Med Environ Health 22, 305-329. 35. Kandel, E. R., and O'Dell, T. J. (1992) Are adult learning mechanisms also used for development?, Science 258, 243-245. 36. Kang, Y. J. (2001) Molecular and cellular mechanisms of cardiotoxicity, Environ Health Perspect 109 Suppl 1, 27-34. 37. Kardami, E., Jiang, Z. S., Jimenez, S. K., Hirst, C. J., Sheikh, F., Zahradka, P., and Cattini, P. A. (2004) Fibroblast growth factor 2 isoforms and cardiac hypertrophy, Cardiovasc Res 63, 458-466. 38. Kimmel, C. A. (1993) Approaches to evaluating reproductive hazards and risks, Environ Health Perspect 101 Suppl 2, 137-143. 39. Kodavanti, U. P., Moyer, C. F., Ledbetter, A. D., Schladweiler, M. C., Costa, D. L., Hauser, R., Christiani, D. C., and Nyska, A. (2003) Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat, Toxicol Sci 71, 237-245. 40. Laskowski, A., Woodman, O. L., Cao, A. H., Drummond, G. R., Marshall, T., Kaye, D. M., and Ritchie, R. H. (2006) Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes, Cardiovasc Res 72, 112-123. 41. Liou, H. H., Tsai, M. C., Chen, C. J., Jeng, J. S., Chang, Y. C., Chen, S. Y., and Chen, R. C. (1997) Environmental risk factors and Parkinson's disease: a case-control study in Taiwan, Neurology 48, 1583-1588. 42. London, E. A. (2000) The environment as an etiologic factor in autism: a new direction for research, Environ Health Perspect 108 Suppl 3, 401-404. 43. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent, J Biol Chem 193, 265-275. 44. Maeder, M., Fehr, T., Rickli, H., and Ammann, P. (2006) Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides, Chest 129, 1349-1366. 45. Magga, J., Vuolteenaho, O., Tokola, H., Marttila, M., and Ruskoaho, H. (1998) B-type natriuretic peptide: a myocyte-specific marker for characterizing load-induced alterations in cardiac gene expression, Ann Med 30 Suppl 1, 39-45. 46. Manji, H. K., Drevets, W. C., and Charney, D. S. (2001) The cellular neurobiology of depression, Nat Med 7, 541-547. 47. Mendola, P., Selevan, S. G., Gutter, S., and Rice, D. (2002) Environmental factors associated with a spectrum of neurodevelopmental deficits, Ment Retard Dev Disabil Res Rev 8, 188-197. 48. Mergler, D., and Baldwin, M. (1997) Early manifestations of manganese neurotoxicity in humans: an update, Environ Res 73, 92-100. 49. Minami, M., Endo, T., Hamaue, N., Hirafuji, M., Mori, Y., Hayashi, H., Sagai, M., and Suzuki, A. K. (1999) Electrocardiographic changes induced by diesel exhaust particles (DEP) in guinea pigs, Res Commun Mol Pathol Pharmacol 105, 67-76. 50. Minneman, K.P., Wecker, L. (2005) Brody's Human Pharmacology, 4th edition. 51. Miyoshi, M., and Watanabe, T. (2010) Role of anterior hypothalamic natriuretic peptide in lipopolysaccharide-induced fever in rats, Eur J Appl Physiol 109, 49-57. 52. MohanKumar, S. M., Campbell, A., Block, M., and Veronesi, B. (2008) Particulate matter, oxidative stress and neurotoxicity, Neurotoxicology 29, 479-488. 53. Molkentin, J. D., and Dorn, G. W., 2nd. (2001) Cytoplasmic signaling pathways that regulate cardiac hypertrophy, Annu Rev Physiol 63, 391-426. 54. Nelson, E., Jodscheit, K., and Guo, Y. (1999) Maternal passive smoking during pregnancy and fetal developmental toxicity. Part 1: gross morphological effects, Hum Exp Toxicol 18, 252-256. 55. Ohkawa, H., Ohishi, N., and Yagi, K. (1978) Reaction of linoleic acid hydroperoxide with thiobarbituric acid, J Lipid Res 19, 1053-1057. 56. Pearce, M. S., Glinianaia, S. V., Rankin, J., Rushton, S., Charlton, M., Parker, L., and Pless-Mulloli, T. (2010) No association between ambient particulate matter exposure during pregnancy and stillbirth risk in the north of England, 1962-1992, Environ Res 110, 118-122. 57. Peters, A., and Pope, C. A., 3rd. (2002) Cardiopulmonary mortality and air pollution, Lancet 360, 1184-1185. 58. Porsolt, R. D., Bertin, A., and Jalfre, M. (1977) Behavioral despair in mice: a primary screening test for antidepressants, Arch Int Pharmacodyn Ther 229, 327-336. 59. Rajkowska, G. (2003) Depression: what we can learn from postmortem studies, Neuroscientist 9, 273-284. 60. Rich, D. Q., Demissie, K., Lu, S. E., Kamat, L., Wartenberg, D., and Rhoads, G. G. (2009) Ambient air pollutant concentrations during pregnancy and the risk of fetal growth restriction, J Epidemiol Community Health 63, 488-496. 61. Risom, L., Moller, P., and Loft, S. (2005) Oxidative stress-induced DNA damage by particulate air pollution, Mutat Res 592, 119-137. 62. Rivas-Arancibia, S., Guevara-Guzman, R., Lopez-Vidal, Y., Rodriguez-Martinez, E., Zanardo-Gomes, M., Angoa-Perez, M., and Raisman-Vozari, R. (2010) Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats, Toxicol Sci 113, 187-197. 63. Sacchetti, B., Scelfo, B., and Strata, P. (2009) Cerebellum and emotional behavior, Neuroscience 162, 756-762. 64. Schultz, J. E., Witt, S. A., Nieman, M. L., Reiser, P. J., Engle, S. J., Zhou, M., Pawlowski, S. A., Lorenz, J. N., Kimball, T. R., and Doetschman, T. (1999) Fibroblast growth factor-2 mediates pressure-induced hypertrophic response, J Clin Invest 104, 709-719. 65. Semchuk, K. M., Love, E. J., and Lee, R. G. (1993) Parkinson's disease: a test of the multifactorial etiologic hypothesis, Neurology 43, 1173-1180. 66. Shimada, T., Matsumoto, K., Osanai, M., Matsuda, H., Terasawa, K., and Watanabe, H. (1995) The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs, Gen Pharmacol 26, 205-210. 67. Slezak, J., Tribulova, N., Okruhlicova, L., Dhingra, R., Bajaj, A., Freed, D., and Singal, P. (2009) Hibernating myocardium: pathophysiology, diagnosis, and treatment, Can J Physiol Pharmacol 87, 252-265. 68. Slotkin, T. A. (2004) Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates, Toxicol Appl Pharmacol 198, 132-151. 69. Slotkin, T. A., Pinkerton, K. E., Tate, C. A., and Seidler, F. J. (2006) Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke, Brain Res 1111, 30-35. 70. Song, H., Kwon, K., Lim, S., Kang, S. M., Ko, Y. G., Xu, Z., Chung, J. H., Kim, B. S., Lee, H., Joung, B., Park, S., Choi, D., Jang, Y., Chung, N. S., Yoo, K. J., and Hwang, K. C. (2005) Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions, Mol Cells 19, 402-407. 71. Song, X., Seidler, F. J., Saleh, J. L., Zhang, J., Padilla, S., and Slotkin, T. A. (1997) Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade, Toxicol Appl Pharmacol 145, 158-174. 72. Strong, M. J. (2004) Amyotrophic lateral sclerosis: contemporary concepts in etiopathogenesis and pharmacotherapy, Expert Opin Investig Drugs 13, 1593-1614. 73. Thiel, R., and Chahoud, I. (1997) Postnatal development and behaviour of Wistar rats after prenatal toluene exposure, Arch Toxicol 71, 258-265. 74. Thomas, J. A. (1975) Effects of pesticides on reproduction, Adv Sex Horm Res 1, 205-223. 75. Trauth, J. A., Seidler, F. J., and Slotkin, T. A. (2000) Persistent and delayed behavioral changes after nicotine treatment in adolescent rats, Brain Res 880, 167-172. 76. Tsai, J.H., Chiang, H.L., Hsu, Y.C., Weng, H.C., Yang, C.Y. (2003) The speciation of volatile organic compounds (VOCs) from motorcycle engine exhaust at different driving modes, Atmos Environ 37, 2485-2496. 77. Tsuchimochi, H., Kurimoto, F., Ieki, K., Koyama, H., Takaku, F., Kawana, M., Kimata, S., and Yazaki, Y. (1988) Atrial natriuretic peptide distribution in fetal and failed adult human hearts, Circulation 78, 920-927. 78. Tubek, S., Bunio, A., Szygula, R., and Tubek, A. (2010) Frequency of hospitalization for angina pectoris, stroke, and peripheral venous thrombosis and its relationship to elements in rainwater in Opole Voivodship, Poland, during 2000-2002, Biol Trace Elem Res 133, 243-250. 79. Ueng, T. H., Hu, S. H., Chen, R. M., Wang, H. W., and Kuo, M. L. (2000) Induction of cytochrome P-450 1A1 in human hepatoma HepG2 and lung carcinoma NCI-H322 cells by motorcycle exhaust particulate, J Toxicol Environ Health A 60, 101-119. 80. Ueng, T. H., Wang, H. W., Huang, Y. P., and Hung, C. C. (2004) Antiestrogenic effects of motorcycle exhaust particulate in MCF-7 human breast cancer cells and immature female rats, Arch Environ Contam Toxicol 46, 454-462. 81. Ueng, T. H., Wang, H. W., Hung, C. C., and Chang, H. L. (2004) Effects of motorcycle exhaust inhalation exposure on cytochrome P-450 2B1, antioxidant enzymes, and lipid peroxidation in rat liver and lung, J Toxicol Environ Health A 67, 875-888. 82. Van Herck, H., Baumans, V., Brandt, C.J., Boere, H.A., Hesp, A.P., van Lith, H.A., Schurink, M., and Beynen, A.C. (2001) Blood sampling from the retro-orbital plexus, the saphenous vein and the tail vein in rats: comparative effects on selected behavioural and blood variables, Lab Anim 35, 131-139. 83. Virag, J. A., Rolle, M. L., Reece, J., Hardouin, S., Feigl, E. O., and Murry, C. E. (2007) Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function, Am J Pathol 171, 1431-1440. 84. Wann, B. P., Audet, M. C., Gibb, J., and Anisman, H. (2010) Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice, Psychoneuroendocrinology 35, 233-240. 85. Weinstock, M. (2008) The long-term behavioural consequences of prenatal stress, Neurosci Biobehav Rev 32, 1073-1086. 86. Win-Shwe, T. T., Mitsushima, D., Yamamoto, S., Fujitani, Y., Funabashi, T., Hirano, S., and Fujimaki, H. (2009) Extracellular glutamate level and NMDA receptor subunit expression in mouse olfactory bulb following nanoparticle-rich diesel exhaust exposure, Inhal Toxicol 21, 828-836. 87. Woods, R. L. (2004) Cardioprotective functions of atrial natriuretic peptide and B-type natriuretic peptide: a brief review, Clin Exp Pharmacol Physiol 31, 791-794. 88. Wu, J., Ren, C., Delfino, R. J., Chung, J., Wilhelm, M., and Ritz, B. (2009) Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California, Environ Health Perspect 117, 1773-1779. 89. Wu, L. J., Kim, S. S., and Zhuo, M. (2008) Molecular targets of anxiety: from membrane to nucleus, Neurochem Res 33, 1925-1932. 90. Xiao, G. G., Wang, M., Li, N., Loo, J. A., and Nel, A. E. (2003) Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line, J Biol Chem 278, 50781-50790. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/46590 | - |
| dc.description.abstract | 在盛行以機車為交通運輸工具的地區，機車排放廢氣乃空氣污染的主要來源。機車廢氣組成當中包含許多致毒物質與致癌物質，能對囓齒類動物或哺乳類細胞造成氧化壓力、DNA 損傷、發炎反應、酵素誘導以及其他毒性反應。本研究主要目的為探討以呼吸曝露或經雄性或雌性親代曝露方式，曝露十倍稀釋的機車廢氣，對雄性與雌性大鼠造成心臟、生殖發育與神經行為毒性之可能性。親代雄性或雌性大鼠在經每天兩小時，每週五天，為期八週的機車廢氣呼吸曝露後，分別與未經處理的雌性或雄性大鼠交配。結果顯示，呼吸曝露機車廢氣引發雄性大鼠的心臟毒性，且該毒性機轉與心房排鈉素 (atrial natriuretic peptide)、纖維母細胞生成因子第二亞型 (fibroblast growth factor-2 ) 與白間素1β 亞型 (interleukin-1β) 之 mRNA 表現量上升有正相關性。經雄性或雌性親代曝露機車廢氣，雄性子代陰莖包皮分離與雌性子代陰道開口天數無提早或延遲現象。呼吸曝露機車廢氣後，僅有雌性而非雄性大鼠，會在明暗穿箱測詴中發現焦慮行為，在閃尾測詴中展現疼痛耐受度增加表現，以及在血清中有乙醯膽鹼酶活性降低現象；但於強迫游泳測詴中卻發現，無論是呼吸曝露或經雌性親代曝露機車廢氣，雄性大鼠與雌性大鼠皆產生憂鬱行為。曝露機車廢氣雌性大鼠在大腦皮質和小腦的5羥色胺（2A）受體之 mRNA 表現量並有下降趨勢。結果指出，機車廢氣會造成大鼠心臟及神經行為毒性，但未出現下一代以陰莖包皮分離與陰道開口年齡為指標的生殖發育毒性。機車廢氣對大鼠系統毒性作用機轉仍有待進一步研究。 | zh_TW |
| dc.description.abstract | The emission of motorcycle exhaust (ME) are a major source of air pollution in areas where motorcycles are a popular means of transportation. ME contains many toxicants and carcinogens which can cause oxidative stress, DNA damage, inflammation, enzyme induction, and other toxicological responses in rodents or mammalian cell lines. The major objectives of the present study were to explore the possible effects on cardiac, reproductive development, and neurobehavior toxicities of male and female rats exposed to 1:10 diluted ME by inhalation 2 hours daily and five days a week for 8 weeks. ME-exposed female or male rats were then mated with untreated males or females, respectively. ME exposure of male rats caused cardiotoxicity which was associated with increased mRNA expression of atrial natriuretic peptide, fibroblast growth factor-2, and interleukin-1β. Paternal and maternal exposures had no effects on the dates of preputial separation of male offspring and vaginal opening of female offspring. ME exposure induced changes in anxiety-like behavior in light-dark transition test and analgesia-like behavior in tail-flick test and reduced serum acetylcholinesterase activity of female rats but not of males. ME and maternal ME exposures changed depression-like behavior in forced-swimming test in males and females. ME exposure decreased 5-hydroxytryptamine 2A receptor mRNA expression in female rat brain cortex and cerebellum. These present findings demonstrate that ME causes cardiotoxicity and neurobehavior toxicity. The mechanisms underlying these ME systemic effects require further investigations. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T05:17:26Z (GMT). No. of bitstreams: 1 ntu-99-R97447009-1.pdf: 1928656 bytes, checksum: b01609f815fe47991e5d0330acbe09c5 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 中文摘要………………………………………………………………………………1
英文摘要………………………………………………………………………………2 第一章、前言…………………………………………………………………………4 第二章、實驗方法 第一節、呼吸曝露實驗……………………………………………………………10 第二節、系統毒性評估…………………………………………………………..13 第三章、實驗流程 第一節、雄性大鼠呼吸曝露機車廢氣……………………………………………15 第二節、雌性大鼠呼吸曝露機車廢氣……………………………………………17 第四章、結果 第一節、呼吸曝露機車廢氣對心臟之影響……………………………………..18 第二節、呼吸曝露機車廢氣對親代神經行為之影響…………………………..18 第三節、呼吸曝露機車廢氣對子代生殖發育之影響…………………………..21 第四節、雌性大鼠呼吸曝露機車廢氣對子代神經行為毒性之影響…………..22 第五章、討論………………………………………………………………………..24 第六章、結論……………………….………………………………………………...29. 參考文獻……………………………………………………………………………..30 表……………………………………………………………………………………..42 圖……………………………………………..………………………………………58 附錄 農藥愛殺松器官毒性之探討 一、正文……………………………………………………………………………62 二、實驗方法………………………………………………………………………66 參考文獻………………………………………………………………………….69 表………………………………………………………………………………….70 表目錄 表一、引子序列暨反轉錄聚合鏈鎖反應反應條件………………………………..42 表二、機車廢氣呼吸曝露雄性大鼠心臟之 ANP, FGF-2, IL-1β mRNA 表現量影響之數值化結果………………………………………………………………………44 表三、機車廢氣呼吸曝露對雄性大鼠心臟脂質過氧化和麩胱甘肽含量 之影響………………………………………………………………………………45 表四、機車廢氣呼吸曝露對雄性大鼠行為毒性之影響…………………………..46 表五、機車廢氣呼吸曝露對雄性大鼠血清及腦中乙醯膽鹼酶活性之影響……..47 表六、機車廢氣呼吸曝露對雌性大鼠行為毒性暨行為毒性可逆性之影響……..48 表七、機車廢氣呼吸曝露對雌性大鼠血清中乙醯膽鹼酶活性之影響…………..49 表八、機車廢氣呼吸曝露對雌性大鼠腦部各分區神經傳導物受體 mRNA 表現量之影響........................................................................................................................50 表九、呼吸曝露機車廢氣之親代雄性大鼠對子代雄性仔鼠陰莖包皮分離及雌性仔鼠陰道開口年齡之影響……………………………………………………………52 表十、呼吸曝露機車廢氣之親代雌性大鼠對子代雄性仔鼠陰莖包皮分離及雌性仔鼠陰道開口年齡之影響……………………………………………………………53 表十一、呼吸曝露機車廢氣之親代雌性大鼠對子代雄性與雌性仔鼠行為毒性 之影響……………………………………………………………………………....54 表十二、呼吸曝露機車廢氣之親代雌性大鼠對子代雄性與雌性仔鼠血清中乙醯膽鹼酶活性之影響……………………………………………………………………55 圖目錄 圖一、機車廢氣呼吸曝露對雄性大鼠心臟之 ANP, FGF-2, IL-1β mRNA 表現量 之影響……………………………………………………………………………...56 圖二、機車廢氣呼吸曝露對雌性大鼠大腦皮質之5-HT2A, GluR5, NR2B mRNA 表現量之影響……………………………………………………………………..57 圖三、機車廢氣呼吸曝露對雌性大鼠小腦之5-HT2A, GluR5, NR2B mRNA 表現量之影響…………………………………………………………………………..58 圖四、機車廢氣呼吸曝露對雌性大鼠紋狀體之5-HT2A, GluR5, NR2B mRNA 表現量之影響………………………………………………………………………..59 圖五、機車廢氣呼吸曝露對雌性大鼠海馬迴之5-HT2A, GluR5, NR2B mRNA 表現量之影響………………………………………………………………………...60 | |
| dc.language.iso | zh-TW | |
| dc.subject | 心臟毒性 | zh_TW |
| dc.subject | 子代 | zh_TW |
| dc.subject | 神經行為毒性 | zh_TW |
| dc.subject | 機車廢氣 | zh_TW |
| dc.subject | 生殖發育毒性 | zh_TW |
| dc.subject | cardiotoxicity | en |
| dc.subject | motorcycle exhaust | en |
| dc.subject | the second generation | en |
| dc.subject | neurobehavior toxicity | en |
| dc.subject | reproductive development toxicity | en |
| dc.title | 機車廢氣對大鼠系統毒性之影響 | zh_TW |
| dc.title | Effects of Motorcycle Exhaust on Systemic Toxicity in Rats | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳大樑(Da-Liang Chen),吳鋼治(Gang-Jhih Wu) | |
| dc.subject.keyword | 機車廢氣,心臟毒性,生殖發育毒性,神經行為毒性,子代, | zh_TW |
| dc.subject.keyword | motorcycle exhaust,cardiotoxicity,reproductive development toxicity,neurobehavior toxicity,the second generation, | en |
| dc.relation.page | 78 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-07-21 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 毒理學研究所 | zh_TW |
| Appears in Collections: | 毒理學研究所 | |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| ntu-99-1.pdf Restricted Access | 1.88 MB | Adobe PDF |
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