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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 黃慶怡(Ching-I Huang) | |
| dc.contributor.author | Cheng-Hsun Liao | en |
| dc.contributor.author | 廖晟勛 | zh_TW |
| dc.date.accessioned | 2021-06-15T05:04:33Z | - |
| dc.date.available | 2012-07-28 | |
| dc.date.copyright | 2010-07-28 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-07-26 | |
| dc.identifier.citation | 參考文獻
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/46343 | - |
| dc.description.abstract | 近年來多間隔微胞的發展持續受到學者的注意，是因為其能在微胞內產生多個相互分離的區間，在藥物釋放等應用方面具有極大的發展潛力。在本論文中，我們運用秏散粒子動力學，探討A2-star-(B-alt-C)共聚合物在選擇性溶劑的添加下其多間隔微胞的形成。在添加一對A有選擇性的溶劑、也就是喜歡A討厭B與C，當共聚物處在稀薄溶液的情況之下，我們發現了豐富多樣的多間隔微胞型態。首先，藉由改變溶劑對B與C兩者的選擇性，我們發現彼此互斥的BC交替塊狀可以形成兩種不同的分層排列行為：同心(concentric)和彼此相疊(segmented)。再加上B與C交替塊狀數目的多寡(也就是改變組成fA)以及B與C間作用力參數的大小，會影響B與C分層數目的多寡，進而影響大尺寸的微胞型態，所以藉由改變組成fA以及作用力參數aBC、aBS和aCS，我們得到了BC相混球狀、BC分層球狀、BC分層蟲狀、BC分層短柱、B-C-B漢堡狀、C-B-C漢堡狀、BC雙螺旋、B單螺旋、C單螺旋、BC分層同心球狀、BC同軸短柱、BC同軸碗狀等微胞型態。這些多元的多間隔微胞型態是基於此共聚物分子結構的特性，在不同的疏水塊狀之間都有連接點的存在，將能使連接點深入疏水區域的內部形成同心或是分層等不同的排列。 | zh_TW |
| dc.description.abstract | In recent years, multicompartment micelles have attracted wide attention due to their potential applications in drug delivery. In this study, we employ dissipative particle dynamics (DPD) to explore the formation of multicomponent micelles of A2-star-(B-alt-C) copolymers when a selective solvent is added, which is selective for A-blocks. Most interestingly, we find the various multicompartment micellar morphologies, such as multiple BC-mixed spherical micelles, segmented spherical micelles, segmented worm-like micelles, segmented short cylinders, B-C-B hamburger micelles, C-B-C hamburger micelles, Double helices, B-single helix, C-single helix, concentric layers within spherical micelles, coaxial short cylinders and coaxial bowl-like micelles. These multicompartment micelles are strongly affected by varying the solvent selectivity, solvent amount, copolymer composition and copolymer chain length. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T05:04:33Z (GMT). No. of bitstreams: 1 ntu-99-R97549033-1.pdf: 4246846 bytes, checksum: 21d695d311bddfc1068760e209013736 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 目 錄
口試委員會審定書 ......................................... I 致謝...................................................... II 中文摘要................................................. III 英文摘要................................................. IV 目錄...................................................... V 圖例說明................................................. VI 1.簡介.................................................... 1 2.耗散粒子動力學模擬方法與參數設定 ....................... 11 3.結果與討論 ............................................. 16 4.結論 ................................................... 22 參考文獻................................................. 24 | |
| dc.language.iso | zh-TW | |
| dc.subject | 型態 | zh_TW |
| dc.subject | 多間隔微胞 | zh_TW |
| dc.subject | 選擇性溶劑 | zh_TW |
| dc.subject | 線性-交替式分子結構 | zh_TW |
| dc.subject | 耗散粒子動力學 | zh_TW |
| dc.subject | coil-alternating molecule | en |
| dc.subject | morphology | en |
| dc.subject | solvent selectivity | en |
| dc.subject | dissipative particle dynamics | en |
| dc.subject | multicompartment micelle | en |
| dc.title | A2-star-(B-alt-C)共聚合物在選擇性溶劑中多間隔微胞型態的探討 | zh_TW |
| dc.title | Multicompartment Micelles from A2-star-(B-alt-C) Molecules in Selective Solvents | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳彥龍,童世煌 | |
| dc.subject.keyword | 多間隔微胞,選擇性溶劑,線性-交替式分子結構,耗散粒子動力學,型態, | zh_TW |
| dc.subject.keyword | multicompartment micelle,coil-alternating molecule,dissipative particle dynamics,solvent selectivity,morphology, | en |
| dc.relation.page | 46 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-07-27 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 高分子科學與工程學研究所 | |
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