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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 許文翰 | |
| dc.contributor.author | Wei-Jen Chen | en |
| dc.contributor.author | 陳韋仁 | zh_TW |
| dc.date.accessioned | 2021-06-15T05:02:01Z | - |
| dc.date.available | 2010-07-30 | |
| dc.date.copyright | 2010-07-30 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-07-28 | |
| dc.identifier.citation | [1] Dewey, J.. Southern Illinois University Press, Carbondale. The Middle Works, Vol. 4,
1907-1909 [2] Bailey,M.R.,Khokhlova,V.A.,Sapozhnikov,O.A.,Kargl,S.G.,Crum,L.A.,2003. Physical mecha- nism of the therapeutic e®ect of ultrasound(A review) Acoustic Physics, Vol. 49, No. 9, 369-388 [3] J.W.S.,Rayleigh,1878. The theory of sound Vol. 2, 278 [4] D.R.,Daum,K.,Hynynen. A 256 element ultrasonic phased array system for treatment of large volumes of deep seated tissue, IEEE Trans Ultrason. Ferroelect. Freq Contr., Vol. 46(5), 1254-1268(1999) [5] H.H.,Pennes. Analysis of tissue and arterial blood temperatures in the resting human forearm, J. Appl. Physiol., 2, 93-122(1948) [6] T.Kamakura, M.Matsuda, Y.Kumamoto, M.A. Breazeale. Acoustic streaming induced in fo- cused Gaussian beams. J. Acoust. Soc. Am., 97, 2740-2746(1995) [7] Jinlan Huang, R.Glynn Holt, Robin O.Cleveland, Ronald A.Roy. Experimental validation of atractable medical model for focused ultrasound heating in °ow through tissue phantoms. J. Acoust. Soc. Am., 116(4) pt(1), 2451-2458(2004) [8] H. T. O'Neil, Theory of Focusing Radiator, The Journal Of The Acoustic Society Of America, Vol. 21, No. 5, 516-526, 1949. [9] CFD research corporation (CFDRC), 216 Wynn Drive Huntsville, AL 35805, USA [10] Patankar, S. V. , Numerical Heat Transfer and Fluid Flow, Hemisphere, Washington, D.C. [11] 阮辰帷,'模擬超音波燒灼肝腫瘤過程',碩士論文國立台灣大學工程科學及海洋工程所,4-15 June, 2008. [12] Hao-Li Liu, Hsu Chang, Wen-Shiang Chen, Tzu-Ching Shih, Jong-Kai Hsiao, Win-Li Lin, Feasibility of transrib focused ultrasound thermal ablation for liver tumors using a spherically curved 2D array A numerical study, Medical Physics, Vol. 34, 3436, 2007. [13] P.Hariharan, M.R.Myers, R.K.Banerjee, HIFU procedures at moderate intensities!e®ect of large blood vessels, Physics in Medicine and Biology, Vol. 52, No. 12, 3493-3513, 2007. [14] Liu. X, Nonlinear absorption in biological tissue for high intensity focused ultrasound, Ul- trasonics, Vol. 44, 27-30, 2006. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/46292 | - |
| dc.description.abstract | 肝癌是一種細胞異常變化的一種疾病，
它因不受控制而形成癌化腫瘤。 過去有許多文獻探討肝腫瘤以超音波產生熱方式治療， 卻少有文獻針對真正的肝臟外型做熱治療的研究， 本篇研究利用MRI取得肝臟外型後， 並在肝臟內部置入一動脈血管以及腫瘤， 將此三組織肝臟、腫瘤以及動脈血管做為研究對象。 利用聚焦型超音波換能器， 能夠在聚焦點產生高能量之特性， 將此能量打入腫瘤內部， 來觀察、分析腫瘤以及肝臟的溫度分布， 是否能有效使得腫瘤細胞因受高溫而死亡， 並且完整保護肝臟組織， 進而討論動脈血管的血液流動對於此手術過程所造成之影響。 並且將結合實驗來與吾人利用數值方法模擬之結果做一比對。 | zh_TW |
| dc.description.abstract | The study is aimed at predicting liver tumor temperature during thermal
ablation using acoustics-thermal-fluid coupling model. The Rayleigh-Sommerfeld diffraction equation for HIFU(High-Intensity Focused Ultrasound) takes into account the wave distortion due to the finite-amplitude propagation. The nonlinear hemodynamic equations are also involved in the simulation domain that contains hepatic tissue domain, where homogenization dominates in perfusion, and vascular domain, where convective cooling is essential. Pennes Bioheat equation takes into account the thermal conduction with two heat sinks to account for tissue perfusion and forced convection-induced cooling. Acoustic streaming is also included in the numerical study. This article also designs a measurement to compare. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T05:02:01Z (GMT). No. of bitstreams: 1 ntu-99-R97525044-1.pdf: 33198958 bytes, checksum: 9c952a200e77a7fcc57b7cceb107fa01 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 致謝...2
摘要...i Abstract...ii 第一章 導論...7 1.1 肝腫瘤手術介紹...1 1.2 超音波之介紹...3 1.2.1 診斷用超音波...3 1.2.2 治療用超音波...3 1.3 超音波熱治療之介紹...5 1.4 研究動機...6 1.5 論文架構...6 第二章 三場聯立之分析架構...7 2.1 線性波方程...7 2.2 生物熱傳方程...11 2.3 聲流方程...13 第三章 數值方法..14 3.1 線性波方程求解之驗證...14 3.2 生物熱傳方程之離散...17 3.2.1 顯示離散方法...17 3.2.2 生物熱傳方程式之驗證...18 3.3 CFDRC軟體之簡介...19 3.3 結果之比較...21 第四章 計算結果...28 4.1 問題描述及參數設定...28 4.2 超音波場...31 4.3 Acoustic Streaming...33 4.3.1 無Acoustic時對血液流動的影響...34 4.3.2 有Acoustic時對血液流動的影響...35 4.3.3 比較有、無Acoustic時對血液流動的影響...36 4.4 溫度場...37 4.4.1 超音波加熱肝腫瘤過程中，在無血液流動下之溫度分佈...37 4.4.2 超音波加熱肝腫瘤過程中，在有血液流動下之溫度分佈...39 4.4.3 比較有、無血液流動對超音波加熱肝腫瘤之溫度分佈...40 4.4.4 超音波加熱肝腫瘤過程中于血管內之血液流動情況...41 4.5 在不同頻率下之結果探討...42 4.5.1 超音波頻率0.8MHz...42 4.5.2 超音波頻率1.2MHz...43 4.5.3 各頻率計算結果之比較...44 第五章 實驗...77 5.1 實驗介紹...77 5.2 實驗結果...79 5.3 實驗與模擬結果之比較...81 第六章 結論...83 6.1 研究結果與討論...83 6.2 未來展望...84 參考文獻...85 | |
| dc.language.iso | zh-TW | |
| dc.title | 高能聚焦超音波燒灼肝腫瘤的數值研究 | zh_TW |
| dc.title | Numerical studys of ablating liver tumor by high-intensity focused ultrasound(HIFU) | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蔣德普,林文澧,李佳翰 | |
| dc.subject.keyword | 肝癌,超音波熱治療,高能聚焦型超音波, | zh_TW |
| dc.subject.keyword | Rayleigh-Sommerfeld,HIFU,Pennes Bioheat equation,Acoustic streaming, | en |
| dc.relation.page | 86 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2010-07-28 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 工程科學及海洋工程學研究所 | zh_TW |
| 顯示於系所單位： | 工程科學及海洋工程學系 | |
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