碘乙酸(Iodoacetic acid)於人類肺癌細胞對Notch3 基因
的影響

Hui-Ling Chen; 陳惠玲

請用此 Handle URI 來引用此文件： http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/45317

完整後設資料紀錄

DC 欄位	值	語言
dc.contributor.advisor	吳美玲
dc.contributor.author	Hui-Ling Chen	en
dc.contributor.author	陳惠玲	zh_TW
dc.date.accessioned	2021-06-15T04:13:57Z	-
dc.date.available	2015-03-12
dc.date.copyright	2010-03-12
dc.date.issued	2010
dc.date.submitted	2010-01-19
dc.identifier.citation	Akiyoshi, T., M. Nakamura, et al. (2008). 'Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells.' Gastroenterology 134(1): 131-44. Apffel, C. A., B. G. Arnason, et al. (1966). 'Induction of tumour immunity with tumour cells treated with iodoacetate.' Nature 209(5024): 694-6. Artavanis-Tsakonas, S., K. Matsuno, et al. (1995). 'Notch signaling.' Science 268(5208): 225-32. Aviel-Ronen, S., F. H. Blackhall, et al. (2006). 'K-ras mutations in non-small-cell lung carcinoma: a review.' Clin Lung Cancer 8(1): 30-8. Badar, F., F. Meerza, et al. (2006). 'Characteristics of lung cancer patients--the Shaukat Khanum Memorial experience.' Asian Pac J Cancer Prev 7(2): 245-8. Beevers, H. and E. W. Simon (1949). 'Effect of pH on the activity of some respiratory inhibitors.' Nature 163(4141): 408. Bellavia D, C. A., Alesse E, Vacca A, Felli MP, Balestri A, Stoppacciaro A, Tiveron C, Tatangelo L, Giovarelli M, Gaetano C, Ruco L, Hoffman ES, Hayday AC, Lendahl U, Frati L, Gulino A, Screpanti I. (2000). 'constitutive activation of NFkB and T-cell leukemia/lymphoma in notch3 transgenic mice.' The EMBO journal 19(13): 3337-3348. Bettenhausen, B., M. Hrabe de Angelis, et al. (1995). 'Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta.' Development 121(8): 2407-18. Beurel, E. and R. S. Jope (2006). 'The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways.' Prog Neurobiol 79(4): 173-89. Beurel, E., M. Kornprobst, et al. (2004). 'GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 76 (Fas/APO-1) expression.' Exp Cell Res 300(2): 354-64. Biedermann, K. A. and J. R. Landolph (1987). 'Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts.' Cancer Res 47(14): 3815-23. Blaumueller, C. M., H. Qi, et al. (1997). 'Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.' Cell 90(2): 281-91. Boffetta, P. and F. Nyberg (2003). 'Contribution of environmental factors to cancer risk.' Br Med Bull 68: 71-94. Brown, N. S. and R. Bicknell (2001). 'Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer.' Breast Cancer Res 3(5): 323-7. Brownlee, M., A. Cerami, et al. (1988). 'Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications.' N Engl J Med 318(20): 1315-21. Cardenas-Rodriguez, N., S. Guzman-Beltran, et al. (2009). 'The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons.' J Biochem Mol Toxicol 23(2): 137-42. Cerfolio, R. J., A. S. Bryant, et al. (2006). 'Women with pathologic stage I, II, and III non-small cell lung cancer have better survival than men.' Chest 130(6): 1796-802. Chipuk, J. E. and D. R. Green (2005). 'Do inducers of apoptosis trigger caspase-independent cell death?' Nat Rev Mol Cell Biol 6(3): 268-75. Chipuk, J. E., T. Kuwana, et al. (2004). 'Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.' Science 303(5660): 1010-4. Chitnis, A., D. Henrique, et al. (1995). 'Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta.' Nature 375(6534): 761-6. 77 Choi, J. H., J. T. Park, et al. (2008). 'Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion.' Cancer Res 68(14): 5716-23. Colell, A., J. E. Ricci, et al. (2007). 'GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.' Cell 129(5): 983-97. Colosimo, P. F., X. Liu, et al. (2009). 'GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels.' Dev Dyn. Craig S. Malcolma, K. R. B., Helen Lamba, David Bebbingtona and Richard H. P. Porter (2000). 'Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells ' Free Radical Biology & Medicine 28(1): 102-107. Curry, C. L., L. L. Reed, et al. (2005). 'Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.' Oncogene 24(42): 6333-44. Dai, R. M., E. Chen, et al. (1998). 'Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha.' J Biol Chem 273(6): 3562-73. Dang, L., X. Fan, et al. (2006). 'Notch3 signaling initiates choroid plexus tumor formation.' Oncogene 25(3): 487-91. Daniel, B., A. Rangarajan, et al. (1997). 'The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions.' J Gen Virol 78 ( Pt 5): 1095-101. De Keersmaecker, K., I. Lahortiga, et al. (2008). 'In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.' Haematologica 93(4): 533-42. del Amo, F. F., M. Gendron-Maguire, et al. (1993). 'Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch.' Genomics 15(2): 259-64. 78 Demarest, R. M., F. Ratti, et al. (2008). 'It's T-ALL about Notch.' Oncogene 27(38): 5082-91. Doucas, H., C. D. Mann, et al. (2008). 'Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt.' J Surg Oncol 97(1): 63-8. Downward, J. (2003). 'Targeting RAS signalling pathways in cancer therapy.' Nat Rev Cancer 3(1): 11-22. Dringen, M. M. S. a. R. (2009). 'Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes.' Frontiers in Neuroenergetics 1. Dunwoodie, S. L., D. Henrique, et al. (1997). 'Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo.' Development 124(16): 3065-76. Ehebauer, M., P. Hayward, et al. (2006). 'Notch, a universal arbiter of cell fate decisions.' Science 314(5804): 1414-5. Embi, N., D. B. Rylatt, et al. (1980). 'Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.' Eur J Biochem 107(2): 519-27. Eom, T. Y. and R. S. Jope (2009). 'GSK3 beta N-terminus binding to p53 promotes its acetylation.' Mol Cancer 8: 14. Esme, H., M. Cemek, et al. (2008). 'High levels of oxidative stress in patients with advanced lung cancer.' Respirology 13(1): 112-6. Fahim, F. A., A. Y. Esmat, et al. (2003). 'Antitumor activities of iodoacetate and dimethylsulphoxide against solid Ehrlich carcinoma growth in mice.' Biol Res 36(2): 253-62. Fortini, M. E. (2002). 'Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.' Nat Rev Mol Cell Biol 3(9): 673-84. 79 Freedman, V. H. and S. I. Shin (1974). 'Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.' Cell 3(4): 355-9. Grimes, C. A. and R. S. Jope (2001). 'The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.' Prog Neurobiol 65(4): 391-426. Hallahan, A. R., J. I. Pritchard, et al. (2004). 'The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.' Cancer Res 64(21): 7794-800. Haruki, N., K. S. Kawaguchi, et al. (2005). 'Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.' Cancer Res 65(9): 3555-61. Hengartner, M. O. (2000). 'The biochemistry of apoptosis.' Nature 407(6805): 770-6. Henrique, D., E. Hirsinger, et al. (1997). 'Maintenance of neuroepithelial progenitor cells by Delta-Notch signalling in the embryonic chick retina.' Curr Biol 7(9): 661-70. Hurst, R. D., S. Azam, et al. (2001). 'Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier.' Brain Res 894(2): 181-8. Hynes, N. E. and H. A. Lane (2005). 'ERBB receptors and cancer: the complexity of targeted inhibitors.' Nat Rev Cancer 5(5): 341-54. Jemal, A., R. Siegel, et al. (2008). 'Cancer statistics, 2008.' CA Cancer J Clin 58(2): 71-96. Jones, P., G. May, et al. (1998). 'Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells.' Blood 92(5): 1505-11. Jope, R. S. and G. V. Johnson (2004). 'The glamour and gloom of glycogen synthase kinase-3.' Trends Biochem Sci 29(2): 95-102. 80 Joutel, A., F. Andreux, et al. (2000). 'The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients.' J Clin Invest 105(5): 597-605. Joutel, A., C. Corpechot, et al. (1996). 'Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia.' Nature 383(6602): 707-10. Joutel, A., K. Vahedi, et al. (1997). 'Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients.' Lancet 350(9090): 1511-5. Kamps, M. P., A. T. Look, et al. (1991). 'The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.' Genes Dev 5(3): 358-68. Kamps, M. P., C. Murre, et al. (1990). 'A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.' Cell 60(4): 547-55. Kimble, J. and P. Simpson (1997). 'The LIN-12/Notch signaling pathway and its regulation.' Annu Rev Cell Dev Biol 13: 333-61. King, T. D. and R. S. Jope (2005). 'Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress.' Neuroreport 16(6): 597-601. Koch, U. and F. Radtke (2007). 'Notch and cancer: a double-edged sword.' Cell Mol Life Sci 64(21): 2746-62. Kolev, V., A. Mandinova, et al. (2008). 'EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.' Nat Cell Biol 10(8): 902-11. Kondo, Y., T. Kanzawa, et al. (2005). 'The role of autophagy in cancer development and response to therapy.' Nat Rev Cancer 5(9): 726-34. Konishi, J., K. S. Kawaguchi, et al. (2007). 'Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers.' Cancer Res 67(17): 8051-7. 81 Krysko, D. V., K. D'Herde, et al. (2006). 'Clearance of apoptotic and necrotic cells and its immunological consequences.' Apoptosis 11(10): 1709-26. Lacouture, M. E. (2006). 'Mechanisms of cutaneous toxicities to EGFR inhibitors.' Nat Rev Cancer 6(10): 803-12. Lardelli, M., J. Dahlstrand, et al. (1994). 'The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium.' Mech Dev 46(2): 123-36. Larsen, M., M. L. Tremblay, et al. (2003). 'Phosphatases in cell-matrix adhesion and migration.' Nat Rev Mol Cell Biol 4(9): 700-11. Le Calvez, F., A. Mukeria, et al. (2005). 'TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers.' Cancer Res 65(12): 5076-83. Lee, C. W., C. M. Raskett, et al. (2008). 'Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis.' Cancer Res 68(13): 5273-81. Lee, K. Y., S. H. Koh, et al. (2007). 'Glycogen synthase kinase-3beta activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells.' Brain Res 1129(1): 89-99. Lewis, J. (1996). 'Neurogenic genes and vertebrate neurogenesis.' Curr Opin Neurobiol 6(1): 3-10. Lewis, J. (1998). 'Notch signalling and the control of cell fate choices in vertebrates.' Semin Cell Dev Biol 9(6): 583-9. Li, D. (2006). 'GSK-3beta as a driving force in ovarian cancer.' Cell Res 16(7): 609. Liang, C. C., A. Y. Park, et al. (2007). 'In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.' Nat Protoc 2(2): 329-33. Lindsell, C. E., C. J. Shawber, et al. (1995). 'Jagged: a mammalian ligand that activates Notch1.' Cell 80(6): 909-17. 82 Liu, G., W. Zhou, et al. (2005). 'Molecular epidemiology of non-small cell lung cancer.' Semin Respir Crit Care Med 26(3): 265-72. Logeat, F., C. Bessia, et al. (1998). 'The Notch1 receptor is cleaved constitutively by a furin-like convertase.' Proc Natl Acad Sci U S A 95(14): 8108-12. Martinez, A. (2008). 'Preclinical efficacy on GSK-3 inhibitors: towards a future generation of powerful drugs.' Med Res Rev 28(5): 773-96. Mascaux, C., N. Iannino, et al. (2005). 'The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis.' Br J Cancer 92(1): 131-9. Matthews, R. T., R. J. Ferrante, et al. (1997). 'Iodoacetate produces striatal excitotoxic lesions.' J Neurochem 69(1): 285-9. McNeil, P. L., L. Muthukrishnan, et al. (1989). 'Growth factors are released by mechanically wounded endothelial cells.' J Cell Biol 109(2): 811-22. Mihara, M., S. Erster, et al. (2003). 'p53 has a direct apoptogenic role at the mitochondria.' Mol Cell 11(3): 577-90. Morgan, T. H. (1917). 'the theory of the gene.' the american naturalist 51: 513-544. Morrison, S. J., S. E. Perez, et al. (2000). 'Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.' Cell 101(5): 499-510. Mulholland, D. J., S. Dedhar, et al. (2006). 'PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer.' Oncogene 25(3): 329-37. Nair, A., M. Venkatraman, et al. (2003). 'NF-kappaB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix.' Oncogene 22(1): 50-8. Nefedova, Y., D. M. Sullivan, et al. (2008). 'Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy.' Blood 111(4): 83 2220-9. Nguyen, B. C., K. Lefort, et al. (2006). 'Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.' Genes Dev 20(8): 1028-42. Nicolas, M., A. Wolfer, et al. (2003). 'Notch1 functions as a tumor suppressor in mouse skin.' Nat Genet 33(3): 416-21. Nourse, J., J. D. Mellentin, et al. (1990). 'Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.' Cell 60(4): 535-45. O'Neil, J., J. Calvo, et al. (2006). 'Activating Notch1 mutations in mouse models of T-ALL.' Blood 107(2): 781-5. Osipo, C., T. E. Golde, et al. (2008). 'Off the beaten pathway: the complex cross talk between Notch and NF-kappaB.' Lab Invest 88(1): 11-7. Osipo, C., P. Patel, et al. (2008). 'ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.' Oncogene 27(37): 5019-32. Ougolkov, A. V., M. E. Fernandez-Zapico, et al. (2005). 'Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.' Cancer Res 65(6): 2076-81. Pao, W., T. Y. Wang, et al. (2005). 'KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.' PLoS Med 2(1): e17. Park, J. T., M. Li, et al. (2006). 'Notch3 gene amplification in ovarian cancer.' Cancer Res 66(12): 6312-8. Park, J. T., M. Shih Ie, et al. (2008). 'Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer.' Cancer Res 68(21): 8852-60. Parkin, D. M., F. Bray, et al. (2005). 'Global cancer statistics, 2002.' CA Cancer J Clin 55(2): 74-108. Pear, W. S. and F. Radtke (2003). 'Notch signaling in lymphopoiesis.' Semin 84 Immunol 15(2): 69-79. Perez, R. P. (1998). 'Cellular and molecular determinants of cisplatin resistance.' Eur J Cancer 34(10): 1535-42. Phelan, M. L., I. Rambaldi, et al. (1995). 'Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif.' Mol Cell Biol 15(8): 3989-97. Prusty, B. K., S. A. Husain, et al. (2005). 'Constitutive activation of nuclear factor -kB: preferntial homodimerization of p50 subunits in cervical carcinoma.' Front Biosci 10: 1510-9. Qi, R., H. An, et al. (2003). 'Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.' Cancer Res 63(23): 8323-9. Qiu, Y., Y. Tomita, et al. (2007). 'Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth.' Am J Pathol 170(1): 152-9. Rangarajan, A., R. Syal, et al. (2001). 'Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt.' Virology 286(1): 23-30. Rasul, S., R. Balasubramanian, et al. (2009). 'Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells.' Br J Cancer 100(12): 1879-88. Rego, A. C., M. S. Santos, et al. (1999). 'Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress.' Free Radic Biol Med 26(11-12): 1405-17. Ridley, A. J., M. A. Schwartz, et al. (2003). 'Cell migration: integrating signals from front to back.' Science 302(5651): 1704-9. Rizzo, P., H. Miao, et al. (2008). 'Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.' Cancer Res 68(13): 5226-35. 85 Roy, M., W. S. Pear, et al. (2007). 'The multifaceted role of Notch in cancer.' Curr Opin Genet Dev 17(1): 52-9. Sahai, E. and C. J. Marshall (2003). 'Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis.' Nat Cell Biol 5(8): 711-9. Sakai, K., K. Hasumi, et al. (1990). 'Two glyceraldehyde-3-phosphate dehydrogenase isozymes from the koningic acid (heptelidic acid) producer Trichoderma koningii.' Eur J Biochem 193(1): 195-202. Schreiber, M., A. Kolbus, et al. (1999). 'Control of cell cycle progression by c-Jun is p53 dependent.' Genes Dev 13(5): 607-19. Schwartz, A. G., G. M. Prysak, et al. (2007). 'The molecular epidemiology of lung cancer.' Carcinogenesis 28(3): 507-18. Selkoe, D. and R. Kopan (2003). 'Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.' Annu Rev Neurosci 26: 565-97. Sengupta, S. and C. C. Harris (2005). 'p53: traffic cop at the crossroads of DNA repair and recombination.' Nat Rev Mol Cell Biol 6(1): 44-55. Seoane, J., H. V. Le, et al. (2002). 'Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage.' Nature 419(6908): 729-34. Shah, S., S. F. Lee, et al. (2005). 'Nicastrin functions as a gamma-secretase-substrate receptor.' Cell 122(3): 435-47. Shakoori, A., A. Ougolkov, et al. (2005). 'Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.' Biochem Biophys Res Commun 334(4): 1365-73. Shani, V., Y. Bromberg, et al. (2009). 'Involvement of Src tyrosine kinases (SFKs) and of focal adhesion kinase (FAK) in the injurious mechanism in rat primary neuronal cultures exposed to chemical ischemia.' J Mol Neurosci 37(1): 50-9. 86 Sharma, P., T. Wang, et al. (2001). 'Fits and strokes.' Lancet 358(9276): 120. Sharma, S. V., D. W. Bell, et al. (2007). 'Epidermal growth factor receptor mutations in lung cancer.' Nat Rev Cancer 7(3): 169-81. Shawber, C., J. Boulter, et al. (1996). 'Jagged2: a serrate-like gene expressed during rat embryogenesis.' Dev Biol 180(1): 370-6. Shields, P. G. (2002). 'Molecular epidemiology of smoking and lung cancer.' Oncogene 21(45): 6870-6. Shigematsu, H. and A. F. Gazdar (2006). 'Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.' Int J Cancer 118(2): 257-62. Shigematsu, H., L. Lin, et al. (2005). 'Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.' J Natl Cancer Inst 97(5): 339-46. Shin, S. Y., C. G. Kim, et al. (2004). 'Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin.' Cancer Lett 212(2): 225-31. Shiraishi, K., K. Yamasaki, et al. (2007). 'Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.' Oncogene 26(3): 339-48. Shutter, J. R., S. Scully, et al. (2000). 'Dll4, a novel Notch ligand expressed in arterial endothelium.' Genes Dev 14(11): 1313-8. Skurk, C., H. Maatz, et al. (2005). 'Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells.' Circ Res 96(3): 308-18. Song, L. L., Y. Peng, et al. (2008). 'Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.' Oncogene 27(44): 5833-44. Sriuranpong, V., M. W. Borges, et al. (2001). 'Notch signaling induces cell cycle arrest in small cell lung cancer cells.' Cancer Res 61(7): 3200-5. 87 Stahel, R. A. (2007). 'Adenocarcinoma, a molecular perspective.' Ann Oncol 18 Suppl 9: ix147-9. Sun, S., J. H. Schiller, et al. (2007). 'Lung cancer in never smokers--a different disease.' Nat Rev Cancer 7(10): 778-90. Tan, J., L. Zhuang, et al. (2005). 'Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells.' Cancer Res 65(19): 9012-20. Taylor, B. M., W. E. Fleming, et al. (1996). 'The mechanism of cytoprotective action of lazaroids I: Inhibition of reactive oxygen species formation and lethal cell injury during periods of energy depletion.' J Pharmacol Exp Ther 276(3): 1224-31. Thiery, J. P. and J. P. Sleeman (2006). 'Complex networks orchestrate epithelial-mesenchymal transitions.' Nat Rev Mol Cell Biol 7(2): 131-42. Uyttendaele, H., G. Marazzi, et al. (1996). 'Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene.' Development 122(7): 2251-9. Vahakangas, K. H., W. P. Bennett, et al. (2001). 'p53 and K-ras mutations in lung cancers from former and never-smoking women.' Cancer Res 61(11): 4350-6. Varnum-Finney, B., L. E. Purton, et al. (1998). 'The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.' Blood 91(11): 4084-91. Venkatraman, M., R. J. Anto, et al. (2005). 'Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis.' Mol Carcinog 44(1): 51-9. Vermes, I., C. Haanen, et al. (2000). 'Flow cytometry of apoptotic cell death.' J Immunol Methods 243(1-2): 167-90. Villa, N., L. Walker, et al. (2001). 'Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.' Mech Dev 108(1-2): 161-4. Visbal, A. L., B. A. Williams, et al. (2004). 'Gender differences in non-small-cell lung 88 cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002.' Ann Thorac Surg 78(1): 209-15; discussion 215. Wakelee, H. A., E. T. Chang, et al. (2007). 'Lung cancer incidence in never smokers.' J Clin Oncol 25(5): 472-8. Wang, T., C. M. Holt, et al. (2007). 'Notch3 activation modulates cell growth behaviour and cross-talk to Wnt/TCF signalling pathway.' Cell Signal 19(12): 2458-67. Wang, W., S. Goswami, et al. (2005). 'Tumor cells caught in the act of invading: their strategy for enhanced cell motility.' Trends Cell Biol 15(3): 138-45. Wang, Z., Y. Li, et al. (2008). 'Exploitation of the Notch signaling pathway as a novel target for cancer therapy.' Anticancer Res 28(6A): 3621-30. Watcharasit, P., G. N. Bijur, et al. (2003). 'Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53.' J Biol Chem 278(49): 48872-9. Watcharasit, P., G. N. Bijur, et al. (2002). 'Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage.' Proc Natl Acad Sci U S A 99(12): 7951-5. Webb, J. L. (1950). 'The actions of metabolic substrates and inhibitors on the rabbit auricle.' Br J Pharmacol Chemother 5(1): 87-117. Webb, J. L., P. R. Saunders, et al. (1949). 'The metabolism of the heart in relation to drug action; the action of metabolic inhibitors on rat heart slice respiration.' Arch Biochem 22(3): 458-66. Weinmaster, G., V. J. Roberts, et al. (1992). 'Notch2: a second mammalian Notch gene.' Development 116(4): 931-41. Wolf, M. B. and J. W. Baynes (2006). 'The anti-cancer drug, doxorubicin, causes oxidant stress-induced endothelial dysfunction.' Biochim Biophys Acta 1760(2): 267-71. 89 Woodgett, J. R. (1991). 'cDNA cloning and properties of glycogen synthase kinase-3.' Methods Enzymol 200: 564-77. Yamaguchi, H., J. Wyckoff, et al. (2005). 'Cell migration in tumors.' Curr Opin Cell Biol 17(5): 559-64. Yamaguchi, N., T. Oyama, et al. (2008). 'NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells.' Cancer Res 68(6): 1881-8. Yang, Z., P. J. Faustino, et al. (2000). 'Decreased cisplatin/DNA adduct formation is associated with cisplatin resistance in human head and neck cancer cell lines.' Cancer Chemother Pharmacol 46(4): 255-62. Ying Qiu, E. M., Yasuhiko Tomita, Binglin Zhang, Akihide Matsumura,Masanori Kitaichi, and M. O. a. K. Aozasa (2009). 'Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.' cancer science 100(7): 1198. Yoeli-Lerner, M., Y. R. Chin, et al. (2009). 'Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.' Mol Cancer Res 7(3): 425-32. Yugawa, T., K. Handa, et al. (2007). 'Regulation of Notch1 gene expression by p53 in epithelial cells.' Mol Cell Biol 27(10): 3732-42. Zagouras, P., S. Stifani, et al. (1995). 'Alterations in Notch signaling in neoplastic lesions of the human cervix.' Proc Natl Acad Sci U S A 92(14): 6414-8. Zmijewski, J. W. and R. S. Jope (2004). 'Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts.' Aging Cell 3(5): 309-17.
dc.identifier.uri	http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/45317	-
dc.description.abstract	根據衛生署2008 年的統計，惡性腫瘤自民國71 年起為國人死因之榜首，而其中肺癌居癌症死因之首位。肺癌病人平均存活時間約九至十二個月，並且整體五年存活時間約百分之十。80％病人在手術後兩年內會發生癌症轉移導致死亡，少於20%病人能接受根除性手術性治療。因此，尋找更有效的藥物治療而且改善存活率對於肺癌病人是必要且急需的。由之前研究結果顯示，碘乙酸(IAA)的處理下會釋放cytochrome C 造成活化caspase 3，造成人類肺癌細胞株的細胞核濃染之細胞凋亡，因此可能為一個有潛力的治療藥物。在本篇實驗中，我們著重探討碘乙酸造成肺癌細胞死亡可能的分子機制。研究結果顯示碘乙酸會造成藥效與劑量成正相關的細胞死亡，且anchorage dependent 和anchorage independent assay 的結果顯示碘乙酸會抑制肺癌細胞株的移動(migration)，而且大部分肺癌細胞株此反應會被DTT 或NAC 抑制，其中包括A549、 H1299、HOP62、H23 、EKVX、PC14、H1975、H441 、H460 等肺癌細胞株。根據碘乙酸microarray 結果，Notch3 基因為碘乙酸處理下的目標基因之ㄧ。而從RT-PCR 結果得知，碘乙酸處理16 或24 小時後，可造成大部份的肺癌細胞株Notch3 基因以及其下游目標基因PbX1 mRNA dose-dependent 的下降，且此反應亦可被DTT 或NAC 所恢復。综合上述結果，Notch3 和其下游目標基因PbX1 可能參與在碘乙酸所造成的細胞凋亡訊息傳遞中，因此在肺癌治療中可能為一新且有潛力的治療策略。	zh_TW
dc.description.abstract	Lung cancer is one of the tenth leading causes of death in Taiwan. The average survival duration for patients with lung cancer is about 9-12 months and overall 5-year survival rate is about 10%. There are less than 20% lung cancer patients able to undergo curative resection. 80% of lung cancer patients undergo surgery died of metastasis within two years. More effective treatments for this devastating disease are urgently needed. Based on our previous findings, IAA induced cytochrome C release resulting in activation of caspase-3 and nuclear condensation in non-small cell lung cancer (NSCLC). In this study, we investigate possible molecular mechanism(s) of how IAA induced cell death in human lung cancer cell lines. Our results showed that IAA induced dose-dependent cell death as well as inhibited migration in anchorage dependent and anchorage independent assays. These responses could be reversed by dithiothreitol (DTT) or N-acetyl-L cystein (NAC) in most tested lung cancer cell lines, such as A549, H1299, H522, HOP62, H23, EKVX, PC14, H1975, H441 and H460. Though RT-PCR and microarray analysis, Notch-3 can be confirmed as the target of IAA. Pbx-1 is predicted as downstream oncogene of Notch-3. Cells treated with IAA for 16 or 24 hours, RT-PCR assay showed Pbx-1 mRNA suppression. However, this symptom can be reversed by DTT or NAC. As a conclusion, Notch-3 and it’s downstream, Pbx-1, involved in IAA-induced cell death, which suggesting that inactivation of Notch-3 or Pbx-1 may be a potential therapy for lung cancer.	en
dc.description.provenance	Made available in DSpace on 2021-06-15T04:13:57Z (GMT). No. of bitstreams: 1 ntu-99-R96441016-1.pdf: 4544351 bytes, checksum: 0ab7291d11c22e4b94384673b766e39e (MD5) Previous issue date: 2010	en
dc.description.tableofcontents	圖次…………………………………………………………………... I 附錄………………………………………………………………….. II 摘要………………………………………………………………….. III Abstract………………………………………………………………. IV 緒論………………………………………………………………….. 1 材料與方法…………………………………………..……………… 16 結果………………………………………………………………….. 30 討論………………………………………………………………….. 40 結論與展望………………………………………………………….. 52 圖…………………………………………………………………….. 53 附錄………………………………………………………………….. 75 參考文獻…………………………………………………………….. 76
dc.language.iso	zh-TW
dc.title	碘乙酸(Iodoacetic acid)於人類肺癌細胞對Notch3 基因的影響	zh_TW
dc.title	The Effects of Iodoacetic acid-Induced Notch3 reduction in Human Lung Cancer Cells	en
dc.type	Thesis
dc.date.schoolyear	98-1
dc.description.degree	碩士
dc.contributor.oralexamcommittee	胡孟君,蘇慧敏
dc.subject.keyword	碘乙酸,Notch3基因,肺癌,	zh_TW
dc.subject.keyword	Iodoacetic acid,Notch3,lung cancer,	en
dc.relation.page	90
dc.rights.note	有償授權
dc.date.accepted	2010-01-19
dc.contributor.author-college	醫學院	zh_TW
dc.contributor.author-dept	生理學研究所	zh_TW
顯示於系所單位：	生理學科所

文件中的檔案：

檔案	大小	格式
ntu-99-1.pdf 目前未授權公開取用	4.44 MB	Adobe PDF

顯示文件簡單紀錄

系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。