請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44306完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 胡務亮(Wuh-Liang Hwu) | |
| dc.contributor.author | Lih-Maan Chang | en |
| dc.contributor.author | 張麗滿 | zh_TW |
| dc.date.accessioned | 2021-06-15T02:50:07Z | - |
| dc.date.available | 2009-09-15 | |
| dc.date.copyright | 2009-09-15 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-08-05 | |
| dc.identifier.citation | 林秀娟 (1991)。《國人唐氏症患兒發生率與生長情形之研究》。行政院衛生署研究報告，六月。
林秀娟 (1994)。《唐氏症》。中兒醫誌，35卷 (增刊A)，28-31頁。 陳榮華 (1997)。《魏氏兒童智力量表第三版 (WISC-Ⅲ) 中文版指導手冊》。台北：中國行為科學社。 陳榮華、陳心怡 (2000)。《魏氏幼兒智力量表修訂版 (WPPSI-R) 中文版指導手冊》。台北：中國行為科學社。 陳榮華、陳心怡 (2002)。《魏氏成人智力量表第三版 (WAIS-Ⅲ) 中文版指導手冊》。台北：中國行為科學社。 郭義興 (2002)。《台灣母血唐氏症篩檢對唐氏症出生趨勢之影響》。碩士論文。台北：國立臺灣大學。 蘇純瑩 (2001)。《唐氏症和X染色體脆折症的神經心理特徵與治療策略之探討》。職能治療學會雜誌，19卷，43-57頁。 Adler, B. & Kushnick, T. (1982). Genetic counseling in prenatally diagnosed trisomy 18 and 21: Psychosocial aspects. Pediatrics, 69, 94-99. al-Awadi, S. A., Farag, T. I., Teebi, A. S., Naguib, K. K., Sundareshan, T. S., & Murthy, D. S. (1990). Down syndrome in Kuwait. American Journal of Medical Genetics (Suppl.), 7, 87-88. American Academy of Pediatrics Committee on Genetics (2001). American Academy of Pediatrics: Health supervision for children with Down syndrome. Pediatrics, 107 (2), 442-449. Bayley, N. (2005). Bayley Scales of Infant and Toddler Development, Third Edition: Technical Manual. San Antonio, Texas: Psychological Corporation. Bellugi, U., Mills, D., Jernigan, T., Hickok, G., & Galaburda, A. (1999). Linking Cognition, Brain Structure, and Brain Function in Williams Syndrome. In Tager-Flusberg, H. (Ed.), Neurodevelopmental Disorders, pp. 111-136. Cambridge: The MIT Press. Bihrle, A. M., Bellugi, U., Delis, D., & Marks, S. (1989). Seeing either the forest or the trees: Dissociation in visuospatial processing. Brain and Cognition, 11, 37-49. Brown, F. R., Greer, M. K., Aylward, E. H., & Hunt, H. H. (1990). Intellectual and adaptive functioning in individuals with Down syndrome in relation to age and environmental placement. Pediatrics, 85, 450–452. Carr, J. (2005). Stability and change in cognitive ability over the life span: A comparison of populations with and without Down's syndrome. Journal of Intellectual Disability Research, 49(12), 915-928. Cattell, R. B. (1963). Theory of fluid and crystallized intelligence: A critical experiment. Journal of Educational Psychology, 54, 1-22. Chapman, R. S. & Hesketh, L. J. (2001). Language, cognition, and short-term memory in individuals with Down syndrome. Down Syndrome: Research and Practice, 7, 1-7. Chapman, R. S., Hesketh, L. J., & Kistler, D. (2002). Predicting longitudinal change in language production and comprehension in individuals with Down syndrome: Hierarchical linear modeling. Journal of Speech, Language, and Hearing Research, 45, 902-915. Chen, B. Y., Hwang, B. F., Guo, Y. L. (2009). Epidemiology of congenital anomalies in a population-based birth registry in Taiwan, 2002. Journal of Formosan Medical Association, 108(6), 460-468. Connolly, B. H., Morgan, S. B., Russell, F. F., & Fulliton, W. L. (1993). A longitudinal study of children with Down syndrome who experienced early intervention programming. Physical Therapy, 73(3), 170-179. Cunningham, C. C. (1996). Families of children with Down syndrome. Down Syndrome: Research and Practice, 4(3), 87-95. Devlin, L. & Morrison, P. J. (2004). Mosaic Down's syndrome prevalence in a complete population study. Archives of Disease in Childhood, 89(12), 1177-1178. Dierssen, M. & Ramakers, G. J. A. (2006). Dendritic pathology in mental retardation: From molecular genetics to neurobiology. Genes, Brain and Behavior (Suppl. 2), 5, 48–60. Down, J. L. H. (1866). Observations on an ethnic classification on idios. Clinical Lecture Reports, London Hospital, 3, 259. Ettlinger, G. (1990). 'Object vision' and 'spatial vision': the neuropsychological evidence for the distinction. Cortex, 26(3), 319-341. Fabbro, F., Alberti, B., Gagliardi, C., & Borgatti, R. (2002). Differences in native and foreign language repetition tasks between subjects with William's and Down's syndromes. Journal of Neurolinguistics, 15, 1-10. Fidler, D. J., Most, D. E., & Guiberson, M. M. (2005). Neuropsychological correlates of word identification in Down syndrome. Research in Developmental Disabilities, 26(5), 487-501. Fishler, K. & Koch, R. (1991). Mental development in Down syndrome mosaicism. American Journal of Mental Retardation, 96(3), 345-351. Fowler, A. E. (1990). Language abilities in children with Down syndrome: Evidence for a specific syntactic delay. In Cicchetti, D. & Beeghly, M. (Eds.), Children with Down syndrome, pp. 302-308. Cambridge: Cambridge University press. Frenkel, S. & Bourdin, B. (2009). Verbal, visual, and spatio-sequential short-term memory: assessment of the storage capacities of children and teenagers with Down's syndrome. Journal of Intellectual Disability Research, 53(2), 152-160. Glenn, S. & Cunningham, C. (2005). Performance of young people with Down Syndrome on the Leiter-R and British Picture Vocabulary Scales. Journal of Intellectual Disability Research, 49(4), 239-244. Haier, R. J., Chueh, D., Touchette, P., Lott, I., Buchsbaum, M. S., MacMillan, D., Sandman, C., LaCasse, L., & Sosa, E. (1995). Brain size and cerebral glucose metabolic rate in non-specific mental retardation and Down syndrome. Intelligence, 20(2), 191–210. Hattori, M., Fujiyama, A., Taylor, T. D., Watanabe, H., Yada, T., Park, H. S., Toyoda, A., Ishii, K., Totoki, Y., Choi, D. K., Groner, Y., Soeda, E., Ohki, M., Takagi, T., Sakaki, Y., Taudien, S., Blechschmidt, K., Polley, A., Menzel, U., Delabar, J., Kumpf, K., Lehmann, R., Patterson, D., Reichwald, K., Rump, A., Schillhabel, M., Schudy, A., Zimmermann, W., Rosenthal, A., Kudoh, J., Schibuya, K., Kawasaki, K., Asakawa, S., Shintani, A., Sasaki, T., Nagamine, K., Mitsuyama, S., Antonarakis, S. E., Minoshima, S., Shimizu, N., Nordsiek, G., Hornischer, K., Brant, P., Scharfe, M., Schon, O., Desario, A., Reichelt, J., Kauer, G., Blocker, H., Ramser, J., Beck, A., Klages, S., Hennig, S., Riesselmann, L., Dagand, E., Haaf, T., Wehrmeyer, S., Borzym, K., Gardiner, K., Nizetic, D., Francis, F., Lehrach, H., Reinhardt, R., & Yaspo, M. L. (2000). The DNA sequence of human chromosome 21. Nature, 405, 311–319. Jyothy, A., Kumar, K. S., Rao, G. N., Rao, V. B., Swarna, M., Devi, B. U., Sujatha, M., Kumari, C. K., & Reddy, P. P. (2000). Cytogenetic studies of 1001 Down syndrome cases from Andhra Pradesh, India. Indian Journal of Medical Research, 111, 133-137. Kernan, K. T. & Sabsay, S. (1996). Linguistic and cognitive ability of adults with Down syndrome and mental retardation of unknown etiology. Journal of Communication Disorder, 29, 401-421. Koulischer, L. & Gillerot, Y. (1980). Down's syndrome in Wallonia (South Belgium) , 1971-1978: Cytogenetic and incidence. Human Genetics, 54(2), 243-250. Lejeune, J., Gautier, M., & Turpin, R. (1959). Etude des chromosomes somatiques de neu enfants mongoliens. CR Acad Sci Paris, 248, 1721-1722. Masaki, M. (1981). Mortality and survival for Down syndrome in Japan. American Journal of Human Genetics, 33, 629-639. McAlaster, R. (1992). Postnatal cerebral maturation in Down’s syndrome children: a developmental EEG coherence study. Internal Journal of Neuroscience, 65, 221–237. McDade, H. L. & Adler, S. (1980). Down syndrome and short-term memory impairment: A storage or retrieval deficit? American Journal of Mental Deficiency, 84, 561-567. McDonald, J. L. (1997). Language acquisition: The acquisition of linguistic structure in normal and special populations. Annual Review of Psychology, 48, 215-241. Mulcahy, M. T. (1979). Down's syndrome in Western Australia: Cytogenetics and incidence. Human Genetics, 48(1), 67-72. Nadel, L. (2003). Down’s syndrome: a genetic disorder in biobehavioral perspective. Genes, Brain and Behavior, 2, 156–166. Nilholm, C. (1996). Early intervention with children with Down syndrome - past and future issues. Down Syndrome Research and Practice, 4(2), 51-58. Oliver, C. & Holland, A. J. (1986). Down's syndrome and Alzheimer's disease: A review. Psychological Medicine, 16, 307-322. Papp, Z., Osztovics, M., Schuler, D., Mehes, K., Czeizel, E., Horvath, L., Szemere, G., & Laszlo, J. (1977). Down's syndrome: Chromosome analysis of 362 cases in Hungary. Human Heredity, 27(5), 305-309. Pennington, B. F., Moon, J., Edgin, J., Stedron, J., & Nadel, L. (2003). The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction. Child Development, 74, 75–93. Piaget, J. (1983). Piaget's theory. In P. Mussen (ed). Handbook of Child Psychology, 4th edition. New York: Wiley. Pinter, J. D., Eliez, S., Schmitt, J. E., Capone, G. T., & Reiss, A. L. (2001). Neuroanatomy of Down's Syndrome: A high-resolution MRI study. American Journal of Psychiatry, 158, 1659-1665. Pueschel, S. P., Zartler, G. A., & Pezzullo, J. (1987). Cognitive and learning processes in children with Down's syndrome. Research in Developmental Disabilities, 8(1), 21-37. Pueschel, S. M. (1990). Clinical aspects of Down syndrome from infancy to adulthood. American Journal of Medical Genetics (suppl.), 7, 52-6. Rachidi, M. & Lopes, C. (2007). Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms. Neuroscience Research, 59(4), 349-369. Roberts, J. E., Price, J., & Malkin, C. (2007). Language and communication development in Down syndrome. Mental Retardation and Developmental Disabilities Research Reviews, 13(1), 26-35. Roid, G. H. (2005). Stanford-Binet Intelligence Scales (SB5), Fifth Edition: Technical Manual. Rolling Meadows, IL: Riverside Publishing Company. Schmidt-Sidor, B., Wisniewski, K., Shepard, T. H., & Sersen, E. A. (1990). Brain growth in Down syndrome subjects 15–22 weeks of gestational age and birth to 60 months. Clinical Neuropathology, 9, 181–190. Seung, H-K. & Chapman, R. S. (2004). Sentence memory in individuals with Down syndrome and typically developing children. Journal of Intellectual Disability Research, 48, 160-171.s Shapiro, B. L. (2001). Developmental instability of the cerebellum and its relevance to Down syndrome. Journal of Neural Transmission (Suppl.), 61, 11–34. Stefaninia, S., Casellib, M. C., & Volterrab, V. (2007). Spoken and gestural production in a naming task by young children with Down syndrome. Brain and Language, 101(3), 208-221. Teipel, S. J. & Hampel, H. (2006). Neuroanatomy of Down syndrome in vivo: A model of preclinical Alzheimer's disease. Behavior Genetics, 36(3), 405-415. Tomas, M. S., Annaz, D., Ansari, D., Scerif, G., Jarrold, C., & Karmiloff-Smith, A. (2009). Using developmental trajectories to understand developmental disorders. Journal of Speech Language & Hearing Research, 52(2), 336-358. Tsao, R. & Kindelberger, C. (2009). Variability of cognitive development in children with Down syndrome: relevance of good reasons for using the cluster procedure. Research in Developmental Disabilities, 30(3), 426-432. Vicari, S., Albertini, G., & Caltagirone, C. (1992). Cognitive profiles in adolescents with mental retardation. Journal of Intellectual Disability Research, 36(5), 415-423. Vicari, S. (2006). Motor development and neuropsychological patterns in persons with Down syndrome. Behavior Genetics, 36(3), 355-364. Wang, P. P. & Bellugi, U. (1993). Williams syndrome, Down syndrome and cognitive neuroscience. American Journal of Diseases of Children, 147, 1246-1251. Whittle, N., Sartori, S. B., Dierssen, M., Lubec, G., & Singewald, N. (2007). Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics, 120(6), 1465-1471. Wisniewski, K. E. (1990). Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis. American Journal of Medical Genetics (Suppl.), 7, 274-281. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44306 | - |
| dc.description.abstract | 國外文獻資料顯示，隨著年齡增長，唐氏症患者的智商有下降的趨勢，但國內仍缺乏相關研究資料。臨床案例觀察可發現唐氏症患者的語言能力較弱，且文獻資料已顯示唐氏症之神經心理功能與其腦部生理特徵有所關聯，因此，本研究進一步探討：隨年齡增長，患者之語文-非語文能力之發展分歧是否增大。
本研究以2002-2009年曾於臺大醫院就診並接受筆者評估之57名唐氏症患者為受試者 (男性23人、女性34人；平均年齡為8歲3個月)，其中12人 (男性4人、女性8人) 有追蹤評估資料，可作前後測之比較 (前測之平均年齡為4歲6個月，後測之平均年齡為6歲9個月，前後測之時間間隔介於14-50個月)。納入分析的心理測驗資料包含貝莉嬰幼兒認知發展量表、斯比智力量表及魏氏幼兒/兒童/成人智力量表等測驗分數；在分數指標上，則有語文智商、非語文智商及總智商等三項智能指標，以及發展心理年齡指標。 本研究結果指出： (一) 在語文智商上，女生顯著高於男生；在非語文智商及總智商上，男女生則無顯著差異。 (二) 智商有隨年齡增長而下降之趨勢，且在5歲之前的降幅最明顯。 (三) 在語言功能和聽覺記憶功能上，不同年齡組之發展心理年齡皆無顯著差異；在視覺空間功能上，不同年齡組之發展心理年齡則有顯著差異，尤其是大於10歲的受試者，其非語文之視覺空間功能有較明顯的發展。此外，語文-非語文能力之發展分歧隨前後測時間間隔越長而有差距增大的傾向，呈正相關但未達統計顯著水準。 | zh_TW |
| dc.description.abstract | Background Previous foreign studies revealed that the IQ in Down syndrome (DS) declines with age, but not any investigation of domestic data in Taiwan was available. Individuals with DS are characterized by limited verbal development, and in this article, authors look into the diverging verbal-nonverbal abilities in the DS phenotype.
Method The present study investigated this by analysis the test results of development /intelligence scales of 57 people with DS (34 females, 23 males; mean age 8 years 3 months). To compare initial cross-sectional data with longitudinal follow-up, 12 in 57 people were included (8 females, 4 males; initial mean age 4 years 6 months, follow-up mean age 6 years 9 months). Results 1) Female subjects had higher verbal IQ, but no significant gender differences in nonverbal IQ and full-scale IQ; 2) IQs declined with age, that came up before age 5 years; 3) There was a significant increase in mental age (MA) of visuospatial function at follow-up, but no such increases was found in MA of verbal subscale(s). Besides, there was a positive correlation between follow-up age interval and verbal-nonverbal divergence, but not be statistically significant. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T02:50:07Z (GMT). No. of bitstreams: 1 ntu-98-P96448008-1.pdf: 634312 bytes, checksum: ea822d9e87c77151a4c709d8c38d3e46 (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | 口試委員會審定書 i
誌謝 ii 中文摘要 iii 英文摘要 iv 第一章 緒論 1 第一節 研究動機 1 第二節 文獻探討 1 壹、唐氏症簡介 1 貳、唐氏症之身心發展 4 参、智能障礙和唐氏症的病理機制 6 肆、唐氏症患者之腦部生理特徵 7 伍、唐氏症患者之神經心理功能 10 第三節 研究目的 12 第二章 研究方法 14 第一節 研究對象 14 第二節 資料分析架構 14 壹、全部個案資料分析 (研究一) 14 貳、個案資料縱貫分析 (研究二) 15 第三節 測量工具 16 壹、貝莉嬰幼兒發展量表 17 貳、斯比智力量表 17 参、魏氏智力量表系列 18 第四節 分數指標 20 壹、智能指標 20 貳、神經心理功能指標 21 第五節 統計分析 22 第三章 研究結果 23 第一節 受試樣本之人口統計資料 23 第二節 研究一：全部個案資料分析 24 壹、不同性別之智商差異比較 25 貳、不同年齡層之智商變化趨勢 25 参、語文/非語文能力發展之差異比較 31 第三節 研究二：個案資料縱貫分析 32 壹、智商發展趨勢及前後測之差異比較 32 貳、語文/非語文能力之前後測的差異比較 35 第四章 討論 39 第一節 研究結果與文獻資料之比較 39 壹、性別差異 39 貳、智能發展趨勢 39 参、神經心理功能之發展程度 40 第二節 研究限制及未來研究方向 42 壹、受試者取樣之限制 42 貳、心理測驗結果分析與解釋之限制 43 第三節 研究結果之應用 45 參考文獻 49 | |
| dc.language.iso | zh-TW | |
| dc.subject | 遺傳諮詢 | zh_TW |
| dc.subject | 唐氏症 | zh_TW |
| dc.subject | 智商 | zh_TW |
| dc.subject | 心理年齡 | zh_TW |
| dc.subject | 神經心理功能 | zh_TW |
| dc.subject | Down syndrome | en |
| dc.subject | genetic counseling | en |
| dc.subject | neuropsychological function | en |
| dc.subject | mental age | en |
| dc.subject | IQ | en |
| dc.title | 唐氏症患者智能發展趨勢及語文與非語文能力分歧之探討 | zh_TW |
| dc.title | Trends in intellectual development, and diverging verbal and non-verbal abilities in the Down syndrome phenotype | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 黃璉華,郭乃文 | |
| dc.subject.keyword | 唐氏症,智商,心理年齡,神經心理功能,遺傳諮詢, | zh_TW |
| dc.subject.keyword | Down syndrome,IQ,mental age,neuropsychological function,genetic counseling, | en |
| dc.relation.page | 54 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-08-05 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 分子醫學研究所 | zh_TW |
| 顯示於系所單位： | 分子醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-98-1.pdf 未授權公開取用 | 619.45 kB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。