請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44201完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 施文彬 | |
| dc.contributor.author | Tz-Shian Chen | en |
| dc.contributor.author | 陳資憲 | zh_TW |
| dc.date.accessioned | 2021-06-15T02:44:40Z | - |
| dc.date.available | 2009-08-11 | |
| dc.date.copyright | 2009-08-11 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-08-10 | |
| dc.identifier.citation | Reference
[1] M. J. Madou, Fundamentals of microfabrication-the science of miniaturization second edition, second ed.: CRC PRESS, 2002. [2] S. Haeberle and R. Zengerle, 'Microfluidic platforms for lab-on-a-chip applications,' Lab on a Chip, vol. 7, pp. 1094-1110, 2007. [3] J. C. Giddings, 'Field-flow fractionation - analysis of macromolecular, colloidal, and particulate materials,' Science, vol. 260, pp. 1456-1465, 1993. [4] Y. C. Tan, J. S. Fisher, A. I. Lee, V. Cristini, and A. P. Lee, 'Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting,' Lab on a Chip, vol. 4, pp. 292-298, 2004. [5] M. Berger, 'Design of a microfabricated magnetic cell separator,' Electrophoresis, vol. 22, pp. 3883-3892, 2001. [6] S. Zheng, R. Yung, Y. Tai, and H. Kasdan, 'Deterministic lateral displacement MEMS device for continuous blood cell separation,' Proc. IEEE MEMS’05 Conference, Miami, pp. 851-854, 2005. [7] A. E. Guber, M. Heckele, D. Herrmann, A. Muslija, V. Saile, L. Eichhorn, T. Gietzelt, W. Hoffmann, P. C. Hauser, J. Tanyanyiwa, A. Gerlach, N. Gottschlich, and G. Knebel, 'Microfluidic lab-on-a-chip systems based on polymers - fabrication and application,' Chemical Engineering Journal, vol. 101, pp. 447-453, 2004. [8] P. Wilding, L. J. Kricka, J. Cheng, G. Hvichia, M. A. Shoffner, and P. Fortina, 'Integrated cell isolation and polymerase chain reaction analysis using silicon microfilter chambers,' Analytical Biochemistry, vol. 257, pp. 95-100, 1998. [9] X. Yang, J. Yang, Y. Tai, and C. Ho, 'Micromachined membrane particle filters,' Sensors & Actuators: A. Physical, vol. 73, pp. 184-191, 1999. [10] H. Sato, T. Kakinuma, J. S. Go, and S. Shoji, 'In-channel 3-D micromesh structures using maskless multi-angle exposures and their microfilter application,' Sensors and Actuators a-Physical, vol. 111, pp. 87-92, 2004. [11] J. Han, S. H. Lee, Y. Heo, C. J. Hwang, C. H. Ahn, and Ieee, 'An on-chip blood serum separator using self-assembled silica microsphere filter,' in 13th International Conference on Solid-State Sensors, Actuators and Microsystems, Seoul, South Korea, pp. 1688-1691, 2005. [12] S. Thorslund, O. Klett, F. Nikolajeff, K. Markides, and J. Bergquist, 'A hybrid poly (dimethylsiloxane) microsystem for on-chip whole blood filtration optimized for steroid screening,' Biomedical Microdevices, vol. 8, pp. 73-79, 2006. [13] S. Khumpuang, T. Tanaka, F. Aita, Z. Meng, K. Ooe, M. Ikeda, Y. Omori, K. Miyamura, H. Yonezawa, K. Matsumoto, and S. Sugiyama, 'Blood plasma separation device using capillary phenomenon,' Transducers '07 , pp. 1967-1970, 2007. [14] L.-J. Yang, T.-J. Yao, and Y.-C. Tai, 'The marching velocity of the capillary meniscus in a microchannel,' Journal of Micromechanics and Microengineering, vol. 14, pp. 220-225, 2004. [15] K. Y. Suh, S. Chu, and H. H. Lee, 'W-shaped meniscus from thin polymer films in microchannels,' Journal of Micromechanics and Microengineering, vol. 14, pp. 1185-1189, 2004. [16] W. F. Huang, Q. S. Liu, and Y. Li, 'Capillary filling flows inside patterned-surface microchannels,' Chemical Engineering & Technology, vol. 29, pp. 716-723, 2006. [17] Budiono, D. Byun, V. D. Nyugen, J. Kim, and H. S. Ko, 'Free surface transition and momentum augmentation of liquid flow in Micro/Nano-scale channels with hydrophobic and hydrophilic surfaces,' Journal of Mechanical Science and Technology, vol. 22, pp. 2554-2562, 2008. [18] D. Cheng, Y. Choe, and H. Jiang, 'Controlled Liquid–Air Interfaces and Interfacial Polymer Micromembranes in Microfluidic Channels,' Microelectromechanical Systems, Journal of, vol. 17, pp. 962-973, 2008. [19] P. F. Man, C. H. Mastrangelo, M. A. Burns, and D. T. Burke, 'Microfabricated capillarity-driven stop valve and sample injector,' in Micro Electro Mechanical Systems, 1998. MEMS 98. Proceedings., The Eleventh Annual International Workshop on, pp. 45-50, 1998. [20] T. S. Leu and P. Y. Chang, 'Pressure barrier of capillary stop valves in micro sample separators,' Sensors and Actuators a-Physical, vol. 115, pp. 508-515, 2004. [21] J. M. Chen, C. Y. Chen, and C. H. Liu, 'Pressure barrier in an axisymmetric capillary microchannel with sudden expansion,' Japanese Journal of Applied Physics, vol. 47, pp. 1683-1689, 2008. [22] H. Cho, H. Y. Kim, J. Y. Kang, and T. S. Kim, 'How the capillary burst microvalve works,' Journal of Colloid and Interface Science, vol. 306, pp. 379-385, 2007. [23] R. Clift, Bubbles, drops, and particles, New York : Academic Press, 1978. [24] P.-G. de Gennes, F. Brochard-Wyart, and D. Quere, Capillarity and Wetting Phenomena: Drops, Bubbles, Pearls, Waves: Springer, 2004. [25] R. Johnson Jr and R. Dettre, 'Wettability and contact angles,' Surface and Colloid Science, vol. 2, pp. 85–153, 1969. [26] T. Dang-vu and J. Hupka, 'Characterization of porous materials by capillary rise method,' Physicochemical Problems of Mineral Processing, vol. 39, pp. 47-65, 2005. [27] Neil A. Campbell, J. B. Reece, M. R. Taylor, and E. J. Simon, Biology. San Francisco : Pearson/Benjamin Cummings, 2009. [28] D. E. Brooks, 'Interactions among erythrocytes under shear,' Journal of Applied Physiology, vol. 28, p. 172, 1970. [29] W. P. Shih, C. Y. Hui, and N. C. Tien, 'Collapse of microchannels during anodic bonding: Theory and experiments,' Journal of Applied Physics, vol. 95, pp. 2800-2808, 2004. [30] Y. Lung-Jieh, L. Wei-Zhi, Y. Tze-Jung, and T. Yu-Chong, 'Photo-patternable gelatin as protection layers in surface micromachinings,' Sensors Actuators A, vol. 103, pp. 284-290, 2003 [31] L. Wei-Chih and Y. Lung-Jieh, 'The patterning of glutaraldehyde-crosslinked gelatin,' Proc. IEEE MEMS’04 Conference, Maastricht, The Netherlands, pp. 173-176, 2004. [32] E. Ermantraut, K. Wohlfart, and W. Tichelaar, 'Perforated support foils with pre-defined hole size, shape and arrangement,' Ultramicroscopy, vol. 74, pp. 75-81, 1998. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44201 | - |
| dc.description.abstract | 本研究設計一具有全血分離功能之生醫晶片，藉由嵌入在微流道中的濾層，將血球與血漿做分離。製作研發多孔隙的尼龍材料作為濾層，此濾層孔徑大小約100 nm。血漿中的特殊抗原可以通過此濾層之孔洞。可嵌入濾層的微流道利用毛細力幫助血漿在其內流動。此晶片具有可拋棄的特性，並可運用於重點照護檢驗( point-of-care diagnostics)或微全分析系統 (micro total analysis system)。並且從表面能量理論出發，對在毛細管內的流動的液體建立模型與分析。最後建立一個觀測測量實驗，量測毛細管內新月形液面的變化。藉由所拍攝的新月形液面形狀，分析新月形液面的改變，並將實驗結果與理論模型做比較。 | zh_TW |
| dc.description.abstract | A bio-chip with the capability of conducting blood separation for whole blood diagnostics has been proposed in this study. Blood cells and serum are separated by embedding filters in the microchannel. The filter have been fabricated and evaluated. The filter is made of porous nylon with the pore size of about 100 nm. Specific antibodies in the serum can pass through the filter. The microchannel which contains the filter has been properly designed so that the serum flow is facilitated by the capillary force. The fabricated device is disposable and can be potentially applied in point-of-care diagnostics or micro total analysis system (μTAS). And base on the surface energy theory to model and analyze the liquid flow in a capillary. Final, an observation experiment of measuring the variation of meniscus in a capillary is set up. By capturing the figures of meniscus shape, analyze the meniscus variation and compare the experiment data with the model solution. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T02:44:40Z (GMT). No. of bitstreams: 1 ntu-98-R96522515-1.pdf: 7045238 bytes, checksum: 310a7eb181fd957107a30374793070c6 (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | Table of Contents
致謝 I 摘要 II Abstract III Table of Contents IV List of Figures VIII List of Tables XIII List of Appendix Figures XIII Chapter1. Introduction 1 1.1. Background 1 1.2. Motivation 2 1.3. Document Review 3 Chapter2. Design Principle and Consideration 13 2.1. Design Concept and Purpose 13 2.2. Buckingham Pi Theorem 14 2.2.1. Bond Number 14 2.2.2. Capillary Length 16 2.2.3. Capillary Number 17 2.2.4. Theory Analysis 17 2.3. Capillarity 18 2.3.1. Washburn’s Law 18 2.3.2. Young-Laplace Equation 19 2.3.3. Surface Energy 20 2.4. Darcy’s Law for Porous Material 22 2.5. Blood Properties 23 2.5.1. Blood Composition 23 2.5.2. Blood Cells 23 2.5.3. Blood Flow Characteristic 24 2.5.4. Blood Diagnostics 25 Chapter3. Blood Separation Chip 26 3.1. Material 26 3.2. Blood Separation Chip Fabrication 27 3.2.1. Porous Nylon Filter 27 3.2.2. Poly-di-methyl-siloxane (PDMS) Microchannel 34 3.2.3. Poly-methyl-meth-acrylate (PMMA) Mold 37 3.2.4. Silicon Substrate and Oxygen Plasma Bonding 38 3.3. Whole Blood Filtration Experiment 38 3.4. Summary 40 Chapter4. Capillary Modeling and Observation of Meniscus Evolution 41 4.1. Capillary Modeling 41 4.2. Observation of Meniscus Evolution 56 4.2.1. Capillary Channel Chip Fabrication 56 4.2.2. Observation Apparatus Setting 60 Chapter5. Experiment Results and Discussion 63 5.1. Observation Experiment 63 5.1.1. Meniscus Evolution 63 5.1.2. Relation between Pressure Drop and Meniscus 69 5.2. Measurement Method 73 5.3. Experiment Result 73 5.4. Discussion 77 Chapter6. Conclusion and Future Work 79 6.1. Blood Separation Chip 79 6.2. Capillary Modeling 79 6.3. Future Work 80 Appendix: a 3D Biological Filtration Matrix using Self-assembled Microspheres inside Microchannels and Gelatin Sacrificial layer 82 Abstract 82 Introduction 83 Design and Fabrication 83 Demonstration and Experiment Result 91 Conclusion 93 Reference 96 | |
| dc.language.iso | en | |
| dc.subject | 毛細管 | zh_TW |
| dc.subject | 壓力阻礙 | zh_TW |
| dc.subject | 新月形液面 | zh_TW |
| dc.subject | 表面能量 | zh_TW |
| dc.subject | 多孔隙 | zh_TW |
| dc.subject | 分離 | zh_TW |
| dc.subject | meniscus | en |
| dc.subject | surface energy | en |
| dc.subject | capillary | en |
| dc.subject | separation | en |
| dc.subject | porous | en |
| dc.subject | pressure barrier | en |
| dc.title | 多孔隙材應用於生醫晶片之製備與流體特性探討 | zh_TW |
| dc.title | Fabrication and Microfluidic Investigation of Porous Materials for Bio-chip Applications | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 楊龍杰,戴慶良 | |
| dc.subject.keyword | 多孔隙,分離,毛細管,表面能量,新月形液面,壓力阻礙, | zh_TW |
| dc.subject.keyword | porous,separation,capillary,surface energy,meniscus,pressure barrier, | en |
| dc.relation.page | 99 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-08-10 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
| 顯示於系所單位： | 機械工程學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-98-1.pdf 未授權公開取用 | 6.88 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。