以自我編排方式合成複雜車輪烷

Abstract

本實驗室先前發表了利用固態Diels-Alder反應來合成車輪烷，進一步的希望利用不同大環分子與分子辨識單元之間的鍵結強弱與尺寸，以及封鎖基團反應性的差異，透過自我編排的方式在固態條件下進行複雜車輪烷的合成。

The efficient synthesis of asymmetrical rotaxanes with different macrocycles and stoppers remains to be a challenged task in the field of supramolecular chemistry. Recently, we report a solvent-free stoppering approach, which allows the efficient interlocking of few macrocycles in the form of [2]rotaxanes. Combining the concept of self-sorting, we plan to construct an asymmetrical [3]rotaxane, in which two macrocycles in different sizes are interlocked efficiently by their corresponding stoppers through a simple solvent-free reaction.