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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈雅敬(Ya-Ching Shen) | |
| dc.contributor.author | Tzu-Ching Liao | en |
| dc.contributor.author | 廖梓晴 | zh_TW |
| dc.date.accessioned | 2021-06-15T01:16:28Z | - |
| dc.date.available | 2014-09-15 | |
| dc.date.copyright | 2009-09-15 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-07-28 | |
| dc.identifier.citation | 1. W. Z. Song and P. G. Xiao, Chin. Tradit. Herbal Drugs, 1982, 13, 40-43.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42566 | - |
| dc.description.abstract | 本論文主要研究台灣產阿里山五味子 (Schisandra arisanensis Hayata) 果實之丙酮萃取物，並分析鑑定所含的降三萜類成分，共分離得到十個降三萜類化合物。其中包括了六個新化合物，分別命名為arisanlactones A-F (1-6)，以及四個已知化合物，分別是schindilactone D (7)、schindilactone E (8)、pre-schisanartanin A (9)和pre-schisanartanin B (10)。
新化合物1-6為降三萜類，其中化合物1為一新骨架具有5/5/7/9/5-fused pentacyclic環系統，化合物2為wuweiziartane-type骨架，包含一新的合環結構；而化合物3-5為pre-schisanartane-type 骨架，化合物6和7為schisanartane-type骨架。以上所有化合物結構鑑定主要是利用一維及二維核磁共振圖譜 (包括1H-NMR、13C-NMR、DEPT90與DEPT135、1H-1H COSY、HMQC、HMBC、NOESY等實驗)，再加上質譜與各種光譜數據，包括紅外光、紫外光、旋光儀，並且比對過去文獻相關化合物的數據而得。在立體結構解析方面，則是利用NOESY圖譜、分子模型以及X-ray單晶繞射來建立。同時，對化合物1-10的生合成路徑做了推測與討論。 | zh_TW |
| dc.description.abstract | This research focuses on nortriterpenoids isolated from the fruits of Taiwanese medicinal plant Schisandra arisanensis Hayata. Fractionatin of acetone extract by extensive chromatographic analysis afforded six new nortriterpenoids, arisanlactones A-F (1-6), together with four known compounds, schindilactone D (7), schindilactone E (8), pre-schisanartanin A (9) and pre-schisanartanin B (10).
Compound 1 belongs to an unprecedented skeleton possessing a 5/5/7/9/5-fused pentacyclic ring system. Compound 2, a wuweiziartane-type skeleton, also contains a new class of fused ring system. Compounds 3-5 are categorized as a pre-schisanartane-type, and compound 6 is a schisanartane-type nortriterpenoid. All the structures of the above compounds were elucidated by 1D, 2D-NMR and Mass, in addition to several physical methods including IR, UV, and single crystal X-ray diffraction analysis, and comparing the spectroscopic data with those in the published papers. The relative configuration of compounds 1-6 was established by NOESY spectra and single crystal X-ray diffraction analysis. Plausible biosynthesis pathway of compounds 1-10 were also discussed. | en |
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| dc.description.tableofcontents | 中文摘要 I
英文摘要 II 第一章序論 1 第一節前言 1 第二節研究動機與展望 2 第三節相關化合物之文獻回顧 3 第二章材料及方法 24 第一節 材料介紹 24 第二節分離流程 25 第三節實驗儀器 29 第三章實驗結果 31 第一節化合物1 之結構解析 32 第二節化合物2 之結構解析 43 第三節化合物3 之結構解析 51 第四節化合物4 之結構解析 59 第五節 化合物5 之結構解析 66 第六節 化合物6 之結構解析 73 第七節 化合物7 之結構 80 第八節 化合物8 之結構 87 第九節 化合物9 之結構 94 第十節化合物10 之結構 101 第四章討論與結論 109 第五章參考文獻 120 | |
| dc.language.iso | zh-TW | |
| dc.subject | schisanartane-type | zh_TW |
| dc.subject | 阿里山五味子 | zh_TW |
| dc.subject | 類 | zh_TW |
| dc.subject | 降三萜 | zh_TW |
| dc.subject | wuweiziartane-type | zh_TW |
| dc.subject | pre-schisanartane-type | zh_TW |
| dc.subject | Schisandra arisanensis Hayata | en |
| dc.subject | schisanartane-type | en |
| dc.subject | pre-schisanartane-type | en |
| dc.subject | wuweiziartane-type | en |
| dc.subject | nortriterpenoid | en |
| dc.title | 阿里山五味子果實新穎三萜類成分之研究 | zh_TW |
| dc.title | Studies on the Novel Triterpenoids from Fruits of Schisandra arisanensis Hayata | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李水盛(Shoei-Sheng Lee),周宏農(Hung-Nung Chou) | |
| dc.subject.keyword | 阿里山五味子,降三萜,類,wuweiziartane-type,pre-schisanartane-type,schisanartane-type, | zh_TW |
| dc.subject.keyword | Schisandra arisanensis Hayata,nortriterpenoid,wuweiziartane-type,pre-schisanartane-type,schisanartane-type, | en |
| dc.relation.page | 129 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-07-28 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥學研究所 | zh_TW |
| 顯示於系所單位： | 藥學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-98-1.pdf 未授權公開取用 | 6.52 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。