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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 盧國賢 | |
| dc.contributor.author | Hsiu-Ni Kung | en |
| dc.contributor.author | 龔秀妮 | zh_TW |
| dc.date.accessioned | 2021-06-15T00:56:36Z | - |
| dc.date.available | 2013-09-11 | |
| dc.date.copyright | 2008-09-11 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-08-04 | |
| dc.identifier.citation | 1. Alessi, D.R., A.Cuenda, P.Cohen, D.T.Dudley, and A.R.Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489-27494.
2. Assimopoulou, A.N. and V.P.Papageorgiou. 2005. Radical scavenging activity of Alkanna tinctoria root extracts and their main constituents, hydroxynaphthoquinones. Phytother. Res. 19:141-147. 3. Awale, S., T.Kawakami, Y.Tezuka, J.Y.Ueda, K.Tanaka, and S.Kadota. 2005. Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil. Chem. Pharm. Bull. (Tokyo) 53:710-713. 4. Ben-Yosef, Y., N.Lahat, S.Shapiro, H.Bitterman, and A.Miller. 2002. Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation. Circ. Res. 90:784-791. 5. Bose, C., C.Bhuvaneswaran, and K.B.Udupa. 2005. Age-related alteration in hepatic acyl-CoA: cholesterol acyltransferase and its relation to LDL receptor and MAPK. Mech. Ageing Dev. 126:740-751. 6. Chang, H. and S.E.Suzuka. 1982. Lawsone (2-OH-1,4-naphthoquinone) derived form the henna plant increases the oxygen affinity of sickle cell blood. Biochem. Biophys. Res. Commun. 107:602-608. 7. Chang, T.W. and L.Weinstein. 1975. Inactivation of Treponema pallidum by silver sulfadiazine. Antimicrob. Agents Chemother. 7:538-539. 8. Chau, Y.P., S.G.Shiah, M.J.Don, and M.L.Kuo. 1998. Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells. Free Radic. Biol. Med. 24:660-670. 9. Chen, H., O.Charlat, L.A.Tartaglia, E.A.Woolf, X.Weng, S.J.Ellis, N.D.Lakey, J.Culpepper, K.J.Moore, R.E.Breitbart, G.M.Duyk, R.I.Tepper, and J.P.Morgenstern. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495. 10. Daniel Mowrey. 1993. Herbal tonic Therapies. Keats Publishing, Inc., New Canaan, Connecticut. pp.70-89 11. Davidson, J.M. 1992. Inflammation: Basic Pirinciples and Clinical Correlates. Raven Press, New York. pp.809-819 12. Davis, R.J. 1993. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:14553-14556. 13. de Almeida, E.R., A.A.da Silva Filho, E.R.dos Santos, and C.A.Lopes. 1990. Antiinflammatory action of lapachol. J. Ethnopharmacol. 29:239-241. 14. De Meyts P., C.T.Christoffersen, B.Urso, B.Wallach, K.Gronskov, F.Yakushiji, and R.M.Shymko. 1995. Role of the time factor in signaling specificity: application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases. Metabolism 44:2-11. 15. Denton, R.M. and J.M.Tavare. 1995. Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against. Eur. J. Biochem. 227:597-611. 16. Don, M.J., Y.H.Chang, K.K.Chen, L.K.Ho, and Y.P.Chau. 2001. Induction of CDK inhibitors (p21(WAF1) and p27(Kip1)) and Bak in the beta-lapachone-induced apoptosis of human prostate cancer cells. Mol. Pharmacol. 59:784-794. 17. Doza, Y.N., A.Cuenda, G.M.Thomas, P.Cohen, and A.R.Nebreda. 1995. Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. FEBS Lett. 364:223-228. 18. Edgell, C.J., J.E.Haizlip, C.R.Bagnell, J.P.Packenham, P.Harrison, B.Wilbourn, and V.J.Madden. 1990. Endothelium specific Weibel-Palade bodies in a continuous human cell line, EA.hy926. In Vitro Cell Dev. Biol. 26:1167-1172. 19. Edgell, C.J., C.C.McDonald, and J.B.Graham. 1983. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. U. S. A 80:3734-3737. 20. Ellinger-Ziegelbauer, H., K.Brown, K.Kelly, and U.Siebenlist. 1997. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivatives. J. Biol. Chem. 272:2668-2674. 21. Fischer, J.W., C.Tschope, A.Reinecke, C.M.Giachelli, and T.Unger. 1998. Upregulation of osteopontin expression in renal cortex of streptozotocin-induced diabetic rats is mediated by bradykinin. Diabetes 47:1512-1518. 22. Forbes, J.M., M.E.Cooper, M.D.Oldfield, and M.C.Thomas. 2003. Role of advanced glycation end products in diabetic nephropathy. J. Am. Soc. Nephrol. 14:S254-S258. 23. Frey, M.R., R.S.Dise, K.L.Edelblum, and D.B.Polk. 2006. p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J. 25:5683-5692. 24. Frey, M.R., A.Golovin, and D.B.Polk. 2004. Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling. J. Biol. Chem. 279:44513-44521. 25. Gabbiani, G., B.J.Hirschel, G.B.Ryan, P.R.Statkov, and G.Majno. 1972. Granulation tissue as a contractile organ. A study of structure and function. J. Exp. Med. 135:719-734. 26. Gadeau, A.P., M.Campan, D.Millet, T.Candresse, and C.Desgranges. 1993. Osteopontin overexpression is associated with arterial smooth muscle cell proliferation in vitro. Arterioscler. Thromb. 13:120-125. 27. Ghilardi, N., S.Ziegler, A.Wiestner, R.Stoffel, M.H.Heim, and R.C.Skoda. 1996. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. U. S. A 93:6231-6235. 28. Gosens, R., G.L.Stelmack, G.Dueck, K.D.McNeill, A.Yamasaki, W.T.Gerthoffer, H.Unruh, A.S.Gounni, J.Zaagsma, and A.J.Halayko. 2006. Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Am. J. Physiol Lung Cell Mol. Physiol 291:L523-L534. 29. Gratton, J.P., P.Bernatchez, and W.C.Sessa. 2004. Caveolae and caveolins in the cardiovascular system. Circ. Res. 94:1408-1417. 30. Greenhalgh, D.G., K.H.Sprugel, M.J.Murray, and R.Ross. 1990. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am. J. Pathol. 136:1235-1246. 31. Grinnell, F. 1994. Fibroblasts, myofibroblasts, and wound contraction. J. Cell Biol. 124:401-404. 32. Haynes, M.P., D.Sinha, K.S.Russell, M.Collinge, D.Fulton, M.Morales-Ruiz, W.C.Sessa, and J.R.Bender. 2000. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ. Res. 87:677-682. 33. Hosoi, T., Y.Okuma, and Y.Nomura. 2002. Leptin induces IL-1 receptor antagonist expression in the brain. Biochem. Biophys. Res. Commun. 294:215-219. 34. Hunter, T. 1995. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80:225-236. 35. Juliano, R.L. and S.Haskill. 1993. Signal transduction from the extracellular matrix. J. Cell Biol. 120:577-585. 36. Katz, M.H., A.F.Alvarez, R.S.Kirsner, W.H.Eaglstein, and V.Falanga. 1991. Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth. J. Am. Acad. Dermatol. 25:1054-1058. 37. Keyse, S.M. 1995. An emerging family of dual specificity MAP kinase phosphatases. Biochim. Biophys. Acta 1265:152-160. 38. Kim, T.J. and Y.P.Yun. 2007. Potent inhibition of serum-stimulated responses in vascular smooth muscle cell proliferation by 2-chloro-3-(4-hexylphenyl)-amino-1,4-naphthoquinone, a newly synthesized 1,4-naphthoquinone derivative. Biol. Pharm. Bull. 30:121-127. 39. Kinghorn AD, B.M.e. 1992. American Chemical Symposium Series. Human Medicinal Agents from Plan . American Chemical Society, Washington, DC. pp.16-17 40. Kohn, R.R., A.Cerami, and V.M.Monnier. 1984. Collagen aging in vitro by nonenzymatic glycosylation and browning. Diabetes 33:57-59. 41. Kumara Swamy, H.M., V.Krishna, K.Shankarmurthy, R.B.Abdul, K.L.Mankani, K.M.Mahadevan, B.G.Harish, and N.H.Raja. 2007. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm. J. Ethnopharmacol. 109:529-534. 42. Lai, C.C., T.J.Liu, L.K.Ho, M.J.Don, and Y.P.Chau. 1998. beta-Lapachone induced cell death in human hepatoma (HepA2) cells. Histol. Histopathol. 13:89-97. 43. Liaw, L., D.M.Lombardi, M.M.Almeida, S.M.Schwartz, D.deBlois, and C.M.Giachelli. 1997. Neutralizing antibodies directed against osteopontin inhibit rat carotid neointimal thickening after endothelial denudation. Arterioscler. Thromb. Vasc. Biol. 17:188-193. 44. Lin, M.T., C.C.Chang, S.T.Chen, H.L.Chang, J.L.Su, Y.P.Chau, and M.L.Kuo. 2004. Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation. J. Biol. Chem. 279:24015-24023. 45. Lira, A.A., E.A.Sester, A.L.Carvalho, R.R.Strattmann, M.M.Albuquerque, A.G.Wanderley, and D.P.Santana. 2008. Development of lapachol topical formulation: anti-inflammatory study of a selected formulation. AAPS. PharmSciTech. 9:163-168. 46. Liu, B., E.J.Ryer, R.Kundi, K.Kamiya, H.Itoh, P.L.Faries, K.Sakakibara, and K.C.Kent. 2007. Protein kinase C-delta regulates migration and proliferation of vascular smooth muscle cells through the extracellular signal-regulated kinase 1/2. J. Vasc. Surg. 45:160-168. 47. Liu, S.H., H.P.Tzeng, M.L.Kuo, and S.Y.Lin-Shiau. 1999. Inhibition of inducible nitric oxide synthase by beta-lapachone in rat alveolar macrophages and aorta. Br. J. Pharmacol. 126:746-750. 48. Liu, T.J., S.Y.Lin, and Y.P.Chau. 2002. Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. Toxicol. Appl. Pharmacol. 182:116-125. 49. Lollmann, B., S.Gruninger, A.Stricker-Krongrad, and M.Chiesi. 1997. Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues. Biochem. Biophys. Res. Commun. 238:648-652. 50. Lowbury, E.J., J.R.Babb, K.Bridges, and D.M.Jackson. 1976. Topical chemoprophylaxis with silver sulphadiazine and silver nitrate chlorhexidine creams: emergence of sulphonamide-resistant Gram-negative bacilli. Br. Med. J. 1:493-496. 51. Lu, F.L., R.A.Johnston, L.Flynt, T.A.Theman, R.D.Terry, I.N.Schwartzman, A.Lee, and S.A.Shore. 2006. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am. J. Physiol Lung Cell Mol. Physiol 290:L856-L865. 52. Lum, H. and K.A.Roebuck. 2001. Oxidant stress and endothelial cell dysfunction. Am. J. Physiol Cell Physiol 280:C719-C741. 53. Martin, P. 1997. Wound healing - Aiming for perfect skin regeneration. Science 276:75-81. 54. Meadows, K.N., P.Bryant, and K.Pumiglia. 2001. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J. Biol. Chem. 276:49289-49298. 55. Mehrotra, M., S.M.Krane, K.Walters, and C.Pilbeam. 2004. Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cells. J. Cell Biochem. 93:741-752. 56. Monnier, V.M., R.R.Kohn, and A.Cerami. 1984. Accelerated age-related browning of human collagen in diabetes mellitus. Proc. Natl. Acad. Sci. U. S. A. 81:583-587. 57. Moon, D.O., Y.H.Choi, N.D.Kim, Y.M.Park, and G.Y.Kim. 2007. Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. Int. Immunopharmacol. 7:506-514. 58. Muller, L., O.Valdenaire, A.Barret, P.Korth, F.Pinet, P.Corvol, and C.Tougard. 2000. Expression of the endothelin-converting enzyme-1 isoforms in endothelial cells. J. Cardiovasc. Pharmacol. 36:S15-S18. 59. Munoz-Chapuli, R., A.R.Quesada, and M.M.Angel. 2004. Angiogenesis and signal transduction in endothelial cells. Cell Mol. Life Sci. 61:2224-2243. 60. Murray, A.W. 1998. MAP kinases in meiosis. Cell 92:157-159. 61. Neel, B.G. and N.K.Tonks. 1997. Protein tyrosine phosphatases in signal transduction. Curr. Opin. Cell Biol. 9:193-204. 62. Nishina, P.M., S.Lowe, J.Wang, and B.Paigen. 1994. Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43:549-553. 63. Ono, K. and J.Han. 2000. The p38 signal transduction pathway: activation and function. Cell Signal. 12:1-13. 64. Ough, M., A.Lewis, E.A.Bey, J.Gao, J.M.Ritchie, W.Bornmann, D.A.Boothman, L.W.Oberley, and J.J.Cullen. 2005. Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. Cancer Biol. Ther. 4:95-102. 65. Payne, D.M., A.J.Rossomando, P.Martino, A.K.Erickson, J.H.Her, J.Shabanowitz, D.F.Hunt, M.J.Weber, and T.W.Sturgill. 1991. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J. 10:885-892. 66. Pereira, C.F., L.A.Boven, J.Middel, J.Verhoef, and H.S.Nottet. 2000. Induction of cyclooxygenase-2 expression during HIV-1-infected monocyte-derived macrophage and human brain microvascular endothelial cell interactions. J. Leukoc. Biol. 68:423-428. 67. Pereira, E.M., T.B.Machado, I.C.Leal, D.M.Jesus, C.R.Damaso, A.V.Pinto, M.Giambiagi-deMarval, R.M.Kuster, and K.R.Santos. 2006. Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis. Ann. Clin. Microbiol. Antimicrob. 5:5. 68. Peterson, T.E., M.E.Guicciardi, R.Gulati, L.S.Kleppe, C.S.Mueske, M.Mookadam, G.Sowa, G.J.Gores, W.C.Sessa, and R.D.Simari. 2003. Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arterioscler. Thromb. Vasc. Biol. 23:1521-1527. 69. Pink, J.J., S.M.Planchon, C.Tagliarino, M.E.Varnes, D.Siegel, and D.A.Boothman. 2000. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J. Biol. Chem. 275:5416-5424. 70. Pizzorno JE, M.MT. 1999. Textbook of Natural Medicine. Churchill Livingstone, New York. pp. 967-974 71. Robbers JE, T.VE. 1999. Herbs of Choice: The Therapeutic Use of Phytomedicinals. The Haworth Herbal Press, New York, NY. pp. 246-247 72. Rothberg, K.G., J.E.Heuser, W.C.Donzell, Y.S.Ying, J.R.Glenney, and R.G.Anderson. 1992. Caveolin, a protein component of caveolae membrane coats. Cell 68:673-682. 73. Rudolph, R.B.J.V.a.E.H.P. 1992. Wound contraction and scar contracture. In Wound Healing: Biochemical and Clinical Aspects. Philadelphia, editor. W. B. Saunders., 114. 74. Ruoslahti, E. and E.Engvall. 1997. Integrins and vascular extracellular matrix assembly. J. Clin. Invest 99:1149-1152. 75. Saika, S. 2004. TGF-beta signal transduction in corneal wound healing as a therapeutic target. Cornea 23:S25-S30. 76. Sakurai, S., H.Yonekura, Y.Yamamoto, T.Watanabe, N.Tanaka, H.Li, A.K.Rahman, K.M.Myint, C.H.Kim, and H.Yamamoto. 2003. The AGE-RAGE system and diabetic nephropathy. J. Am. Soc. Nephrol. 14:S259-S263. 77. Salameh, A., F.Galvagni, M.Bardelli, F.Bussolino, and S.Oliviero. 2005. Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. Blood 106:3423-3431. 78. Schaeffer, H.J. and M.J.Weber. 1999. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell Biol. 19:2435-2444. 79. Schaffner-Sabba, K., K.H.Schmidt-Ruppin, W.Wehrli, A.R.Schuerch, and J.W.Wasley. 1984. beta-Lapachone: synthesis of derivatives and activities in tumor models. J. Med. Chem. 27:990-994. 80. Serra, A., M.L.Granada, R.Romero, B.Bayes, A.Canton, J.Bonet, M.Rull, A.Alastrue, and X.Formiguera. 2006. The effect of bariatric surgery on adipocytokines, renal parameters and other cardiovascular risk factors in severe and very severe obesity: 1-year follow-up. Clin. Nutr. 25:400-408. 81. Shakarjian, M.P. and R.A.Carchman. 1990. Alteration of human granulocyte functional responses by menadione. Arch. Biochem. Biophys. 283:1-11. 82. Sharma, G.D., J.He, and H.E.Bazan. 2003. p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. J. Biol. Chem. 278:21989-21997. 83. Shaul, P.W. and R.G.Anderson. 1998. Role of plasmalemmal caveolae in signal transduction. Am. J. Physiol 275:L843-L851. 84. Shiah, S.G., S.E.Chuang, Y.P.Chau, S.C.Shen, and M.L.Kuo. 1999. Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor beta-lapachone-induced apoptosis through an oxidation-dependent pathway. Cancer Res. 59:391-398. 85. Siegel, D. and D.Ross. 2000. Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. Free Radic. Biol. Med. 29:246-253. 86. Singer, A.J. and R.A.Clark. 1999. Cutaneous wound healing. N. Engl. J. Med. 341:738-746. 87. Sodhi, C.P., D.Batlle, and A.Sahai. 2000. Osteopontin mediates hypoxia-induced proliferation of cultured mesangial cells: role of PKC and p38 MAPK. Kidney Int. 58:691-700. 88. Stan, R.V. 2002. Structure and function of endothelial caveolae. Microsc. Res. Tech. 57:350-364. 89. Staton, C.A., N.J.Brown, and C.E.Lewis. 2003. The role of fibrinogen and related fragments in tumour angiogenesis and metastasis. Expert. Opin. Biol. Ther. 3:1105-1120. 90. Stehr, M., R.M.Adam, J.Khoury, L.Zhuang, K.R.Solomon, C.A.Peters, and M.R.Freeman. 2003. Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling. J. Urol. 169:1165-1170. 91. Stula, M., H.D.Orzechowski, S.Gschwend, R.Vetter, H.R.von, R.Dietz, and M.Paul. 2000. Influence of sustained mechanical stress on Egr-1 mRNA expression in cultured human endothelial cells. Mol. Cell Biochem. 210:101-108. 92. Tagliarino, C., J.J.Pink, K.E.Reinicke, S.M.Simmers, S.M.Wuerzberger-Davis, and D.A.Boothman. 2003. Mu-calpain activation in beta-lapachone-mediated apoptosis. Cancer Biol. Ther. 2:141-152. 93. Tanaka, K., M.Abe, and Y.Sato. 1999. Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis. Jpn. J. Cancer Res. 90:647-654. 94. Tzeng, H.P., F.M.Ho, K.F.Chao, M.L.Kuo, S.Y.Lin-Shiau, and S.H.Liu. 2003. beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality. Am. J. Respir. Crit Care Med. 168:85-91. 95. Ueda, S., T.Umemura, K.Dohguchi, T.Matsuzaki, H.Tokuda, H.Nishino, and A.Iwashima. 1994. Production of anti-tumour-promoting furanonaphthoquinones in Tabebuia avellanedae cell cultures. Phytochemistry 36:323-325. 96. van der Geer P., T.Hunter, and R.A.Lindberg. 1994. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10:251-337. 97. van Oost, B.A., C.J.Edgell, C.W.Hay, and R.T.MacGillivray. 1986. Isolation of a human von Willebrand factor cDNA from the hybrid endothelial cell line EA.hy926. Biochem. Cell Biol. 64:699-705. 98. Vincent, A.M., M.J.Stevens, C.Backus, L.L.McLean, and E.L.Feldman. 2005. Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury. Antioxid. Redox. Signal. 7:1494-1506. 99. Wagner, H., B.Kreher, and K.Jurcic. 1986. Immunological Investigations of Naphthaquinone-containing Plant Extracts, Isolated Quinones and other Cytostatic Compounds in Cellular Immunosystems. Planta Med. 52:550. 100. Wahab, N.A., L.Schaefer, B.S.Weston, O.Yiannikouris, A.Wright, A.Babelova, R.Schaefer, and R.M.Mason. 2005. Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli. Diabetologia 48:2650-2660. 101. Werner, S. and R.Grose. 2003. Regulation of wound healing by growth factors and cytokines. Physiol Rev. 83:835-870. 102. Wetzler, C., H.Kampfer, B.Stallmeyer, J.Pfeilschifter, and S.Frank. 2000. Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J. Invest Dermatol. 115:245-253. 103. Widmann, C., S.Gibson, M.B.Jarpe, and G.L.Johnson. 1999. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev. 79:143-180. 104. Winstanley, E.W. 1976. The connective-tissue reaction in the healing of full-thickness excised skin wounds in the thoracic and metatarsal regions of the dog. J. Comp Pathol. 86:211-219. 105. Wu, T.W., L.H.Zeng, J.Wu, and K.P.Fung. 1994. Morin: a wood pigment that protects three types of human cells in the cardiovascular system against oxyradical damage. Biochem. Pharmacol. 47:1099-1103. 106. Yamaguchi, M., S.Uchiyama, and Y.Tsukamoto. 2002. Stimulatory effect of menaquinone-7 on bone formation in elderly female rat femoral tissues in vitro: prevention of bone deterioration with aging. Int. J. Mol. Med. 10:729-733. 107. Yashima, R., M.Abe, K.Tanaka, H.Ueno, K.Shitara, S.Takenoshita, and Y.Sato. 2001. Heterogeneity of the signal transduction pathways for VEGF-induced MAPKs activation in human vascular endothelial cells. J. Cell Physiol 188:201-210. 108. Zavan, B., P.Brun, V.Vindigni, A.Amadori, W.Habeler, P.Pontisso, D.Montemurro, G.Abatangelo, and R.Cortivo. 2005. Extracellular matrix-enriched polymeric scaffolds as a substrate for hepatocyte cultures: in vitro and in vivo studies. Biomaterials 26:7038-7045. 109. Zhang, J.H., T.D.Chung, and K.R.Oldenburg. 1999. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen. 4:67-73. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42269 | - |
| dc.description.abstract | beta-lapachone，是由lapacho樹(Tabebuia avellanedae)樹皮中萃取出來的天然聚合物，目前已證實：在不同的濃度和條件下，beta-lapachone對癌症、發炎、病毒和寄生蟲有很好的抵抗性。但beta-lapachone對傷口癒合的影響則仍懸而未解，尚需要進ㄧ步的研究證實。本論文的研究目的就是探討 beta-lapachone是否能刺激不同的細胞生長及移行能力的效應、並且探究 beta-lapachone促進傷口癒合的過程機轉，進而討論 beta-lapachone作為傷口癒合促進藥劑的可能性。
傷口癒合是個相當複雜的過程，需要許多不同種類細胞的合作才能完成。在這樣的過程中，內皮細胞和纖維母細胞佔有非常重要的角色，他們負責產生新的細胞外基質，讓其他的細胞得以移動到傷口處生長，使傷口復原。在我們的實驗中，證實：(1) 低濃度的beta-lapachone確實可以增加細胞增生，包括有人類新生兒角質細胞(HEKn)、老鼠角質細胞(XB-2)、人類纖維母細胞(HS68)、老鼠纖維母細胞(3T3)、人類臍帶靜脈內皮細胞(HUVEC)及人類內皮細胞(EAhy926)；(2) beta-lapachone透過MAPK訊息傳遞路徑促進老鼠纖維母細胞(3T3)和人類內皮細胞(EAhy926)的增生和移行能力；(3) 不論在正常(C57BL/6)老鼠或是糖尿病(db/db)鼠身上，beta-lapachone都可以透過ERK 訊息傳遞路徑加速傷口的癒合。另外，beta-lapachone還可以刺激巨噬細胞分泌血管內皮生長因子(VEGF)和表皮生長因子(EGF)，這兩種生長因子對於許多種類細胞的生長都是非常有助益的。 全球糖尿病盛行率正以驚人的速度攀升，糖尿病儼然成為醫界之最大挑戰。糖尿病患者常受神經病變、傷口不易癒合、和全身感染之苦。對糖尿病患者來說，傷口癒合的延遲是ㄧ個很嚴重的問題，若能加速傷口癒合可以免除截肢的危險。 在本論文中，我們確認 beta-lapachone可以增加角質細胞、纖維母細胞和內皮細胞的增生；促進纖維母細胞和內皮細胞的移動能力；並且加速正常和糖尿病老鼠傷口癒合的過程。因此，beta-lapachone具有成為傷口癒合治療藥物的潛力，也許能成為臨床用藥。 | zh_TW |
| dc.description.abstract | Impaired wound healing is a serious problem for diabetic patients. Wound healing is a complex process that requires the cooperation of many cell types, including keratinocytes, fibroblasts, endothelial cells, and macrophages. beta-Lapachone, a natural compound extracted from the bark of the lapacho tree (Tabebuia avellanedae), is well known for its anti-tumor, anti-inflammatory, and anti-neoplastic effects at different concentrations and conditions, but its effects on wound-healing have not been studied. The purpose of the present study was to investigate the effects of beta-lapachone on the wound healing and its underlying mechanism.
In this study, we demonstrated that a low dose of beta-lapachone enhanced the proliferation in several types of cells, including keratinocytes, fibroblasts, and endothelial cells, facilitated the migration of mouse 3T3 fibroblasts and human endothelial EAhy926 cells through different MAPK signaling pathways, and accelerated scrape-wound healing in vitro. Application of ointment with or without beta-lapachone to a punched wound in normal and diabetic (db/db) mice showed that the healing process was faster in beta-lapachone-treated animals than in those treated with vehicle only. In addition, beta-lapachone induced macrophages to release VEGF and EGF that are beneficial for growth of many cells. We also proved that ERK signal is indeed involved in the beta-lapachone-facilitated wound healing in vivo. Our results showed that beta-lapachone can increase the cell proliferation including keratinocytes, fibroblasts and endothelial cells and the migration of fibroblasts and endothelial cells and thus accelerate wound healing in vitro and in vivo. Therefore, we suggest that beta-lapachone may have potential for therapeutic use for wound healing. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T00:56:36Z (GMT). No. of bitstreams: 1 ntu-97-D92446007-1.pdf: 6672136 bytes, checksum: fb7a24d47c5e942472225d35e75e069c (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 目錄
致謝 -------------------------------------------- 1 縮寫表------------------------------------------- 3 中文摘要----------------------------------------- 4 Abstract ------------------------------------------ 6 Part I: beta-lapachone promotes cell proliferation and migration through MAPK signaling. ----------------------------------------- 8 Abstract --------------------------------------------------------- 9 Introduction ----------------------------------------------------- 11 Materials and Methods --------------------------------------- 16 Results ---------------------------------------------------------- 22 Discussion ------------------------------------------------------ 27 Part II: beta-lapachone facilitates wound healing in vivo. ------- 32 Abstract --------------------------------------------------------- 33 Introduction ----------------------------------------------------- 34 Materials and Methods ---------------------------------------- 40 Results ----------------------------------------------------------- 44 Discussions ----------------------------------------------------- 47 Part III: Conclusion ------------------------------------------------ 50 Conclusion ------------------------------------------------------ 51 Part IV Figures ---------------------------------------------------- 52 References --------------------------------------------------------- 81 Appendix ----------------------------------------------------------- 103 Perspective I --------------------------------------------------- 104 Perspective II -------------------------------------------------- 106 Perspective III ------------------------------------------------- 108 Papers-----------------------------------------------------------------110 | |
| dc.language.iso | en | |
| dc.subject | 傷口癒合 | zh_TW |
| dc.subject | 細胞增生 | zh_TW |
| dc.subject | MAPK訊息傳遞 | zh_TW |
| dc.subject | wound healing | en |
| dc.subject | MAPK signaling pathways | en |
| dc.subject | cell proliferation | en |
| dc.subject | β-Lapachone | en |
| dc.title | beta-lapachone在傷口癒合上的效應 | zh_TW |
| dc.title | Effects of beta-lapachone on wound healing | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 王淑美,謝松蒼,周逸鵬,歐陽品,郭明良 | |
| dc.subject.keyword | 細胞增生,MAPK訊息傳遞,傷口癒合, | zh_TW |
| dc.subject.keyword | β-Lapachone,cell proliferation,MAPK signaling pathways,wound healing, | en |
| dc.relation.page | 114 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-08-04 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 解剖學暨生物細胞學研究所 | zh_TW |
| 顯示於系所單位： | 解剖學暨細胞生物學科所 | |
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