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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 董成淵 | |
| dc.contributor.author | Hsien-Chung Lee | en |
| dc.contributor.author | 李憲忠 | zh_TW |
| dc.date.accessioned | 2021-06-15T00:46:10Z | - |
| dc.date.available | 2010-09-02 | |
| dc.date.copyright | 2008-09-02 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-08-26 | |
| dc.identifier.citation | 1.Hsin-Yuan Tan et al. Multiphoton Fluorescence and Second Harmonic Generation Imaging of the Structural Alterations in Keratoconus Ex Vivo. IOVS. 2006;47:5251-5259.
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Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627. 11.Cosimo Mazzotta et al. Treatment of Progressive Keratoconus by Riboflavin-UVA-Induced Cross-Linking of Corneal Collagen. Cornea. 2007;26:390-397. 12.Eberhard Spoerl, Theo Seiler, et al. Safety of UVA-Riboflavin Cross-Linking of the Cornea. Cornea. 2007;26:385-389. 13.Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine cornea after riboflavin/ultraviolet-A-induced crosslinking. J Cataract Refract Surg. 2003;29:1780-1785. 14.Denk W, Strickler JH, Web WW. 2-Photon laser scanning fluorescence microscopy. Science. 1990;248:73-76. 15.So PTC, Dong CY, Masters BR, Berland KM. Two-photon excitation fluorescence microscopy. Annu Rev Biomed Eng. 2000;2:399-429. 16.Zoumi A, Yeh A, Tromberg BJ. Imaging cells and extracellular matrix in vivo by using second-harmonic generation and twophoton excited fluorescence. 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An Integral Representation of the Image Field. Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences. 1959;253:349-357. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42091 | - |
| dc.description.abstract | The purpose of this study is to assess the possible application of second harmonic generation (SHG) microscopy for demonstrating the structural alterations of bovine cornea following riboflavin-UVA-induced cross-linking treatment, and to investigate its potential as being a clinical in vivo monitoring technique of cross-linking treatment. Riboflavin and UVA cross-linking treatment has been applied in the clinics for improving biomechanical strength in ecstatic corneal diseases including keratoconus and keratectasia following refractive surgery. Increasing the degree of cross-linking of stromal collagen may help to halt the progression of ecstatic changes of cornea. However, the efficacy and extension of current cross-linking protocol could not be quantified using current optical monitoring system. In this work, we attempted to use the non-invasive optical SHG imaging technique for demonstrating and quantifying the degree of cross-linking of stromal collagen in an experimental bovine corneal model. We found that significant curvy changes of parallel aligned corneal collagen fibers could be identified with SHG imaging. We proposed that SHG imaging can be an effective monitoring and quantifying system for evaluation of the efficacy of cross-linking treatment in the cornea. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T00:46:10Z (GMT). No. of bitstreams: 1 ntu-97-P94222001-1.pdf: 3747798 bytes, checksum: ddaaa8df3051762904dbce6b7aa8a833 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | Table of Contents
口試委員會審定書…………………………………………………i Acknowledgement………………………………………………ii 中文摘要……………………………………………………………iii Abstract………………………………………………………………iv List of Figures………………………………………………………vi List of Tables…………………………………………………………vii Chapter 1 Introduction……………………………………………1 1.1 Cornea and Collagen………………………………………3 1.2 Keratoconus and Treatments………………………………6 Chapter 2 Second Harmonic Generation (SHG) Microscopy………10 2.1 Second Harmonic Generation (SHG)……………………10 2.2 Related Concepts for BSHG, FSHG, and PSHG………15 Chapter 3 Riboflavin-UVA-induced Cross-linking Treatment……20 3.1 Riboflavin and Ultraviolet Irradiation……………………20 3.2 Performance and Safety…………………………………23 Chapter 4 Materials and Methods…………………………………27 4.1 Sample Preparation……………27 4.2 Riboflavin-UVA Cross-linking Procedures…………………………………………………31 4.3 SHG Imaging of Cornea Specimens……………………32 Chapter 5 Results and Discussion………………………33 Chapter 6 Conclusion……………………………………………40 References…………………………………………………………41 | |
| dc.language.iso | en | |
| dc.subject | 交聯 | zh_TW |
| dc.subject | 牛眼角膜 | zh_TW |
| dc.subject | 二倍頻 | zh_TW |
| dc.subject | 核黃素 | zh_TW |
| dc.subject | 紫外光 | zh_TW |
| dc.subject | second harmonic generation | en |
| dc.subject | cross-linking | en |
| dc.subject | UVA | en |
| dc.subject | riboflavin | en |
| dc.subject | bovine cornea | en |
| dc.title | 以二倍頻顯微術觀測核黃素與紫外光誘導牛眼角膜膠原蛋白產生之交聯作用 | zh_TW |
| dc.title | Second Harmonic Generation Imaging of Riboflavin-UVA-Induced Cross-linking In Bovine Cornea | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張顏輝,石明豐,林頌然 | |
| dc.subject.keyword | 牛眼角膜,二倍頻,核黃素,紫外光,交聯, | zh_TW |
| dc.subject.keyword | bovine cornea,second harmonic generation,riboflavin,UVA,cross-linking, | en |
| dc.relation.page | 44 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-08-26 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 物理研究所 | zh_TW |
| 顯示於系所單位： | 物理學系 | |
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