犬隻糖尿病回溯性研究

Abstract

糖尿病是因為胰島素缺乏或胰島素不活化造成的複雜的症候群。狗的糖尿病和遺傳、性別、年齡以及飲食高度有關。我們以臺灣大學生物資源暨農學院附屬動物醫院的犬糖尿病病例為基礎，完成這份研究報告；內容包括犬糖尿病的盛行率、危險因子和臨床表現，以及兩種不同類型的胰島素(Caninsulin和IInsulatard)的治療狀況。和其他的報告一樣，我們的報告顯示糖尿病主要發生在母犬和中上年紀的犬隻。在接受胰島素治療的28隻狗裡面，使用的胰島素劑量也與其他報告類似。而且使用這兩種胰島素都能在四小時內有效地降低血糖濃度。而Insulatard(依照人的基因序列，利用基因工程技術製成的胰島素)和Caninsulin (豬來源的胰島素)兩者在控制糖尿病的劑量、最低血糖值以及降到最低血糖值所需的時間都很相近。顯示人來源或豬來源的胰島素，在治療犬糖尿病上，可以有同樣的藥效和作用。

Diabetes mellitus (DM) is a group of conditions of insulin deficient or insulin insensitivity. In dogs, DM is highly related to genetic background, gender, age and diet. The incidence, risk factors and clinical profile of canine diabetes mellitus was studied based on the medical records in the National Taiwan University Veterinary Hospital. The pharmaceutical action of two different types of insulin, Caninsulin and Insulatard, in diabetic dogs was also investigated. In the present study, we found that the condition was mainly affected female, middle to aged canine population which was similar to that of other investigations. The insulin dosage used in our well-controlled 28 cases was also similar as other studies. In these cases, both insulins have the ability to decrease blood glucose to the normal level in four hours. The resembling insulin dosage, nadir, and the time to nadir all suggest that in dogs, recombinant human insulin has similar potency and kinetics as porcine insulin.